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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | Study of heteroserum-induced rat liver fibrosis model and its mechanism显示文摘StudyofheteroseruminducedratliverfibrosismodelanditsmechanismHUANGZhiGang,ZHAIWeiRong,ZHANGYueEandZHANGXiuRongSubjecthea... | HUANG Zhi Gang, ZHAI Wei Rong, ZHANG Yue E and ZHANG Xiu Rong | 1998 | World Journal of Gastroenterology1998，4，3： | 22 |
| 3 | Pore throat characteristics of tight sandstone of Yanchang Formation in eastern Gansu,Ordos Basin显示文摘An important factor to evaluate reservoir quality is the pore-throat size.However,the strong heterogeneity makes it difficult to characterize the pore-throat distribution in tight reservoirs.The field emission scanning electron microscope(FESEM),high pressure mercury injection and rate-controlled mercury injection are used to investigate the pore-throat size distribution in tight sandstone reservoirs of Member 7 of the Yanchang Formation in eastern Gansu,Ordos Basin,and studies of the pore throat size controlling on physical property of the tight sandstone reservoirs are also carried out.The result shows that the pore type is mainly dominated by the residual intergranular pore,dissolution pore,micropore and a few micro-fractures;the high-pressure mercury injection experiment indicates that the pore-throat size ranges from 0.0148 μm to 40mm,the pore throat more than 1 mm is less;the ratecontrolled mercury injection experiment reveals that for samples with different physical properties,the pore radius mainly varies from 80 μm to 350 μm;the throat radius exhibits the strong heterogeneity,and is from 0.12 μm to 30μm;the pore-throat size can be effectively characterized by combination of high-pressure and rate-controlled mercury injections,and it varies from 0.0148 μm to 350 μm.The permeability is mainly controlled by the large pore throat(>R_(50))which accounts for a small proportion;in the tight sandstone with the permeability greater than 0.1 mD,the permeability is mainly controlled by the micropore and mesopore;in the tight sandstone with the permeability smaller than 0.1 mD,the permeability is mainly controlled by the nanopore and micropore;the proportion of small pore throat increases with reduction of permeability,it is important that the small pore throat influences the reservoir storage property though its effect on permeability are small. | Hao Wu Chunlin Zhang Youliang Ji Rui'e Liu Shang Cao Sheng Chen Yunzhao Zhang Ye Wang Wei Du Gang Liu | 2018 | Petroleum Research2018，3，1： | 7 |
| 4 | Support Vector Machines for Cloud Detection over Ice-Snow Areas显示文摘In polar regions, cloud and underlying ice-snow areas are difficult to distinguish in satellite images because of their high albedo in the visible band and low surface temperature of ice-snow areas in the infrared band. A cloud detection method over ice-snow covered areas in Antarctica is presented. On account of different texture features of cloud and ice-snow areas, five texture features are extracted based on GLCM. Nonlinear SVM is then used to obtain the optimal classification hyperplane from training data. The experiment results indicate that this algorithm performs well in cloud detection in Antarctica, especially for thin cirrus detection. Furthermore, when images are resampled to a quarter or 1/16 of the full size, cloud percentages are still at the same level, while the processing time decreases exponentially. | CHEN Gang E Dongchen | 2007 | Geo-Spatial Information Science2007，10，2： | 6 |
| 5 | The Low Lake-Level Record according to the Selin Co Stratigraphical Basis and Multi-Proxies during the Last Glacial Maximum in the Central Tibetan Plateau显示文摘Objective The lake levels in the eastern and southern Asia are regarded as low lake-level owing to precipitation decreasing based on the records of lake-level fluctuation in the continental interior lakes since the last glacial maximum(LGM)(14C 18±1 kaBP,since 20 kaBP)in the Central Asia.Higher lake-level appeared in the transition belt between western Kunlun Mountain and the central Tibetan Plateau.Furthermore,the highest lake-level | ZHANG Chengjun DEMBELE Blaise ZHANG Wanyi ZHANG Jingya WANG Hansheng E Gang ZHENG Qi | 2018 | Acta Geologica Sinica(English Edition)2018，92，5： | 5 |
| 6 | 急性心肌梗塞心室晚电位检出率及其与梗塞早期室性心律失常...显示文摘 | 马虹 Gang,E | 1990 | 中华心血管病杂志1990，18，6： | 3 |
| 7 | Rapid phenotypic evolution with shallow genomic differentiation during early stages of high elevation adaptation in Eurasian Tree Sparrows显示文摘Known as the‘third polar region’,the Qinghai-Tibet Plateau represents one of the harshest highland environments in the world and yet a number of organisms thrive there.Previous studies of birds,animals and humans have focused on well-differentiated populations in later stages of phenotypic divergence.The adaptive processes during the initial phase of highland adaptation remain poorly understood.We studied a human commensal,the Eurasian Tree Sparrow,which has followed human agriculture to the Qinghai-Tibet Plateau.Despite strong phenotypic differentiation at multiple levels,in particular in muscle-related phenotypes,highland and lowland populations show shallow genomic divergence and the colonization event occurred within the past few thousand years.In a one-month acclimation experiment investigating phenotypic plasticity,we exposed adult lowland tree sparrows to a hypoxic environment and did not observe muscle changes.Through population genetic analyses,we identified a signature of polygenic adaptation,whereby shifts in allele frequencies are spread across multiple loci,many of which are associated with muscle-related processes.Our results reveal a case of positive selection in which polygenic adaptation appears to drive rapid phenotypic evolution,shedding light on early stages of adaptive evolution to a novel environment. | Yanhua Qu Chunhai Chen Ying Xiong Huishang She Yong E Zhang Yalin Cheng Shane DuBay Dongming Li Per G P Ericson Yan Hao Hongyuan Wang Hongfeng Zhao Gang Song Hailin Zhang Ting Yang Chi Zhang Liping Liang Tianyu Wu Jinyang Zhao Qiang Gao Weiwei Zhai Fumin Lei | 2020 | National Science Review2020，7，1： | 2 |
| 8 | GATA3 controls Foxp3^sup +^ regulatory T cell fate during inflammation in mice显示文摘 | Wohlfert Elizabeth A Grainger John R Bouladoux Nicolas Konkel Joanne E Oldenhove Guillaume Ribeiro Carolina Hager Hall Jason A Yagi Ryoji Naik Shruti Bhairavabhotla Ravikiran Paul William E Bosselut Remy Wei Gang Zhao Keji Oukka Mohamed Zhu | 2011 | Journal of Clinical Investigation2011，，11： | 2 |
| 9 | Variant angina associated with bitter orange in a dietary supplement显示文摘 | Gange C A Madias C Felix Gretzik E M | 2006 | Mayo Clinic Proc2006，81，： | 1 |
| 10 | Pax3 activation pro- motes the differentiation of mesenchymal stem cells toward the myogeniclinea显示文摘 | Gang E J Bosnakovski D Simsek T | 2008 | Exp Cell Res2008，314，8： | 1 |
| 11 | Pax3 activation promotes the differentiation of mesenchymal stem cells to- ward the myogenic lineage显示文摘 | Gang E J Bosnakovski D Simsek T | 2008 | Exp Cell Res2008，314，8： | 1 |
| 12 | Ⅲ EFIE-MFIE hybrid simulation using NEC:VSWR for the WISP experiment显示文摘 | Richie J E Gang H R | 1995 | IEEE Transactions on Electromagnetic Compatibility1995，37，2： | 1 |
| 13 | Relation- ship of chlorinedecay and THMs formation to NOM size 显示文摘 | GANG D CLEVENGER T E BANERJI S K | 2003 | Hazard Mater2003，96，： | 1 |
| 14 | Time-stepping along characteristics for a mixed finite- element approximation for compressible flow of contamination from nuclear waste in porous media显示文摘 | Ewing R E Yuan Yirang Li Gang | 1989 | SIAM J Numer Anal1989，26，6： | 1 |
| 15 | Nanotibrous membrane of wool keratose/silk fibroin blend for heavy metal ion adsorption显示文摘 | KI C S GANG E H UM I C | 2007 | J Membrance Sci2007，302，12： | 1 |
| 16 | In vitro differentiation of human umbilical cord blood-derived mesenchymal stem cells into hepatocyte-like ceils显示文摘 | Hong SH Gang E J Jeong JA | 2005 | Biochem Biophys Res Commun2005，330，4： | 1 |
| 17 | Cardiac surgery in Germany during 1997 显示文摘 | Kalmar P ln'gang E | 1998 | Thorac Cardiovasc Surg1998，46，5： | 1 |
| 18 | Linear response theory in stochastic resonance 显示文摘 | M I Dykman H Hakenb Gang Hud D G Luchinskya R Mannellaa P V E McClintocka C Z Ninggb N D Steina N G Stockse | 1993 | Physics Letters A1993，180，45： | 1 |
| 19 | Integral Sliding-Mode Control of a Magnetically Suspended Balance Beam: Analysis, Simulation, and Experiment 显示文摘 | Jun-Ho Lee Paul E Allaire Gang Tao Xuerui Zhang | 2001 | IEEE/ASME Transactions on Mechatronics (S 1004-731X)2001，6，3： | 1 |
| 20 | Using chlorine demand to predict TTHM and HAA9 formation显示文摘 | Daniel Dianchen Gang Robert L Segar Jr Thomas E Clevenger | 2002 | J AWWA2002，94，10： | 1 |
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