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| 1 | Renin-angiotensin system in the pathogenesis of liver fibrosis显示文摘Hepatic fibrosis is considered a common response to many chronic hepatic injuries.It is a multifunctional process that involves several cell types,cytokines,chemokines and growth factors leading to a disruption of homeostatic mechanisms that maintain the liver ecosystem.In spite of many studies regarding the development of fibrosis,the understanding of the pathogenesis remains obscure.The hepatic tissue remodeling process is highly complex,resulting from the balance between collagen degradation and synthesis.Among the many mediators that take part in this process,the components of the Renin angiotensin system(RAS) have progressively assumed an important role.Angiotensin(Ang)□acts as a profibrotic mediator and Ang-(1-7),the newly recognized RAS component,appears to exert a counter-regulatory role in liver tissue.We briefly review the liver fibrosis process and current aspects of the RAS.This review also aims to discuss some experimental evidence regarding the participation of RAS mediators in the pathogenesis of liver fibrosis,focusing on the putative role of the ACE2-Ang-(1-7)-Mas receptor axis. | Regina Maria Pereira Robson Augusto Souza dos Santos Filipi Leles da Costa Dias Mauro Martins Teixeira Ana Cristina Simoes e Silva | 2009 | World Journal of Gastroenterology2009，15，21： | 37 |
| 2 | Current knowledge on esophageal atresia显示文摘Esophageal atresia (EA) with or without tracheoesophageal fistula (TEF) is the most common congenital anomaly of the esophagus. The improvement of survival observed over the previous two decades is multifactorial and largely attributable to advances in neonatal intensive care, neonatal anesthesia, ventilatory and nutritional support, antibiotics, early surgical intervention, surgical materials and techniques. Indeed, mortality is currently limited to those cases with coexisting severe life-threatening anomalies. The diagnosis of EA is most commonly made during the first 24 h of life but may occur either antenatally or may be delayed. The primary surgical correction for EA and TEF is the best option in the absence of severe malformations. There is no ideal replacement for the esophagus and the optimal surgical treatment for patients with long-gap EA is still contro-versial. The primary complications during the postoperative period are leak and stenosis of the anastomosis, gastro-esophageal reflux, esophageal dysmotility, fistula recurrence, respiratory disorders and deformities of the thoracic wall. Data regarding long-term outcomes and follow-ups are limited for patients following EA/TEF repair. The determination of the risk factors for the complicated evolution following EA/TEF repair may positively impact long-term prognoses. Much remains to be studied regarding this condition. This manuscript provides a literature review of the current knowledge regarding EA. | Paulo Fernando Martins Pinheiro Ana Cristina Simoes e Silva Regina Maria Pereira | 2012 | World Journal of Gastroenterology2012，18，28： | 35 |
| 3 | Helicobacter pylori infection: Beyond gastric manifestations显示文摘Helicobacter pylori(H.pylori)is a bacterium that infects more than a half of world’s population.Although it is mainly related to the development of gastroduodenal diseases,several studies have shown that such infection may also influence the development and severity of various extragastric diseases.According to the current evidence,whereas this bacterium is a risk factor for some of these manifestations,it might play a protective role in other pathological conditions.In that context,when considered the gastrointestinal tract,H.pylori positivity have been related to Inflammatory Bowel Disease,Gastroesophageal Reflux Disease,Non-Alcoholic Fatty Liver Disease,Hepatic Carcinoma,Cholelithiasis,and Cholecystitis.Moreover,lower serum levels of iron and vitamin B12 have been found in patients with H.pylori infection,leading to the emergence of anemias in a portion of them.With regards to neurological manifestations,a growing number of studies have associated that bacterium with multiple sclerosis,Alzheimer’s disease,Parkinson’s disease,and Guillain-Barrésyndrome.Interestingly,the risk of developing cardiovascular disorders,such as atherosclerosis,is also influenced by the infection.Besides that,the H.pylori-associated inflammation may also lead to increased insulin resistance,leading to a higher risk of diabetes mellitus among infected individuals.Finally,the occurrence of dermatological and ophthalmic disorders have also been related to that microorganism.In this sense,this minireview aims to gather the main studies associating H.pylori infection with extragastric conditions,and also to explore the main mechanisms that may explain the role of H.pylori in those diseases. | Maria Luisa Cordeiro Santos Breno Bittencourt de Brito Filipe Antonio França da Silva Mariana Miranda Sampaio Hanna Santos Marques Natalia Oliveira e Silva Dulciene Maria de Magalhaes Queiroz Fabricio Freire de Melo | 2020 | World Journal of Gastroenterology2020，26，28： | 34 |
| 4 | Cerebral ischemia and neuroregeneration显示文摘Cerebral ischemia is one of the leading causes of morbidity and mortality worldwide. Although stroke(a form of cerebral ischemia)-related costs are expected to reach 240.67 billion dollars by 2030, options for treatment against cerebral ischemia/stroke are limited. All therapies except anti-thrombolytics(i.e., tissue plasminogen activator) and hypothermia have failed to reduce neuronal injury, neurological deficits, and mortality rates following cerebral ischemia, which suggests that development of novel therapies again st stroke/cerebral ischemia are urgently needed. Here, we discuss the possible mechanism(s) underlying cerebral ischemia-induced brain injury, as well as current and future novel therapies(i.e., growth factors, nicotinamide adenine dinucleotide, melatonin, resveratrol, protein kinase C isozymes, pifithrin, hypothermia, fatty acids, sympathoplegic drugs, and stem cells) as it relates to cerebral ischemia. | Reggie H.C.Lee Michelle H.H.Lee Celeste Y.C.Wu Alexandre Couto e Silva Harlee E.Possoit Tsung-Han Hsieh Alireza Minagar Hung Wen Lin | 2018 | Neural Regeneration Research2018，13，3： | 30 |
| 5 | Study of the production of Λ_b^0 band ~0 hadrons in pp collisions and first measurement of the Λ_b^0→J/ψpK^- branching fraction显示文摘The product of the A_b^0(B^0) differential production cross-section and the branching fraction of the decay A_b^0→J/ψpK^-(B^0→J/ψK~*(892)~0) is measured as a function of the beauty hadron transverse momentum,p_T,and rapidity,y.The kinematic region of the measurements is p_T <20 GeV/c and 2.0 | O.Kochebina M.Kolpin I.Komarov R.F.Koopman P.Koppenburg M.Kozeiha L.Kravchuk K.Kreplin M.Kreps G.Krocker P.Krokovny F.Kruse W.Krzemien W.Kucewicz M.Kucharczyk V.Kudryavtsev A.K.Kuonen K.Kurek T.Kvaratskheliya D.Lacarrere G.Lafferty A.Lai D.Lambert G.Lanffanchi C.Langenbruch B.Langhans T.Latham C.Lazzeroni R.Le Gac J.van Leerdam J.-P.Lees R.Lefevre A.Leflat J.Lefrancois E.Lemos Cid O.Leroy T.Lesiak B.Leverington Y.Li T.Likhomanenko M.Liles R.Lindner C.Linn F.Lionetto B.Liu X.Liu D.Loh I.Longstaff J.H.Lopes D.Lucchesi M.Lucio Martinez H.Luo A.Lupato E.Luppi O.Lupton A.Lusiani F.Machefert F.Maciuc O.Maev K.Maguire S.Malde A.Malinin G.Manca G.Mancinelli P.Manning A.Mapelli J.Maratas J.F.Marchand U.Marconi C.Marin Benito P.Marino J.Marks G.Martellottil M.Martin M.Martinelli D.Martinez Santos F.Martinez Vidal D.Martins Tostes A.Massafferri R.Matev A.Mathad Z.Mathe C.Matteuzzi A.Mauri B.Maurin A.Mazurov M.McCann J.McCarthy A.McNab R.McNulty B.Meadows F.Meier M.Meissner D.Melnychuk M.Merk E Michielin D.A.Milanes M.-N.Minard D.S.Mitzel J.Molina Rodrigue I.A.Monroy S.Monteil M.Morandin P.Morawski A.Morda M.J.Morello J.Moron A.B.Morris R.Mountain F.Muheim D.Miiller J.Muller K.Muller V.Muller M.Mussini B.Muster P.Naik T.Nakada R.Nandakumar A.Nandi I.Nasteva M.Needham N.Neri S.Neubert N.Neufeld M.Neuner A.D.Nguyen T.D.Nguyen C.Nguyen-Mau V.Niess R.Niet N.Nikitin T.Nikodem D.Ninci A.Novoselov D.P.O'Hanlon A.Oblakowska-Mucha V.Obraztsov S.Ogilvy O.Okhrimenko R.Oldeman C.J.G.Onderwater B.Osorio Rodrigues J.M.Otalora Goicochea A.Otto P.Owen A.Oyanguren A.Palano F.Palombo M.Palutan J.Panman A.Papanestis M.Pappagallo L.L.Pappalardo C.Pappenheimer C.Parkes G.Passaleva G.D.Patel M.Patel C.Patrignani A.Pearce A.Pellegrino G.Penso M.Pepe Altarelli S.Perazzini P.Perret L.Pescatore K.Petridis A.Petrolini M.Petruzzo E.Picatoste Olloqui B.Pietrzyk T:.Pilar D.Pinci A.Pistone A.Piucci S.Playfer M.Plo Casasus T.Poikela F.Polci A.Poluektov I.Polyakov E.Polycarpo A.Popov D.Popov B.Popovici C.Potterat E.Price J.D.Price J.Prisciandaro A.Pritchard C.Prouve V.Pugatch A.Puig Navarro G.Punzi W.Qian R.Quagliani B.Rachwal J.H.Rademacker M.Rama M.S.Rangel I.Raniuk N.Rauschmayr G.Raven F.Redi S.Reichert M.M.Reid A.C.dos Reis S.Ricciardi S.Richards M.Rihl K.Rinnert V.Rives Molina P.Robbe A.B.Rodrigues E.Rodrigues J.A.Rodriguez Lopez P.Rodriguez Perez S.Roiser V.Romanovsky A.Romero Vidalt J.W.R onayne M.Rotondo J.Rouvinet T.Ruf P.Ruiz Valls J.J.Saborido Silva N.Sagidova P.Sail B.Saitta V.Salustino Guimaraes C.Sanchez Mayordomo B.Sanmartin Sedes R.Santacesaria C.Santamarina Rios M.Santimaria E.Santovetti A.Sarti C.Satriano A.Satta D.M.Saunders D.Savrina M.Schiller H.Schindler M.Schlupp M.Schmelling T.Schmelzer B.Schmidt O.Schneider A.Schopper M.Schubiger M.-H.Schune R.Schwemmer B.Sciascia A.Sciubba A.Semennikov N.Serra J.Serrano L.Sestini P.Seyfert M.Shapkin I.Shapoval Y.Shcheglov T.Shears L.Shekhtman V.Shevchenko A.Shires B.G.Siddi R.Silva Coutinho L.Silva de Oliveira G.Simi M.Sirendi N.Skidmore T.Skwarnicki E.Smith E.Smith I.T.Smith J.Smith M.Smith H.Snoek M.D.Sokoloff F.J.P.Soler F.Soomro D.Souza B.Souza De Paula B.Spaan P.Spradlin S.Sridharan F.Stagni M.Stahl S.Stahl S.Stefkova O.Steinkamp O.Stenyakin S.Stevenson S.Stoica S.Stone B.Storaci S.Stracka M.Straticiuc U.Straumann L.Sun W.Sutcliffe K.Swientek S.Swientek V.Syropoulos M.Szczekowski P.Szczypka T.Szumlak S.T'Jampens A.Tayduganov T.Tekampe M.T eklishyn G.Teilarini F.Teubert C.Thomas E.Thomas J.van Tilburg V.Tisserand M.Tobin J.Todd S.Tolk L.Tomassetti D.Tonelli S.Topp-Joergensen N.Torr E.Tournefier S.Tourneur K.Trabelsi M.T.Tran M.Tresch A.Trisovic A.Tsaregorodtsev P.Tsopelas N.Tuning A.Ukleja A.Ustyuzhanin U.Uwer C.Vacca V.Vagnonit G.Valentit A.Vallier R.Vazquez Gomez P.Vazquez Regueiro C.Vazquez Sierra S.Vecchi J.J.Velthuis M.Veltri G.Veneziano M.Vesterinen B.Viaud D.Vieira M.Vieites Diaz X.Vitasis-Cardona V.Volkov A.Vollhardt D.Volyanskyy D.Voong A.Vorobyev V.Vorobyev C.Voβ J.A.de Vries R.Waldi C.Wallace R.Wallace J.Walsh S.Wandernoth J.Wang D.R.Ward N.K.Watson D.Websdale A.Weiden M.Whitehead G.Wilkinson M.Wilkinson M.Williams M.P.Williams T.Williams F.F.Wilson J.Wimberley J.Wishahi W.Wislicki M.Witek G.Wormser S.A.Wotton S.Wright K.Wyllie Y.Xie Z.Xu Z.Yang J.Yu X.Yuan O.Yushchenko M.Zangoli M.Zavertyaev L.Zhang Y.Zhang A.Zhelezov A.Zhokhov L.Zhong S.Zucchelli | 2016 | Chinese Physics C2016，40，1： | 23 |
| 6 | SMARCA4表达缺失是诊断卵巢高钙血症型小细胞癌既敏感又特异性的指标显示文摘卵巢高钙血症型小细胞癌是一种非常罕见的卵巢肿瘤,好发于年轻女性,预后差。临床因其罕见并具有相对非特异性的组织学特征,仅依靠组织学诊断极具有挑战性。组织学上卵巢高钙血症型小细胞癌具有从经典的、最初描述的小细胞形态到含丰富嗜酸性胞质的大细胞形态,因此需与多种肿瘤实体进行鉴别诊断。 | Conlon N Silva A Guerra E 魏建国(摘译) 许春伟(审校) | 2016 | 临床与实验病理学杂志2016，32，7： | 15 |
| 7 | Histone Acetyltransferase AtGCN5/HAG1 Is a Versatile Regulator of Developmental and Inducible Gene Expression in Arabidopsis显示文摘Histone acetylation/deacetylation 是一个动态过程并且在基因规定起一个重要作用。Histone acetylation 动态平衡被 histone acetyltransferases (帽子) 和 deacetylases (HDAC ) 的对手行动调整。植物染色体编码多重帽子和 HDAC。在许多植物开发的一个必要角色处理的 Arabidopsis 帽子基因 AtGCN5/HAG1plays 例如分裂组织功能,房间区别,叶和花的 organogenesis ,并且对象光和寒冷那样的环境条件的回答,在长期的发展开关和短期的可诱导的基因表示的规定显示这顶帽子的一个重要角色。AtGCN5 目标到很多倡导者并且为几 histone H3 离氨酸残余的 acetylation 被要求。到目标倡导者的 AtGCN5 的招募是可能的被和 DNA 有约束力的抄写因素的直接或间接的相互作用或由和 acetylated histone 离氨酸残余的相互作用在目标上调停。在 AtGCN5 和另外的帽子和 HDAC 之间的相互影响被表明控制特定的规章的小径。在光可诱导的基因表示的 AtGCN5 的角色的分析在为 priming 准备染色质承诺建议 AtGCN5 的功能在植物的可诱导的基因激活。 | Caroline Servet Natalia Conde e Silva Dao-Xiu Zhou | 2010 | Molecular Plant2010，3，4： | 14 |
| 8 | Renin angiotensin system in liver diseases: Friend or foe?显示文摘In the last three decades,the understanding of the renin angiotensin system(RAS)has been changed by the discoveries of functional local systems,novel biologically active peptides,additional specific receptors,alternative pathways of angiotensin(Ang)?Ⅱ?generation,and new roles for enzymes and precursor components other than those in Ang?Ⅱ?synthesis.In this regard,the discovery that Ang-(1-7)opposes the pressor,proliferative,pro-fibrotic,and pro-inflammatory effects mediated by Ang?Ⅱ?has contributed to the realization that the RAS is composed of two axes.The first axis consists of the angiotensin-converting enzyme(ACE),with Ang?Ⅱ?as the end product,and the angiotensin type 1(AT1)receptor as the main effector mediating the biological actions of Ang?Ⅱ.The second axis results from ACE2-mediated hydrolysis of Ang?Ⅱ,leading to the production of Ang-(1-7),with the Mas receptor as the main effector conveying the vasodilatory,antiproliferative,anti-fibrotic,and anti-inflammatory effects of Ang-(1-7).Experimental and clinical studies have shown that both axes of the RAS may take part in the pathogenesis of liver diseases.In this manuscript,we summarize the current evidence regarding the role of RAS in hepatic cirrhosis and its complications,including hemodynamic changes and hepatorenal syndrome.The therapeutic potential of the modulation of RAS molecules in liver diseases is also discussed. | Ana Cristina Simoes e Silva Aline S Miranda Natália P Rocha Antonio L Teixeira | 2017 | World Journal of Gastroenterology2017，23，19： | 12 |
| 9 | Relationship between angiotensin-(1-7) and angiotensin Ⅱ correlates with hemodynamic changes in human liver cirrhosis显示文摘AIM:To measure circulating angiotensins at different stages ofhuman cirrhosis and to further evaluate a possible relationship between renin angiotensin system (RAS) components and hemodynamic changes.METHODS: Patients were allocated into 4 groups: mild-to-moderate liver disease (MLD), advanced liver disease (ALD), patients undergoing liver transplantation, and healthy controls. Blood was collected to determine plasma renin activity (PRA), angiotensin (Ang) , Ang Ⅱ, and Ang-(1-7) levels using radioimmunoassays. During liver transplantation, hemodynamic parameters were determined and blood was simultaneously obtained from the portal vein and radial artery in order to measure RAS components.RESULTS: PRA and angiotensins were elevated in ALD when compared to MLD and controls (P < 0.05). In contrast, Ang was signicantly reduced in MLD. Ang-(1-7)/Ang Ⅱ ratios were increased in MLD when compared to controls and ALD. During transplantation, Ang Ⅱ levels were lower and Ang-(1-7)/Ang Ⅱ ratios were higher in the splanchnic circulation than in the peripheral circulation (0.52 ± 0.08 vs 0.38 ± 0.04, P < 0.02), whereas the peripheral circulating Ang /Ang ratio was elevated in comparison to splanchnic lev-els (0.18 ± 0.02 vs 0.13 ± 0.02, P < 0.04). Ang-(1-7)/Ang Ⅱ ratios positively correlated with cardiac output (r= 0.66) and negatively correlated with systemic vascular resistance (r =-0.70).CONCLUSION: Our ndings suggest that the relation-ship between Ang-(1-7) and Ang Ⅱmay play a role in the hemodynamic changes ofhuman cirrhosis. | Walkíria Wingester Vilas-Boas Antnio Ribeiro-Oliveira Jr Regina Maria Pereira Renata da Cunha Ribeiro Jerusa Almeida Ana Paula Nadu Ana Cristina Simoes e Silva Robson Augusto Souza dos Santos | 2009 | World Journal of Gastroenterology2009，15，20： | 11 |
| 10 | Comparative stability analyses of traditional and selective room-and-pillar mining techniques for sub-horizontal tungsten veins显示文摘The stability and productivity concerning a modification on the traditional room and pillar for a new selective technique at the Portuguese Panasqueira Mine have been described.The traditional room-and-pillar stoping uses 5.0-m wide rooms with 3.0 m×3.0 m pillars,while the selective room-and-pillar mining technique consists in stoping with rooms of 4.0 m wide and pillars of 4 m×4 m with a subsequent selective cutting of the quartz veins at the mid pillar of approximately 0.5 m high,to obtain a pillar section with an area of 3.0 m×3.0 m.The stability and productivity analyses indicate that the selective technique obtains smaller average pillar safety factor,more rock mass displacement,more extraction and selectivity ratios,and ore grade improvement,compared with the traditional technique.These results show that the selective technique is also more convenient.This proposed selective room-and-pillar mining technique is applicable to any sub-horizontal narrow quartz veins with wolfram,gold,etc.such as the famous La Rinconada gold mine in the Peruvian Andes. | Vidal Felix Navarro Torres Carlos Dinis da Gama Matilde Costa e Silva Paula Falcao Neves Qiang Xie | 2011 | International Journal of Minerals,Metallurgy and Materials2011，18，1： | 7 |
| 11 | Resistance and susceptibility of alfalfa (Medicago sativa L.) cultivars to the aphid Therioaphis maculata (Homoptera: Aphididae): insect biology and cultivar evaluation显示文摘蚜虫 Therioaphis maculata 的抽象生物学在苜蓿(Medicago sativa L.) 上被学习,包括四抵抗(Mesa-Sirsa, CUF101,贝克和 Lahontan ) 并且二易受影响(弧和 Caliverde ) 苜蓿栽培变种,并且大多数之一收割了巴西栽培变种, Crioula。在控制条件下面,抗生现象(即,减少的长寿,肥沃和蚜虫的增加的死亡) 主要在抵抗苜蓿栽培变种上被观察,除了在 Lahontan 上。Crioula 似乎对蚜虫容忍。现在的数据支持栽培变种的地理限制用法,并且我们作为抗生现象的来源建议贝克和 Mesa-Sirsa,并且提供热带 T 的生物信息。苜蓿上的 maculata 遗传因子型。 | ALEXANDRE DE ALMEIDA E SILVA ELENICE MOURO VARANDA JOSE RICARDO BAROSELA | 2006 | Insect Science2006，13，1： | 5 |
| 12 | Thermodynamic aspects of inclusion engineering in steels显示文摘Tailoring non-metallic inclusions in accordance to the desired effect on steel properties has gained widespread acceptance in the last decades and has become known as “inclusion engineering”. Effective inclusion engineering involves three steps: (a) a good knowledge of how inclusions influence properties, (b) understanding what is the effect of each type of inclusions on these properties and thus which is the most desirable inclusion in a given product and (c) adjusting the processing parameters to obtain these inclusions. A significant portion of the process adjustment is done during steel refin- ing, where the steel can be tailored so that the desired chemical composition of the non-metallic inclusions that will precipi- tate can be altered. Understanding the relations between steel chemistry, processing variables and inclusion chemical com- position requires significant understanding of the thermodynamics of the systems involved. These complex equilibrium calculations are best done using computational thermodynamics. In this work some of the basic techniques used to control inclusion composition are reviewed and the thermodynamic information required to perform this task is presented. Several examples of the application of computational thermodynamics to inclusion engineering of different steels grades are pre- sented and compared with experimental results, whenever possible. The potential and limitations of the method are high- lighted, in special those related to thermodynamic data and databases. | A.Costa e Silva | 2006 | Rare Metals2006，25，5： | 4 |
| 13 | 象山港水交换能力研究显示文摘为深入研究象山港水交换现状,并为港区生态模型等后续研究提供数据,运用Delft3D软件运行了一个已校准的水动力模型,用模型输出的水位和流速数据分析象山港纳潮量和水流特征.并用模型输出的盐度和示踪剂数据求得基于箱式模型的水更新时间和基于Delft3D示踪剂模型的水更新时间.结果表明:港区平均纳潮量为1.32×10^9m^3,大潮纳潮量为1.82×10^9m^3,小潮纳潮量为0.82×10^9m^3.箱式模型得出滞留系数为0.9,水更新时间约13-21d.Delft3D示踪剂对流-扩散模型得出水更新时间约4个月,置换35%的水体需5d,置换65%的水体需125d,置换90%的水体需305d;示踪剂垂直混合充分,水平差异显著,口门区示踪剂平均滞留时间少于10d,港中区约170d,港顶区超过250d.因此象山港是口门水交换强烈,但中顶部水交换很弱的港湾,其排污口应设在西泽码头以东,港顶应养殖大型海藻,并控制鱼虾养殖规模以减轻富营养化. | 林忠洲 严小军 Lencart E Silva J D | 2014 | 宁波大学学报(理工版)2014，27，1： | 4 |
| 14 | Hepatic encephalopathy:Lessons from preclinical studies显示文摘Hepatic encephalopathy(HE) is a major complication that is closely related to the progression of end-stage liver disease.Metabolic changes in advanced liver failure can promote cognition impairment,attention deficits and motor dysfunction that may result in coma and death.HE can be subdivided according to the type of hepatic injury,namely,type A,which results from acute liver failure,type B,which is associated with a portosystemic shunting without intrinsic liver disease,and type C,which is due to chronic liver disease.Several studies have investigated the pathogenesis of the disease,and most of the mechanisms have been explored using animal models.This article aimed to review the use of preclinical models to investigate HE.The most used animal species are rats and mice.Experimental models of type A HE include surgical procedures and the administration of hepatotoxic medications,whereas models of types B and C HE are generally surgically induced lesions in liver tissue,which evolve to hepatic cirrhosis.Preclinical models have allowed the comprehension of the pathways related to HE. | Luiza Cioglia Dias Lima Aline Silva Miranda Rodrigo Novaes Ferreira Milene Alvarenga Rachid Ana Cristina Sim?es e Silva | 2019 | World Journal of Hepatology2019，11，2： | 4 |
| 15 | Autoimmune hepatitis in childhood: The role of genetic and immune factors显示文摘Autoimmune hepatitis (AIH) is a rare chronic inflammatory disease of the liver, which affects a group of patients who lost their immunological tolerance to antigens of the liver. It is clinically characterized by hypergammaglobulinemia, elevated liver enzymes, presence of autoantibodies and histological changes. Although being rare in children, it represents a serious cause of chronic hepatic disease that can lead to cirrhosis and hepatic failure. Clinical findings, exclusion of more common liver disorders and the detection of antibodies antinuclear antibodies, smooth muscle antibodies and anti-LKM1 are usually enough for diagnosis on clinical practice. The pathogenic mechanisms that lead to AIH remain obscure, but some research findings suggest the participation of immunologic and genetic factors. It is not yet knew the triggering factor or factors that stimulate inflammatory response. Several mechanisms proposed partially explain the immunologic findings of AIH. The knowledge of immune factors evolved might result in better markers of prognosis and response to treatment. In this review, we aim to evaluate the findings of research about genetic and immune markers and their perspectives of application in clinical practice especially in pediatric population. | Priscila Menezes Ferri Liu Débora Marques de Miranda Eleonora Druve Tavares Fagundes Alexandre Rodrigues Ferreira Ana Cristina Simoes e Silva | 2013 | World Journal of Gastroenterology2013，19，28： | 3 |
| 16 | Playing Well on the Data FAIRground:Initiatives and Infrastructure in Research Data Management显示文摘Over the past five years,Elsevier has focused on implementing FAIR and best practices in data management,from data preservation through reuse.In this paper we describe a series of efforts undertaken in this time to support proper data management practices.In particular,we discuss our journal data policies and their implementation,the current status and future goals for the research data management platform Mendeley Data,and clear and persistent linkages to individual data sets stored on external data repositories from corresponding published papers through partnership with Scholix.Early analysis of our data policies implementation confirms significant disparities at the subject level regarding data sharing practices,with most uptake within disciplines of Physical Sciences.Future directions at Elsevier include implementing better discoverability of linked data within an article and incorporating research data usage metrics. | Danielle Descoteaux Chiara Farinelli Marina Soares e Silva Anita de Waard | 2019 | Data Intelligence2019，1，4： | 3 |
| 17 | Diagnostic criteria for autoimmune hepatitis in children: A challenge for pediatric hepatologists显示文摘Autoimmune hepatitis (AIH) is a progressive inflammatory liver disorder that is rare in children and adolescents. AIH has a broad clinical spectrum and a quick response to treatment with corticosteroids and immunosuppressive medication. The available diagnosis criteria have limitations and should be evaluated in pediatric populations. Recently, some studies reported that the 2008 simplified diagnostic criteria for AIH could be used in children with high sensibility and specificity. In addition, the authors reported that globulin and immunoglobulin G levels can be used interchangeably for diagnostic purposes. They also demonstrated that the 2008 simplified criteria fail in identifying patients with fulminant hepatic failure. Here, we discuss the limitations of the use of these criteria in pediatric patients and the requirement of more studies to improve the diagnosis of AIH in children. | Priscila Menezes Ferri Alexandre Rodrigues Ferreira Débora Marques Miranda Ana Cristina Sim■es e Silva | 2012 | World Journal of Gastroenterology2012，18，33： | 3 |
| 18 | Serum levels of angiotensin converting enzyme as a biomarker of liver fibrosis显示文摘The renin angiotensin system(RAS) is classically conceived as a circulating hormonal system involved in blood pressure control and hydroelectrolyte balance. The discovery that RAS components are locally expressed in a wide range of organs and tissues,including the liver,pointed to a role for this system in the pathogenesis of several conditions including hepatic fibrosis and cirrhosis. It has been widely reported that the classical RAS axis composed by the angiotensin converting enzyme(ACE)-angiotensin(Ang) Ⅱ-Ang type 1(AT1) receptor mediates pro-inflammatory,pro-thrombotic,and pro-fibrotic processes. On the other hand,the alternative axis comprising ACE2-Ang-(1-7)-Mas receptor seems to play a protective role by frequently opposing Ang Ⅱ action. Chronic hepatitis B(CHB) is one of the leading causes of liver fibrosis,accounting for the death of nearly one million people worldwide. Liver fibrosis is a key factor to determine therapeutic interventions for patients with CHB. However,the establishment of non-invasive and accurate methods to detect reversible stages of liver fibrosis is still a challenge. In an elegant study published in the 36 th issue of the World Journal of Gastroenterology,Noguchi et al showed the predictive value of serum ACE levels in detecting not only advanced stages of liver fibrosis but also initial and intermediate fibrotic stages. The serum levels of ACE might represent an accurate,non-invasive,widely available,and easy method to evaluate fibrosis related to CHB. Moreover,therapies involving the inhibition of the classical RAS axis components might be promising in the control of CHB-related liver fibrosis. | Aline Silva Miranda Ana Cristina Sim?es e Silva | 2017 | World Journal of Gastroenterology2017，23，48： | 2 |
| 19 | Toxicity assessment of polyethylene microplastics in combination with a mix of emerging pollutants on Physalaemus cuvieri tadpoles显示文摘Studies in recent years have shown that aquatic pollution by microplastics(MPs)can be considered to pose additional stress to amphibian populations.However,our knowledge of how MPs affect amphibians is very rudimentary,and even more limited is our understanding of their effects in combination with other emerging pollutants.Thus,we aimed to evaluate the possible toxicity of polyethylene MPs(PE-MPs)(alone or in combination with a mix of pollutants)on the health of Physalaemus cuvieri tadpoles.After 30 days of exposure,multiple biomarkers were measured,including morphological,biometric,and developmental indices,behavioral parameters,mutagenicity,cytotoxicity,antioxidant and cholinesterase responses,as well as the uptake and accumulation of PE-MPs in animals.Based on the results,there was no significant change in any of the parameters measured in tadpoles exposed to treatments,but induced stress was observed in tadpoles exposed to PE-MPs combined with themixture of pollutants,reflecting significant changes in physiological and biochemical responses.Through principal component analysis(PCA)and integrated biomarker response(IBR)assessment,effects induced by pollutants in each test group were distinguished,confirming that the exposure of P.cuvieri tadpoles to the PE-MPs in combination with a mix of emerging pollutants induces an enhanced stress response,although the uptake and accumulation of PE-MPs in these animalswas reduced.Thus,our study provides newinsight into the danger to amphibians of MPs coexisting with other pollutants in aquatic environments. | Amanda Pereira da Costa Araújo Thiarlen Marinho da Luz Mohamed Ahmed Ibrahim Ahmed Mir Mohammad Ali Md.Mostafizur Rahman Bojan Nataraj Daniela de Melo e Silva DamiàBarceló Guilherme Malafaia | 2023 | Journal of Environmental Sciences2023，，5： | 2 |
| 20 | Global surveillance of cancer survival 1995–2009: analysis of individual data for 25 676 887 patients from 279 population-based registries in 67 countries (CONCORD-2)显示文摘 | Claudia Allemani Hannah K Weir Helena Carreira Rhea Harewood Devon Spika Xiao-Si Wang Finian Bannon Jane V Ahn Christopher J Johnson Audrey Bonaventure Rafael Marcos-Gragera Charles Stiller Gulnar Azevedo e Silva Wan-Qing Chen Olufemi J Ogunbiyi Bernard R | 2015 | The Lancet . 2015 (9972)2015，，： | 2 |
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