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| 1 | Ultrafast epitaxial growth of metre-sized single-crystal graphene on industrial Cu foil显示文摘A foundation of the modern technology that uses single-crystal silicon has been the growth of highquality single-crystal Si ingots with diameters up to 12 inches or larger. For many applications of graphene, large-area high-quality(ideally of single-crystal) material will be enabling. Since the first growth on copper foil a decade ago, inch-sized single-crystal graphene has been achieved. We present here the growth, in 20 min, of a graphene film of(5 ×50) cm^2 dimension with >99% ultra-highly oriented grains.This growth was achieved by:(1) synthesis of metre-sized single-crystal Cu(1 1 1) foil as substrate;(2)epitaxial growth of graphene islands on the Cu(1 1 1) surface;(3) seamless merging of such graphene islands into a graphene film with high single crystallinity and(4) the ultrafast growth of graphene film.These achievements were realized by a temperature-gradient-driven annealing technique to produce single-crystal Cu(1 1 1) from industrial polycrystalline Cu foil and the marvellous effects of a continuous oxygen supply from an adjacent oxide. The as-synthesized graphene film, with very few misoriented grains(if any), has a mobility up to ~23,000 cm^2 V^(-1)s^(-1)at 4 K and room temperature sheet resistance of ~230 Ω/□. It is very likely that this approach can be scaled up to achieve exceptionally large and high-quality graphene films with single crystallinity, and thus realize various industrial-level applications at a low cost. | Xiaozhi Xu Zhihong Zhang Jichen Dong Ding Yi Jingjing Niu Muhong Wu Li Lin Rongkang Yin Mingqiang Li Jingyuan Zhou Shaoxin Wang Junliang Sun Xiaojie Duan Peng Gao Ying Jiang Xiaosong Wu Hailin Peng Rodney S. Ruoff Zhongfan Liu Dapeng Yu Enge Wang Feng Ding Kaihui Liu | 2017 | Science Bulletin2017，62，15： | 40 |
| 2 | Poor performance of the modified early warning score for predicting mortality in critically ill patients presenting to an emergency department显示文摘BACKGROUND:This study was undertaken to validate the use of the modified early warning score(MEWS) as a predictor of patient mortality and intensive care unit(ICU)/ high dependency(HD)admission in an Asian population.METHODS:The MEWS was applied to a retrospective cohort of 1 024 critically ill patients presenting to a large Asian tertiary emergency department(ED) between November 2006 and December2007.Individual MEWS was calculated based on vital signs parameters on arrival at ED.Outcomes of mortality and ICU/HD admission were obtained from hospital records.The ability of the composite MEWS and its individual components to predict mortality within 30 days from ED visit was assessed.Sensitivity,specificity,positive and negative predictive values were derived and compared with values from other cohorts.A MEWS of ≥4 was chosen as the cut-off value for poor prognosis based on previous studies.RESULTS:A total of 311(30.4%) critically ill patients were presented with a MEWS ≥4.Their mean age was 61.4 years(SD 18.1) with a male to female ratio of 1.10.Of the 311 patients,53(17%)died within 30 days,64(20.6%) were admitted to ICU and 86(27.7%) were admitted to HD.The area under the receiver operating characteristic curve was 0.71 with a sensitivity of 53.0%and a specificity of 72.1%in addition to a positive predictive value(PPV) of 17.0%and a negative predictive value(NPV)of 93.4%(MEWS cut-off of ≥4) for predicting mortality.CONCLUSION:The composite MEWS did not perform well in predicting poor patient outcomes for critically ill patients presenting to an ED. | Le Onn Ho Huihua Li Nur Shahidah Zhi Xiong Koh Papia Sultana Marcus Eng Hock Ong | 2013 | World Journal of Emergency Medicine2013，4，4： | 12 |
| 3 | Comparison of peripapillary retinal nerve fiber layer thickness between myopia severity groups and controls显示文摘AIM: To compare the peripapillary retinal nerve fiber layer(RNFL) thickness measured via optical coherence tomography(OCT) between different groups of myopia severity and controls. METHODS: This was a prospective cross-sectional study. All subjects underwent a full ophthalmic examination, refraction, visual field analysis and A-scan biometry. Myopic patients were classified as low myopia(LM) [spherical equivalent(SE) from greater than-0.5 D, up to-3.0 D], moderate myopia(MM; SE greater than-3.0 D, up to-6.0 D) and high myopia(HM; SE greater than-6.0 D). The control group consisted of emmetropic(EM) patients(SE from +0.5 D to-0.5 D). A Zeiss Cirrus HD-OCT machine was used to measure the peripapillary RNFL thickness of both eyes of each subject. The mean peripapillary RNFL thickness between groups was compared using both analysis of variance and analysis of covariance.RESULTS: A total of 403 eyes of 403 subjects were included in this study. The mean age was 31.48±10.23 y. There were 180(44.7%) eyes with EM, 124(30.8%) with LM, 73(18.1%) with MM and 26(6.5%) with HM. All groups of myopia severity had a thinner average RNFL than the EM group, but after controlling for gender, age, and axial eye length, only the HM group differed significantly from the EM group(P=0.017). Likewise, the superior, inferior and nasal RNFL was thinner in all myopia groups compared to controls, but after controlling for confounders, only the inferior quadrant RNFL was significantly thinner in the HM group, when compared to the EM group(P=0.017). CONCLUSION: The average and inferior quadrant RNFL is thinner in highly myopic eyes compared to emmetropic eyes. Refractive status must be taken into consideration when interpreting the OCT of myopic patients, as RNFL thickness varies with the degree of myopia. | Evelyn Li Min Tai Jiunn Loong Ling Eng Hui Gan Hussein Adil Wan-Hiram Wan-Hazabbah | 2018 | International Journal of Ophthalmology(English edition)2018，11，2： | 7 |
| 4 | A review of silicon-based wafer bonding processes,an approach to realize the monolithic integration of Si-CMOS and III-V-on-Si wafers显示文摘The heterogeneous integration of III-V devices with Si-CMOS on a common Si platform has shown great promise in the new generations of electrical and optical systems for novel applications,such as HEMT or LED with integrated control circuitry.For heterogeneous integration,direct wafer bonding(DWB)techniques can overcome the materials and thermal mismatch issues by directly bonding dissimilar materials systems and device structures together.In addition,DWB can perform at wafer-level,which eases the requirements for integration alignment and increases the scalability for volume production.In this paper,a brief review of the different bonding technologies is discussed.After that,three main DWB techniques of single-,double-and multi-bonding are presented with the demonstrations of various heterogeneous integration applications.Meanwhile,the integration challenges,such as micro-defects,surface roughness and bonding yield are discussed in detail. | Shuyu Bao Yue Wang Khaw Lina Li Zhang Bing Wang Wardhana Aji Sasangka Kenneth Eng Kian Lee Soo Jin Chua Jurgen Michel Eugene Fitzgerald Chuan Seng Tan Kwang Hong Lee | 2021 | Journal of Semiconductors2021，42，2： | 5 |
| 5 | Determinants of delayed diagnosis and treatment of tuberculosis in Cambodia:a mixed-methods study显示文摘Background:Cambodia is among the 30 countries in the world with the highest burden of tuberculosis(TB),and it is estimated that 40%of people with TB remain undiagnosed.In this study,we aimed to investigate the determinants of delayed diagnosis and treatment of TB in Cambodia.Methods:This mixed-method explanatory sequential study was conducted between February and September 2019 in 12 operational districts in Cambodia.It comprised of a retrospective cohort study of 721 people with TB,followed by a series of in-depth interviews.We assessed factors associated with time to TB diagnosis and treatment initiation using Cox proportional hazards model.Subsequently,we conducted in-depth interviews with 31 people with TB purposively selected based on the time taken to reach TB diagnosis,sex,and residence.Transcripts were coded,and thematic analyses were performed.Results:The median time from the onset of symptoms to TB diagnosis was 49 days(Interquartile range[IQR]:21–112).We found that longer time to diagnosis was significantly associated with living in rural area(Adjusted hazards ratio[aHR]=1.25;95%confidence interval[CI]:1.06–1.48);TB symptoms-cough(aHR:1.52;95%CI:1.18–1.94),hemoptysis(aHR 1.32;95%CI:1.07–1.63),and night sweats(aHR:1.24;95%CI:1.05–1.46);seeking private health care/self-medication(aHR:1.23;95%CI:1.04–1.45);and higher self-stigma(aHR:1.02;95%CI:1.01–1.03).Participants who received education level above the primary level were inversely associated with longer time to diagnosis(aHR:0.78;95%CI:0.62–0.97).The median time from TB diagnosis to the initiation of treatment was two days(IQR:1–3).The use of smear microscopy for TB diagnosis(aHR:1.50;95%CI:1.16–1.95)was associated with longer time to treatment initiation.Seeking private health care and self-medication before TB diagnosis,lack of perceived risk,threat,susceptibility,and stigma derived qualitatively further explained the quantitative findings.Conclusions:TB diagnostic delay was substantial.Increasing public awareness about TB and consciousness regarding stigma,engaging the private healthcare providers,and tailoring approaches targeting the rural areas could further improve early detection of TB and narrowing the gap of missing cases in Cambodia. | Alvin Kuo Jing Teo Chetra Ork Sothearith Eng Ngovlyly Sok Sovannary Tuot Li Yang Hsu Siyan Yi | 2020 | Infectious Diseases of Poverty2020，9，3： | 2 |
| 6 | Sex-specific differences in white matter microvascular integrity after ischaemic stroke显示文摘background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adjusting for differences in comorbidities and treatment approaches.White matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic stroke.The aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic stroke.Methods A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was performed.In the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)values.Regression analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were performed.results 105 men and 79 women met inclusion criteria for analysis.Despite no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) coefficient.In multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not men.Conclusions In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural integrity.Prospective studies investigating sex-specific differences in white matter microvascular integrity are needed. | Mark R Etherton Ona Wu Pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark J R J Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost | 2019 | Stroke & Vascular Neurology2019，4，4： | 2 |
| 7 | THERMAL DECOMPOSITION OF ZINC CARBONATE HYDROXIDE HYDRATE POWDERS OF DIFFERENT PARTICLE SIZE AND SAMPLE MASS显示文摘THERMALDECOMPOSITIONOFZINCCARBONATEHYDROXIDEHYDRATEPOWDERSOFDIFFERENTPARTICLESIZEANDSAMPLEMASS①ChenJianxun,ZhaoRuirongandJian... | Chen Jianxun, Zhao Ruirong and Jiang HanyingInstitute of Metallurgy Physical Chemistry and New Chemical Materials,Central South University of Technology, Changsha 410083, P. R. ChinaLi Yanhong, Bao GailingInstitute of Chemistry and Chemical Eng | 1998 | 中国有色金属学会会刊:英文版1998，8，1： | 2 |
| 8 | National population based survey on the prevalence of first aid, cardiopulmonary resuscitation and automated external defibrillator skills in Singapore显示文摘 | Marcus Eng Hock Ong Joy Li Juan Quah Andrew Fu Wah Ho | 2013 | Resuscitation2013，84，： | 1 |
| 9 | Some effects of different additives on dielectric and piezoelectric properties of Bi1/2 Na1/2 TiOs-Ba- TiO3 morphotropic-phase-boundary composition显示文摘 | LI H D ENG C D YAO W L | 2003 | Mater Lett2003，58，78： | 1 |
| 10 | Rapid detection of Enterovirus 71 by real-time TaqMan RT-PCR显示文摘 | Eng Lee Tan Li Li Gaynor Yong Seng Hock Quak Wei Cheng Andrea Yeo Vincent Tak Kwong Chow Chit Laa Poh | 2008 | Journal of Clinical Virology2008，，2： | 1 |
| 11 | The upregulation of gllal gluta- mate transporter-1 participates in the induction of brain isehemic tol- erance in rats 显示文摘 | Zhang M Li W-B C eng J-X | 2007 | Journal of Cerebral Blood Flow & Metabolism2007，27，7： | 1 |
| 12 | Drug Resistance Pattern of Mycobac- terium Tuberculosis Complex at a Medical Center in Cen- tral Taiwan,2003 - 2007 显示文摘 | Chia - Chuan Yu Chih - Yen Chang Chun - Eng Liu Li - Fong Shih | 2010 | Microbiol Immunol Infect2010，43，4： | 1 |
| 13 | Role of osteopontin in induction of monocyte chemoatU-actant proteinl and macrophage inflammation protein 1 beta through the NF-Kappa B and MAPK pathways in rheumatoid arthritis显示文摘 | 2~eng W Li R Pan H | 2009 | Arthritis Rheum2009，60，： | 1 |
| 14 | Parallel boundary and best neighbor searching sampling algorithm for drawbead design optimization in sheet metal forming显示文摘 | WANG Hu LI Enging LI Gangyai | | 0，，2： | 1 |
| 15 | Intrahepatic Cholangiocarcinoma Treated with Local-Regional Therapy: Quantitative Volumetric Apparent Diffusion Coefficient Maps for Assessment of Tumor Response显示文摘 | Vivek Gowdra Halappa Susanne Bonekamp Celia Pamela Corona-Villalobos Zhen Li Margaret Mensa Diane Reyes John Eng Nikhil Bhagat Timothy M. Pawlik Jean-Fran?ois Geschwind Ihab R. Kamel | 2012 | Radiology2012，，1： | 1 |
| 16 | Pulmonary lymphangioleiomyomatosis:high-resolution CT findings in 11 patients and compared with the literature显示文摘 | Kun Eng Lim Ying Huang Tsai Yuan li Hsu | 2004 | J Clin Imag2004，28，6： | 1 |
| 17 | Superior efficacy of a Cremophor free albumin-bound paclitaxel compared with solvent-based paclitaxel in Chinese metastatic breast cancer显示文摘 | Guan ZZ Li QL eng FY eng FY | | 0，，3： | 1 |
| 18 | Experimental and numerical study of auto-ignition and pilot ignition of PMMA plates in a cone calorimeter 显示文摘 | Tsai Tzung-hang Li Mao-j eng Shih I-you | 2001 | Combustion and Flame2001，124，： | 1 |
| 19 | The Implications of Longterm Performance Plans and Institutional Ownership for Firms' Research and Development Investments显示文摘 | Eng Li Shackell M | 2001 | Journal of Accounting Auditing and Finance2001，16，2： | 1 |
| 20 | The spatial distribution of archaeal lipids in a mesoscale subtropical watershed, Southeast China显示文摘Archaea play an important role in global carbon and nitrogen cycles. Archaeal lipids, such as isoprenoid glycerol diakyl glycerol tetraethers(i GDGTs), are important biomarkers tracing change in archaeal community structure and biogeochemical processes in the natural environments. In this research, the spatial distributions of archaeal lipids in the surface sediments of the Jiulong River(JR) and the Jiulong River estuary(JRE) were examined. GDGT-0(containing zero cyclopentyl ring) and crenarchaeol were the most abundant i GDGTs in the JR and JRE. From the rivers to the estuary, the total i GDGTs, GDGT-0, crenarchaeol and archaeol concentrations showed significant spatial variation; in particular, GDGT-0 and archaeol in the river may be predominantly derived in situ from methanogens, whereas crenarchaeol in the estuary mainly derived in situ from Thaumarchaeota. We inferred that archaeal community was dominated by methanogens in the Jiulong River and by Thaumarchaeota in the Jiulong River estuary, which are consistent with change in archaeal community structure observed in other estuarine environments. | LI Xue Ying ZHENG FengF eng CHEN Yu Fei GUO Wen Ting ZHANG TingT ing HU AnY i YU Chang Ping ZHANG Chuan Lun | 2016 | Science China Earth Sciences2016，59，7： | 1 |
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