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| 1 | Phytochrome Signaling in Green Arabidopsis Seedlings: Impact Assessment of a Mutually Negative phyB-PIF Feedback Loop显示文摘reversibly 红的(R)/far-red (FR )-light-responsive phytochrome (phy ) photosensory 系统在第一暴露之上在发芽黑暗的幼苗开始 deetiolation 进程到光,和阴影回避过程在充分,在到 vegetational 的暴露之上的 deetiolated 幼苗遮。到驾驶这些回答的 transcriptional 网络的从激活光的光敏电阻器 conformer (Pfr ) 的细胞内部的发信号小径与 bHLH 抄写因素的一个小亚科包含 Pfr 的直接、物理相互作用,称为的交往 Phy 因素(程序信息文件) ,它导致快速的程序信息文件解朊的降级。另外,有在光成年的幼苗的进一步的复杂性的证据, phyBPIF 相互作用由此相互地导致 phyB 降级,在里面一互相否定,反馈环配置。这里,在光成年的幼苗估计这些对抗活动的相对贡献到网 phenotypic 读出,我们检验了 light-shade-induced 的大小和 pentuple phyBpif1pif3pif4pif5 (phyBpifq ) 的 simulated-shade-induced 回答变异、各种各样的多重 pif 变异的联合。数据( 1 )重申 phyB 是占优势不独占,响应延长连续 R 照耀在 deetiolating 幼苗强加胚轴延伸的抑制的光敏电阻器并且( 2 )出现 PIF 四重唱( PIF1 , PIF3 , PIF4 ,并且 PIF5 )保留并且施加一个双能力在这些条件下面调制胚轴延伸由附随地通过内在的transcriptional规章的活动支持房间延伸,并且通过 feedb 减少phyB禁止的能力在暴露阴影的幼苗, immunoblot 分析证明在 Pfr 层次的强加阴影的减小在许多 PIF3 导致增加,并且变异的分析显示 PIF3 行动,到,与 PIF4 和 PIF5 一起支持胚轴延伸的已知的导致阴影的加速。相反地,尽管四倍的 pifq 异种显示清楚地减少了胚轴延伸与相比响应延长色泽野类型, immunoblot 分析不在变异的幼苗在 phyB 层次检测举起与相比在导致阴影的生长时期的多数期间野类型,并且 phyB 层次要用体力地没越过比较的pif变异的联合与生长显型被相关。这些结果建议 phyB 丰富的程序信息文件反馈调整不在在这些下面的支持程序信息文件的、阴影应答的显型的大小调节的 modulating 起一个主导的作用。在成长在下面的幼苗日报 lightdark 周期,在黑暗经期(End-of-Day-FR (EOD-FR ) 治疗) 的开始的 Pfr 的 FR-pulse-induced 移动相对没有 EOD-FR 治疗导致更长的胚轴并且这效果在 pif 变异的联合被稀释的数据表演测试了。这结果同样显示 PIF 四重唱成员能够内在地在光成年的植物支持胚轴房间延伸,独立于 photoactivated-phyB 丰富的程序信息文件反馈调整的效果。 | Pablo Leivar Elena Monte Megan M. Cohn Peter H. Quail | 2012 | Molecular Plant2012，5，3： | 20 |
| 2 | Cloning and expression analysis of a gene that shows developmental regulation upon tuberization in potato显示文摘 | Stephen Jackson Jordi Gascón Esther Carrera Elena Monte Salomé Prat | 1997 | Plant Molecular Biology1997，，1： | 1 |
| 3 | Pathology of Drug-Eluting Stents in Humans显示文摘 | Michael Joner Aloke V. Finn Andrew Farb Erik K. Mont Frank D. Kolodgie Elena Ladich Robert Kutys Kristi Skorija Herman K. Gold Renu Virmani | 2006 | Journal of the American College of Cardiology2006，，1： | 1 |
| 4 | Atrial Fibrillation Catheter Ablation Versus Surgical Ablation Treatment (FAST): A 2-Center Randomized Clinical Trial显示文摘 | Lucas V.A. Boersma Manuel Castella WimJan van Boven Antonio Berruezo Alaaddin Yilmaz Mercedes Nadal Elena Sandoval Naiara Calvo Josep Brugada Johannes Kelder Maurits Wijffels Lluís Mont | 2012 | Circulation2012，，1： | 1 |
| 5 | 1-MCP treatment preserves aroma quality of ‘Packham’s Triumph’ pears during long-term storage显示文摘 | María Alejandra Moya-León Mireya Vergara Carolina Bravo María Elena Montes Claudia Moggia | 2006 | Postharvest Biology and Technology2006，，2： | 1 |
| 6 | Pathology of Drug-Eluting Stents in Humans显示文摘 | Michael Joner Aloke V. Finn Andrew Farb Erik K. Mont Frank D. Kolodgie Elena Ladich Robert Kutys Kristi Skorija Herman K. Gold Renu Virmani | 2006 | Journal of the American College of Cardiology2006，，1： | 1 |
| 7 | Decline in subarachnoid haemorrhage volumes associated with the first wave of the COVID- 19 pandemic显示文摘Background During the COVID-19 pandemic,decreased volumes of stroke admissions and mechanical thrombectomy were reported.The study’s objective was to examine whether subarachnoid haemorrhage(SAH)hospitalisations and ruptured aneurysm coiling interventions demonstrated similar declines.Methods We conducted a cross-sectional,retrospective,observational study across 6 continents,37 countries and 140 comprehensive stroke centres.Patients with the diagnosis of SAH,aneurysmal SAH,ruptured aneurysm coiling interventions and COVID-19 were identified by prospective aneurysm databases or by International Classification of Diseases,10th Revision,codes.The 3-month cumulative volume,monthly volumes for SAH hospitalisations and ruptured aneurysm coiling procedures were compared for the period before(1 year and immediately before)and during the pandemic,defined as 1 March-31 May 2020.The prior 1-year control period(1 March-31 May 2019)was obtained to account for seasonal variation.Findings There was a significant decline in SAH hospitalisations,with 2044 admissions in the 3 months immediately before and 1585 admissions during the pandemic,representing a relative decline of 22.5%(95%CI−24.3%to−20.7%,p<0.0001).Embolisation of ruptured aneurysms declined with 1170-1035 procedures,respectively,representing an 11.5%(95%CI−13.5%to−9.8%,p=0.002)relative drop.Subgroup analysis was noted for aneurysmal SAH hospitalisation decline from 834 to 626 hospitalisations,a 24.9%relative decline(95%CI−28.0%to−22.1%,p<0.0001).A relative increase in ruptured aneurysm coiling was noted in low coiling volume hospitals of 41.1%(95%CI 32.3%to 50.6%,p=0.008)despite a decrease in SAH admissions in this tertile.Interpretation There was a relative decrease in the volume of SAH hospitalisations,aneurysmal SAH hospitalisations and ruptured aneurysm embolisations during the COVID-19 pandemic.These findings in SAH are consistent with a decrease in other emergencies,such as stroke and myocardial infarction. | Thanh N Nguyen Diogo C Haussen Muhammad M Qureshi Hiroshi Yamagami Toshiyuki Fujinaka Ossama Y Mansour Mohamad Abdalkader Michael Frankel Zhongming Qiu Allan Taylor Pedro Lylyk Omer F Eker Laura Mechtouff Michel Piotin Fabricio Oliveira Lima Francisco Mont'Alverne Wazim Izzath Nobuyuki Sakai Mahmoud Mohammaden Alhamza R Al-Bayati Leonardo Renieri Salvatore Mangiafico David Ozretic Vanessa Chalumeau Saima Ahmad Umair Rashid Syed Irteza Hussain Seby John Emma Griffin John Thornton Jose Antonio Fiorot Rodrigo Rivera Nadia Hammami Anna M Cervantes-Arslanian Hormuzdiyar H Dasenbrock Huynh Le Vu Viet Quy Nguyen Steven Hetts Romain Bourcier Romain Guile Melanie Walker Malveeka Sharma Don Frei Pascal Jabbour Nabeel Herial Fawaz Al-Mufti Atilla Ozcan Ozdemir Ozlem Aykac Dheeraj Gandhi Chandril Chugh Charles Matouk Pascale Lavoie Randall Edgell Andre Beer-Furlan Michael Chen Monika Killer-Oberpfalzer Vitor Mendes Pereira Patrick Nicholson Vikram Huded Nobuyuki Ohara Daisuke Watanabe Dong Hun Shin Pedro SC Magalhaes Raghid Kikano Santiago Ortega-Gutierrez Mudassir Farooqui Amal Abou-Hamden Tatsuo Amano Ryoo Yamamoto Adrienne Weeks Elena A Cora Rotem Sivan-Hoffmann Roberto Crosa Markus Möhlenbruch Simon Nagel Hosam Al-Jehani Sunil A Sheth Victor S Lopez Rivera James E Siegler Achmad Fidaus Sani Ajit S Puri Anna Luisa Kuhn Gianmarco Bernava Paolo Machi Daniel G Abud Octavio M Pontes-Neto Ajay K Wakhloo Barbara Voetsch Eytan Raz Shadi Yaghi Brijesh P Mehta Naoto Kimura Mamoru Murakami Jin Soo Lee Ji Man Hong Robert Fahed Gregory Walker Eiji Hagashi Steve M Cordina Hong Gee Roh Ken Wong Juan F Arenillas Mario Martinez-Galdamez Jordi Blasco Alejandro Rodriguez Vasquez Luisa Fonseca M Luis Silva Teddy Y Wu Simon John Alex Brehm Marios Psychogios William J Mack Matthew Tenser Tatemi Todaka Miki Fujimura Roberta Novakovic Jun Deguchi Yuri Sugiura Hiroshi Tokimura Rakesh Khatri Michael Kelly Lissa Peeling Yuichi Murayama Hugh Stephen Winters Johnny Wong Mohamed Teleb Jeremy Payne Hiroki Fukuda Kosuke Miyake Junsuke Shimbo Yusuke Sugimura Masaaki Uno Yohei Takenobu Yuji Matsumaru Satoshi Yamada Ryuhei Kono Takuya Kanamaru Masafumi Morimoto Junichi Iida Vasu Saini Dileep Yavagal Saif Bushnaq Wenguo Huang Italo Linfante Jawad Kirmani David S Liebeskind Viktor Szeder Ruchir Shah Thomas G Devlin Lee Birnbaum Jun Luo Anchalee Churojana Hesham E Masoud Carlos Ynigo Lopez Brendan Steinfort Alice Ma Ameer E Hassan Amal Al Hashmi Mollie McDermott Maxim Mokin Alex Chebl Odysseas Kargiotis Georgios Tsivgoulis Jane G Morris Clifford J Eskey Jesse Thon Leticia Rebello Dorothea Altschul Oriana Cornett Varsha Singh Jeyaraj Pandian Anirudh Kulkarni Pablo M Lavados Veronica V Olavarria Kenichi Todo Yuki Yamamoto Gisele Sampaio Silva Serdar Geyik Jasmine Johann Sumeet Multani Artem Kaliaev Kazutaka Sonoda Hiroyuki Hashimoto Adel Alhazzani David Y Chung Stephan A Mayer Johanna T Fifi Michael D Hill Hao Zhang Zhengzhou Yuan Xianjin Shang Alicia C Castonguay Rishi Gupta Tudor G Jovin Jean Raymond Osama O Zaidat Raul G Nogueira SVIN COVID-19 Registry,the Middle East North Africa Stroke and Interventional Neurotherapies Organization(MENA-SINO),Japanese Society of Vascular and Interventional Neurology Society(JVIN) | 2021 | Stroke & Vascular Neurology2021，6，4： | 0 |
| 8 | Could JC virus provoke metastasis in colon cancer?显示文摘AIM: To evaluate the prevalence of John Cunningham virus(JC virus) in a small cohort of patients with colon cancer and to assess its presence in hepatic metastasis.METHODS: Nineteen consecutive patients with histologically diagnosed colon cancer were included in our study, together with ten subjects affected by histologically and serologically diagnosed hepatitis C virus infection. In the patients included in the colon cancer group, JC virus was searched for in the surgical specimen; in the control group, JC virus was searched for in the hepatic biopsy. The difference in the prevalence of JC virus in the hepatic biopsy between the two groups was assessed through the χ2 test.RESULTS: Four out of 19 patients with colon cancer had a positive polymerase chain reaction(PCR) test for JC virus, and four had liver metastasis. Among the patients with liver metastasis, three out of four had a positive PCR test for JC virus in the surgical specimen and in the liver biopsy; the only patient with liver metastasis with a negative test for JC virus also presented a negative test for JC virus in the surgical specimen. In the control group of patients with hepatitis C infection, none of the ten patients presented JC virus infection in the hepatic biopsy. The difference between the two groups regarding JC virus infection was statistically significant(χ2 = 9.55, P = 0.002).CONCLUSION: JC virus may play a broader role than previously thought, and may be mechanistically involved in the late stages of these tumors. | Emanuele Sinagra Dario Raimondo Elena Gallo Mario Stella Mario Cottone Ambrogio Orlando Francesca Rossi Emanuele Orlando Marco Messina Giovanni Tomasello Attilio Ignazio Lo Monte Ennio La Rocca Aroldo Gabriele Rizzo | 2014 | World Journal of Gastroenterology2014，20，42： | 0 |
| 9 | Characterization of oral yeasts isolated from healthy individuals attended in different Colombian dental clinics显示文摘The aim of this study was to identify the most frequent yeasts in the oral cavity of adult individuals without immune disorders and to associate the presence of these oral yeasts with different characteristics of each individual. Oral rinse samples were obtained from 96 healthy adults and cultured in Sabouraud dextrose agar media and CHROMagar. Yeasts were identified by sequencing the D1/D2 region of the 28 S rRNA gene. Probable association among the socio-demographic characteristics, body mass index, family and personal medical history,oral hygiene, tobacco and/or alcohol consumption habits and presence of oral fungi was analyzed. Contingency tables and logistic regression were employed to evaluate possible relationships between the presence of oral fungi and mixed colonization with these variables. 57.3% of the healthy individuals had oral yeasts and 21.8% had mixed colonization. The most prevalent yeasts were Candida albicans(52%), C. parapsilosis(17.9%), and C.dubliniensis(7.57%). Yeasts with most frequently mixed colonization were C. albicans and C. parapsilosis. No relationships were found among the variables analyzed. However, the presence of mixed colonization was related to the presence of dental prostheses(P<0.006), dental apparatuses(P=0.016) and O’Leary index(P=0.012). This is the first study that characterized oral yeasts in Colombian healthy individuals, determined the most prevalent oral yeasts C. albicans, C. parapsilosis and C. dublinensis and an association of mixed colonization with the use of dental prostheses and aparatology and poor hygiene. | Raul Eduardo Rivera Alejandra Zuluaga Karen Arango Itzjak Kadar Paola Andrea Pinillos Luis Fernando Montes Eugenia Catalina Cepeda Ernesto Gonzalez Pedro Antonio Alfonso Andrea Alejandra Villalba Luis Fernando Casanova Adolfo Perez Armando Roa Martha Jhoana Arias Jorge Orlando Francisco Cuellar Lorena Pedraza Adiel Alberto Vasquez Blanca Lynne Suarez Beatriz LGomez Catalina De Bedout Luz Elena Cano | 2019 | The Journal of Biomedical Research2019，33，5： | 0 |
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