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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Osteoprotegerin: A Novel Secreted Protein Involved in the Regulation of Bone Density显示文摘 | W.S Simonet D.L Lacey C.R Dunstan M Kelley M.-S Chang R Lüthy H.Q Nguyen S Wooden L Bennett T Boone G Shimamoto M DeRose R Elliott A Colombero H.-L Tan G Trail J Sullivan E Davy N Bucay L Renshaw-Gegg T.M Hughes D Hill W Pattison P Campbell S Sander G Van | 1997 | Cell1997，，2： | 6 |
| 3 | Osteoprotegerin Ligand Is a Cytokine that Regulates Osteoclast Differentiation and Activation显示文摘 | D.L Lacey E Timms H.-L Tan M.J Kelley C.R Dunstan T Burgess R Elliott A Colombero G Elliott S Scully H Hsu J Sullivan N Hawkins E Davy C Capparelli A Eli Y.-X Qian S Kaufman I Sarosi V Shalhoub G Senaldi J Guo J Delaney W.J Boyle | 1998 | Cell1998，，2： | 4 |
| 4 | 利用抗高血压药相关的遗传变异发现其潜在的功效和副作用显示文摘通过研究药物靶蛋白基因的自然变异可以了解药物的功效。本研究旨在利用这种方法探索抗高血压药的潜在副作用和再利用潜力。研究者首先确定了血管紧张素转换酶抑制剂(angiotensin converting enzyme inhibitor,ACEI)、β受体阻滞剂和钙拮抗剂的合适代表基因。 | 刘青(译) 叶鹏(校) Gill D Georgakis MK Koskeridis F Jiang L Feng Q Wei WQ Theodoratou E Elliott P Denny JC Malik R Evangelou E Dehghan A Dichgans M Tzoulaki I | 2019 | 中华高血压杂志2019，0，9： | 3 |
| 5 | 脊髓损伤后残存自主神经功能载录国际标准显示文摘近年来,脊髓损伤神经学分类园际标准(International Stand- ards for the Neurological Classification of Spinal Cord Injury, ISNCSCI)被用来记载脊髓损伤后运动和感觉功能的损害,目前该标准已是第六版。1992年第一份国际认可的标准出版时,曾进行了较大的修订,修订内容包括完全性损伤与不完全性损伤的定义, | MS Alexander AB Jackson W Donovan DE Graves SL Elliott A Krassioukov AW Sheel I Estoresl B Green A Gousse NL Braekett D Cardenas M Kennelly A-K Karlason F Biering-Sorensen K Krogh T Linsenmeyer R Marino J Ditunno CJ Mathias I Perkash G Creasey G Schilero J Wecht B Schurch V Dietz J Sonksen S Stiens D Bodner LA Wuermser J-J Wyndaele 周谋望 刘楠 S Charlifue | 2010 | 中华物理医学与康复杂志2010，32，4： | 2 |
| 6 | Vagus nerve stimulation in 436 consecutive patients with treatment-resistant epilepsy:long-term outcomes and predictors of response显示文摘 | Elliott R E Morsi A Kalhorn S P | | 0，，01： | 1 |
| 7 | Pulmonary Artery Sling显示文摘 | Pawade A De Leval M R Elliott M J | 1992 | Ann Thorac Surg1992，54，5： | 1 |
| 8 | Optical properties and applications of chalcogenide glasses: a review 显示文摘 | ZAKERY A ELLIOTT S R | 2003 | J Non-Cryst Solids2003，330，123： | 1 |
| 9 | Optical properties and applications of chalcogenide glasses: A review显示文摘 | Zakery A Elliott S R | 2003 | Journal of Non-Crystalline Solids2003，330，1： | 1 |
| 10 | Triply bridged dinuclear tris (bipyridine)iron(11) complex: synthesis and electrochemical and structural studies 显示文摘 | Serr B R Andersen K A Elliott C M | 1988 | Inorg Chem1988，27，： | 1 |
| 11 | Estimation of nutrient sources and transport for New Zealand using the hybrid model SPARROW 显示文摘 | Elliott A Alexander R B Schwarz G E | 2005 | Journal of Hydrology (New Zealand)2005，44，1： | 1 |
| 12 | The Design of Small Slot Arrays显示文摘 | Elliott R S Kurtz L A | 1978 | IEEE Transaction on Antennas and Propagation1978，26，3： | 1 |
| 13 | Corruption, Governance and FDI Location in China: A Province -level Analysis 显示文摘 | Cole M A Elliott R J Zhang J | 2009 | Journal of Development Studies2009，45，9： | 1 |
| 14 | Estimating the sources and transport of nutrients in the Waikato River Basin, New Zealand 显示文摘 | Alexander R B Elliott A H Shankar U | 2002 | Water Resources Research2002，38，12： | 1 |
| 15 | Trade, Environmental Regulations and Industrial Mobility: An Industry-Level Study of Japan显示文摘 | Cole M A RoertJ R Elliott Okuo T | 2010 | Ecological Economics2010，，2： | 1 |
| 16 | In Search of Environmental Spillovers显示文摘 | Albornoz F Cole M A Elliott R J | | 0，，01： | 1 |
| 17 | Piperidine-derived gamma-secretase modulators 显示文摘 | HALL A ELLIOTT R L GIBLIN G M | 2010 | Bioorg Med Chem Lett2010，20，3： | 1 |
| 18 | Green - fluorescent pro-tein facilitates rapid in vivo detection of genetically transformed plantceUs显示文摘 | Elliott A R Campbell J A Dugdale B | 1999 | Plant Cell Reports1999，18，： | 1 |
| 19 | Isolation of bitter and astrin- gent fractions from cheddar cheese显示文摘 | Harwalkar V R Elliott J A Elliott | 1971 | Journal of Dairy Science1971，54，1： | 1 |
| 20 | Light-induced oxidation and band-edge shifts in thermally evaporated films of germanium chalcogenide glasses 显示文摘 | SPENCE C A ELLIOTT S R | 1989 | Phys Rev B1989，39，8： | 1 |
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