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| 1 | Long-term outcomes and prognostic factors of patients with obstructive colorectal cancer: A multicenter retrospective cohort study显示文摘AIM: To investigate the long-term oncologic outcomes and prognostic factors in patients with obstructive colorectal cancer(CRC) at multiple Japanese institutions.METHODS: We identified 362 patients diagnosed with obstructive colorectal cancer from January 1, 2002 to December 31, 2012 in Yokohama Clinical Oncology Group's department of gastroenterological surgery. Among them, 234 patients with stage Ⅱ/Ⅲ disease who had undergone surgical resection of their primary lesions were analyzed, retrospectively. We report the long-term outcomes, the risk factors for recurrence, and the prognostic factors.RESULTS: The five-year disease free survival and cancer-specific survival were 50.6% and 80.3%, respectively. A multivariate analysis showed the ASAPS(HR = 2.23, P = 0.026), serum Albumin ≤ 4.0 g/d L(HR = 2.96, P = 0.007), T4 tumor(HR = 2.73, P = 0.002) and R1 resection(HR = 6.56, P = 0.02) to be independent risk factors for recurrence. Furthermore, poorly differentiated cancers(HR = 6.28, P = 0.009), a T4 tumor(HR = 3.46, P = 0.011) and R1 resection(HR = 6.16, P = 0.006) were independent prognostic factors in patients with obstructive CRC.CONCLUSION: The outcomes of patients with obstructive CRC was poor. T4 tumor and R1 resection were found to be independent prognostic factors for both recurrence and survival in patients with obstructive CRC. | Ishibe Atsushi Ota Mitsuyoshi Yamaguchi Kazuya Kaida Syuhei Kamiya Noriyuki Momiyama Masashi Watanabe Akira Sekizawa Kentaro Kamimukai Nobuyuki Sugimasa Natsuko Watanabe Jun Ichikawa Yasushi Kunisaki Chikara Endo Itaru | 2016 | World Journal of Gastroenterology2016，22，22： | 9 |
| 2 | Short-term results of a randomized study between laparoscopic and open surgery in elderly colorectal cancer patients显示文摘 | Shoichi Fujii Atsushi Ishibe Mitsuyoshi Ota Shigeru Yamagishi Kazuteru Watanabe Jun Watanabe Amane Kanazawa Yasushi Ichikawa Mari Oba Satoshi Morita Yojiro Hashiguchi Chikara Kunisaki Itaru Endo | 2014 | Surgical Endoscopy2014，，2： | 2 |
| 3 | Transposon tagging in rice显示文摘 | Takeshi Izawa Tohru Ohnishi Toshitsugu Nakano Nobuhiro Ishida Hiroyuki Enoki Hisako Hashimoto Kimiko Itoh Rie Terada Chuanyn Wu Chikara Miyazaki Tomoko Endo Shigeru Iida Ko Shimamoto | 1997 | Plant Molecular Biology (-)1997，，1： | 1 |
| 4 | Identification of anther-specific genes in a cruciferous model plant, Arabidopsis thaliana, by using a combination of Arabidopsis macroarray and mRNA derived from Brassica oleracea显示文摘 | Masayuki Amagai Tohru Ariizumi Makoto Endo Katsunori Hatakeyama Chikara Kuwata Daisuke Shibata Kinya Toriyama Masao Watanabe | 2003 | Sexual Plant Reproduction2003，，5： | 1 |
| 5 | Comparison of short, long-term surgical outcomes and mid-term health-related quality of life after laparoscopic and open resection for colorectal cancer: a case-matched control study显示文摘 | Shoichi Fujii Mitsuyoshi Ota Yasushi Ichikawa Shigeru Yamagishi Kazuteru Watanabe Kenji Tatsumi Jun Watanabe Hirokazu Suwa Takashi Oshima Chikara Kunisaki Shigeo Ohki Itaru Endo Hiroshi Shimada | 2010 | International Journal of Colorectal Disease2010，，11： | 1 |
| 6 | Ozone-cleavale Gemini surfactants,a new candidate for an enviromantally friendly surfactant显示文摘 | Masuyama Araki Endo Chikara Takeda Shin-ya | 1998 | Chem Commun1998，，： | 1 |
| 7 | Prognostic Factors After Resection of Pancreatic Cancer显示文摘 | Michio Ueda Itaru Endo Masayuki Nakashima Yuta Minami Kazuhisa Takeda Kenichi Matsuo Yasuhiko Nagano Kuniya Tanaka Yasushi Ichikawa Shinji Togo Chikara Kunisaki Hiroshi Shimada | 2009 | World Journal of Surgery2009，，1： | 1 |
| 8 | Transposon tagging in rice显示文摘 | Takeshi Izawa Tohru Ohnishi Toshitsugu Nakano Nobuhiro Ishida Hiroyuki Enoki Hisako Hashimoto Kimiko Itoh Rie Terada Chuanyn Wu Chikara Miyazaki Tomoko Endo Shigeru Iida Ko Shimamoto | 1997 | Plant Molecular Biology (-)1997，，1： | 1 |
| 9 | Surgical outcomes of laparoscopy-assisted gastrectomy versus open gastrectomy for gastric cancer: a case-control study显示文摘 | Chikara Kunisaki Hirochika Makino Takashi Kosaka Takashi Oshima Shoichi Fujii Ryo Takagawa Jun Kimura Hidetaka A. Ono Hirotoshi Akiyama Masataka Taguri Satoshi Morita Itaru Endo | 2012 | Surgical Endoscopy2012，，3： | 1 |
| 10 | Efficacy of neoadjuvant chemotherapy for initially resectable colorectal liver metastases:A retrospective cohort study显示文摘BACKGROUND The liver is the most common metastatic site of colorectal cancer.Hepatectomy is the mainstay of treatment for patients with colorectal liver metastases(CRLMs).However,there are cases of early recurrence after upfront hepatectomy alone.In selected high-risk patients,neoadjuvant chemotherapy(NAC)may improve longterm survival.AIM To determine the efficacy of NAC for initially resectable CRLMs.METHODS Among 644 patients who underwent their first hepatectomy for CRLMs at our institution,297 resectable cases were stratified into an upfront hepatectomy group(238 patients)and a NAC group(59 patients).Poor prognostic factors for upfront hepatectomy were identified using multivariate logistic regression analysis.Propensity score matching was used to compare clinical outcomes between the upfront hepatectomy and NAC groups,according to the number of poor prognostic factors.Survival curves were estimated using the Kaplan-Meier method and compared using the log-rank test.RESULTS Preoperative carcinoembryonic antigen levels(≥10 ng/mL)(P=0.003),primary histological type(other than well/moderately differentiated)(P=0.04),and primary lymph node metastases(≥1)(P=0.04)were identified as independent poor prognostic factors for overall survival(OS)in the upfront hepatectomy group.High-risk status was defined as the presence of two or more risk factors.After propensity score matching,50 patients were matched in each group.Among high-risk patients,the 5-year OS rate was significantly higher in the NAC group(13 patients)than in the upfront hepatectomy group(18 patients)(100%vs 34%;P=0.02).CONCLUSION NAC may improve the prognosis of high-risk patients with resectable CRLMs who have two or more risk factors. | Kazuhisa Takeda Yu Sawada Yasuhiro Yabushita Yuki Honma Takafumi Kumamoto Jun Watanabe Ryusei Matsuyama Chikara Kunisaki Toshihiro Misumi Itaru Endo | 2022 | World Journal of Gastrointestinal Oncology2022，14，7： | 1 |
| 11 | Preoperative S-1 and docetaxel combination chemotherapy in patients with locally advanced gastric cancer显示文摘 | Takashi Kosaka Hirotoshi Akiyama Hirochika Makino Ryo Takagawa Jun Kimura Hidetaka Ono Chikara Kunisaki Itaru Endo | 2014 | Cancer Chemotherapy and Pharmacology2014，，2： | 1 |
| 12 | Preoperative S-1 and docetaxel combination chemotherapy in patients with locally advanced gastric cancer显示文摘 | Takashi Kosaka Hirotoshi Akiyama Hirochika Makino Ryo Takagawa Jun Kimura Hidetaka Ono Chikara Kunisaki Itaru Endo | 2014 | Cancer Chemotherapy and Pharmacology2014，，2： | 1 |
| 13 | STBC AF Relay for Unmanned Aircraft Systems显示文摘 | Fumiyuki Adachi Hiroyuki Miyazaki Chikara Endo | 2015 | Proceedings of SPIE2015，，： | 1 |
| 14 | Surgical outcomes of laparoscopy-assisted gastrectomy versus open gastrectomy for gastric cancer: a case-control study显示文摘 | Chikara Kunisaki Hirochika Makino Takashi Kosaka Takashi Oshima Shoichi Fujii Ryo Takagawa Jun Kimura Hidetaka A. Ono Hirotoshi Akiyama Masataka Taguri Satoshi Morita Itaru Endo | 2012 | Surgical Endoscopy2012，，3： | 1 |
| 15 | Ozone- cleavable Gemini surfactants, their surface-active properties, ozo- nolysis, and biodegradability 显示文摘 | Araki Masuyama Chikara Endo Shin-ya Takeda | 2000 | Langmuir2000，16，2： | 1 |
| 16 | High Expression of Atypical Protein Kinase C λ/ι in Gastric Cancer as a Prognostic Factor for Recurrence显示文摘 | Ryo Takagawa MD Kazunori Akimoto PhD Yasushi Ichikawa MD PhD Hirotoshi Akiyama MD PhD Yasuyuki Kojima MD Hitoshi Ishiguro PhD Yoshiaki Inayama MD PhD Ichiro Aoki MD PhD Chikara Kunisaki MD PhD Itaru Endo MD PhD Yoji Nagashima MD PhD Shigeo Ohno PhD | 2010 | Annals of Surgical Oncology2010，，1： | 1 |
| 17 | Predictive Factors of Microvascular Invasion in Patients with Hepatocellular Carcinoma Larger Than 5 cm显示文摘 | Yasuhiko Nagano Hiroshi Shimada Kazuhisa Takeda Michio Ueda Kenichi Matsuo Kuniya Tanaka Itaru Endo Chikara Kunisaki Shinji Togo | 2008 | World Journal of Surgery2008，，10： | 1 |
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