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| 1 | Photoperiod- and thermo-sensitive genic male sterility in rice are caused by a point mutation in a novel noncoding RNA that produces a small RNA显示文摘光周期敏感、 thermo 敏感的遗传因子的男绝育(PGMS 和 TGMS ) 是为在庄稼的混合繁殖的核心部件。基于使用的较普通活字大一倍的系统, PGMS 和 TGMS 衬里的混合大米是成功地在农业广泛地发展了并且适用。然而,位于 PGMS 和 TGMS 的控制下面的分子的机制仍然保持阴暗。在这研究,我们印射并且克隆一个主要地点, p/tms12-1 (染色体 12 上的感光性或 thermo 敏感的遗传因子的男绝育地点) 它在装饰用的梨树米饭线 Nongken 58S (NK58S ) 授与 PGMS 和在 indica 米饭的 TGMS 衬里 Peiai 64S (PA64S,源于 NK58S ) 。包含野类型的等位基因 P/TMS12-1 的 A 2.4-kb DNA 碎片能在基因互补恢复 NK58S 和 PA64S 植物的花粉富饶。P/TMS12-1 编码唯一的 noncoding RNA,它生产 21 核苷酸我们说出 osa-smR5864w 的小 RNA。在 p/tms12-1 的 C-to-G 的替换,相对 P/TMS12-1 的唯一的多型性,在变异的小 RNA 是在场的,也就是 osa-smR5864m。而且,在转基因的 NK58S 和 PA64S 植物的 P/TMS12-1 的一个 375-bp 序列的 overexpression 也生产了 osa-smR5864w 并且恢复了花粉富饶。小 RNA 在年轻圆锥花序优先地被表示,但是它的表示没被不同的天长度或温度显著地影响。我们的结果表明在 p/tms12-1 的点变化,可能为 osa-smR5864m 导致 loss-of-function,分别地在装饰用的梨树和 indica 线为 PGMS 和 TGMS 组成一个普通原因。我们的调查结果因此建议那小 RNA 基因是的这 noncoding 男开发的一个重要管理者由在基因网络和环境条件之间的串音控制了。 | Hai Zhou Qinjian Liu Jing Li Dagang Jiang Lingyan Zhou Ping Wu Sen Lu Feng Li Liya Zhu Zhenlan Liu Letian Chen Yao-Guang Liu Chuxiong Zhuang | 2012 | Cell Research2012，22，4： | 99 |
| 2 | Correlation between women's sub-health and reproductive diseases with pregnancies and labors显示文摘OBJECTIVE: To investigate whether female sub-health conditions and reproductive diseases areassociated with pregnancies and labors.METHODS: A cross-sectional survey was performed by using a structured questionnaire. A total of 1343 women aged 35 years or younger in six urban areas of Chengdu were included in the study.According to the Screening Criteria of sub-health conditions, these women were categorized into three groups: postpartum healthy group,sub-healthy group, and reproductive disease group. Data were double-entered using EpiData and the nanalyzed by SPSS.RESULTS: Pregnancy and labor were correlated with postpartum sub-health conditions. The number of pregnancies was negatively correlated with women's postnatal health but was positively correlated with the incidence of postpartum reproductive diseases.CONCLUSION: The number of pregnancies and labors is probably an important factor leading to sub-health conditions and the occurrence of reproductive diseases in women. Avoiding or reducing unwanted pregnancies and labors, enhancing the awareness of health among child bearing-age women are effective measures for preventing sub-health conditions. | Xiaojuan Xu Qian Zeng Hong Ding Lingyan Feng Linwen Deng | 2014 | Journal of Traditional Chinese Medicine2014，34，4： | 14 |
| 3 | High-throughput experiments facilitate materials innovation:A review显示文摘Since the Material Genome Initiative(MGI) was proposed, high-throughput based technology has been widely employed in various fields of materials science. As a theoretical guide, material informatics has been introduced based on machine learning and data mining and high-throughput computation has been employed for large scale search, narrowing down the scope of the experiment trials. High-throughput materials experiments including synthesis, processing, and characterization technologies have become valuable research tools to pin down the prediction experimentally, enabling the discovery-to-deployment of advances materials more efficiently at a fraction of cost. This review aims to summarize the recent advances of high-throughput materials experiments and introduce briefly the development of materials design based on material genome concept. By selecting representative and classic works in the past years, various high-throughput preparation methods are introduced for different types of material gradient libraries, including metallic, inorganic materials, and polymers. Furthermore, high-throughput characterization approaches are comprehensively discussed, including both their advantages and limitations. Specifically, we focus on high-throughput mass spectrometry to analyze its current status and challenges in the application of catalysts screening. | LIU Yi Hao HU ZiHeng SUO ZhiGuang HU LianZhe FENG LingYan GONG XiuQing LIU Yi ZHANG JinCang | 2019 | Science China(Technological Sciences)2019，62，4： | 7 |
| 4 | Electrochemically and DNA-triggered cell release from ferrocene/β-cyclodextrin and aptamer modified dual- functionalized graphene substrate显示文摘这里,我们报导 dual-functionalized 基于在 -cyclodextrin 之间的超分子的相互作用触发癌症房间版本的电气化学的底层(临床的试用 II aptamer AS1411 functionalized graphene 上的 -CD) 和 Fc 站台。一方面,主人客人相互作用能电气化学地是可逆的控制了认识到癌症房间捕获 / 释放,和 1-adamantylamine 绑定能进一步由和 CD 的竞争相互作用放大这个表面变化。在另一方面, AS1411 aptamer 和它的互补 DNA (cDNA ) 能也为房间粘附被用作一个可切换的锚。我们的工作给一个例子为没有标签, multi-functionalized 在修改表面也提供的 graphene 上为房间 catch-and-release 基于 aptamer 和 -CD/graphene-modified 表面和这个多方法触发了房间版本他们的潜在的生物医学的申请。 | Lingyan Feng Wen Li Jinsong Ren Xiaogang Qu | 2015 | Nano Research2015，8，3： | 3 |
| 5 | KIR2DL2/C1 is a Risk Factor for Chronic Infection and Associated with Non-response to PEG-IFN and RBV Combination Therapy in Hepatitis C Virus Genotype 1b Patients in China显示文摘Dear Editor,Natural killer(NK)cells are lymphocytes that play important roles in the host defense against hepatitis C virus(HCV)infection.Killer cell immunoglobulin-like receptors(KIRs)are a group of regulatory molecules expressed on NK cells and a subset of T cells(Parham 2005).Ligands for KIRs are human leukocyte antigen(HLA)class Ⅰ molecules,and HLA-C1 is a ligand for the | Song Hu Fahu Yuan Lingyan Feng Fang Zheng Feili Gong Hanju Huang Binlian Sun | 2018 | Virologica Sinica2018，33，4： | 3 |
| 6 | A Target Grabbing Strategy for Telerobot Based on Improved Stiffness Display Device显示文摘Most target grabbing problems have been dealt with by computer vision system, however, computer vision method is not always enough when it comes to the precision contact grabbing problems during the teleoperation process, and need to be combined with the stiffness display to provide more effective information to the operator on the remote side. Therefore, in this paper a more portable stiffness display device with a small volume and extended function is developed based on our previous work. A new static load calibration of the improved stiffness display device is performed to detect its accuracy, and the relationship between the stiffness and the position is given. An effective target grabbing strategy is presented to help operator on the remote side to judge and control and the target is classified by multi-class SVM(supporter vector machine). The teleoperation system is established to test and verify the feasibility. A special experiment is designed and the results demonstrate that the improved stiffness display device could greatly help operator on the remote side control the telerobot to grab target and the target grabbing strategy is effective. | Pengwen Xiong Xiaodong Zhu Aiguo Song Lingyan Hu Xiaoping P.Liu Lihang Feng | 2017 | IEEE/CAA Journal of Automatica Sinica2017，4，4： | 2 |
| 7 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 8 | Artificial Intelligence in Pharmaceutical Sciences显示文摘Drug discovery and development affects various aspects of human health and dramatically impacts the pharmaceutical market.However,investments in a new drug often go unrewarded due to the long and complex process of drug research and development(R&D).With the advancement of experimental technology and computer hardware,artificial intelligence(AI)has recently emerged as a leading tool in analyzing abundant and high-dimensional data.Explosive growth in the size of biomedical data provides advantages in applying AI in all stages of drug R&D.Driven by big data in biomedicine,AI has led to a revolution in drug R&D,due to its ability to discover new drugs more efficiently and at lower cost.This review begins with a brief overview of common AI models in the field of drug discovery;then,it summarizes and discusses in depth their specific applications in various stages of drug R&D,such as target discovery,drug discovery and design,preclinical research,automated drug synthesis,and influences in the pharmaceutical market.Finally,the major limitations of AI in drug R&D are fully discussed and possible solutions are proposed. | Mingkun Lu Jiayi Yin Qi Zhu Gaole Lin Minjie Mou Fuyao Liu Ziqi Pan Nanxin You Xichen Lian Fengcheng Li Hongning Zhang Lingyan Zheng Wei Zhang Hanyu Zhang Zihao Shen Zhen Gu Honglin Li Feng Zhu | 2023 | Engineering2023，，8： | 1 |
| 9 | A grapheme functionalized electrochemical aptasensor for selective label-free detection of cancer cell显示文摘 | Lingyan Feng Yong chen Jinsong Ren | 2011 | Biomaterial2011，32，11： | 1 |
| 10 | Flocculating Properties and Production of the Compound Bioflocculant by Rhizobium Radiobacter F2 and Bacillus Sphaeicus F6显示文摘A compound bioflocculant CBF,produced by mixed culture of Rhizobium radiobacter F2 and Bacillus sphaeicus F6, was investigated with regard to its production and flocculating properties. The optimization of the culture medium constituents including carbon source,nitrogen source and C / N ratio,metal ions and ionic strength on CBF production were studied. Flocculating properties of CBF were examined by a series of experiments and CBF had good flocculating activities in kaolin suspension with divalent cations and stable over wide range of p H. Studies of the flocculating properties revealed that the flocculation could be stimulated by cations Ca2+,Mg2+,Fe2+,Al3+and Fe3+. In addition,it was stable at 4-30 ℃ in the presence of Ca Cl2. It was found to be effective for flocculation of a kaolin suspension under neutral and weak alkaline conditions( p H 7. 0- 9. 0),and flocculating activities of higher than 95% were obtained when the CBF concentrations among 6- 14 mg / L at p H 8. 0. The results of this study indicate that CBF is a potential replacement of conventional synthetic flocculants and is widely applied in water treatment and downstream processing of food and fermentation industries. | Lixin Li Lingyan Feng Fang Ma Qianshen Zhao | 2015 | Journal of Harbin Institute of Technology(New Series)2015，22，4： | 1 |
| 11 | A graphene funetionalized electrochemical aptasensor for selective la- bel-free detection of cancer cells 显示文摘 | Lingyan Feng Yong Chen Jinsong Ren | 2011 | B/omateHa/s2011，32，11： | 1 |
| 12 | Antioxidant properties and sensory evaluation of microgreens from commercial and local farms显示文摘Microgreens are young and tender vegetables or herbs that provide attractive color,flavor,and nutrition.The purpose of this study was to evaluate the nutritional and sensory qualities of broccoli microgreens grown by different methods(hydroponically vs.soil grown)and from different sources(commercial vs.local farm).No significant difference in total phenolic concentration and antioxidant capacity was found in all broccoli microgreens,but a significantly higher chlorophyll concentration was found in farm microgreens than the commercial ones.Moreover,the soil-grown farm microgreens possessed a significantly higher vitamin C concentration than hydroponically-grown farm sample and commercial sample.Participants in the sensory study favored farm samples regardless of growing method,and their overall liking was significantly correlated with taste of the microgreens.In addition,six other microgreens from the local farm were analyzed for their nutritional quality.These conclusions suggested a potential for consumers to still benefit nutritionally by purchasing commercial microgreens at a lower cost;however,it may be worthwhile for consumers to purchase microgreens from local farms for a better sensory experience. | Libo Tan Holly Nuffer Jiannan Feng Shu Hang Kwan Hsiangting Chen Xiao Tong Lingyan Kong | 2020 | Food Science and Human Wellness2020，9，1： | 0 |
| 13 | In-situ formation of“electron conductive wires”threaded ZIF-8 membrane for multiplexed immunoassay of human interleukins显示文摘To address the challenge of highly sensitive and accurate detection of biomarkers in complex environments,a rational engineering strategy for designing electrochemical immunosensing platform is proposed.Herein,we develop a microsensor chip through the combination of multiplexed electrodes and microfluidic channels for the parallel detection of human interleukins(IL-6 and IL-8).For the construction of an efficient sensing interface,the conductive silver nanowires(Ag NWs)wrapped with zeolitic imidazolate framework(ZIF-8)thin film(denoted as ZIF-8@Ag NWs)are prepared,and then employed for the multi-functionalization of electrodes.The immunodetection of ILs is based on the direct signal transduction ability of Ag NWs and specific interaction of periodically arranged Zn2+ions in ZIF-8 films with biomolecules,which offer the high assay sensitivity and good specificity.The immunosensor chip achieves a wide detection range from pg/mL to ng/mL and possesses the ability to resist non-specific proteins adsorption in biological complex media.Further clinical serum samples assay verifies that the combination of IL-6 and IL-8 levels yields high diagnostic accuracy.Principal component analysis(PCA)reveals that 18 patient samples could be fully separated from healthy control samples.The low-cost,easily fabricated electrochemical immunosensing platform provides a rapid serum test for diagnosis and personalized therapy of inflammatory diseases,and can also be generalized to other immunoreaction-based biomarkers detections. | Yu Lv Mingshi Deng Xuefeng Wang Xinghua Gao Lingyan Feng Wei Chen Chung-Chiun Liu Xinxin Li Yuan Zhang | 2023 | Nano Research2023，16，2： | 0 |
| 14 | Center-environment deep transfer machine learning across crystal structures: from spinel oxides to perovskite oxides显示文摘In data-driven materials design where the target materials have limited data,the transfer machine learning from large known source materials,becomes a demanding strategy especially across different crystal structures.In this work,we proposed a deep transfer learning approach to predict thermodynamically stable perovskite oxides based on a large computational dataset of spinel oxides.The deep neural network(DNN)source domain model with“Center-Environment”(CE)features was first developed using the formation energy of 5329 spinel oxide structures and then was fine-tuned by learning a small dataset of 855 perovskite oxide structures,leading to a transfer learning model with good transferability in the target domain of perovskite oxides.Based on the transferred model,we further predicted the formation energy of potential 5329 perovskite structures with combination of 73 elements.Combining the criteria of formation energy and structure factors including tolerance factor(0.7 | Yihang Li Ruijie Zhu Yuanqing Wang Lingyan Feng Yi Liu | 2023 | npj Computational Materials2023，，1： | 0 |
| 15 | RhIr@MoS2 nanohybrids based disposable microsensor for the point-of-care testing of NADH in real human serum显示文摘Dihydronicotinamide adenine dinucleotide(NADH)is an important enzyme in all living cells,which is found to be abnormally expressed in cancer cells.Since it is redox-active,an electrochemical detection method would be suitable for monitoring its concentration in biological fluids.Here we present a strategy for specific determination of NADH in real human serum by using RhIr@MoS2 nanohybrids based microsensor.To implement the protocol,RhIr nanocrysrals are in-situ grown onto MoS2 interlayers forming a nanohybrid structure(RhIr@MoS2).After being locally deposited on an electrochemical microsensor,it could be used for the analysis of NADH.The developed RhIr@MoS2 nanohybrids based microsensor possesses the ability for analyzing NADH at the applied potential of 0.07 V(much lower than most reported values).The detection limit is evaluated as low as 1 nmol/L even in bovine serum albumin(BSA)media.In addition,the sampling analysis of human serum from cancer patients and health controls shows that the microsensor displays good diagnostic sensitivity and specificity,illustrating that this developed detection technique is a relatively accurate method for measuring NADH in biological fluids.The proposed electrochemical microsensor assay also owns the benefits of convenience,disposable and easy processing,which make it a great possibility for future point-of-care cancer diagnosis. | Dongqing Ji Zi Ying Yuan Zhang Wei Chen Metini Janyasupab Xinghua Gao Lingyan Feng Weijia Wen | 2020 | Chinese Chemical Letters2020，31，8： | 0 |
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