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| 1 | Effect of Bufei granule on stable chronic obstructive pulmonary disease: a randomized, double blinded, placebo-controlled, and multicenter clinical study显示文摘OBJECTIVE: To study the therapeutic effect Bufei granule, which is a traditional Chinese drug that can enhance the immune function of the lung, on patients with stable chronic obstructive pulmonary disease(COPD).METHODS: This is a randomized, double blinded,placebo-controlled, and multicenter clinical study.Three medical centers in Tianjin, China, participated in the trial. A total of 140 patients with stable COPD were enrolled and randomized into two groups, with 70 patients in each. The treatment group was treated with Bufei granule, while the control group received Bufei placebo. The pharmacological treatment lasted for 12 weeks from the date of enrollment. Then, the indexes of patients were observed. Data were analyzed to study the effect of Bufei granule, with the frequency of acute exacerbation as the primary outcome. Traditional Chinese Medicine syndromes,Modified British Medical Research Council dyspnea scale score, St.George's respiratory questionnaire scores, pulmonary function, and serum inflammatory marker levels [including interleukin-6(IL-6), interleukin-8, tumor necrosis factor-α, and transformation growth factor-β1]were the secondary outcomes.RESULTS: During the 12-week treatment, treatment and control groups had no adverse reactions.The analysis of the indexes obtained from all patients showed that the therapeutic effect in the treatment group was significantly better than that in the control group because most of the similar probabilities of primary and secondary outcomes were less than 0.05,except for the level of IL-6.CONCLUSION: Bufei granule can treat patients with stable COPD by lowering the frequency of acute exacerbation, improving the quality of life,and alleviating the severity of inflammation. | Sijia Guo Zengtao Sun Enshun Liu Jihong Feng Min Fu Yuechuan Li Qi Wu | 2014 | Journal of Traditional Chinese Medicine2014，34，4： | 19 |
| 2 | FY-3 satellite Ultraviolet Total Ozone Unit显示文摘FY-3 satellites are Chinese second-generation polar orbit meteorological satellite series. Ultraviolet Total Ozone Unit (TOU) is one of the main payloads on FY-3 satellite and the first instrument for daily global coverage of total ozone monitoring in China. The main purpose of TOU is to measure the Earth backscatter ultraviolet radiation for retrieving daily global map of atmospheric ozone. TOU will provide the important parameters for environmental monitoring, climate forecasting and global climate changing research. At present, the in-orbit testing of TOU has accomplished and won a consummation, and it will be delivered to National Satellite Meteorological Center for the operational phase of the project. In this paper we introduce the instrument of TOU and its measuring principle, in general. We also analyze the recent working status of the instrument, including the sensitivity, measuring precision of solar irradiance, diffuser degradation and wavelength drift. The inversion results show that TOU can provide good global ozone maps, and a comparison with the OMI total ozone product shows that their RMS deviation is about 5%. It is indicated that the satisfied global distribution of total ozone can be obtained through TOU observational data and self-developed inversion method. | WANG YongMei WANG YingJian WANG WeiHe ZHANG ZhongMou LU JianGong FU LiPing JIANG Fang CHEN Ji WANG JiHong GUAN FengJun HUANG FuXiang ZHANG XingYing | 2010 | Chinese Science Bulletin2010，55，1： | 9 |
| 3 | Progress in quantitative analysis of plant hormones显示文摘Plant hormones are small molecular natural products that regulate all plant developmental processes at low concentrations. Quantitative analysis of plant hormones is increasingly important for in-depth study of their biosynthesis,transport,metabolism and molecular regulatory mechanisms. Although plant hormone analysis remains a bottleneck in plant scientific research owing to the trace concentrations and complex components in plant crude extracts,much progress has been achieved in the development of extraction,purification and detection techniques in recent years. Solid phase extraction and chromatography/mass spectrometry have been applied widely for purification and quantitative analysis of plant hormones owing to their high selectivity and sensitivity. Purification methods such as liquid partition and immunoaffinity chromatography,and detection methods including immunoassay and electrochemical analysis,are employed. The advantages and disadvantages of these methods are discussed. In situ,real-time and multi-plant hormone profiling will comprise mainstream techniques for quantitative analyses in future studies on the regulatory mechanisms and crosstalk of plant hormones. | FU JiHong SUN XiaoHong WANG JiDe CHU JinFang YAN CunYu | 2011 | Chinese Science Bulletin2011，56，4： | 9 |
| 4 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 5 | PhaseⅠdose-escalation and expansion study of PARP inhibitor,fluzoparib(SHR3162),in patients with advanced solid tumors显示文摘Objective:Fluzoparib(SHR3162)is a novel,potent poly(ADP-ribose)polymerases(PARP)1,2 inhibitor that showed anti-tumor activity in xenograft models.We conducted a phaseⅠ,first-in-human,dose-escalation and expansion(D-Esc and D-Ex)trial in patients with advanced solid cancer.Methods:This was a 3+3 phaseⅠD-Esc trial with a 3-level D-Ex at 5 hospitals in China.Eligible patients for DEsc had advanced solid tumors refractory to standard therapies,and D-Ex enrolled patients with ovarian cancer(OC).Fluzoparib was administered orally once or twice daily(bid)at 11 dose levels from 10 to 400 mg/d.Endpoints included dose-finding,safety,pharmacokinetics,and antitumor activity.Results:Seventy-nine patients were enrolled from March,2015 to January,2018[OC(47,59.5%);breast cancer(BC)(16,20.3%);colorectal cancer(8,10.1%),other tumors(8,10.1%)];48 patients were treated in the D-Esc arm and 31 in the D-Ex arm.The maximum tolerated dose(MTD)was 150 mg bid,with a half-life of 9.14 h.Grade 3/4 adverse events included anemia(7.6%)and neutropenia(5.1%).The objective response rate(ORR)was 30%(3/10)in patients with platinum-sensitive OC and 7.7%(1/13)in patients with BC.Among patients treated with fluzoparib≥120 mg/d,median progression-free survival(m PFS)was 7.2[95%confidence interval(95%CI),1.8-9.3]months in OC,9.3(95%CI,7.2-9.3)months in platinum-sensitive OC,and 3.5(range,2.0-28.0)months in BC.In patients with germline BC susceptibility gene mutation(g BRCAMut)(11/43 OC;2/16 BC),m PFS was 8.9 months for OC(range,1.0-23.2;95%CI,1.0-16.8)and 14 and 28 months for BC(those two patients both also had somatic BRCAMut).Conclusions:The MTD of fluzoparib was 150 mg bid in advanced solid malignancies.Fluzoparib demonstrated single-agent antitumor activity in BC and OC,particularly in BRCAMut and platinum-sensitive OC. | Huiping Li Rongrui Liu Bin Shao Ran Ran Guohong Song Ke Wang Yehui Shi Jihong Liu Wenjing Hu Fu Chen Xiaoran Liu Gairong Zhang Chuanhua Zhao Ru Jia Quanren Wang Hope S.Rugo Yifan Zhang Guangze Li Jianming Xu | 2020 | Chinese Journal of Cancer Research2020，32，3： | 4 |
| 6 | Deletion of SMARCA4 impairs alveolar epithelial type II cells proliferation and aggravates pulmonary fibrosis in mice显示文摘Alveolar epithelial cells(AECs)injury and failed reconstitution of the AECs barrier are both integral to alveolar flooding and subsequent pulmonary fibrosis(PF).Nevertheless,the exact mechanisms regulating the regeneration of AECs post-injury still remain unclear.SMARCA4 is a part of the large ATP-dependent chromatin remodelling complex SWI/SNF,which is essential for kidney and heart fibrosis.We investigates SMARCA4 function in lung fibrosis by establishing PF mice model with bleomycin firstly and found that the expression of SMARCA4 was mainly enhanced in alveolar type II(ATII)cells.Moreover,we established an alveolar epithelium-specific SMARCA4-deleted SP-C-rtTA/(tetO)7-Cre/SMARCA4f/f mice(SOSM4D/D)model,as well as a new SMARCA4-deleted alveolar type II(ATII)-like mle-12 cell line.We found that the bleomycin-induced PF was more aggressive in SOSM4D/D mice.Also,the proliferation of ATII cells was decreased with the loss of SMARCA4 in vivo and in vitro.In addition,we observed increased proliferation of ATII cells accompanied by abnormally high expression of SMARCA4 in human PF lung sections.These data uncovered the indispensable role of SMARCA4 in the proliferation of ATII cells,which might affect the progression of PF. | Danyi Peng Daozhu Si Rong Zhang Jiang Liu Hao Gou Yunqiu Xia Daiyin Tian Jihong Dai Ke Yang Enmei Liu Yujun Shi Q.Richard Lu Lin Zou Zhou Fu | 2017 | Genes & Diseases2017，4，4： | 3 |
| 7 | TREATMENT OF INDUSTRIAL WASTEWATER FROM AN ALUMINA PLANT BY MEMBRANE TECHNOLOGY(Ⅱ) ——Study on Technological Process显示文摘The experimental results of producing deionized water for the themoelectric factory from two types of the industrial wastewater of an alumina plant by using membrane technology are reported in this paper. For the treatment of the industrial wastewater with high salinity and pH value, the combination of electrodialysis (ED) and reverse osmosis (RO) is utilized, while for the treatment of the low salinity wastewater with low pH value, RO is directly used. The research results show that the above mentioned methods are effective. The technological process of the wastewater treatment with the capacity of 120 tons is designed on the basis of the experimental results. | Zhou Kanggen Zhang Qixiou Luo Aiping (Department of Metallurgical Science and Engineering, Central South University of Technology, Changhsha 410083, China) Fu Chunsheng Xiang Jihong Li Ming (Department of Technology & Resources, Shanxi Alumin | 1999 | Journal of Central South University1999，11，2： | 2 |
| 8 | Statistical characteristics of atmospheric gravity wave in the mesopause region observed with a sodium lidar at Beijing, China显示文摘 | Shaohua Gong Guotao Yang Jiyao Xu Jihong Wang Sai Guan Wei Gong Jun Fu | 2013 | Journal of Atmospheric and Solar-Terrestrial Physics2013，，： | 1 |
| 9 | 溃疡性结肠炎内镜严重度指数(UCEIS)预测溃疡性结肠炎患者行储袋成形术的截点值:多中心长期随访研究结果显示文摘背景:全结直肠切除回肠储袋肛管吻合(IPAA)是溃疡性结肠炎(UC)患者的首选外科治疗术式。溃疡性结肠炎内镜严重度指数(UCEIS)用以预测UC患者的IPAA手术需求,目前尚缺乏数据。本研究旨在建立明确UCEIS预测UC患者IPAA手术需求的截点值。方法:对1986年6月至2020年3月间两个中心收治的UC患者进行回顾性分析。基于入院后首次结肠镜检查结果进行UCEIS评分。采用受试者操作特征曲线分析确定UCEIS评分预测IPAA需求的截点值。结果:293例UC患者纳入研究,中位UCEIS为4分。13年随访期间,80例(28.3%)患者接受外科治疗,其中75例(93.8%)行IPAA手术,5例(6.2%)行次全结肠切除加永久性造口。采用6分作为截点值,UCEIS对IPAA手术需求的预测价值最高,曲线下面积为0.769(P<0.001),灵敏度和特异度分别为72.0%和81.8%。UCEIS≥6是需要行IPAA手术(P<0.001)和恶性转化(P=0.010)的独立预测因素。UCEIS≥6的患者无IPAA生存时间显著短缩(P<0.001)。结论:UCEIS≥6或可作为IPAA手术决策的依据,推荐对这些UC患者行手术治疗以减少恶性转化的发生率。 | Weimin Xu Weijun Ou Jihong Fu Yubei Gu Long Cui Jie Zhong Peng Du | 2021 | Gastroenterology Report2021，9，5： | 1 |
| 10 | PRRX1 promotes epithelial–mesenchymal transition through the Wnt/β-catenin pathway in gastric cancer显示文摘 | Jinbao Guo Zhongxue Fu Jinlai Wei Weidong Lu Jihong Feng Shouru Zhang | 2015 | Medical Oncology2015，，1： | 1 |
| 11 | Joint observations of sporadic sodium and sporadic E layers at middle and low latitudes in China显示文摘Sporadic sodium layers(SSLs)were studied with sodium(Na)lidar at Beijing(40.5°N,116.0°E)and Haikou(19.5°N,109.1°E)in China.The altitude distribution,strength factors,and occurrence time of SSL and sporadic E(Es)layer events were statistically analyzed at both observing sites.SSL occurrence had a maximum near22:00 local time,and Eslayer occurrence had a maximum before midnight.The altitude distributions of SSL and Es layer events were better correlated at Haikou than at Beijing.All the average values of height and strength factor for SSL and Eslayer events,as well as the average of the maximum frequency that can be reflected by the Eslayer(foEs),at Beijing were higher than those at Haikou.A better correlation between SSL and Eslayer events was also found at Haikou,and the formation of SSLs was considered to likely depend on the seasonal variability of chemical and dynamical processes. | Jing Jiao Guotao Yang Xu Zou Shaohua Gong Jihong Wang Dawei Tian Wenzhen Zhang Tiemin Zhang Xianchang Yang Jun Fu Xuewu Cheng | 2014 | Chinese Science Bulletin2014，59，29： | 1 |
| 12 | Phase I trial of human umbilical cord-derived mesenchymal stem cells for treatment of severe bronchopulmonary dysplasia显示文摘Severe bronchopulmonary dysplasia(BPD)is a chronic lung disorder that primarily affects premature babies with extremely low birth weight and involves in multiple organ system;no effective pharmacotherapy for this disease exists,and mortality remains high.Based on the evidence from previous preclinical studies and phase I clinical trials,this study aims to test the safety of intravenous application of a single dose of human umbilical cord-derived mesenchymal stem cells(hUC-MSCs)in patients with severe BPD.The Mesenchymal Stem cells for Bronchopulmonary Dysplasia Treatment(MSBDT)trial is a single center,open-label,dose-escalation phase I clinical trial.Severe BPD patients were enrolled in Children Hospital of Chongqing Medical University,Chongqing,China.The first six patients were treated with low-dose hUC-MSCs(1×10^(6) cells/kg)and the next seven patients were treated with high-dose hUC-MSCs(5×10^(6) cells/kg).This study is registered with ClinicalTrials.gov,number NCT03558334.No prespecified infusion-associated adverse events,immediate complication,respiratory or cardiovascular compromise were observed during infusion and 24 h after infusion.No significant changes in safety laboratory values were observed.One death event occurred in the low-dose group on study day 10,and one death event occurred in the high-dose group on study day 24,while,after review in detail,the two cases are not believed to be infusion-associated events.In conclusion,intravenous application of a single dose of hUC-MSCs was tolerated in thirteen patients with severe BPD. | Yunqiu Xia Tingyuan Lang Yuqin Niu Xian Wu Ou Zhou Jihong Dai Lei Bao Ke Yang Lin Zou Zhou Fu Gang Geng | 2023 | Genes & Diseases2023，10，2： | 1 |
| 13 | Observation of the Double Sodium Layer Over Haikou,China by Lidar显示文摘A Double Sodium Layer(DSL) structure was observed during the night of August 22, 2011 over Haikou,China(20°N,110°E) by Na lidar.This DSL comprised a typical sodium layer at altitudes of 80~105km and a higher sodium layer at altitudes of 105~115km in about 0.5 h.A wavelength of 589 nm dye laser pumped by a Nd:YAG laser was used to make the measurement. The backscattered fluorescence photons from the sodium layer were collected by a telescope with a primary mirror of 1000 mm in diameter.The sodium density of these layers during the nighttime observation in the Mesosphere and Lower-Thermosphere(MLT) was studied. | ZHANG Tiemin WANG Jihong FU Jun YANG Dali YANG Xianchang WU Wei YANG Guotao | 2013 | 空间科学学报2013，33，4： | 1 |
| 14 | Microwave-assisted synthesis of CoAl-layered double hydroxide/graphene oxide composite and its application in supercapacitors显示文摘 | Jihong Fang Min Li Qianqian Li Weifeng Zhang Qingliang Shou Fu Liu Xiaobin Zhang Jipeng Cheng | 2012 | Electrochimica Acta2012，，： | 1 |
| 15 | Inhibition of phagocytosis reduced the classical activation of BV2 microglia induced by amyloidogenic fragments of beta-amyloid and prion proteins显示文摘在 Alzheimer 的疾病和 prion 疾病的煽动性的回答被 microglia 激活统治。microglial 激活,也就是古典的激活,其他的激活,和获得的释放的三不同显型,被描述了。在这研究,我们调查了 amyloidogenic 碎片的效果淀粉并且 microglial 激活的各种各样的形式上的 prion 蛋白质(A142 和 PrP106126 ) 。我们首先在 cytochalasin D 的 microglial 激活,以及效果的几个标记的 mRNA 表示层次上检验了 A142 和 PrP106126 刺激的效果,一个吞噬作用禁止者,在在刺激 A142 、刺激 PrP106126 的 BV2 microglia 的 microglial 激活上。结果显示出那 A142, PrP106126 导致了 BV2 microglia 的古典激活,减少其他的表示标记的表示水平,并且没在获得的释放标记的表示上有效果。Cytochalasin D 处理显著地减少了 proinflammatory 因素的导致 A142 、导致 PrP106126 的起来规定,但是没改变其他的激活的标记的表示侧面或在暴露于 A142 和 PrP106126 的 BV2 房间获得释放。我们的结果建议 microglia 在细胞外的刺激周围的 microglial 与 amyloidogenic 肽交往古典激活和还原剂它的其他的激活,并且从细胞外的周围的 amyloidogenic 肽的举起放大古典 microglial 激活。 | Fushan Shi Lifeng Yang Jihong Wang Mohammed Kouadir Yang Yang Yongyao Fu Xiangmei Zhou Xiaomin Yin Deming Zhao | 2013 | Acta Biochimica et Biophysica Sinica2013，45，11： | 0 |
| 16 | PARAMETERS OF WATER CIRCULATION NETWORK FOR A DISTRICT HEATING AND COOLING SYSTEM显示文摘In a district heating and cooling system, i.e. Beijing combined heating cooling and power (CHCP) system studied here, high temperature water generated by two cogeneration plants circulates through a network between the plants and heat substations. At heat substations, supply water of high temperature from the network drives absorption chillers for air conditioning in summer and meets space heating demands in winter or domestic hot water demands by heat exchangers in the whole year. The parameters, i.e. supply/return water temperature in the network, has a great impact on primary energy consumption (PEC) of the absorption chillers, circulation pumps and domestic hot water (DHW), which is studied in this paper. | Fu, Lin Pan, Jihong Jiang, Yi | 2000 | Journal of Hydrodynamics2000，12，1： | 0 |
| 17 | TREATMENT OF INDUSTRIAL WASTEWATER FROM AN ALUMINA PLANT BY MEMBRANE (Ⅰ) ——Measurement of Limiting Current Density of Electrodialysis显示文摘In order to design the technological process of desalination by electrodialysis for the industrial wastewater of an alumina plant, the limit current density of the industrial wastewater is measured, and the equations of limit current density, voltage drop of the unit membrane pair at the limiting current and desalination ratio at the limiting current were obtained. | Zhou Kanggen Zhang Qixiou Luo Aiping (Department of Metallurgical Science and Engineering, Central South University of Technology, Changhsha 410083, China) Fu Chunsheng Shang Jihong Li Ming Huang Weiqing ① Zhu Xiaoqing ①(Department of Tech | 1999 | Journal of Central South University1999，11，2： | 0 |
| 18 | High Heat Flux Tests of Small-scale Be/Cu Mock-ups for ITER显示文摘 | LIU Xiang ZHANG Fu CHEN Jiming ZHANG Nianmang PAN Chuanhong WANG X. S. ZHANG P. C. WANG Z.H. WANG L. WAN Z. J. TAN Y.M . WU Jihong XU Zengyu | 2006 | Southwestern Institute of Physics Annual Report2006，，1： | 0 |
| 19 | ITER Shield Blanket Design Activities at SWIP显示文摘 | ZHANG Fu KANG Weishan WU Jihong FU Youkun CHEN Jiming Filippo E. | 2006 | Southwestern Institute of Physics Annual Report2006，，1： | 0 |
| 20 | A control structure for the autonomous locomotion on rough terrain with a hexapod robot显示文摘 | Chen Fu Zang Xizhe Yan Jihong Zhao Jie | 2010 | High Technology Letters2010，16，3： | 0 |
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