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| 1 | Genome-wide Identification and Classification of HSF Family in Grape, and Their Transcriptional Analysis under Heat Acclimation and Heat Stress显示文摘Heat stress is one of the most serious threats in viticulture. Heat shock transcription factors(HSFs) have been proven to be the most important transcriptional factor family in the plant response to heat. In this study, a total of 19 putative HSF genes(VHSFs) were identified from the 12 × Vitis vinifera Pinot Noir PN4002 genome, and their chromosomal location, phylogenetic tree, exon-intron structure and conserved motifs were also analyzed. In addition, these HSFs transcriptional profiles in Vitis vinifera 'Jingxiu'(weak heat tolerance) and Vitis davidii 'Tangwei'(strong heat tolerance) under heat stress(47℃) and heat acclimation(38℃) were presented. Only VHSF01, VHSF05, VHSF15 and VHSF18 among 19 VHSFs showed different transcriptional models in these two genotypes under the same treatment, suggesting that these four VHSFs may be important factors which result in a thermotolerance difference between 'Jingxiu' and 'Tangwei'. This study provides novel insights into the response of 19 VHSFs to heat stress in the grape and suggests that potential key VHSFs in grape thermotolerance have great implications for molecular breeding in grapes. | LIU Guotian CHAI Fengmei WANG Yi JIANG Jinzhu DUAN Wei WANG Yuting WANG Fangfang LI Shaohua WANG Lijun | 2018 | Horticultural Plant Journal2018，4，4： | 13 |
| 2 | Power electronic transformer with adaptive PLL technique for voltage-disturbance ride through显示文摘The power electronic transformer(PET) has recently emerged as a type of power converter. It features the basic functions of power conversion and isolation as well as additional functions related to power quality control. A novel PET for a distribution grid called a flexible power distribution unit is proposed in this paper, and the energy exchange mechanism between the network and the load is revealed. A 30 kW 600 VAC/220 VAC/110 VDC medium-frequency isolated prototype is developed and demonstrated. This paper also presents key control strategies of the PET for electrical distribution grid applications,especially under grid voltage disturbance conditions.Moreover, stability issues related to the grid-connected three-phase PET are discussed and verified with an impedance-based analysis. The PET prototype is tested, and it passes the voltage-disturbance ride-through function. The experimental results verify the power quality control abilities of the PET. | Jianhua WANG Fangfang LUO Qing DUAN Zhendong JI Binshi GU Jun YOU Wei GU Jianfeng ZHAO | 2018 | Journal of Modern Power Systems and Clean Energy2018，6，5： | 7 |
| 3 | Cellular vesicles expressing PD-1-blocking scFv reinvigorate T cell immunity against cancer显示文摘Cancer cells aberrantly express immunosuppressive checkpoint ligands and produce certain metabolites that lead to T cell exhaustion.Immune checkpoint blockade(ICB)therapy that reinvigorates exhausted T cells have achieved impressive response in clinical cancer treatment.However,the limited clinical response rate and off-tumor toxicities restrict ICB therapy.Herein,cellular vesicles displaying anti-programmed cell death-1(PD-1)single-chain variable fragment antibody(aPD-1-scFv)were prepared to reinvigorate T cell immunity to counteract cancer.The nanovesicles displaying aPD-1-scFv(aPD-1-scFv NVs)could enhance the anti-tumor activation of T cells through PD-1 blockade.Furthermore,NVs loading the A_(2a)adenosine receptor(A_(2a)R)antagonist CPI-444 assisted T cells to antagonize adenosine,an immunosuppressive metabolite produced by cancer cells.Hence,CPI-444 loaded aPD-1-scFv NVs could intensively increase the density and activity of tumor infiltrating T cells,directly restraining tumor progress and metastasis. | Tianyuan Xue Zhirang Zhang Tianliang Fang Baoqi Li Yuan Li Liyan Li Yanghua Jiang Fangfang Duan Fanqiang Meng Xin Liang Xudong Zhang | 2022 | Nano Research2022，15，6： | 1 |
| 4 | β-decay Study of Tz=-3/2Proton-rich Nucleus 29S显示文摘The exotic decay of nuclei far from the stability has recently become a hot topic of nuclear structure research.The nuclide 29S is not well investigated in the A=4n+1,Tz=-3/2series of strong+β-delayed proton precursors.The decay schemes of these nuclei are characterized | ZHONG Fupeng XU Xinxing LIN Chengjian WANG Jiansong LI Zhihuan YANG Lei MA Nanru WANG Dongxi WEN Peiwei SUN Lijie WU Hongyi LUO Diwen WU Chenguang JIANG Ying LIU Yang ZANG Hongliang LIANG Pengfei LI Pengjie LI Xiaojing ZHAO Qingqing SHI Guozhu MA Junbing MA Peng YU Gongming Dipikap Patel BAI Zhen YANG Feng JIA Huiming ZHANG Huanqiao WANG Jianguo YANG Yanyun MA Weihu HU Qiang JIN Shuya ZHOU Xiaohong LI Ren HOU Dongsheng LIU Minliang HU Zhengguo MA Xinwen YANG Weiqing GAO Zhihao DUAN Fangfang YU Yuechao WANG Yufeng WANG Peng ZHOU Qingwu CUI Danteng WANG Xiang HU Liyuan PAN Min ZHANG Gaolong WANG Xiaoyu | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 5 | Characterization of 3D DNA Assemblies Using Cryogenic Electron Microscopy显示文摘DNA nanotechnology utilizes DNA double strands as building units for self-assembly of DNA nanostructures.The specific base-pairing interaction between DNA molecules is the basis of these assemblies.After decades of development,this technology has been able to construct complex and programmable structures.With the increase in delicate nature and complexity of the synthesized nanostructures,a characterization technology that can observe these structures in three dimensions has become necessary,and developing such a technology is considerably challenging.DNA assemblies have been studied using different characterization methods including atomic force microscopy(AFM),scanning electron microscopy(SEM),and transmission electron microscopy(TEM).However,the three-dimensional(3D)DNA assemblies always collapse locally due to the dehydration during the drying process.Cryogenic electron microscopy(cryo-EM)can overcome the challenge by maintaining three-dimensional morphologies of the cryogenic samples and reconstruct the 3D models from cryogenic samples accordingly by collecting thousands of two-dimensional(2D)projection images,which can restore their original morphologies in solution.Here,we have reviewed several typical cases of 3D DNA-assemblies and highlighted the applications of cryo-EM in characterization of these assemblies.By comparing with some other characterization methods,we have shown how cryo-EM promoted the development of structural characterization in the field of DNA nanotechnology. | WANG Mingyang DUAN Jialin DAI Lizhi XIN Xiaodong WANG Fangfang LI Zheng TIAN Ye | 2020 | Chemical Research in Chinese Universities2020，36，2： | 0 |
| 6 | Cohort profile: design and methods of the Chinese colorectal, breast, lung, liver, and stomach cancer screening trial(C-BLAST)显示文摘Given the rapid changes in social structure(urbanization),economic structure(industrialization),and demographic structure(population aging)in China,cancer has become a major public health problem1.Extensive evidence has indicated that screening can decrease cancer mortality,particularly among high-risk groups,and several representative national and regional cancer screening programs have been launched in China to cope with the increasing burden of cancer. | Yubei Huang Zhangyan Lyu Yu Zhang Xiaomin Liu Yacong Zhang Ya Liu Chao Sheng Hongyuan Duan Zeyu Fani Chenyang Li Xiao Lin Zhuowei Feng Lu Zheng Zhaoxiang Ye Hong Lu Ying Zhu Dejun Zhou Xi Wei Li Ren Bin Meng Fangfang Song Fengju Song Kexin Chen | 2023 | Cancer Biology & Medicine2023，20，10： | 0 |
| 7 | Evaluation of combined detection of nuclear factor erythroid 2-related factor 2 and glutathione peroxidase 4 in primary hepatic carcinoma and preliminary exploration of pathogenesis显示文摘This study aims to analyze the clinical significance and mechanism of nuclear factor erythroid 2-related factor 2(NRF2)and glutathione peroxidase 4(GPX4)in primary hepatic carcinoma(PHC).Methods:The expression of NRF2 and GPX4 in peripheral blood of patients with PHC was determined to analyze the diagnostic value of the two combined for PHC.The prognostic significance of NRF2 and GPX4 was evaluated by 3-year followup.Human liver epithelial cells THLE-2 and human hepatocellular carcinoma cells HepG2 were purchased,and the expression of NRF2 and GPX4 in the cells was determined.NRF2 and GPX4 aberrant expression vectors were constructed and transfected into HepG2,and changes in cell proliferation and invasion capabilities were observed.Results:The expression of NRF2 and GPX4 in patients with PHC was higher than that in patients with LC or VH(p<0.05),and the two indicators combined was excellent in diagnosing PHC.Moreover,patients with high expression of NRF2 and GPX4 had a higher risk of death(p<0.05).In in vitro experiments,both NRF2 and GPX4 expression was elevated in HepG2(p<0.05).HepG2 activity was enhanced by increasing the expression of the two,vice versa(p<0.05).Conclusion:NRF2 and GPX4 combined is excellent in diagnosing PHC,and promotes the malignant development of PHC. | JIE DUAN AIDONG GU WEI CHEN CHANGHAO CHEN FANGNAN SONG FAXI CHEN FANGFANG JIANG HUIWEN XING | 2023 | BIOCELL2023，47，12： | 0 |
| 8 | 通过^(1)H(^(15)O,p)^(15)O弹性散射来研究^(16)F的能级性质显示文摘The understanding of open quantum systems in unbound nuclei is a challenge to the nuclear structure research[1].The continuum coupling effect may lead to a reordering of the shells in such systems[2].A way to study this effect is to compare the level schemes of two mirror nuclei involving an unbound and a bound nucleus such as 16F and 16N[3].Here we report an experiment of studying the level properties of 16F using the resonant elastic scattering with an 15O radioactive beam delivered by the Radioactive Ion Beam Line at Lanzhou(RIBLL)[4]. | Ru Longhui Hu Jun Liu Enqiang Bai Zhen Duan Fangfang Fang Xiao Hou Suqing Hu Qiang Ji Liancheng Jin Shuya Li Kuoang Li Yiyang Li Ruojie Ma Peng Ma Junbing Sun Xinxin Shi Guozhu Tang Xiaodong Wang Xinyu Wang Jiansong Wang Yufeng Wu Jiatong Xu Xiaodong Xu Shiwei Xin Wenyu Yang Kaiping Yang Yanyun NMichel | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 9 | 2018年重离子核反应组研究进展显示文摘Heavy Ion Reaction Group is in charge of the operation and maintenance of the 1st Radioactive Ion Beam Line in Lanzhou(RIBLL1).Their research works are focused on the direct reactions induced by radioactive ion beams,nuclear reaction dynamics at Fermi energy and some international collaborations.The progress achieved in 2018 are as the following. | Wang Jiansong Yang Yanyun Ma Peng Ma Junbing Liu Xingquan Bai Zhen Hu Qiang Jin Shilun Yu Gongming DPatel Duan Fangfang | 2018 | IMP & HIRFL Annual Report2018，，1： | 0 |
| 10 | Experimental Study of the Elastic Scattering and Breakup Reactions of Proton Drip-line Nucleus^(8)B on^(208)Pb at energies around Four Times of Coulomb Barrier显示文摘First measurement of the angular distribution of breakup reaction for^(8)B on a^(208)Pb target at an energy around four times of Coulomb barrier was carried out at the National Laboratory of Heavy Ion Research of Institute of Modern Physics. | Wang Kang Yang Yanyun Duan Fangfang Pang Danyang Wang Jiansong Gao Zhihao Ma Peng Xu Shiwei Liu Xingquan Ma Junbing Bai Zhen Hu Qiang Jin Shuya Sun Zhiyu | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 11 | Experimental Study of the Elastic Scattering of^(10)Be on^(208)Pb at the Energy around Three Times of the Coulomb Barrier显示文摘Elastic scattering is the simplest nuclear process and has been widely used to investigate the structure of the interacting nuclei[1,2]. | Duan Fangfang Yang Yanyun Pang Danyang Hu Bitao Wang Jiansong Wang Kang Yang Guo Valdir Guimaraes Ma Peng Xu Shiwei Liu Xingquan Ma Junbing Bai Zhen Hu Qiang Shu Jinya Sun Xinxin Yao Jiasheng Qi Hangkai Sun Zhiyu | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 12 | 重离子核反应组研究进展显示文摘The Heavy Ion Reaction Group at IMP has been working in the fields of elastic scattering,breakup reaction and three-body forces both experimentally and theoretically.The progresses of the researches in 2017 are given briefly as follows.Four different experiments employing around 500 h beam-time were carried out at the RIBLL1.The users are from Hongkong University,China Institute of Atomic Energy,National Space Science Center and Institute of Modern Physics.The aims of these experiments were to study the elastic scattering,breakup of neutron-rich nucleus 11Be,and proton decay of ^(26)P,^(27)S,^(23)Si and ^(22)Al. | Wang Jiansong Yang Yanyun Ma Peng Ma Junbing Liu Xingquan Hu Qiang Bai Zhen Yu Gongming D.Patel Duan Fangfang Gao Zhihao Yu Yuechao Ma Weihu | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 13 | Rapid field testing of mercury pollution by designed fluorescent biosensor and its cells-alginate hydrogel-based paper assay显示文摘With increasing industrial activities,mercury has been largely discharged into environment and caused serious environmental problems.The growing level of mercury pollution has become a huge threat to human health due to its significant biotoxicity.Therefore,the simple and fast means for on-site monitoring discharged mercury pollution are highly necessary to protect human beings from its pernicious effects in time.Herein,a'turn off'fluorescent biosensor(mCherry L199 C)for sensing Hg2+was successfully designed based on direct modification of the chromophore environment of fluorescent protein mCherry.For rapid screening and characterization,the designed variant of mCherry(mCherry L199 C)was directly expressed on outer-membrane of Escherichia coli cells by cell surface display technique.The fluorescent biosensor was characterized to have favorable response to Hg2+at micromole level among other metal ions and over a broad pH range.Further,the cells of the fluorescent biosensor were encapsulated in alginate hydrogel to develop the cells-alginate hydrogel-based paper.The cells-alginate hydrogel-based paper could detect mercury pollution in 5 min with simple operation process and inexpensive equipment,and it could keep fluorescence and activity stable at 4℃ for 24 hr,which would be a high-throughput screening tool in preliminarily reporting the presence of mercury pollution in natural setting. | Yanan Zheng Liudan Wei Linwei Duan Fangfang Yang Guixiang Huang Tianyi Xiao Min Wei Yanling Liang Huiting Yang Zhipeng Li Dan Wang | 2021 | Journal of Environmental Sciences2021，33，8： | 0 |
| 14 | 高于库仑位垒能区的^(11)Be+^(208)Pb的弹性散射和破裂反应测量显示文摘Our previous experimental result for proton-rich nucleus ^(8)B at above the Coulomb barrier shows that in spite of its low proton separation energy(0.136 MeV)there is no strong breakup coupling effects[1].The fact is in contrast to the observation of neutron-rich nuclei ^(11)Be around the Coulomb barrier.A systematic study for elastic scattering cross sections of neutron-rich nucleus ^(11)Be and the proton-halo nucleus ^(8)B at low and higher energies shows that the Coulomb rainbow in the elastic scattering of ^(11)Be is still strongly suppressed at high energies[2].In order to examine the predictions,experimental measurements for 11Be elastic scattering and breakup for ^(11)Be+^(208)Pb system at 141 and 209 MeV were performed at the National Laboratory of Heavy Ion Research of the Institute of Modern Physics,Lanzhou,China. | Yang Yanyun Wang Jiansong Liu Xingquan Duan Fangfang Gao Zhihao DPatel Ma Peng Ma Junbing Bai Zhen Hu Qiang Yu Yuechao Yu Gongming Ma Weihu | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 15 | 用于放射性束物理实验的探测硅阵列的研制显示文摘With the development of radioactive beam facilities,several exciting results were provided concerning the understanding of fundamental nuclear physics.However,typical-beam intensities are always low and the production is often in very small quantities,so,new generation detectors need to be developed with large solid angle and angular coverage,which can identify particle effectively as well as possesses high energy resolution,high spatial resolution and high geometric efficiency.The new detector based on Double Side Silicon Strip Detector(DSSD)is foreseen for the study of the reaction production in the experiment of direct nuclear reaction above the Coulomb barrier using RIBLL[1,2]at the HIRFL[3,4].However,the disadvantage of the RIBs is that it has a broad distribution in coordinate spaces.Therefore,new detector system with high resolution and a large solid angle was developed successfully for performing nuclear reaction experiments using RIBs.The geometric efficiency of the new detector array with 5 large area DSSD telescopes increases up to 70%. | Duan Fangfang Yang Yanyun Gao Zhihao Liu Xingquan Ma Peng Wang Jiansong Bai Zhen Ma Junbing Hu Qiang Jin Shilun Jin Shuya Yu Gongming | 2017 | IMP & HIRFL Annual Report2017，，1： | 0 |
| 16 | Parallel aligned Nickel Nanocone Arrays for Multi-band Microwave Absorption显示文摘Magnetic nanostructures with conical shape are highly desired for pursuing extraordinary magnetic properties and microwave absorption.For a soft magnetic nanocone. | Zhang Wanling Zhang Jiaming Huang Ran Xu Fangfang Cheng Hongwei Liu Jie Yao Huijun Mo Dan Chen Yonghui Duan Jinglai | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 17 | Accurate Determination of Water Permeabilities of Sub-anochannels.显示文摘Water permeability of membranes has been the focus of fundamental researches and technical applications.However,water permeability in sub-100 nm regime is not yet well understood as evidenced by the previously published data which are divergent from theory. | Xu Fangfang Liu Zhiwei Huang Ran Zhang Jiaming Liu Jie Hu Zhenguo Ma Jie Yao Huijun Sun Youmei Chen Yonghui Zhang Shengxia Mo Dan Duan Jinglai | 2019 | IMP & HIRFL Annual Report2019，，1： | 0 |
| 18 | 2-16 Experimental Study of 13N(α,p)16O at the Stellar Energies显示文摘The presolar SiC grains[1]carry the original stellar nucleosynthesis signature.Their isotopic anomalies compared to the sun are the strong constrains in the supernovae(SN)model calculations.The 15N-excess in some SiC-AB grains(12C/13C<10 and 14N/15N<272)is one of the challenges of core-collapse supernovae(CCSNe)models[2].Recently,Pignatari pointed out that the entrainment of H-rich material into the He shell before the SN explosion allows the coproduction of 13C,15N and 26Al,which provides a new production scenario for SiC-AB grains[2].In the He shell nucleosynthesis,the 13C is produced through 12C(p,γ)13N(β+γ)13C reaction.The 14N is synthesized through 13N(n,γ)and 13C(p,γ)reactions. | Lin Weiping Ma Shaobo Hu Jun Bai Zhen Chen Han Chen Zhijun Duan Fangfang Gao Bingshui Gao Zhihao Hou Suqing Ji Liancheng Jia Baolu Jiao Lei Jin ShuYa Liu Xingquan Li Kuoang Lu Tan Ma Junbing Ma Peng Tang Xiaodong Wang Xinyu Xu Shiwei Yang Yanyun Yu Gongming Yu Xiangqing Zhai Yaojie Zhang Ningtao Zhang Xing | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 19 | 2-24 Research Progress of Heavy Ion Reaction Group显示文摘In 2016,the environment of the power supply of RIBLL1 is improved by building a closed space with air condition.It will be good for the magnetic stability which is directly affected by the stability of the power supply.There are 9 experiments,more than 1 165.5 h beam-time,carried out at the RIBLL1.The users are from Peking University,China Institute of Atomic Energy,Shanghai Institute of Applied Physics,National Space Science Center,Institute of High Energy Physics and Institute of Modern Physics. | Wang Jiansong Yang Yanyun Ma Peng Jin Shilun Ma Junbing Liu Xingquan Bai Zhen Ma Weihu Wang Qi Hu Qiang Yu Gongming D.Patel Gao Zhihao Duan Fangfang Zhang Xing Jiao Lei Yu Yuechao | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
| 20 | 2-26 Experimental Measurement of 12N,13O on natPb Elastic Scattering Above the Coulomb Barriers显示文摘Elastic scattering is an ideal tool to study the information of the exotic structure and reaction mechanism of the weakly bound nuclei.A great deal of elastic scattering experiments have been performed for neutron halo nuclei,such as 6He,11Li and 11Be[1].However,elastic scattering data for proton halo nuclei above the Coulomb barrier are still scarce.13O and 12N,with small separation energies,are good candidates of proton halo nuclei.The 13O and 12N induced elastic scattering is experimentally investigated. | Liu Xingquan Yang Yanyun Wang Jiansong Duan Fangfang Ma Peng Ma Junbing Jin Shilun Bai Zhen Gao Zhihao Hu Qiang Ma Weihu Yu Yuechao Yu Gongming | 2016 | IMP & HIRFL Annual Report2016，，1： | 0 |
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