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| 1 | Expression Analysis of miRNAs and Highly-expressed Small RNAs in Two Rice Subspecies and their Reciprocal Hybrids显示文摘Heterosis,or hybrid vigor,is the phenomenon whereby progeny of two inbred lines exhibit superior agronomic performance compared with either parent.We analyzed the expression of miRNAs and highly expressed small RNAs (defined according to Solexa sequencing results) in two rice (Oryza sativa) subspecies (japonica cv.Nipponbare and indica cv.93-11) and their reciprocal hybrids using microarrays.We found that of all the 1141 small RNAs tested,140 (12%,140 of 1141) and 157 (13%,157 of 1141) were identified being significantly differentially expressed in two reciprocal hybrids,respectively.All possible modes of action,including additive,high-and low-parent,above high-and below low-parent modes were exhibited.Both F1 hybrids showed non-additive expression patterns,with downregulation predominating.Interestingly,15 miRNAs displayed stark opposite expression trends relative to midparent in reciprocal hybrids.Computational prediction of targets of differentially expressed miRNAs showed that they participated in multifaceted developmental pathways,and were not distinguishable from the targets of non-differentially expressed miRNAs.Together,our findings reveal that small RNAs play roles in heterosis and add a new layer in the understanding and exploitation of molecular mechanisms of heterosis. | Fangfang Chen Guangming He Hang He Wei Chen Xiaopeng Zhu Manzhong Liang Liangbi Chen Xing Wang Deng | 2010 | Journal of Integrative Plant Biology2010，52，11： | 10 |
| 2 | Epitaxial growth of large-area and highly crystalline anisotropic ReSe2 atomic layer显示文摘各向异性二维(2D ) 分层的材料金来二硫化物(因为它的不平常的性质和有希望的应用, ReSe 2) 吸引了可观的注意在电子并且 optoelectronic 设备。因为它的低格子对称和夹层去耦,各向异性的生长和 out-of-plane 生长不管多么容易发生,产出厚薄片,树枝状的结构,或象花的结构。在这研究,我们表明了一个自底向上的方法为控制并且由货车 der Waals 取向附生的 ReSe 2 的可伸缩的合成。完成可控制的生长,一与一个限制反应空格微反应堆被在化学蒸汽免职系统叠二云母底层构造。在限制反应空间以内, ReSe 2 的成核密度和生长率显著地被减少,赞成有一致单层厚度的 ReSe 2 的大区域的合成。有生长温度的 ReSe 2 的词法进化显示各向异性的生长在低生长温度被压制(< 600 吗? | Fangfang Cui Xiaobo Li Qingliang Feng Jianbo Yin Lin Zhou Dongyan Liu Kaiqiang Liu Xuexia He Xing Liang Shengzhong Liu Zhibin Lei Zonghuai Liu Hailin Peng Jin Zhang Jing Kong Hua Xu | 2017 | Nano Research2017，10，8： | 6 |
| 3 | Overexpression of SIRT1 is a poor prognostic factor for advanced colorectal cancer显示文摘 | Jiang Kewei Lyu Liang Shen Zhanlong Zhang Jizhun Zhang Hui Dong Jianqiang Yan Yichao Liu Fangfang Wang Shan | 2014 | Chinese Medical Journal2014，，11： | 5 |
| 4 | IDSRadar:a real-time visualization framework for IDS alerts显示文摘Intrusion Detection Systems(IDS) is an automated cyber security monitoring system to sense malicious activities.Unfortunately,IDS often generates both a considerable number of alerts and false positives in IDS logs.Information visualization allows users to discover and analyze large amounts of information through visual exploration and interaction efficiently.Even with the aid of visualization,identifying the attack patterns and recognizing the false positives from a great number of alerts are still challenges.In this paper,a novel visualization framework,IDSRadar,is proposed for IDS alerts,which can monitor the network and perceive the overall view of the security situation by using radial graph in real-time.IDSRadar utilizes five categories of entropy functions to quantitatively analyze the irregular behavioral patterns,and synthesizes interactions,filtering and drill-down to detect the potential intrusions.In conclusion,IDSRadar is used to analyze the mini-challenges of the VAST challenge 2011 and 2012. | ZHAO Ying ZHOU FangFang FAN XiaoPing LIANG Xing LIU YongGang | 2013 | Science China(Information Sciences)2013，56，8： | 5 |
| 5 | Methyltransferase like 13 mediates the translation of Snail in head and neck squamous cell carcinoma显示文摘Methyltransferase like 13(METTL13),a kind of methyltransferase,is implicated in protein binding and synthesis.The upregulation of METTL13 has been reported in a variety of tumors.However,little was known about its potential function in head and neck squamous cell carcinoma(HNSCC)so far.In this study,we found that METTL13 was significantly upregulated in HNSCC at both mRNA and protein level.Increased METTL13 was negatively associated with clinical prognosis.And METTL13 markedly affected HNSCC cellular phenotypes in vivo and vitro.Further mechanism study revealed that METTL13 could regulate EMT signaling pathway by mediating enhancing translation efficiency of Snail,the key transcription factor in EMT,hence regulating the progression of EMT.Furthermore,Snail was verified to mediate METTL13-induced HNSCC cell malignant phenotypes.Altogether,our study had revealed the oncogenic role of METTL13 in HNSCC,and provided a potential therapeutic strategy. | Xiaochen Wang Kang Li Yuehan Wan Fangfang Chen Maosheng Cheng Gan Xiong Ganping Wang Shuang Chen Zhi Chen Jianwen Chen Xiuyun Xu Cheng Wang Liang Peng Demeng Chen | 2021 | International Journal of Oral Science2021，13，3： | 3 |
| 6 | A compact polarization-integrated long wavelength infrared focal plane array based on In As/GaSb superlattice显示文摘Real-time polarization imaging plays a vital role in target detection,recognition,and tracking in complex scenes.However,large optical crosstalk and the integration technology are difficult problems in the development of polarization-integrated infrared detectors.We demonstrate a monolithic long wavelength infrared(LWIR)In As/Ga Sb superlattice focal plane array(FPA)integrated with the polarizer.To obtain high performance and real-time polarization imaging devices,the parameters of the grating were optimized and the optical crosstalk between adjacent polarization bands was studied.We analyze the light diffraction depending on the distance between the polarizer and photosensitive elements and the coupling between oblique incident light and device.The fabrication process of the antireflective polarizer,the integration technology of the polarizer and the FPA composed of 512×4×3 pixels were explored.Finally,a polarization integrated focal plane array(PI-FPA)was fabricated to detect polarized light with different oscillating directions.The large response extinction ratio of corresponding polarization bands was measured as 50:1,49:1,and 44:1 of 0°,60°,and 120°,respectively. | Jian ZHOU Yi ZHOU Ying SHI Fangfang WANG Zhicheng XU Zhizhong BAI Min HUANG Lulu ZHENG Zhaoming LIANG Yihong ZHU Qingqing XU Yiming SHEN Xiangxiao YING Jianxin CHEN | 2022 | Science China(Information Sciences)2022，65，2： | 2 |
| 7 | Serum mitochondrial tsRNA serves as a novel biomarker for hepatocarcinoma diagnosis显示文摘Hepatocellular carcinoma(HCC),which makes up the majority of liver cancer,is induced by the infection of hepatitis B/C virus.Biomarkers are needed to facilitate the early detection of HCC,which is often diagnosed too late for effective therapy.The tRNA-derived small RNAs(tsRNAs)play vital roles in tumorigenesis and are stable in circulation.However,the diagnostic values and biological functions of circulating tsRNAs,especially for HCC,are still unknown.In this study,we first utilized RNA sequencing followed by quantitative reverse-transcription PCR to analyze tsRNA signatures in HCC serum.We identified tRF-Gln-TTG-006,which was remarkably upregulated in HCC serum(training cohort:24 HCC patients vs.24 healthy controls).In the validation stage,we found that tRF-Gln-TTG-006 signature could distinguish HCC cases from healthy subjects with high sensitivity(80.4%)and specificity(79.4%)even in the early stage(Stage I:sensitivity,79.0%;specificity,74.8%;155 healthy controls vs.153 HCC patients from two cohorts).Moreover,in vitro studies indicated that circulating tRF-Gln-TTG-006 was released from tumor cells,and its biological function was predicted by bioinformatics assay and validated by colony formation and apoptosis assays.In summary,our study demonstrated that serum tsRNA signature may serve as a novel biomarker of HCC. | Shoubin Zhan Ping Yang Shengkai Zhou Ye Xu Rui Xu Gaoli Liang Chenyu Zhang Xi Chen Liuqing Yang Fangfang Jin Yanbo Wang | 2022 | Frontiers of Medicine2022，16，2： | 2 |
| 8 | Effect of Fanbaicao(Herba Potentillae Discoloris) oil on the expression of p21 and CDK4 in HepG2 cells显示文摘OBJECTIVE:To research the anti-cancer mechanism of the Traditional Chinese Medicine Fanbaicao(Herba Potentillae Discoloris) oil in the human hepatoma cell line Hep G2.METHODS:Gas chromatography was used to analyze the components of Fanbaicao(Herba Potentillae Discoloris).We tested the inhibitory effect of Fanbaicao(Herba Potentillae Discoloris) oil on the human hepatoma cell line Hep G2 in vitro using 3-(4,5-Dimet hylt hiazol-2-yl)-2,5-dip henyltetrazoliumbromide assays.Fluorescence activating cell sorter analysis was used to examine the levels of apoptosis,and western blot and immunofluorescence were used to detect the expression of p21,p-p21 and CDK4 proteins.RESULTS:Fanbaicao(Herba Potentillae Discoloris)oil contains 45 ingredients,and L-ascorbic acid 2,6-bispalmitate was the main component and accounted for 44.96% of total drive-off peak area.Other components included(Z)-14-met hyl-8-exadecenal-acetal(8.56%),phytol(7.74%) and lauric acid(6.31%).Fanbaicao(Herba Potentillae Discoloris)oil treatment reduced the proliferation of Hep G2 cells and the half growth inhibition concentration(IC50) was 2.03 mg/m L.Furthermore,we also observed significantly increased Hep G2 cell apoptosis in a dose-dependent manner(P < 0.05).Fanbaicao(Herba Potentillae Discoloris) oil significantly increased the expression of p21 and p-p21 and significantly decreased the expression of CDK4 in Hep G2 cells compared with controls(P < 0.01).CONCLUSION:Our results showed that Fanbaicao(Herba Potentillae Discoloris) oil has anti-cancer activities in Hep G2 cells,which is probably related to the upregulation of p21 and p-p21 and downregulation of CDK4 expression. | Liu Lei Chen Guang Wang Baixin Chen Liping Wang Shuqiu Liu Zhixin Ma Xiaoru Wang Fangfang Liang Yanfeng Wu Jiamei Yang Zhiwei | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 1 |
| 9 | Trends of Mortality in End-Stage Liver Disease—China,2008–2020显示文摘Introduction:Liver cancer and cirrhosis represent the most prevalent forms of end-stage liver diseases(ESLDs).Notably,in China,deaths attributed to ESLDs contribute significantly to the global mortality rate of these disorders.Enhanced comprehension of the mortality profile associated with ESLDs in China could provide crucial insights into intervention prioritization,which could in turn help reduce the overall global burden of these diseases.Methods:Data were obtained from China’s Disease Surveillance Points system.The presentation includes both crude and age-standardized mortality rates,stratified by sex,residential location,and region.Using Joinpoint Regression,trends in annual mortality rates were estimated from the period of 2008 to 2020 and expressed as the average annual percentage change(AAPC).Results:In 2020,the gross mortality rate of ESLD stood at 30.08 cases per 100,000 individuals.A higher age-standardized ESLD mortality rate was observed in males and rural populations in comparison to their female and urban counterparts,respectively.Noticeably,the highest mortality rates associated with liver cancer and cirrhosis were reported in South and Southwest China,respectively.A positive correlation was noticed between age-specific ESLD mortality rates and advancing age.Interestingly,an annual decrease in the ESLD mortality rate was observed from 2008 to 2020.In urban contexts,the AAPC of cirrhosis was noted to be higher than that of liver cancer.Conclusions:The mortality rate associated with ESLDs in China decreased between 2008 and 2020.Nevertheless,the death burden attributable to ESLD continues to be alarmingly high.Future initiatives should prioritize the reduction of ESLD mortality in particular populations:males,elderly individuals,and those residing in rural regions of South and Southwest China.The emphasis of future interventions should beplaced on antiviral therapy for adults diagnosed with viral hepatitis,and on the prevention of hepatitis B virus(HBV)infection across all demographics. | Xiaoxiao Wang Huixin Liu Jinlei Qi Fangfang Zeng Lijun Wang Peng Yin Feng Liu Hongbo Li Yunning Liu Jiangmei Liu Lai Wei Xiaofeng Liang Yu Wang Huiying Rao Maigeng Zhou | 2023 | China CDC weekly2023，5，30： | 1 |
| 10 | Cellular vesicles expressing PD-1-blocking scFv reinvigorate T cell immunity against cancer显示文摘Cancer cells aberrantly express immunosuppressive checkpoint ligands and produce certain metabolites that lead to T cell exhaustion.Immune checkpoint blockade(ICB)therapy that reinvigorates exhausted T cells have achieved impressive response in clinical cancer treatment.However,the limited clinical response rate and off-tumor toxicities restrict ICB therapy.Herein,cellular vesicles displaying anti-programmed cell death-1(PD-1)single-chain variable fragment antibody(aPD-1-scFv)were prepared to reinvigorate T cell immunity to counteract cancer.The nanovesicles displaying aPD-1-scFv(aPD-1-scFv NVs)could enhance the anti-tumor activation of T cells through PD-1 blockade.Furthermore,NVs loading the A_(2a)adenosine receptor(A_(2a)R)antagonist CPI-444 assisted T cells to antagonize adenosine,an immunosuppressive metabolite produced by cancer cells.Hence,CPI-444 loaded aPD-1-scFv NVs could intensively increase the density and activity of tumor infiltrating T cells,directly restraining tumor progress and metastasis. | Tianyuan Xue Zhirang Zhang Tianliang Fang Baoqi Li Yuan Li Liyan Li Yanghua Jiang Fangfang Duan Fanqiang Meng Xin Liang Xudong Zhang | 2022 | Nano Research2022，15，6： | 1 |
| 11 | Porcine skeletal muscle differentially expressed gene ATP5B : molecular characterization, expression patterns, and association analysis with meat quality traits显示文摘 | Haixia Xu Yongjie Xu Xiaojuan Liang Yanbo Wang Fangfang Jin Dengying Liu Yun Ma Hongyu Yuan Xinqiang Song Wenxian Zeng | 2013 | Mammalian Genome2013，，3： | 1 |
| 12 | Stabilization of Uncertain Fractional Memristor Chaotic Time⁃Delay System Based on Fractional Order Sliding Mode Control显示文摘Based on Lyapunov theorem and sliding mode control scheme,the chaos control of fractional memristor chaotic time⁃delay system was studied.In order to stabilize the system,a fractional sliding mode control method for fractional time⁃delay system was proposed.In addition,Lyapunov stability theorem was used to analyze the control scheme theoretically,which guaranteed the stability of commensurate and non⁃commensurate order systems with or without uncertainties and disturbances.Furthermore,to illustrate the feasibility of controller,the conditions for designing the controller parameters were derived.Finally,the simulation results presented the effectiveness of the designed strategy. | Dawei Ding Fangfang Liu Nian Wang Dong Liang | 2020 | Journal of Harbin Institute of Technology(New Series)2020，27，4： | 1 |
| 13 | Comprehensive Humoral and Cellular Immune Responses to SARS-CoV-2 Variants in Diverse Chinese Population显示文摘The SARS-CoV-2 variants have been emerging and have made great challenges to current vaccine and pandemic control strategies.It is urgent to understand the current immune status of various Chinese populations given that the preexisting immunity has been established by national vaccination or ex posure to past variants.Using sera from 85 individuals(including 21 convalescents of natural infection,15 cases which suffered a breakthrough infection after being fully vaccinated,and 49 healthy vaccinees),we showed signifcantly enhanced neutralizing activities against SRAS-CoV-2 variants in convalescent sera,especially those who had been fully vaccinated.The neut ralizing antibodies against Omicron were detectable in 75%of convalescents and 4.9%of healthy vaccinees(p=0.006),with a GMT of 289.5,180.9-463.3,and 42.6,31.3-59,respetively.However,the neutralizing activities were weaker in young convalescents(aged<18y),with a detectable rate of 50%and a GMT of 46.4 against Omicron.We also examined and found no pan.sarbecovirus neutralizing activities in vaccinated SARS-CoV-I survivors.A booster dose could further increase the breadth and magnitude of neutralization against WT and variants of concern(VOCs)to different degrees.In addition,we showed that COVID-19-inactivated vaccines can elicit Omicron-specific T-cell responses.The positive rates of ELISpot reactions were 26.7%(4/15)and 43.8%(7/16)in the full vaccination group and the booster vaccination group,respectively,although without statistically significant difference.The neutralizing antibody titers declined while T-cell responses remain consistent over 6 months.These findings will inform the optimization of public health vaccination and intervention strategies to protect diverse populations against SARS-CoV-2 variants.Advances.Breakthrough infection significantly boosted neutralizing activities against SARS-CoV-2 variants a compared to booster immunization with inaclivated vaccine.Vaccine-induced vir us-specific T-cell immunity,on the other hand,may compensate for the shortall.Furthermore,the public health system should target the most vulnerable group due to a poorer protective serological response in both infected and vaccinated adolescents. | Jiwei Li Jing Wu Qiuyue Long Yan'an Wu Xiaoyi Hu Yukun He Mingzheng Jiang Jia Li Lili Zhao Shuoqi Yang Xiaoyong Chen Minghui Wang Jianshi Zheng Fangfang Wu Ruiliang Wu Lihong Ren Liang Bu Houzhao Wang Ke Li Lijuan Fu Guojun Zhang Yali Zheng Zhancheng Gao | 2022 | Research2022，，2： | 1 |
| 14 | Effect of Y contenl on microstructure and mechanical properties of 2519 aluminum alloy 显示文摘 | Li Huizhong Liang Xiaopeng Li Fangfang | 2007 | Trans Nonferrous Met Soc China2007，17，： | 1 |
| 15 | Long-Term Trend Analysis of Major Human Helminth Infections — Guangdong Province, China, 1988–2021显示文摘Introduction:Although helminth infections threaten millions of people worldwide,the spatiotemporal characteristics remain unclear across China.This study systematically describes the spatiotemporal changes of major human helminth infections and their epidemiological characteristics from 1988 to 2021 in Guangdong Province,China.Methods:The survey data in Guangdong Province were primarily obtained from 3 national surveys implemented during 1988–1992,2001–2004,and 2014–2016,respectively,and from the China Information System for Disease Control and Prevention during 2019–2021.A modified Kato-Katz technique was used to detect parasite eggs in collected fecal samples.Results:The overall standardized infection rates(SIRs)of any soil-transmitted helminths(STH)and Clonorchis sinensis decreased from 65.27%during 1988–1992 to 4.23%during 2019–2021.In particular,the SIRs of STH had even more of a decrease,from 64.41%during 1988–1992 to 0.31%during 2019–2021.The SIRs of Clonorchis sinensis in the 4 surveys were 2.40%,12.17%,5.20%,and 3.93%,respectively.This study observed different permutations of gender,age,occupation,and education level on the SIRs of helminths.Conclusions:The infection rate of STH has substantially decreased.However,the infection rate of Clonorchis sinensis has had fewer changes,and it has become the dominant helminth. | Yueyi Fang Jiong Wang Guanhao He Qiming Zhang Jianpeng Xiao Jianxiong Hu Zuhua Rong Lihua Yin Fangfang Zeng Pan Yang Xiaomei Dong Dan Liu Xiaofeng Liang Zhuohui Deng Tao Liu Wenjun Ma | 2022 | China CDC weekly2022，4，41： | 1 |
| 16 | Magnesium ion-implantation-based gallium nitride p-i-n photodiode for visible-blind ultraviolet detection显示文摘In this work, a GaN p-i-n diode based on Mg ion implantation for visible-blind UV detection is demonstrated.With an optimized implantation and annealing process, a p-GaN layer and corresponding GaN p-i-n photodiode are achieved via Mg implantation. As revealed in the UV detection characterizations, these diodes exhibit a sharp wavelength cutoff at 365 nm, high UV/visible rejection ratio of 1.2 × 10~4, and high photoresponsivity of 0.35 A/W, and are proved to be comparable with commercially available GaN p-n photodiodes. Additionally, a localized states-related gain mechanism is systematically investigated, and a relevant physics model of electricfield-assisted photocarrier hopping is proposed. The demonstrated Mg ion-implantation-based approach is believed to be an applicable and CMOS-process-compatible technology for GaN-based p-i-n photodiodes. | WEIZONG XU YATING SHI FANGFANG REN DONG ZHOU LINLIN SU QING LIU LIANG CHENG JIANDONG YE DUNJUN CHEN RONG ZHANG YOUDOU ZHENG HAI LU | 2019 | Photonics Research2019，7，8： | 1 |
| 17 | β-decay Study of Tz=-3/2Proton-rich Nucleus 29S显示文摘The exotic decay of nuclei far from the stability has recently become a hot topic of nuclear structure research.The nuclide 29S is not well investigated in the A=4n+1,Tz=-3/2series of strong+β-delayed proton precursors.The decay schemes of these nuclei are characterized | ZHONG Fupeng XU Xinxing LIN Chengjian WANG Jiansong LI Zhihuan YANG Lei MA Nanru WANG Dongxi WEN Peiwei SUN Lijie WU Hongyi LUO Diwen WU Chenguang JIANG Ying LIU Yang ZANG Hongliang LIANG Pengfei LI Pengjie LI Xiaojing ZHAO Qingqing SHI Guozhu MA Junbing MA Peng YU Gongming Dipikap Patel BAI Zhen YANG Feng JIA Huiming ZHANG Huanqiao WANG Jianguo YANG Yanyun MA Weihu HU Qiang JIN Shuya ZHOU Xiaohong LI Ren HOU Dongsheng LIU Minliang HU Zhengguo MA Xinwen YANG Weiqing GAO Zhihao DUAN Fangfang YU Yuechao WANG Yufeng WANG Peng ZHOU Qingwu CUI Danteng WANG Xiang HU Liyuan PAN Min ZHANG Gaolong WANG Xiaoyu | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 18 | Key factors governing alkaline pretreatment of waste activated sludge显示文摘Alkaline pretreatment is an effective technology to disintegrate sewage sludge, where alkali dosage and sludge concentration are two important factors. p H value or alkali concentration is usually adjusted in order to determine a proper dosage of alkali. Our work has found that this is not a good strategy. A new parameter, the ratio of alkali to sludge(Ra/s), is more sensitive in controlling the alkali dosage. The sludge concentration Csand retention time t are two other important factors to consider. The validity of these arguments is confirmed with modeling and experiments. The individual effect of Ra/s, Csand t was studied separately. Then the combined effect of these three factors was evaluated. The sludge disintegration degree of 44.7% was achieved with the optimized factors. Furthermore, an alkaline-microwave combined pretreatment process was carried out under these optimized conditions. A high disintegration degree of 62.3% was achieved while the energy consumption of microwave was much lower than previously reported. | Xianli Shi Li Deng Fangfang Sun Jieyu Liang Xu Deng | 2015 | Chinese Journal of Chemical Engineering2015，23，5： | 0 |
| 19 | An Effective Power Optimization Approach Based on Whale Optimization Algorithm with Two-Populations and Mutation Strategies显示文摘Power is an issue that must be considered in the design of logic circuits.Power optimization is a combinatorial optimization problem,since it is necessary to search for a logical expression that consumes the least amount of power from a large number of Reed-Muller(RM)logical expressions.The existing approach for optimizing the power of multi-output mixed polarity RM(MPRM)logic circuits suffer from poor optimization results.To solve this problem,a whale optimization algorithm with two-populations strategy and mutation strategy(TMWOA)is proposed in this paper.The two-populations strategy speeds up the convergence of the algorithm by exchanging information about the two-populations.The mutation strategy enhances the ability of the algorithm to jump out of the local optimal solutions by using the information of the current optimal solution.Based on the TMWOA,we propose a multi-output MPRM logic circuits power optimization approach(TMMPOA).Experiments based on the benchmark circuits of the Microelectronics Center of North Carolina(MCNC)validate the effectiveness and superiority of the proposed TMMPOA. | Juncai HE Zhenxue HE Jia LIU Yan ZHANG Fan ZHANG Fangfang LIANG Tao WANG Limin XIAO Xiang WANG | 2024 | Chinese Journal of Electronics2024，33，2： | 0 |
| 20 | When and How to Adjust Non-Pharmacological Interventions Concurrent with Booster Vaccinations Against COVID-19—Guangdong,China,2022显示文摘Introduction:With the large-scale roll-out of the coronavirus disease 2019(COVID-19)booster vaccination effort(a vaccine dose given 6 months after completing primary vaccination)in China,we explore when and how China could lift non-pharmacological interventions(NPIs)against COVID-19 in 2022.Methods:Using a modified susceptible-infectiousrecovered(SIR)mathematical model,we projected the COVID-19 epidemic situation and required medical resources in Guangdong Province,China.Results:If the number of people entering from overseas recovers to 20%of the number in 2019,the epidemic in 2022 could be controlled at a low level by a containment(215 local cases)or suppression strategy(1,397 local cases).A mitigation strategy would lead to 21,722 local cases.A coexistence strategy would lead to a large epidemic with 6,850,083 local cases that would overwhelm Guangdong’s medical system.With 50%or 100%recovery of the 2019 level of travelers from overseas,the epidemic could also be controlled with containment or suppression,but enormous resources,including more hotel rooms for border quarantine,will be required.However,coexistence would lead to an uncontrollable epidemic with 12,922,032 local cases.Discussion:With booster vaccinations,the number of travelers from overseas could increase slightly in 2022,but a suppression strategy would need to be maintained to ensure a controllable epidemic. | Guanhao He Fangfang Zeng Jianpeng Xiao Jianguo Zhao Tao Liu Jianxiong Hu Sicong Zhang Ziqiang Lin Huaiping Zhu Dan Liu Min Kang Haojie Zhong Yan Li Limei Sun Yuwei Yang Zhixing Li Zuhua Rong Weilin Zeng Xing Li Zhihua Zhu Xiaofeng Liang Wenjun Ma | 2022 | China CDC weekly2022，4，10： | 0 |
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