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| 1 | Circulating tumor cells:biology and clinical significance显示文摘Circulating tumor cells(CTCs)are tumor cells that have sloughed off the primary tumor and extravasate into and circulate in the blood.Understanding of the metastatic cascade of CTCs has tremendous potential for the identification of targets against cancer metastasis.Detecting these very rare CTCs among the massive blood cells is challenging.However,emerging technologies for CTCs detection have profoundly contributed to deepening investigation into the biology of CTCs and have facilitated their clinical application.Current technologies for the detection of CTCs are summarized herein,together with their advantages and disadvantages.The detection of CTCs is usually dependent on molecular markers,with the epithelial cell adhesion molecule being the most widely used,although molecular markers vary between different types of cancer.Properties associated with epithelial-tomesenchymal transition and stemness have been identified in CTCs,indicating their increased metastatic capacity.Only a small proportion of CTCs can survive and eventually initiate metastases,suggesting that an interaction and modulation between CTCs and the hostile blood microenvironment is essential for CTC metastasis.Single-cell sequencing of CTCs has been extensively investigated,and has enabled researchers to reveal the genome and transcriptome of CTCs.Herein,we also review the clinical applications of CTCs,especially for monitoring response to cancer treatment and in evaluating prognosis.Hence,CTCs have and will continue to contribute to providing significant insights into metastatic processes and will open new avenues for useful clinical applications. | Danfeng Lin Lesang Shen Meng Luo Kun Zhang Jinfan Li Qi Yang Fangfang Zhu Dan Zhou Shu Zheng Yiding Chen Jiaojiao Zhou | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 8 |
| 2 | Rolling up MXene sheets into scrolls to promote their anode performance in lithium-ion batteries显示文摘Although Ti3 C2 MXene sheets have attracted extensive attention in lithium-ion storage techniques,their restacking makes against and even hinders the Li ions diffusion within them,thereby decreasing the capacity as well as rate performance of conventional MXene anode.Here,for the first time,we roll up the Ti3 C2 Tx sheets into scrolls with unclosed topological structure and the interlayer galleries to alleviate the restacking problem.Thus,Ti3 C2 Tx scrolls as anode materials in lithium-ion batteries(LIBs)have higher capacity and better rate performance than Ti3 C2 Tx sheets.On the bases of these,high-capacity silicon nanoparticles are added during the rolling process to in-situ produce Ti3 C2 Tx/Si composite scrolls.The addition of 10%silicon nanoparticles shows the best overall improvement among capacity,rate capability and cyclic stability for Ti3 C2 Tx scrolls. | Jianing Meng Fangfang Zhang Li Zhang Lingyang Liu Jiangtao Chen Bingjun Yang Xingbin Yan | 2020 | Journal of Energy Chemistry2020，29，7： | 4 |
| 3 | Neurotoxicity mechanism of aconitine in HT22 cells studied by microfluidic chip-mass spectrometry显示文摘Aconitine,a common and main toxic component of Aconitum,is toxic to the central nervous system.However,the mechanism of aconitine neurotoxicity is not yet clear.In this work,we had the hypothesis that excitatory amino acids can trigger excitotoxicity as a pointcut to explore the mechanism of neurotoxicity induced by aconitine.HT22 cells were simulated by aconitine and the changes of target cell metabolites were real-time online investigated based on a microfluidic chip-mass spectrometry system.Meanwhile,to confirm the metabolic mechanism of aconitine toxicity on HT22 cells,the levels of lactate dehydrogenase,intracellular Ca^(2+),reactive oxygen species,glutathione and superoxide dismutase,and ratio of Bax/Bcl-2 protein were detected by molecular biotechnology.Integration of the detected results revealed that neurotoxicity induced by aconitine was associated with the process of excitotoxicity caused by glutamic acid and aspartic acid,which was followed by the accumulation of lactic acid and reduction of glucose.The surge of extracellular glutamic acid could further lead to a series of cascade reactions including intracellular Ca^(2+)overload and oxidative stress,and eventually result in cell apoptosis.In general,we illustrated a new mechanism of aconitine neurotoxicity and presented a novel analysis strategy that real-time online monitoring of cell metabolites can provide a new approach to mechanism analysis. | Yingrui Zhang Shiyu Chen Fangfang Fan Ning Xu Xian-Li Meng Yi Zhang Jin-Ming Lin | 2023 | Journal of Pharmaceutical Analysis2023，13，1： | 2 |
| 4 | Multifunctional hydrotalcite-derived K/MnMgAlO catalysts used for soot combustion, NOx storage and simultaneous soot–NOx removal显示文摘 | Qian Li Ming Meng Fangfang Dai Yuqing Zha Yaning Xie Tiandou Hu Jing Zhang | 2012 | Chemical Engineering Journal2012，，： | 1 |
| 5 | Performance of Ce substituted hydrotalcite-derived mixed oxide catalysts Co 2.5 Mg 0.5 Al 1<ce:hsp sp='0.12'/>?<ce:hsp sp='0.12'/> x % Ce x % O used for soot combustion and simultaneous NO x -soot removal显示文摘 | Fangfang Dai Ming Meng Yuqing Zha Zhaoqiang Li Tiandou Hu Yaning Xie Jing Zhang | 2012 | Fuel Processing Technology2012，，： | 1 |
| 6 | Cellular vesicles expressing PD-1-blocking scFv reinvigorate T cell immunity against cancer显示文摘Cancer cells aberrantly express immunosuppressive checkpoint ligands and produce certain metabolites that lead to T cell exhaustion.Immune checkpoint blockade(ICB)therapy that reinvigorates exhausted T cells have achieved impressive response in clinical cancer treatment.However,the limited clinical response rate and off-tumor toxicities restrict ICB therapy.Herein,cellular vesicles displaying anti-programmed cell death-1(PD-1)single-chain variable fragment antibody(aPD-1-scFv)were prepared to reinvigorate T cell immunity to counteract cancer.The nanovesicles displaying aPD-1-scFv(aPD-1-scFv NVs)could enhance the anti-tumor activation of T cells through PD-1 blockade.Furthermore,NVs loading the A_(2a)adenosine receptor(A_(2a)R)antagonist CPI-444 assisted T cells to antagonize adenosine,an immunosuppressive metabolite produced by cancer cells.Hence,CPI-444 loaded aPD-1-scFv NVs could intensively increase the density and activity of tumor infiltrating T cells,directly restraining tumor progress and metastasis. | Tianyuan Xue Zhirang Zhang Tianliang Fang Baoqi Li Yuan Li Liyan Li Yanghua Jiang Fangfang Duan Fanqiang Meng Xin Liang Xudong Zhang | 2022 | Nano Research2022，15，6： | 1 |
| 7 | Development AMS Device for 14C Measurement and Its Applications显示文摘Carbon is the main component in the aerosol.In order to study the source of carbon,it isnecessary to analyze the 14C in the particles.Accelerator mass spectrometry(AMS)is the mosteffective analytical instrument for measuring 14C.Therefore,the purpose of this work is to develop an AMS device,so as to analyze the source | PANG Yijun ZHAO Qingzhang ZHANG Yuxuan WANG Fangfang MENG Qi YU Bo WU Shaoyong HE Ming | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 1 |
| 8 | Fruit size control by a zinc finger protein regulating pericarp cell size in tomato显示文摘Fruit size is largely defined by the number and size of cells in the fruit.Endoreduplication–a specialized cell cycle–is highly associated with cell expansion during tomato fruit growth.However,how endoreduplication coupled with cell size is regulated remains poorly understood.In this study,we identified a zinc finger gene SlPZF1(Solanum lycopersicum PERICARP-ASSOCIATED ZINC FINGER PROTEIN 1)that was highly expressed in the pericarp of developing fruits.Plants with altered SlPZF1 expression produced smaller fruits due to the reduction in cell size associated with weakened endoreduplication.Overexpressing SlPZF1 delayed cell division phase by enhancing early expression of several key cell cycle regulators including SlCYCD3;1 and two plant specific mitotic cyclin-dependent protein kinase(SlCDKB1 and SlCDKB2)in the pericarp tissue.Furthermore,we identified 14 putative SlPZF1 interacting proteins(PZFIs)via yeast two hybrid screening.Several PZFIs,including Pre-mRNA-splicing factor(SlSMP1/PZFI4),PAPA-1-like conserved region family protein(PZFI6),Fanconi anemia complex components(PZFI3 and PZFI10)and bHLH transcription factor LONESOME HIGHWAY(SILHW/PZFI14),are putatively involved in cell cycle regulation.Our results demonstrate that fruit growth in tomato requires balanced expression of the novel cell size regulator SlPZF1. | Fangfang Zhao Jiajing Zhang Lin Weng Meng Li Quanhua Wang Han Xiao | 2021 | Molecular Horticulture2021，1，1： | 1 |
| 9 | Two Supporting Factors Greatly Improve the Efficiency of Human iPSC Generation显示文摘 | Yang Zhao Xiaolei Yin Han Qin Fangfang Zhu Haisong Liu Weifeng Yang Qiang Zhang Chengang Xiang Pingping Hou Zhihua Song Yanxia Liu Jun Yong Pengbo Zhang Jun Cai Meng Liu Honggang Li Yanqin Li Xiuxia Qu Kai Cui Weiqi Zhang Tingting Xiang Yetao Wu Yiding Zh | 2008 | Cell Stem Cell2008，，5： | 1 |
| 10 | Generation of Induced Pluripotent Stem Cells from Adult Rhesus Monkey Fibroblasts显示文摘 | Haisong Liu Fangfang Zhu Jun Yong Pengbo Zhang Pingping Hou Honggang Li Wei Jiang Jun Cai Meng Liu Kai Cui Xiuxia Qu Tingting Xiang Danyu Lu Xiaochun Chi Ge Gao Weizhi Ji Mingxiao Ding Hongkui Deng | 2008 | Cell Stem Cell2008，，6： | 1 |
| 11 | Generation of Induced Pluripotent Stem Cells from Adult Rhesus Monkey Fibroblasts显示文摘 | Haisong Liu Fangfang Zhu Jun Yong Pengbo Zhang Pingping Hou Honggang Li Wei Jiang Jun Cai Meng Liu Kai Cui Xiuxia Qu Tingting Xiang Danyu Lu Xiaochun Chi Ge Gao Weizhi Ji Mingxiao Ding Hongkui Deng | 2008 | Cell Stem Cell2008，，6： | 1 |
| 12 | Fluorofenidone Attenuates Inflammation by Inhibiting the NF-кB Pathway显示文摘 | Ling Huang Fangfang Zhang Yiting Tang Jiao Qin Yu Peng Lin Wu Fang Wang Qiongjing Yuan Zhangzhe Peng Jishi Liu Jie Meng Lijian Tao | 2014 | The American Journal of the Medical Sciences2014，，1： | 1 |
| 13 | Understanding energetic disorder in electron-deficient-core-based non-fullerene solar cells显示文摘Recent advances in material design for organic solar cells(OSCs)are primarily focused on developing near-infrared nonfullerene acceptors,typically A-DA′D-A type acceptors(where A abbreviates an electron-withdrawing moiety and D,an electron-donor moiety),to achieve high external quantum efficiency while maintaining low voltage loss.However,the charge transport is still constrained by unfavorable molecular conformations,resulting in high energetic disorder and limiting the device performance.Here,a facile design strategy is reported by introducing the'wing'(alkyl chains)at the terminal of the DA′D central core of the A-DA′D-A type acceptor to achieve a favorable and ordered molecular orientation and therefore facilitate charge carrier transport.Benefitting from the reduced disorder,the electron mobilities could be significantly enhanced for the'wing'-containing molecules.By carefully changing the length of alkyl chains,the mobility of acceptor has been tuned to match with that of donor,leading to a minimized charge imbalance factor and a high fill factor(FF).We further provide useful design strategies for highly efficient OSCs with high FF. | Jun Yuan Chujun Zhang Honggang Chen Can Zhu Sin Hang Cheung Beibei Qiu Fangfang Cai Qingya Wei Wei Liu Hang Yin Rui Zhang Jidong Zhang Ye Liu Huotian Zhang Weifang Liu Hongjian Peng Junliang Yang Lei Meng Feng Gao Shukong So Yongfang Li Yingping Zou | 2020 | Science China Chemistry2020，63，8： | 1 |
| 14 | High Fe^(LS)(C)electrochemical activity of an iron hexacyanoferrate cathode boosts superior sodium ion storage显示文摘Sodium iron hexacyanoferrate(FeHCF)is one of the most promising cathode materials for sodium-ion batteries(SIBs)due to its low cost theoretical capacity.However,the low electrochemical activity of Fe^(LS)(C)in FeHCF drags down its practical capacity and potential plateau.Herein,FeHCF with high Fe^(LS)(C)electrochemical activity(C-FeHCF)is synthesized via a facile citric acid-assisted solvothermal method.As the cathode of SIBs,C-FeHCF shows superior cycling stability(ca.87.3%capacity retention for 1000 cycles at 10 C)and outstanding rate performance(ca.68.5%capacity retention at 50 C).Importantly,the contribution of Fe^(LS)(C)to the whole capacity was quantitatively analyzed via combining dQ/dV and discharge curve for the first time,and the index reaches 44.53%for C-FeHCF,close to the theoretical value.In-situ X-ray diffraction proves the structure stability of C-FeHCF during charge-discharge process,ensuring its superior cycling performance.Furthermore,the application feasibility of the C-FeHCF cathode in quasi-solid SIBs is also evaluated.The quasi-solid SIBs with the C-FeHCF cathode exhibit excellent electrochemical performance,delivering an initial discharge capacity of 106.5 mAh g^(−1) at 5 C and high capacity retention of 89.8%over 1200 cycles.This work opens new insights into the design and development of advanced cathode materials for SIBs and the beyond. | Junhong Guo Fan Feng Shiqiang Zhao Zhenhai Shi Rui Wang Meng Yang Fangfang Chen Suli Chen Zi-Feng Ma Tianxi Liu | 2023 | Carbon Energy2023，5，5： | 1 |
| 15 | Sphingosine-1-Phosphate Suppresses Cyclophosphamide Induced Follicle Apoptosis in Human Fetal Ovarian Xeno-grafts in Nude Mice显示文摘 | Yuanyuan Meng Zhihui Xu Fangfang Wu Wenming Chen Shuangshuang Xie Jun Liu Xuefeng Huang Ying Zhou | 2014 | Fertility and Sterility2014，，： | 1 |
| 16 | Cohort profile: design and methods of the Chinese colorectal, breast, lung, liver, and stomach cancer screening trial(C-BLAST)显示文摘Given the rapid changes in social structure(urbanization),economic structure(industrialization),and demographic structure(population aging)in China,cancer has become a major public health problem1.Extensive evidence has indicated that screening can decrease cancer mortality,particularly among high-risk groups,and several representative national and regional cancer screening programs have been launched in China to cope with the increasing burden of cancer. | Yubei Huang Zhangyan Lyu Yu Zhang Xiaomin Liu Yacong Zhang Ya Liu Chao Sheng Hongyuan Duan Zeyu Fani Chenyang Li Xiao Lin Zhuowei Feng Lu Zheng Zhaoxiang Ye Hong Lu Ying Zhu Dejun Zhou Xi Wei Li Ren Bin Meng Fangfang Song Fengju Song Kexin Chen | 2023 | Cancer Biology & Medicine2023，20，10： | 0 |
| 17 | Measurement Method and Application of 60Fe by Accelerator Mass Spectrometry显示文摘60Fe plays a very important role in nuclear astrophysics,biomedicine,and safety of nuclear facilities.The high sensitive measurement of 60Fe is the basis of realizing the application of 60Fe.The measurement of 60Fe by accelerator mass spectrometry is the only way to achieve high sensitivity measurement of 60Fe.China Institute | WANG Fangfang HE Ming ZHANG Yuxuan ZHAO Qingzhang PANG Yijun MENG Qi YU Bo WU Shaoyong | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 18 | Do methylenetetrahydrofolate dehydrogenase, cyclohydrolase, and formyltetrahydrofolate synthetase 1 polymorphisms modify changes in intelligence of school-age children in areas of endemic fluorosis?显示文摘Background: Excessive exposure to fluoride can reduce intelligence. Methylenetetrahydrofolate dehydrogenase, cyclohydrolase, and formyltetrahydrofolate synthetase 1 (MTHFD1) polymorphisms have important roles in neurodevelopment. However, the association ofMTHFD1 polymorphisms with children’s intelligence changes in endemic fluorosis areas has been rarely explored.Methods: A cross-sectional study was conducted in four randomly selected primary schools in Tongxu County, Henan Province, from April to May in 2017. A total of 694 children aged 8 to 12 years were included in the study with the recruitment by the cluster sampling method. Urinary fluoride (UF) and urinary creatinine were separately determined using the fluoride ion-selective electrode and creatinine assay kit. Children were classified as the high fluoride group and control group according to the median of urinary creatinine-adjusted urinary fluoride (UFCr) level. Four loci ofMTHFD1 were genotyped, and the Combined Raven’s Test was used to evaluate children’s intelligence quotient (IQ). Generalized linear model and multinomial logistic regression model were performed to analyze the associations between children’s UFCr level,MTHFD1 polymorphisms, and intelligence. The general linear model was used to explore the effects of gene-environment and gene-gene interaction on intelligence.Results: In the high fluoride group, children’s IQ scores decreased by 2.502 when the UFCr level increased by 1.0 mg/L (β= –2.502, 95% confidence interval [CI]: –4.411, –0.593), and the possibility for having 'excellent' intelligence decreased by 46.3% (odds ratio = 0.537, 95% CI: 0.290, 0.994). Children with the GG genotype showed increased IQ scores than those with the AA genotype of rs11627387 locus in the high fluoride group (P < 0.05). Interactions between fluoride exposure andMTHFD1 polymorphisms on intelligence were observed (Pinteraction < 0.05).Conclusion: Our findings suggest that excessive fluoride exposure may have adverse effects on children’s intelligence, and changes in children’s intelligence may be associated with the interaction between fluoride andMTHFD1 polymorphisms. | Zichen Feng Ning An Fangfang Yu Jun Ma Na Li Yuhui Du Meng Guo Kaihong Xu Xiangbo Hou Zhiyuan Li Guoyu Zhou Yue Ba | 2022 | Chinese Medical Journal2022，，15： | 0 |
| 19 | Design of Multi Anode Gas Ionization Chamber with Si3N4 Windows for Detection of Low Energy Heavy Ion显示文摘In order to establish accelerator mass spectrometry technology of the detection of low energy heavy ions,gas ionization chambers with thin windows need to be developed.Mylar membranes are generally used for conventional gas | ZHAO Qingzhang HE Ming YU Bo ZHANG Yuxuan PANG Yijun WANG Fangfang MENG Qi WU Shaoyong | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
| 20 | Study on Method of Measuring 128I(n,γ)Reaction Cross Section by Accelerator Mass Spectrometry显示文摘The thermal neutron cross section of 128I(n,γ)129I is an important parameter in the research of nuclear physics.For the national application data,stellar evolution model,reactor design,waste disposal and other research has important applications.At present,this reaction cross section has no experimental data in the world. | ZHANG Yuxuan YIN Xinyi HE Ming ZHAO Qingzhang WANG Fangfang WU Shaoyong PANG Yijun MENG Qi YU Bo | 2017 | Annual Report of China Institute of Atomic Energy2017，，1： | 0 |
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