|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The Sunway TaihuLight supercomputer: system and applications显示文摘The Sunway Taihu Light supercomputer is the world's first system with a peak performance greater than 100 PFlops. In this paper, we provide a detailed introduction to the Taihu Light system. In contrast with other existing heterogeneous supercomputers, which include both CPU processors and PCIe-connected many-core accelerators(NVIDIA GPU or Intel Xeon Phi), the computing power of Taihu Light is provided by a homegrown many-core SW26010 CPU that includes both the management processing elements(MPEs)and computing processing elements(CPEs) in one chip. With 260 processing elements in one CPU, a single SW26010 provides a peak performance of over three TFlops. To alleviate the memory bandwidth bottleneck in most applications, each CPE comes with a scratch pad memory, which serves as a user-controlled cache. To support the parallelization of programs on the new many-core architecture, in addition to the basic C/C++and Fortran compilers, the system provides a customized Sunway Open ACC tool that supports the Open ACC2.0 syntax. This paper also reports our preliminary efforts on developing and optimizing applications on the Taihu Light system, focusing on key application domains, such as earth system modeling, ocean surface wave modeling, atomistic simulation, and phase-field simulation. | Haohuan FU Junfeng LIAO Jinzhe YANG Lanning WANG Zhenya SONG Xiaomeng HUANG Chao YANG Wei XUE Fangfang LIU Fangli QIAO Wei ZHAO Xunqiang YIN Chaofeng HOU Chenglong ZHANG Wei GE Jian ZHANG Yangang WANG Chunbo ZHOU Guangwen YANG | 2016 | Science China(Information Sciences)2016，59，7： | 45 |
| 2 | TGF-β signaling in cancer metastasis显示文摘转变生长因素(TGF )- 发信号的事件是众所周知的控制多样的进程和众多的回答例如房间增长,区别, apoptosis,和移植。在癌症的 TGF- 发信号戏上下文依赖者角色:在 pre 恶意的房间, TGF- 首先作为肿瘤 suppressor 工作,当在癌症的以后的阶段发信号的 TGF- 支持侵略和转移时。最近的研究也建议了在 TGF- 发信号和另外的发信号的小径之间的串音例如河马, Wnt, EGFR/RAS,和 PI3K/AKT 小径,可以实质地贡献我们 TGF- 发信号和癌症的当前的理解。由于 TGF- 的广阔效果, TGF- 和它的下游的发信号部件的封锁提供多重治疗学的机会。因此,为为众多的疾病表明治疗的 anti-TGF- 的眼界显得明亮并且将提供珍贵信息并且想在这药上分子的设计。在这评论,我们集中于最近的卓见进在可以贡献新奇指向癌症的治疗的发展的癌症转移发信号的 TGF- 的规定。 | Feng Xie Li Ling Hans van Dam Fangfang Zhou Long Zhang | 2018 | Acta Biochimica et Biophysica Sinica2018，50，1： | 36 |
| 3 | ;he regulation of TGF-β/SMAD signaling by protein deubiquitination显示文摘 | Juan Zhang Xiaofei Zhang Feng Xie Zhengkui Zhang Hans van Dam Long Zhang Fangfang Zhou | 2014 | Protein & Cell2014，5，7： | 27 |
| 4 | A Novel Mitogen-Activated Protein Kinase Gene in Maize (Zea mays),ZmMPK3,is Involved in Response to Diverse Environmental Cues显示文摘In search for components of mitogen-activated protein kinase (MAPK) cascades in maize (Zea mays) involved in response to abscisic acid (ABA) stimulus,a novel MAPK gene,ZmMPK3,from ABA-treated maize leaves cDNA was isolated and characterized.The full length of the ZmMPK3 gene is 1 520 bp and encodes a 376 amino acid protein with a predicted molecular mass of 43.5 kD and a pI of 5.83.ZmMPK3 contains all 11 MAPK conserved subdomains and the phosphorylation motif TEY.Amino acid sequence alignment revealed that ZmMPK3 shared high identity with group-A MAPK in plants.A time course (30–360 min) experiment using a variety of signal molecules and stresses revealed that the transcripts level of ZmMPK3 accumulated markedly and rapidly when maize seedlings were subjected to exogenous signaling molecules: ABA,H2O2,jasmonic acid and salicylic acid,various abiotic stimuli such as cold,drought,ultraviolet light,salinity,heavy metal and mechanical wounding.Its transcription was also found to be tissue-specific regulated.Here,we show that ABA and H2O2 induced a significant increase in the ZmMPK3 activity using immunoprecipitation and in-gel kinase assay.Furthermore,the results showed that the ZmMPK3 protein is localized mainly to the nucleus.These results suggest that the ZmMPK3 may play an important role in response to environmental stresses. | Jinxiang Wang Haidong Ding Aying Zhang Fangfang Ma Jianmei Cao Mingyi Jiang | 2010 | Journal of Integrative Plant Biology2010，52，5： | 16 |
| 5 | Initial study of biexponential model of intravoxel incoherent motion magnetic resonance imaging in evaluation of the liver fibrosis显示文摘 | Chen Cuiyun Wang Bin Shi Dapeng Fu Fangfang Zhang Jiliang Wen Zejun Zhu Shaocheng Xu Junling Lin Qing Li Jing Dou Shewei | 2014 | Chinese Medical Journal2014，，17： | 15 |
| 6 | Early Serum HBsAg Kinetics as Predictor of HBsAg Loss in Patients with HBeAg-Negative Chronic Hepatitis B after Treatment with Pegylated Interferonα-2a显示文摘Hepatitis B surface antigen(HBsAg)loss is an ideal treatment endpoint for patients with chronic hepatitis B(CHB).We investigated the predictive value of on-treatment HBsAg levels for HBsAg loss in hepatitis B e antigen(HBe Ag)-negative CHB patients who received 120-week PEG-IFNα-2a treatment.Serum HBV DNA,HBsAg,and anti-HBs levels were assayed at baseline and every 3 months during the treatment.Of 81 patients,12 achieved HBsAg loss,20 achieved HBsAg\100 IU/mL,and 49 maintained HBs Ag C 100 IU/mL.HBsAg loss rate was only 3.7%at 48 weeks,while it reached to 11.1%and 14.8%after treatment of 96 weeks and 120 weeks.The cutoff HBs Ag levels at 12 weeks predicting HBsAg loss at 96 weeks and 120 weeks of treatment were 400 IU/mL and 750 IU/mL,with AUC 0.725 and 0.722,positive predictive value(PPV)29.41%and 30.56%,and negative predictive value(NPV)93.75%and 97.78%,respectively.The cutoff HBsAg levels at 24 weeks predicting HBsAg loss at 96 weeks and 120 weeks of treatment were 174 IU/m L and 236 IU/mL respectively,with AUC 0.925 and 0.922,PPV 40.0%and 46.15%,and both NPV 100%.The predictive ability of the cutoff HBsAg levels at 24 weeks was better than that at 12 weeks for HBs Ag loss at either 96 or 120 weeks(χ~2=3.880,P=0.049 andχ~2=4.412,P=0.036).These results indicate that extended therapy is critical to HBsAg loss in HBe Ag-negative CHB patients during PEG-IFN treatment,and the HBsAg level at 24 weeks can be used to predict HBsAg loss during tailoring PEG-IFN therapy. | Minghui Li Lu Zhang Yao Lu Qiqi Chen Huihui Lu Fangfang Sun Zhan Zeng Gang Wan Linqing Zhao Yao Xie | 2021 | Virologica Sinica2021，36，2： | 15 |
| 7 | Streamflow response to climate variability and human activities in the upper catchment of the Yellow River Basin显示文摘Both sensitivity-based method and simulation method are used to analyze the streamflow response to climate variability and human activities in the upper catchment of the Yellow River Basin (UYRB) in this study. The separation regime of effects from climate variability and human activities is investigated. Results show that the changes of streamflow are more sensitive to precipitation than potential evapotranspiration (PET). Effect of climate variability on streamflow estimated using the sensitivity-based method is weak in the upper catchment of Jimai station, and strong in the upper catchment of Lanzhou station, where the climate effects accounted for about 50% of total streamflow changes. Effects of human activities on streamflow accounted for about 40% in the UYRB, with weaker effects in the upper catchment of Tangnaihai station than those in the upper catchment of Lanzhou station. Both climate variability and human activities are main factors to affect the changes of streamflow in the UYRB. | ZHAO FangFang XU ZongXue ZHANG Lu ZUO DePeng | 2009 | Science China(Technological Sciences)2009，52，11： | 12 |
| 8 | Role of pyroptosis in inflammation and cancer显示文摘Pyroptosis is a form of programmed cell death mediated by gasdermin and is a product of continuous cell expansion until the cytomembrane ruptures,resulting in the release of cellular contents that can activate strong inflammatory and immune responses.Pyroptosis,an innate immune response,can be triggered by the activation of inflammasomes by various influencing factors.Activation of these inflammasomes can induce the maturation of caspase-1 or caspase-4/5/11,both of which cleave gasdermin D to release its N-terminal domain,which can bind membrane lipids and perforate the cell membrane.Here,we review the latest advancements in research on the mechanisms of pyroptosis,newly discovered influencing factors,antitumoral properties,and applications in various diseases.Moreover,this review also provides updates on potential targeted therapies for inflammation and cancers,methods for clinical prevention,and finally challenges and future directions in the field. | Xiang Wei Feng Xie Xiaoxue Zhou Yuchen Wu Haiyan Yan Ting Liu Jun Huang Fangwei Wang Fangfang Zhou Long Zhang | 2022 | Cellular & Molecular Immunology2022，19，9： | 11 |
| 9 | Application of cylindrical linear phased array in casing borehole显示文摘一个超声的分阶段执行的数组( UPA )变换器在听觉的 logging.First 为地上凿穿成像和 casing 检查被介绍,一个圆柱的线性分阶段执行的数组( CLPA )它由压电的元素的数字组成一致地在柱体的表面上散布了,被设计并且在电的系统的控制下面用元素的不同的组播送并且收到声学的波浪的 fabricated.By , CLPA 罐头(s)地上凿穿的所有区域能动态地围并且 rapidly.Then | SHI Fangfang WU Xianmei KE Yijing ZHANG Bixing | 2010 | Chinese Journal of Acoustics2010，29，1： | 10 |
| 10 | Ferroptosis in cancer and cancer immunotherapy显示文摘The hallmark of tumorigenesis is the successful circumvention of cell death regulation for achieving unlimited replication and immortality.Ferroptosis is a newly identified type of cell death dependent on lipid peroxidation which differs from classical programmed cell death in terms of morphology,physiology and biochemistry.The broad spectrum of injury and tumor tolerance are the main reasons for radiotherapy and chemotherapy failure.The effective rate of tumor immunotherapy as a new treatment method is less than 30%.Ferroptosis can be seen in radiotherapy,chemotherapy,and tumor immunotherapy;therefore,fer-roptosis activation may be a potential strategy to overcome the drug resistance mechanism of traditional cancer treatments.In this review,the characteristics and causes of cell death by lipid peroxidation in ferroptosis are briefly described.In addition,the three metabolic regulations of ferroptosis and its crosstalk with classical signaling pathways are summarized.Collectively,these findings sug-gest the vital role of ferroptosis in immunotherapy based on the interaction of ferroptosis with tumor immunotherapy,chemotherapy and radiotherapy,thus,indicating the remarkable potential of ferroptosis in cancer treatment. | Lei Zhao Xiaoxue Zhou Feng Xie Lei Zhang Haiyan Yan Jun Huang Chong Zhang Fangfang Zhou Jun Chen Long Zhang | 2022 | Cancer Communications2022，42，2： | 10 |
| 11 | Positioning error compensation of an industrial robot using neural networks and experimental study显示文摘Due to the characteristics of high efficiency,wide working range,and high flexibility,industrial robots are being increasingly used in the industries of automotive,machining,electrical and electronic,rubber and plastics,aerospace,food,etc.Whereas the low positioning accuracy,resulted from the serial configuration of industrial robots,has limited their further developments and applications in the field of high requirements for machining accuracy,e.g.,aircraft assembly.In this paper,a neural-network-based approach is proposed to improve the robots’positioning accuracy.Firstly,the neural network,optimized by a genetic particle swarm algorithm,is constructed to model and predict the positioning errors of an industrial robot.Next,the predicted errors are utilized to realize the compensation of the target points at the robot’s workspace.Finally,a series of experiments of the KUKA KR 500–3 industrial robot with no-load and drilling scenarios are implemented to validate the proposed method.The experimental results show that the positioning errors of the robot are reduced from 1.529 mm to 0.344 mm and from 1.879 mm to 0.227 mm for the no-load and drilling conditions,respectively,which means that the position accuracy of the robot is increased by 77.6%and 87.9%for the two experimental conditions,respectively. | Bo LI Wei TIAN Chufan ZHANG Fangfang HUA Guangyu CUI Yufei LI | 2022 | Chinese Journal of Aeronautics2022，35，2： | 9 |
| 12 | Variation in cis-regulation of a NAC transcription factor contributes to drought tolerance in wheat显示文摘Drought is a major environmental factor limiting wheat production worldwide,and developing drought-tolerant cultivars is a central challenge for wheat breeders globally.Therefore,it is important to identify genetic components determining drought tolerance in wheat.In this study,we identified a wheat NAC gene(TaNAC071-A)that is tightly associated with drought tolerance by a genome-wide association study.Knockdown of TaNAC071-A in wheat attenuated plant drought tolerance,whereas its overexpression significantly enhanced drought tolerance through improved water-use efficiency and increased expression of stress-responsive genes.This heightened water-saving mechanism mitigated the yield loss caused by water deficit.Further candidate gene association analysis showed that a 108-bp insertion in the promoter of TaNAC071-A alters its expression level and contributes to variation in drought tolerance among wheat accessions.This insertion contains two MYB cis-regulatory elements(CREs)that can be directly bound by the MYB transcription activator,TaMYBL1,thereby leading to increased TaNAC071-A expression and plant drought tolerance.Importantly,introgression of this 108-bp insertion allele,TaNAC071-AIn-693,into drought-sensitive cultivars could improve their drought tolerance,demonstrating that it is a valuable genetic resource for wheat breeding.Taken together,our findings highlight a major breakthrough in determining the genetic basis underlying phenotypic variation in wheat drought tolerance and showcase the potential of exploiting CRE-containing indels for improving important agronomical traits. | Hude Mao Shumin Li Bin Chen Chao Jian Fangming Mei Yifang Zhang Fangfang Li Nan Chen Tian Li Linying Du Li Ding Zhongxue Wang Xinxiu Cheng Xiaojing Wang Zhensheng Kang | 2022 | Molecular Plant2022，15，2： | 9 |
| 13 | APP and APLP1 are degraded through autophagy in response to proteasome inhibition in neuronal cells显示文摘Amyloid beta(Aβ)precursor protein(APP)is a key protein in the pathogenesis of Alzheimer’s disease(AD).Both APP and its paralogue APLP1(amyloid beta precursor-like protein 1)have multiple functions in cell adhesion and proliferation.Previously it was thought that autophagy is a novel beta-amyloid peptide(Aβ)-generating pathway activated in AD.However,the protein proteolysis of APLP1 is still largely unknown.The present study shows that APLP1 is rapidly degraded in neuronal cells in response to stresses,such as proteasome inhibition.Activation of the endoplasmic reticulum(ER)stress by proteasome inhibitors induces autophagy,causing reduction of mature APLP1/APP.Blocking autophagy or JNK stress kinase rescues the protein expression for both APP and APLP1.Therefore,our results suggest that APP/APLP1 is degraded through autophagy and the APLP1 proteolysis is mainly mediated by autophagy-lysosome pathway. | Fangfang Zhou Theo van Laar Huizhe Huang Long Zhang | 2011 | Protein & Cell2011，2，5： | 8 |
| 14 | A novel lncRNA, Lnc-OC1, promotes ovarian cancer cell proliferation and migration by sponging miR-34a and miR-34c显示文摘Long non-coding RNAs(lncRNAs) have been reported to be of great importance in tumorigenesis and progression of a variety of cancers. However, the role of lncRNAs in ovarian cancer(OC) remains largely unknown. In the present study, we identified a novel lncRNA, LOC100288181(named as Lnc-OC1), which acted as a key regulator in the development and progression of OC. The combined Gene Expression Omnibus(GEO) database analysis revealed that Lnc-OC1 was significantly upregulated in OC tissues and Kaplan-Meier survival analysis confirmed that high Lnc-OC1 expression was associated with poor prognosis of OC patients. Importantly, we also demonstrated that knockdown of Lnc-OC1 suppressed cell proliferation, colony formation, invasion and migration in vitro and inhibited tumorigenicity in vivo.Mechanistically, Lnc-OC1 repressed the expression of endogenous miR-34 a and miR-34 c as a sponge and vice versa. Moreover, rescue experiments demonstrated that the oncogenic function of Lnc-OC1 at least partially depended on suppressing miR-34 a and miR-34 c. In conclusion, our results suggest that the LncOC1-miR-34 a/34 c axis may play a pivotal role in OC, and may serve as a potential diagnostic biomarker and a powerful therapeutic target for OC. | Fangfang Tao Xinxin Tian Mengxi Lu Zhiqian Zhang | 2018 | Journal of Genetics and Genomics2018，45，3： | 8 |
| 15 | Cuproptosis:a new v form of programmed cell death显示文摘A recent study by Tsvetkov et al.was published in Science and proposed a novel form of copper-induced cell death.Tsvetkov et al.revealed that excess intracellular copper induces the aggregation of lipoylated dihydrolipoamide S-acetyltransferase(DLAT),which is associated with the mitochondrial tricarboxylic acid(TCA)cycle,resulting in proteotoxic stress and leading to a novel form of cell death termed cuproptosis[1]. | Yongqiang Wang Long Zhang Fangfang Zhou | 2022 | Cellular & Molecular Immunology2022，19，8： | 8 |
| 16 | Circulating tumor cells:biology and clinical significance显示文摘Circulating tumor cells(CTCs)are tumor cells that have sloughed off the primary tumor and extravasate into and circulate in the blood.Understanding of the metastatic cascade of CTCs has tremendous potential for the identification of targets against cancer metastasis.Detecting these very rare CTCs among the massive blood cells is challenging.However,emerging technologies for CTCs detection have profoundly contributed to deepening investigation into the biology of CTCs and have facilitated their clinical application.Current technologies for the detection of CTCs are summarized herein,together with their advantages and disadvantages.The detection of CTCs is usually dependent on molecular markers,with the epithelial cell adhesion molecule being the most widely used,although molecular markers vary between different types of cancer.Properties associated with epithelial-tomesenchymal transition and stemness have been identified in CTCs,indicating their increased metastatic capacity.Only a small proportion of CTCs can survive and eventually initiate metastases,suggesting that an interaction and modulation between CTCs and the hostile blood microenvironment is essential for CTC metastasis.Single-cell sequencing of CTCs has been extensively investigated,and has enabled researchers to reveal the genome and transcriptome of CTCs.Herein,we also review the clinical applications of CTCs,especially for monitoring response to cancer treatment and in evaluating prognosis.Hence,CTCs have and will continue to contribute to providing significant insights into metastatic processes and will open new avenues for useful clinical applications. | Danfeng Lin Lesang Shen Meng Luo Kun Zhang Jinfan Li Qi Yang Fangfang Zhu Dan Zhou Shu Zheng Yiding Chen Jiaojiao Zhou | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 8 |
| 17 | Effect of diosmetin on airway remodeling in a murine model of chronic asthma显示文摘支气管的气喘,最普通的过敏疾病之一,被航线 hyperresponsiveness (AHR ) 描绘,发炎,并且改变。抗氧化剂黄酮 aglycone diosmetin 改善在胰腺炎的发炎,而是很少在气喘上对它的影响被知道。在这研究,长期的气喘上的 diosmetin 的效果在航线在与 ovalbumin (卵) 质问的 BALB/c 老鼠改变的调整上与一个重音被调查。diosmetin 显著地在气喘的老鼠的肺减轻了煽动性的细胞渗入,离脚玻璃杯或瓷杯细胞增生,和骨胶原免职并且显著地在这些动物减少了 AHR,这被发现。全部的房间的导致卵的增加和在 bronchoalveolar lavage 液体的嗜曙红血球计数被颠倒,并且在浆液的卵特定的免疫球蛋白 E 的水平被 diosmetin 管理稀释,暗示 diosmetin 的一项 anti-Th2 活动。而且, diosmetin 显著地压制了光滑的肌肉肌动朊 alpha 链的表示,显示航线上的 diosmetin 的有势力 anti-proliferative 效果光滑的肌肉房间(ASMC ) 。矩阵 metallopeptidase-9,转变生长 factor-1,和脉管的 endothelial 生长因素层次是也由 diosmetin 减轻了,建议航线改变的宽恕可能被归因于这些蛋白质的衰落。一起拿,我们的调查结果向 diosmetin 的新奇侧面提供了改变反的治疗学的好处,在在长期的气喘汇寄 ASMC 增长加亮 diosmetin 的一个新潜力。 | Ai Ge Yanan Liu Xiaoning Zeng Hui Kong Yuan Ma Jiaxiang Zhang Fangfang Bai Mao Huang | 2015 | Acta Biochimica et Biophysica Sinica2015，47，8： | 7 |
| 18 | P-doped BN nanosheets decorated graphene as the functional interlayer for Li–S batteries显示文摘Lithium–sulfur(Li–S)batteries have attracted much attention due to their ultrahigh theoretical specific capacity.However,serious capacity attenuation caused by shuttle effect still inhibits the performance improvement.Herein,a modified separator consists of the few-layer graphene as a highly conductive network and stable scaffold to support P-doped boron nitride(denoted as BN-P@GO)as the functional interlayer of Li–S batteries.The cell with the interlayer provides an initial discharge capacity as high as1045.3 mAh g^-1,and retains a high reversible capacity of 728.7 mAh g^-1 at 1 C after 500 cycles with a capacity decay of 0.061%per cycle.Moreover,the rate capability is also superior to cells with BN@GO or BN-P interlayers,i.e.reversible capcity of 457.9 mAh g^-1 even at 3 C.The excellent electrochemical performance is ascribed to the synergistic effect of physical barrier and chemical adsorption for dissolved polysulfides provided by the modified layer.Furhtermore,it also mitigates the polarization and promotes kinetic reactions of the cells.This work provides a concise and effective method for commercialization of lithium–sulfur batteries. | Jing Zhang Wenzhe Ma Zhenyu Feng Fangfang Wu Denghu Wei Baojuan Xi Shenglin Xiong | 2019 | Journal of Energy Chemistry2019，28，12： | 7 |
| 19 | The protective role of myeloid-derived suppressor cells in concanavalin A-induced hepatic injury显示文摘充分位于调停房间的暴发性的肝炎不是的 T 下面的机制理解。在这研究,我们调查了 myeloid 是否导出房间(MDSC ) 能阻止的 suppressor concanavalin A (ConA ) 通过压制 T 房间增长导致了肝炎。我们在 ConA 治疗的早舞台在老鼠怒气和肝在 MDSC 的频率观察了增加,含有 MDSC 可能对调停 ConA 的发炎涉及老鼠的起始的抵抗。Subpopulation 分析证明在导致 ConA 的老鼠的肝的 MDSC 主要是 granulocytic MDSC。骨头的采纳转移进对待 ConA 的老鼠的导出髓的 MDSC 证明 MDSC 移居了进他们通过 ROS 压制了 T 房间增长的肝和怒气小径。另外,在老鼠的 MDSC 的频率被处理显著地也与有免疫力的 suppressor glucocorticoids 增加。进规章的 T 房间(Treg ) 的 MDSC 的转移弄空老鼠证明导致 ConA 的肝炎上的 MDSC 的保护的效果是 Treg 独立的。在结论,我们的结果证明 MDSC 在 T 调停房间的肝炎拥有一个直接保护的角色,并且由采纳转移或 glucocorticoid 治疗增加 MDSC 的频率为急性煽动性的疾病代表潜在的基于房间的治疗学的策略。 | Wenli Diao Fangfang Jin Bing Wang Chen-Yu Zhang Jiangning Chen Ke Zen Limin Li | 2014 | Protein & Cell2014，5，9： | 7 |
| 20 | sLe^(x) expression in invasive micropapillary breast carcinoma is associated with poor prognosis and can be combined with MUC1/EMA as a supplementary diagnostic indicator显示文摘Objective: Mucin 1(MUC1/EMA) and sialyl Lewis X(sLe^(x)) indicate polarity reversal in invasive micropapillary carcinoma(IMPC). The purpose of this study was to evaluate the expression of MUC1/EMA and sLe^(x) and to assess their diagnostic and prognostic value in patients with IMPC.Methods: The expression of sLe^(x) and MUC1/EMA in 100 patients with IMPC and a control group of 89 patients with invasive ductal carcinoma not otherwise specified(IDC-NOS) were analyzed with IHC. Fresh tumor tissues were collected from patients with IMPC or IDC-NOS for primary culture and immunofluorescence analysis.Results: The rate of nodal metastasis was higher in patients with IMPC than those with IDC-NOS, and IMPC cells tended to express more sLe^(x) and MUC1/EMA in the cytomembranes(the stroma-facing surfaces of the micropapillary clusters) than IDC-NOS cells. In IMPC, high cytomembrane expression of sLe^(x), but not MUC1/EMA, indicated poor prognosis. In addition, among the 100 patients with IMPC, 10 patients had sLe^(x)+/EMA-expression patterns, and 8 patients had sLe^(x)-/EMA+ expression patterns. The primary IMPC cells were suspended, non-adherent tumor cell clusters, whereas the primary IDC cells were adherent tumor cells. Immunofluorescence analysis showed that MUC1/EMA and sLe^(x) were co-expressed on the cytomembranes in IMPC cell clusters and in the cytoplasm in IDC-NOS cells.Conclusions: sLe^(x) can be used as a prognostic indicator and can be combined with MUC1/EMA as a complementary diagnostic indicator to avoid missed IMPC diagnosis. | Yawen Song Hui Sun Kailiang Wu Jianke Lyu Jingyue Zhang Feng Gu Yongjie Ma Beibei Shen Chijuan Wang Xiaojiao Chen Jing Xu Weidong Li Fangfang Liu Li Fu | 2021 | Cancer Biology & Medicine2021，18，2： | 7 |
您所在的机构暂未开通此部分的功能，请联系管理员