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| 1 | Relationship between Cognition Function and Hippocampus Structure after Long-term Microwave Exposure显示文摘Objective To analyze the effects of long-term microwave exposure on hippocampal structure and function in the rat.Methods Experiments were performed on 184 male Wistar rats(three exposure groups and a sham group).Microwaves were applied daily for 6 min over 1 month at average power densities of 2.5,5,and 10 mW/cm2.Learning and memory abilities were assessed by Morris water maze.High performance liquid chromatography was used to detect neurotransmitter concentrations in the hippocampus.Hippocampal structures were observed by histopathological analysis.Results Following long-term microwave exposure there was a significant decrease in learning and memory activity in the 7 d,14 d,and 1 m in all three microwave exposure groups.Neurotransmitter concentrations of four amino acids(glutamate,aspartic acid,glycine,and gamma-aminobutyric acid) in hippocampus were increased in the 2.5 and 5 mW/cm2 groups and decreased in the 10 mW/cm2 group.There was evidence of neuronal degeneration and enlarged perivascular spaces in the hippocampus in the microwave exposure groups.Further,mitochondria became swollen and cristae were disordered.The rough endoplasmic reticulum exhibited sacculated distension and there was a decrease in the quantity of synaptic vesicles.Conclusion These data suggest that the hippocampus can be injured by long-term microwave exposure,which might result in impairment of cognitive function due to neurotransmitter disruption. | ZHAO Li PENG Rui Yun WANG Shui Ming WANG Li Feng GAO Ya Bing DONG Ji LI Xiang SU Zhen Tao | 2012 | Biomedical and Environmental Sciences2012，25，2： | 27 |
| 2 | Microwave Exposure Impairs Synaptic Plasticity in the Rat Hippocampus and PC12 Cells through Over-activation of the NMDA Receptor Signaling Pathway显示文摘Objective The aim of this study is to investigate whether microwave exposure would affect the N-methyl-D-aspartate receptor(NMDAR) signaling pathway to establish whether this plays a role in synaptic plasticity impairment. Methods 48 male Wistar rats were exposed to 30 m W/cm2 microwave for 10 min every other day for three times. Hippocampal structure was observed through H&E staining and transmission electron microscope. PC12 cells were exposed to 30 m W/cm2 microwave for 5 min and the synapse morphology was visualized with scanning electron microscope and atomic force microscope. The release of amino acid neurotransmitters and calcium influx were detected. The expressions of several key NMDAR signaling molecules were evaluated. Results Microwave exposure caused injury in rat hippocampal structure and PC12 cells, especially the structure and quantity of synapses. The ratio of glutamic acid and gamma-aminobutyric acid neurotransmitters was increased and the intracellular calcium level was elevated in PC12 cells. A significant change in NMDAR subunits(NR1, NR2 A, and NR2B) and related signaling molecules(Ca2+/calmodulin-dependent kinase II gamma and phosphorylated c AMP-response element binding protein) were examined. Conclusion 30 m W/cm2 microwave exposure resulted in alterations of synaptic structure, amino acid neurotransmitter release and calcium influx. NMDAR signaling molecules were closely associated with impaired synaptic plasticity. | XIONG Lu SUN Cheng Feng ZHANG Jing GAO Ya Bing WANG Li Feng ZUO Hong Yan WANG Shui Ming ZHOU Hong Mei XU Xin Ping DONG Ji YAO Bin Wei ZHAO Li PENG Rui Yun | 2015 | Biomedical and Environmental Sciences2015，28，1： | 16 |
| 3 | Impact of HBV replication in peripheral blood mononuclear cell on HBV intrauterine transmission显示文摘 | Xiaohong Shi Xuefei Wang Xixi Xu Yongliang Feng Shuzhen Li Shuying Feng Bo Wang Suping Wang | 2017 | Frontiers of Medicine2017，11，4： | 11 |
| 4 | A miR-130a-YAP positive feedback loop promotes organ size and tumorigenesis显示文摘 | Shuying Shen Xiaocan Guo Huan Yan Yi Lu Xinyan Ji Li Li Tingbo Liang Dawang Zhou Xin-Hua Feng Jonathan C Zhao Jindan Yu Xing-Guo Gong Lei Zhang Bin Zhao | 2015 | Cell Research2015，25，9： | 10 |
| 5 | A novel mouse model of human breast cancer stem-like cells with high CD44^+CD24^–/lower phenotype metastasis to human bone显示文摘背景转移到骨头的乳癌的一个令人满意的动物模型是无法获得的。在这研究,我们使用了人的乳癌像茎的房间和人的骨头到造人的乳癌的一个新奇“人来源”的模型骨胳的 metastasis.Methods 人乳癌像茎的房间, CD44+/CD24-/lower subpopulation,被分开并且有教养。在有像茎的房间的注射前,老鼠在正确或左的背面的胁腹与人的骨头被植入。在组 A, B,和 C 的动物与 1x105 被注射, 1x106 人乳癌像茎的房间,和 1x106 父母 MDA-MB-231 房间分别地。没有人的骨头的培植的积极控制组(D) 也与 1x106 MDA-MB-231 房间被注射。Immunohistochemistry 为 CD34, CD105,光滑的肌肉抗体, CD44, CD24, cytokine, CXC chemokine receptor-4 (CXCR4 ) ,和 osteopontin (OPN ) 的决心被执行。在骨头转移纸巾的 CD44, CD24, CXCR4,和 OPN 的 mRNA 层次被即时量的聚合酶链反应(PCR ) 分析。我们的结果表明了的结果那在组 B 的植入的人的骨头的房间,它收到了 1x106 癌症像茎的房间,染色为 CD44, CXCR4,和 OPN 强烈积极,而那些不另外的组出现了或最小的染色。而且,组 B 有人的骨头转移的最高的发生(77.8% , P=0.0230 ) 并且另外的织物转移的没有伴随物。即时 PCR 组 C 和 D 与那些相比在组 B 在变形骨头纸巾显示出 CD44, CXCR4,和 OPN mRNA 的增加,然而,在组 B 的 CD24 mRNA 的表示最低。在“新奇人的来源”的结论乳癌当模特儿,像茎的房间表明了的乳癌一个更高人的寻求骨头的能力。它的机制可能与更高的表情有关 CD44, CXCR4,和 OPN,和在乳癌的 CD24 的更低的表示像茎的房间。 | LING Li-jun WANG Shui LIU Xiao-an SHEN En-chao DING Qiang LU Chao XU Jian CAO Qin-hong ZHU Hai-qing WANG Feng | 2008 | Chinese Medical Journal2008，，20： | 10 |
| 6 | Predictive value of K-ras and PIK3CA in non-small cell lung cancer patients treated with EGFR-TKIs: a systemic review and meta-analysis显示文摘Objective: A meta-analysis was performed to augment the insufficient data on the impact of mutative EGFR downstream phosphatidylinositol-3-kinase(PI3K) and mitogen-activated protein kinase(MAPK) pathways on the clinical efficiency of epidermal growth factor receptor tyrosine kinase inhibitor(EGFR-TKI) treatment of non-small cell lung cancer(NSCLC) patients.Methods: Network databases were explored in April, 2015. Papers that investigated the clinical outcomes of NSCLC patients treated with EGFR-TKIs according to the status of K-ras and/or PIK3 CA gene mutation were included. A quantitative meta-analysis was conducted using standard statistical methods. Odds ratios(ORs) for objective response rate(ORR) and hazard ratios(HRs) for progression-free survival(PFS) and overall survival(OS) were calculated.Results: Mutation in K-ras significantly predicted poor ORR [OR =0.22; 95% confidence interval(CI), 0.13-0.35], shorter PFS(HR =1.56; 95% CI, 1.27-1.92), and shorter OS(HR =1.59; 95% CI, 1.33-1.91) in NSCLC patients treated with EGFR-TKIs. Mutant PIK3 CA significantly predicted shorter OS(HR =1.83; 95% CI, 1.05-3.20), showed poor ORR(OR =0.70; 95% CI, 0.22-2.18), and shorter PFS(HR =1.79; 95% CI, 0.91-3.53) in NSCLC patients treated with EGFR-TKIs.Conclusion: K-ras mutation adversely affected the clinical response and survival of NSCLC patients treated with EGFRTKIs. PIK3 CA mutation showed similar trends. In addition to EGFR, adding K-ras and PIK3 CA as routine gene biomarkers in clinical genetic analysis is valuable to optimize the effectiveness of EGFR-TKI regimens and identify optimal patients who will benefit from EGFR-TKI treatment. | Jie-Ying Chen Ya-Nan Cheng Lei Han Feng Wei Wen-Wen Yu Xin-Wei Zhang Shui Cao Jin-Pu Yu | 2015 | Cancer Biology & Medicine2015，12，2： | 6 |
| 7 | Dendritic cell-activated cytokine-induced killer cells enhance the anti-tumor effect of chemotherapy on non-small cell lung cancer in patients after surgery显示文摘 | Hui Li Changli Wang Jinpu Yu Shui Cao Feng Wei Weihong Zhang Ying Han Xiu-bao Ren | 2009 | Cytotherapy2009，，8： | 5 |
| 8 | Transient liquid phase diffusion bonding of copper alloy to stainless steel using CuMn alloys as interlayer显示文摘With CuMn alloy as interlayer, the transient liquid phase (TLP) diffusion bonding of Cu alloys (CuAlBe) to stainless steel (1Cr18Ni9Ti) was studied. The results show that the bonding pressure, time and temperature and the content of Mn in CuMn alloy have great effects on the strength of bonding interface; when they are 1 MPa, 40 min, 1 223 K and 30% respectively, the maximum joint strength of 487 MPa is attained. The fracture occurring at the bonding interface is a plastic one and the effect of Mn has been analyzed. | YU Zhi shui(于治水) WANG Feng jiang(王凤江) LI Xiao quan(李晓泉) WANG Yu(王宇) WU Ming fang(吴铭方) | 2000 | 中国有色金属学会会刊:英文版2000，10，3： | 4 |
| 9 | CD4 +CD25 + Regulatory T Cells Decreased the Antitumor Activity of Cytokine-Induced Killer (CIK) Cells of Lung Cancer Patients显示文摘 | Hui Li Jin-Pu Yu Shui Cao Feng Wei Peng Zhang Xiu-Mei An Zong-Tang Huang Xiu-Bao Ren | 2007 | Journal of Clinical Immunology2007，，3： | 2 |
| 10 | CaWRKY40, a WRKY protein of pepper, plays an important role in the regulation of tolerance to heat stress and resistance to Ralstonia solanacearum infection显示文摘 | FENG‐FENG DANG YU‐NA WANG LU YU THOMAS EULGEM YAN LAI ZHI‐QIN LIU XU WANG AI‐LIAN QIU TING‐XIU ZHANG JING LIN YAN‐SHENG CHEN DE‐YI GUAN HAN‐YANG CAI SHAO‐LIANG MOU SHUI‐LIN HE | 2012 | Plant, Cell & Environment2012，，： | 2 |
| 11 | Field studies of the effectiveness of dynamic compaction in coastal reclamation areas显示文摘 | Shi-Jin Feng Wei-Hou Shui Li-Ya Gao Li-Jun He Ke Tan | 2010 | Bulletin of Engineering Geology and the Environment2010，，1： | 1 |
| 12 | Kinetics of mesophase transformation of coal tar pitch 显示文摘 | Shui H Feng Y Shen B | 1998 | Fuel Proceeding technology1998，55，2： | 1 |
| 13 | Kinetics of mesophase transformation of coal tar pitch显示文摘 | SHUI H FENG Y SHEN B | 1998 | Fuel Processing Technology1998，55，： | 1 |
| 14 | Social support and posttraumatic stress disorder among flood victims inHunan China显示文摘 | Shui dong Feng Hong zhuan Tan Abuaku Benjamin | 2007 | Annals Epidemiology2007，17，10： | 1 |
| 15 | Impact of roxarsone on the UASB reactor performance and its degradation显示文摘 | Mengchuan Shui Feng Ji Rui Tang Shoujun Yuan Xinmin Zhan Wei Wang Zhenhu Hu | 2016 | Frontiers of Environmental Science & Engineering2016，10，6： | 1 |
| 16 | Kinetics of mesophase transformation of coal tar pitch显示文摘 | Shui H F Feng Y T Shen B X | | 0，，02： | 1 |
| 17 | Analytic Search Method for Interferometric SAR Image Registration 显示文摘 | LIU B Q FENG D Z SHUI P L | 2008 | IEEE Geoscience and Remote Sensing Letters2008，5，2： | 1 |
| 18 | Kinetics of mesophase transformation of coal tar pitch 显示文摘 | Shui H F Feng Y T Shen B X | 1998 | Fuel Processing Technology1998，55，2： | 1 |
| 19 | Application of high energy dynamic compaction in coastal reclamation areas显示文摘 | Feng S J Shui W H Gao L Y | 2010 | Marine Georesources and Geotechnology2010，28，2： | 1 |
| 20 | Post-melting anomaly of Pb-Bi alloys observed by internal friction technique显示文摘 | ZU Fang-qiu ZHU Zhen-gang ZHANG Bo FENG Yi SHUI Jia-peng | 2001 | Journal of Physics: Condensed Matter2001，13，11： | 1 |
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