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| 1 | Mesenchymal stem cells-derived exosomal microRNAs contribute to wound inflammation显示文摘Clinical and experimental studies have highlighted the significance of inflammation in coordinating wound repair and regeneration.However,it remains challenging to control the inflammatory response and tolerance at systemic levels without causing toxicity to injured tissues.Mesenchymal stem cells(MSCs) possess potent immunomodulatory properties and facilitate tissue repair by releasing exosomes,which generate a suitable microenvironment for inflammatory resolution.Exosomes contain several effective bioactive molecules and act as a cell-cell communication vehicle to influence cellular activities in recipient cells.During this process,the horizontal transfer of exosomal microRNAs(miRNAs) to acceptor cells,where they regulate target gene expression,is of particular interest for understanding the basic biology of inflammation ablation,tissue homeostasis,and development of therapeutic approaches.In this review,we describe a signature of three specific miRNAs(miR-21,miR-146 a,and miR-181) present in human umbilical cord MSC-derived exosomes(MSC-EXO) identified microarray chip analysis and focus on the inflammatory regulatory functions of these immune-related miRNAs.We also discuss the potential mechanisms contributing to the resolution of wound inflammation and tissue healing. | Dongdong Ti Haojie Hao Xiaobing Fu Weidong Han | 2016 | Science China(Life Sciences)2016，59，12： | 24 |
| 2 | Frequent Mutation of rs13281615 and Its Association with PVT1 Expression and Cell Proliferation in Breast Cancer显示文摘The q24 band of chromosome 8(8q24)is frequently amplified in human cancers including breast cancer,and several SNPs(single nucleotide polymorphisms)at 8q24,including rs13281615,have been identified for their association with cancer risks.These SNPs are in a'gene desert'region,and their functions in cancer development remain to be illustrated,although several of the SNPs appear to influence the genes in the'desert'in a long-range manner,including the v-myc avian myelocytomatosis viral oncogene homolog(MYC)and the nonprotein coding plasmacytoma variant translocation 1(PVT1),both of which have been implicated in human cancers.In the current study,we examined rs13281615 for its potential role in breast cancer using normal and cancer tissues from 121 Chinese women with breast cancer.In addition to confirming the association of the GG genotype of rs13281615 with breast cancer risk,we found that germline GG genotype was significantly associated with estrogen receptor(ER)positivity,higher tumor grade and higher proliferation index.We also found frequent somatic mutations(22/121 or 18.2%)of this SNP in breast cancer.Interestingly,the majority of the mutations(17/22 or 77%)involved a G/A change,resulting in a decrease in the number of cancers with the GG risk genotype and subsequent loss of GG association with higher tumor grade and proliferation index in cancers.Furthermore,PVT1 expression was increased in cancers,and the increase was associated with the GG genotype of rs13281615.These results suggest that the GG genotype of SNP rs13281615 plays a role in breast cancer likely by influencing PVT1 expression,and that during oncogenesis,'protective'mutations could occur. | Zhiqian Zhang Zhengmao Zhu Baotong Zhang Weidong Li Xin Li Xiao Wu Lijuan Wang Liya Fu Li Fu Jin-Tang Dong | 2014 | Journal of Genetics and Genomics2014，41，4： | 12 |
| 3 | Genetic engineering of T cells with chimeric antigen receptors for hematological malignancy immunotherapy显示文摘The host immune system plays an instrumental role in the surveillance and elimination of tumors by recognizing and destroying cancer cells. In recent decades, studies have mainly focused on adoptive immunotherapy using engineered T cells for the treatment of malignant diseases. Through gene engraftment of the patient's own T cells with chimeric antigen receptor(CAR),they can recognize tumor specific antigens effectively and eradicate selectively targeted cells in an MHC-independent fashion.To date, CAR-T cell therapy has shown great clinical utility in patients with B-cell leukemias. Owing to different CAR designs and tumor complex microenvironments, genetically redirected T cells may generate diverse biological properties and thereby impact their long-term clinical performance and outcome. Meanwhile some unexpected toxicities that result from CAR-T cell application have been examined and limited the curative effects. Diverse important parameters are closely related with adoptively transferred cell behaviors, including CAR-T cells homing, CAR constitutive signaling, T cell differentiation and exhaustion. Thus, understanding CARs molecular design to improve infused cell efficacy and safety is crucial to clinicians and patients who are considering this novel cancer therapeutics. In this review, the developments in CAR-T cell therapy and the limitations and perspectives in optimizing this technology towards clinical application are discussed. | Dongdong Ti Yunfei Niu Zhiqiang Wu Xiaobing Fu Weidong Han | 2018 | Science China(Life Sciences)2018，61，11： | 10 |
| 4 | Synthesis, structure and luminescent properties of yellow phosphor La3Si6N11 :Ce^3+ for high power white-LEDs显示文摘A series of high phase purity blue light excitable yellow-emitting La_(3-x)Si_6 N_(11):xCe^(3+) phosphors were synthesized by the high temperature solid state reactions method. The structure and luminescent properties were investigated. The phase structure was studied by means of X-ray diffraction, structures refinements and energy dispersive X-ray spectroscopy. The phosphors effectively excited by the light of450 nm and show intense yellow emission at 535 nm with FWHM of 115 nm corresponding to the5 d →~2 F_(5/2) and 5 d →~2 F_(7/2) transitions of Ce^(3+). In addition,the optimized La_(2.86)Si_6 N_(11):0.14 Ce^(3+) exhibits a weak thermal quenching, which remains 98.2% of the initial emission intensity when heated to 200 ℃,the thermal quenching properties exhibit a modest decline when the temperature returned to room temperature. The above results indicate that La_3 Si_6 N_(11):Ce^(3+) can be regarded as a high promising phosphor for applications in high power white-light LED. | Fu Du Weidong Zhuang Ronghui Liu Yuanhong Liu Wei Gao Xia Zhang Yuan Xue Hongrui Hao | 2017 | Journal of Rare Earths2017，35，11： | 8 |
| 5 | Management and outcome of pelvic fractures in elderly patients: a retrospective study of 40 cases显示文摘 | Dong Jinlei Hao Wei Wang Bomin Wang Lubo Li Lianxin Mu Weidong Yang Yongliang Xin Maoyuan Wang Fu Zhou Dongsheng | 2014 | Chinese Medical Journal2014，，15： | 8 |
| 6 | Observation-based Estimation of Aerosol-induced Reduction of Planetary Boundary Layer Height显示文摘Radiative aerosols are known to influence the surface energy budget and hence the evolution of the planetary boundary layer. In this study, we develop a method to estimate the aerosol-induced reduction in the planetary boundary layer height(PBLH) based on two years of ground-based measurements at a site, the Station for Observing Regional Processes of the Earth System(SORPES), at Nanjing University, China, and radiosonde data from the meteorological station of Nanjing. The observations show that increased aerosol loads lead to a mean decrease of 67.1 W m-2for downward shortwave radiation(DSR) and a mean increase of 19.2 W m-2for downward longwave radiation(DLR), as well as a mean decrease of 9.6W m-2for the surface sensible heat flux(SHF) in the daytime. The relative variations of DSR, DLR and SHF are shown as a function of the increment of column mass concentration of particulate matter(PM2.5). High aerosol loading can significantly increase the atmospheric stability in the planetary boundary layer during both daytime and nighttime. Based on the statistical relationship between SHF and PM2.5column mass concentrations, the SHF under clean atmospheric conditions(same as the background days) is derived. In this case, the derived SHF, together with observed SHF, are then used to estimate changes in the PBLH related to aerosols. Our results suggest that the PBLH decreases more rapidly with increasing aerosol loading at high aerosol loading. When the daytime mean column mass concentration of PM2.5reaches 200 mg m-2, the decrease in the PBLH at 1600 LST(local standard time) is about 450 m. | Jun ZOU Jianning SUN Aijun DING Minghuai WANG Weidong GUO Congbin FU | 2017 | Advances in Atmospheric Sciences2017，34，9： | 8 |
| 7 | sLe^(x) expression in invasive micropapillary breast carcinoma is associated with poor prognosis and can be combined with MUC1/EMA as a supplementary diagnostic indicator显示文摘Objective: Mucin 1(MUC1/EMA) and sialyl Lewis X(sLe^(x)) indicate polarity reversal in invasive micropapillary carcinoma(IMPC). The purpose of this study was to evaluate the expression of MUC1/EMA and sLe^(x) and to assess their diagnostic and prognostic value in patients with IMPC.Methods: The expression of sLe^(x) and MUC1/EMA in 100 patients with IMPC and a control group of 89 patients with invasive ductal carcinoma not otherwise specified(IDC-NOS) were analyzed with IHC. Fresh tumor tissues were collected from patients with IMPC or IDC-NOS for primary culture and immunofluorescence analysis.Results: The rate of nodal metastasis was higher in patients with IMPC than those with IDC-NOS, and IMPC cells tended to express more sLe^(x) and MUC1/EMA in the cytomembranes(the stroma-facing surfaces of the micropapillary clusters) than IDC-NOS cells. In IMPC, high cytomembrane expression of sLe^(x), but not MUC1/EMA, indicated poor prognosis. In addition, among the 100 patients with IMPC, 10 patients had sLe^(x)+/EMA-expression patterns, and 8 patients had sLe^(x)-/EMA+ expression patterns. The primary IMPC cells were suspended, non-adherent tumor cell clusters, whereas the primary IDC cells were adherent tumor cells. Immunofluorescence analysis showed that MUC1/EMA and sLe^(x) were co-expressed on the cytomembranes in IMPC cell clusters and in the cytoplasm in IDC-NOS cells.Conclusions: sLe^(x) can be used as a prognostic indicator and can be combined with MUC1/EMA as a complementary diagnostic indicator to avoid missed IMPC diagnosis. | Yawen Song Hui Sun Kailiang Wu Jianke Lyu Jingyue Zhang Feng Gu Yongjie Ma Beibei Shen Chijuan Wang Xiaojiao Chen Jing Xu Weidong Li Fangfang Liu Li Fu | 2021 | Cancer Biology & Medicine2021，18，2： | 7 |
| 8 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 9 | Microenvironment-induced myofibroblast-like conversion of engrafted keratinocytes显示文摘Myofibroblasts,recognized classically by-smooth muscle actin(-SMA)expression,play a key role in the wound-healing process,promoting wound closure and matrix deposition.Although a body of evidence shows that keratinocytes explanted onto a wound bed promote closure of a skin injury,the underlying mechanisms are not well understood.The basal layer of epidermis is rich in undifferentiated keratinocytes(UKs).We showed that UKs injected into granulation tissue could switch into-SMA positive cells,and accelerate the rate of skin wound healing.In addition,when the epidermis sheets isolated from foreskin cover up the wound bed or are induced in vitro,keratinocytes located at the basal layers or adjacent sites were observed to convert into myofibroblast-like cells.Thus,UKs have a potential for myofibroblastic transition,which provides a novel mechanism by which keratinocyte explants accelerate skin wound healing. | LI MeiRong TI DongDong HAN WeiDong FU XiaoBing | 2014 | Science China(Life Sciences)2014，57，2： | 4 |
| 10 | The role of the microenvironment on the fate of adult stem cells显示文摘Adult stem cells(SCs) exist in all tissues that promote tissue growth, regeneration, and healing throughout life. The SC niche in which they reside provides signals that direct them to proliferate, differentiate, or remain dormant; these factors include neighboring cells, the extracellular matrix, soluble molecules, and physical stimuli. In disease and aging states, stable or transitory changes in the microenvironment can directly cause SC activation or inhibition in tissue healing as well as functional regulation. Here, we discuss the microenvironmental regulation of the behavior of SC and focus on plasticity approaches by which various environmental factors can enhance the function of SCs and more effectively direct the fate of SCs. | DONG Liang HAO HaoJie HAN WeiDong FU XiaoBing | 2015 | Science China(Life Sciences)2015，58，7： | 4 |
| 11 | Long-term observation of air pollution-weather/climate interactions at the SORPES station: a review and outlook显示文摘 | Aijun Ding Wei Nie Xin Huang Xuguang Chi Jianning Sun Veli-Matti Kerminen Zheng Xu Weidong Guo Tuukka Petaja Xiuqun Yang Markku Kulmala Congbin Fu | 2016 | Frontiers of Environmental Science & Engineering2016，10，5： | 3 |
| 12 | Second-order schemes for solving decoupled forward backward stochastic differential equations显示文摘In this paper,by using trapezoidal rule and the integration-by-parts formula of Malliavin calculus,we propose three new numerical schemes for solving decoupled forward-backward stochastic differential equations.We theoretically prove that the schemes have second-order convergence rate.To demonstrate the effectiveness and the second-order convergence rate,numerical tests are given. | ZHAO WeiDong LI Yang FU Yu | 2014 | Science China Mathematics2014，57，4： | 3 |
| 13 | Dynamic Rollover Prediction of Heavy Vehicles Considering Critical Frequency显示文摘Rollover of commercial heavy vehicles can cause enormous economic losses and fatalities.It is easier for such vehicles to rollover if the driver’s steering frequency is close to the critical frequency of the vehicle’s roll motion;however,the critical roll frequency has rarely been investigated.In this study,the second-order transfer function between the steering input and roll angle was developed to calculate the critical frequency of the vehicle’s roll motion.The simulated spectrum and transfer function were then used to dynamically predict the peak lateral load transfer ratio.Laboratory experiments were conducted using a scaled vehicle to verify the critical roll frequency.The results suggest that the peak value of the lateral load transfer ratio during steering can be accurately determined from the driver’s input,and the critical roll frequency has a dominant effect on the dynamic rollover of heavy vehicles. | Zhansheng Ye Weidong Xie Yuming Yin Zhijun Fu | 2020 | Automotive Innovation2020，3，2： | 3 |
| 14 | A LIL for independent non-identically distributed random variables in Banach space and its applications显示文摘In this paper,we prove a general law of the iterated logarithm (LIL) for independent non-identically distributed B-valued random variables.As an interesting application,we obtain the law of the iterated logarithm for the empirical covariance of Hilbertian autoregressive processes. | LIU WeiDong FU KeAng ZHANG LiXin | 2008 | Science China Mathematics2008，51，2： | 2 |
| 15 | Phase decomposition behavior and its effects on mechanical properties of TiNbTa0.5ZrAl0.5 refractory high entropy alloy显示文摘The mechanical properties of refractory high entropy alloys(RHEAs) strongly depend on their phase structures. In this work, the phase stability of a BCC TiNbTa0.5ZrAl0.5 refractory high entropy alloy subjected to thermomechanical processing was evaluated, and the effects of phase decomposition on room/high temperature mechanical properties were quantitatively studied. It was found that, the thermomechanical processing at 800℃and 1200℃ leads to phase decomposition in the TiNbTa0.5ZrAl0.5 alloy. The phase decomposition is caused by the rapid rising of free energy of the primary BCC phase. The effect of the precipitates on room temperature strength is determined by the competition between the increasing in precipitation strengthening and the decreasing in solid solution strengthening. But at high temperatures(800-1200℃), the phase decomposition causes significant reduction in strength, mainly due to the grain boundary sliding and the decreasing in solid solution strengthening. | Yuankui Cao Weidong Zhang Bin Liu Yong Liu Meng Du Ao Fu | 2021 | Journal of Materials Science & Technology2021，，7： | 2 |
| 16 | National Alveolar Echinococcosis Distribution--China, 2012−2016显示文摘What is already known about this topic?Both alveolar echinococcosis(AE)and cystic echinococcosis are endemic in China,among which alveolar echinococcosis has a very high mortality rate.What is added by this report?The survey results showed the prevalence and scope of AE in China and identified high-risk groups including children,monks,herdsmen and illiterate people.At the same time,all the cases found in the survey(more than 90%of the patients did not go to the hospital for diagnosis and treatment before survey)were promptly diagnosed and treated.What are the implications for public health practice?This study provides information for the development of a plan for AE prevention and control and for the implementation of interventions targeted to high-risk populations. | Canjun Zheng Chuizhao Xue Shuai Han Zhongjie Li Hu Wang Liying Wang Ying Wang Qian Wang Yu Feng Yanyan Hou Xiao Ma Junying Ma Xiumin Han Gongsang Quzhen Xiaofeng Jiang Weidong Guo Xianglin Wu Yaming Yang Lei Cao Fanka Li Weiqi Chen Xinliu Yan Shicheng Yu Meihua Fu Qing Yu Ning Xiao Jiangping Cao Jun Yan Weiping Wu Xiao-nong Zhou | 2020 | China CDC weekly2020，2，1： | 2 |
| 17 | Criterion of local energy release rate of gob instability in deep mines considering unloading stress path显示文摘The stress path characteristics of surrounding rock in the formation of gob were analyzed and the unloading was solved. Taking Chengchao Iron Mine as the engineering background, the model for analyzing the instability of deep gob was established based on the mechanism of stress relief in deep mining.The energy evolution law was analyzed by introducing the local energy release rate index(LERR), and the energy criterion of the instability of surrounding rock was established based on the cusp catastrophe theory. The results show that the evolution equation of the local energy release of the surrounding rock is a quartic function with one unknown and the release rate increases gradually during the mining process.The calculation results show that the gob is stable. The LERR per unit volume of the bottom structure is relatively smaller which means that the stability is better. The LERR distribution showed that there was main energy release in the horizontal direction and energy concentration in the vertical direction which meets the characteristics of deep mining. In summary, this model could effectively calculate the stability of surrounding rock in the formation of gob. The LERR could reflect the dynamic process of energy release,transfer and dissipation and that provided an important reference for the study of the stability of deep mined out area. | Fu Jianxin Song Weidong Tan Yuye | 2017 | International Journal of Mining Science and Technology2017，27，6： | 2 |
| 18 | The Solar Upper Transition Region Imager(SUTRI)Onboard the SATech-01 Satellite显示文摘The Solar Upper Transition Region Imager(SUTRI)onboard the Space Advanced Technology demonstration satellite(SATech-01),which was launched to a Sun-synchronous orbit at a height of~500 km in 2022 July,aims to test the on-orbit performance of our newly developed Sc/Si multi-layer reflecting mirror and the 2k×2k EUV CMOS imaging camera and to take full-disk solar images at the Ne VII 46.5 nm spectral line with a filter width of~3 nm.SUTRI employs a Ritchey-Chrétien optical system with an aperture of 18 cm.The on-orbit observations show that SUTRI images have a field of view of~416×416 and a moderate spatial resolution of~8″without an image stabilization system.The normal cadence of SUTRI images is 30 s and the solar observation time is about16 hr each day because the earth eclipse time accounts for about 1/3 of SATech-01's orbit period.Approximately15 GB data is acquired each day and made available online after processing.SUTRI images are valuable as the Ne VII 46.5 nm line is formed at a temperature regime of~0.5 MK in the solar atmosphere,which has rarely been sampled by existing solar imagers.SUTRI observations will establish connections between structures in the lower solar atmosphere and corona,and advance our understanding of various types of solar activity such as flares,filament eruptions,coronal jets and coronal mass ejections. | Xianyong Bai Hui Tian Yuanyong Deng Zhanshan Wang Jianfeng Yang Xiaofeng Zhang Yonghe Zhang Runze Qi Nange Wang Yang Gao Jun Yu Chunling He Zhengxiang Shen Lun Shen Song Guo Zhenyong Hou Kaifan Ji Xingzi Bi Wei Duan Xiao Yang Jiaben Lin Ziyao Hu Qian Song Zihao Yang Yajie Chen Weidong Qiao Wei Ge Fu Li Lei Jin Jiawei He Xiaobo Chen Xiaocheng Zhu Junwang He Qi Shi Liu Liu Jinsong Li Dongxiao Xu Rui Liu Taijie Li Zhenggong Feng Yamin Wang Chengcheng Fan Shuo Liu Sifan Guo Zheng Sun Yuchuan Wu Haiyu Li Qi Yang Yuyang Ye Weichen Gu Jiali Wu Zhe Zhang Yue Yu Zeyi Ye Pengfeng Sheng Yifan Wang Wenbin Li Qiushi Huang Zhong Zhang | 2023 | Research in Astronomy and Astrophysics2023，23，6： | 1 |
| 19 | Innovative and propagable translational research model established for cell-based therapy at Chinese PLA General Hospital显示文摘The use of translational medicine in Chinese hospitals appears to have become easier over the last decade.Products developed in the laboratory can sometimes be applied in the clinic under life-saving circumstances.Arteannuin is one of the most successful examples of translation during the | Weidong Han Xiaobing Fu | 2016 | Science China(Life Sciences)2016，59，10： | 1 |
| 20 | How far are induced pluripotent stem cells from the clinic?显示文摘 | Meirong Li Meixia Chen Weidong Han Xiaobing Fu | 2010 | Ageing Research Reviews2010，，： | 1 |
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