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| 1 | Establishment of cell clones with different metastatic potential from the metastatic hepatocellular carcinoma cell line MHCC97显示文摘ALM To establish clone cells with different metastatic potential for the study of metastasis-related mechanisms. METHODS Cloning procedure was performed on parental hepatocellular carcinoma (HCC) cell line MHCC97. andbiological characteristics of the target clones selected by in vivo screening were studied.``RESULTS Two clones with high MHCC97-H and IowMHCC9--L1 metastatic potential were isolated from theparent cell line. Compared with MHCC97-L. MHCC97-H hadsmaller cell size average cell diameter 43 um vs 50 μmand faster in vitro and in vivo growth rate tumor celldoubling time was 34.2 h vs 60.0 h. The main ranges ofchromosomes were 5.5 58 in MHCC97-H and 57 62 inMHCC97-L. Boyden chamber in vitro invasion assay demonstrated that the number of penetrating cells through the artificial basement membrane was 137.5 - 11 .0) cellsfield for MHC_C99--H vs 17.7 - 6.3) field for MHCC97-L.The proportions of cells in GO Gl phase. S phase, and G_ M phase for MHCC97-H MHCC97-L were 0.56 6.65.0.28 0.25 and 0.l6 0.10, respectively, as measured by flow cytometry. The serum AFP levels in nude mice 5 wk after orthotopic implantation of tumor tissue were ( 24666 μg. L for MHCC97-H and (91- 66) μg' L 1 for MHCC97L. The pulmonary metastatic rate was 100% (10-10) vs40% 4- 10).``CONCLUSION Two clones of the same genetic background but with different biological behaviors were established, which could be valuable models for investigation on HCC metastasis. | Yan Li Zhao-You Tang Sheng-Long Ye Yin-Kun Liu Jie Chen Qiong Xue Jun Chen Dong-Mei Gao Wei-Hua Bao Liver Cancer Institute and Zhongshan Hospital of Fudan University (Former Liver Cancer Institute of Shanghai Medical University),Shanghai 200032,China | 2001 | World Journal of Gastroenterology2001，7，5： | 111 |
| 2 | The Hardy Rubber Tree Genome Provides Insights into the Evolution of Polyisoprene Biosynthesis显示文摘Eucommia ulmoides,也叫的强壮的橡胶树,是一棵经济地重要的树;然而,它的染色体顺序的缺乏 ?限制基本生物研究和这植物种的应用研究。这里,我们在场它的 1.2-Gb 染色体的一个高质量的集会(支架 N50 ?=? 1.88 Mb ) 与至少 26 ? 为 E 的 723 预言的基因。ulmoides,顺序 Garryales 的首先定序的染色体,它用联合定序的 Illumina 的综合策略被获得,定序的 PacBio,和印射的 BioNano。作为到 lamiids 和 campanulids 的姐妹 taxon, E。ulmoides 经历了三倍由核心 eudicots 而是没有进一步整个染色体的复制分享了的一个古老的染色体 ? 在最后 1.25 亿年里。E。ulmoides 为涉及压力回答和第二等的代谢物的生合成的多重基因展出高表达式层次或基因数字扩大,它可以说明它的可观的环境适应性。与橡胶树(Hevea brasiliensis ) 相对照,它生产 cis 聚异式戊二我烯, E。ulmoides 演变综合经由 farnesyl diphosphate synthases (FPS ) 的长链的 trans 聚异式戊二我烯。而且, FPS 和橡胶延伸 factor/small 橡胶粒子蛋白质基因家庭从 H 独立地被扩展。brasiliensis 系。这些结果提供新卓见进 E. 的生物学 ? ulmoides 和聚异式戊二我烯生合成的起源。 | Ta-na Wuyun Lin Wang Huimin Liu Xuewen Wang Liangsheng Zhang Jeffrey L. Bennetzen Tiezhu Li Lirong Yang Panfeng Liu Lanying Du Lu Wang Mengzhen Huang Jun Qing Iili Zhu Wenquan Bao Hongguo Li Qingxin Du Jingle Zhu Hong Yang Shuguang Yang Hui Liu Hui Yue Jiang Hu Suoliang Yu Yu Tian Fan Liang Jingjing Hu Depeng Wang Ruiwen Gao Dejun Li Hongyan Du | 2018 | Molecular Plant2018，11，3： | 24 |
| 3 | A novel strong tracking cubature Kalman filter and its application in maneuvering target tracking显示文摘The fading factor exerts a significant role in the strong tracking idea. However, traditional fading factor introduction method hinders the accuracy and robustness advantages of current strong-tracking-based nonlinear filtering algorithms such as Cubature Kalman Filter(CKF) since traditional fading factor introduction method only considers the first-order Taylor expansion. To this end, a new fading factor idea is suggested and introduced into the strong tracking CKF method.The new fading factor introduction method expanded the number of fading factors from one to two with reselected introduction positions. The relationship between the two fading factors as well as the general calculation method can be derived based on Taylor expansion. Obvious superiority of the newly suggested fading factor introduction method is demonstrated according to different nonlinearity of the measurement function. Equivalent calculation method can also be established while applied to CKF. Theoretical analysis shows that the strong tracking CKF can extract the thirdorder term information from the residual and thus realize second-order accuracy. After optimizing the strong tracking algorithm process, a Fast Strong Tracking CKF(FSTCKF) is finally established. Two simulation examples show that the novel FSTCKF improves the robustness of traditional CKF while minimizing the algorithm time complexity under various conditions. | An ZHANG Shuida BAO Fei GAO Wenhao BI | 2019 | Chinese Journal of Aeronautics2019，32，11： | 22 |
| 4 | Age-related rhesus macaque models of COVID-19显示文摘Background:Since December 2019,an outbreak of the Corona Virus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus(SARS-CoV-2)in Wuhan,China,has become a public health emergency of international concern.The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.Methods:Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2,and then analyzed by clinical signs,viral replication,chest X-ray,histopathological changes and immune response.Results:Viral replication of nasopharyngeal swabs,anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge.Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema,notably,old monkeys exhibited diffuse severe interstitial pneumonia.Viral antigens were detected mainly in alveolar epithelial cells and macrophages.Conclusion:SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys.Rhesus macaque models infected with SARS-CoV-2 provided insight into the pathogenic mechanism and facilitated the development of vaccines and therapeutics against SARS-CoV-2 infection. | Pin Yu Feifei Qi Yanfeng Xu Fengdi Li Peipei Liu Jiayi Liu Linlin Bao Wei Deng Hong Gao Zhiguang Xiang Chong Xiao Qi Lv Shuran Gong Jiangning Liu Zhiqi Song Yajin Qu Jing Xue Qiang Wei Mingya Liu Guanpeng Wang Shunyi Wang Haisheng Yu Xing Liu Baoying Huang Wenling Wang Li Zhao Huijuan Wang Fei Ye Weimin Zhou Wei Zhen Jun Han Guizhen Wu Qi Jin Jianwei Wang Wenjie Tan Chuan Qin | 2020 | Animal Models and Experimental Medicine2020，3，1： | 22 |
| 5 | Efficacy of Add-on Montelukast in Nonasthmatic Eosinophilic Bronchitis: The Additive Effect on Airway Inflammation, Cough and Life Quality显示文摘 | Wuping Bao Ping Liu Zhongmin Qiu Li Yu Jingqing Hang Xiaohua Gao Xin Zhou | 2015 | Chinese Medical Journal2015，，1： | 19 |
| 6 | Neoadjuvant chemotherapy for locally advanced cervical cancer reduces surgical risks and lymph-vascular space involvement显示文摘Neoadjuvant chemotherapy(NACT),which can reduce the size and therefore increase the resectability of tumors,has recently evolved as a treatment for locally advanced cervical cancer.NACT has been reported to decrease the risk of pathologic factors related to prognosis of cervical cancer.To further assess the effects of NACT on surgery and the pathologic characteristics of cervical cancer,we reviewed 110 cases of locally advanced cervical cancer treated with radical hysterectomy with or without NACT at the People's Hospital of Peking University between January 2006 and December 2010.Of 110 patients,68 underwent platinum-based NACT prior to surgery(NACT group) and 42 underwent primary surgery treatment(PST group).Our results showed 48 of 68(70.6%) patients achieved a complete response or partial response to NACT.Estimated blood loss,operation time,and number of removed lymph nodes during surgery,as well as complication rates during and after surgery were not significantly different between the NACT group and the PST group.The rates of deep stromal invasion,positive parametria,positive surgical vaginal margins,and lymph node metastasis were not significantly different between the two groups.However,the rate of lymph-vascular space involvement(LVSI) was significantly lower in the NACT group than in the PST group(P = 0.021).In addition,the response rate of NACT was significantly higher in the patients with chemotherapeutic drugs administrated via artery than via vein.Our results suggest that NACT is a safe and effective treatment for locally advanced cervical cancer and significantly decreases the rate of LVSI. | Yue Wang Guang Wang Li-Hui Wei Ling-Hui Huang Jian-Liu Wang Shi-Jun Wang Xiao-Ping Li Dan-Hua Shen Dong-Mei Bao Jian Gao | 2011 | Chinese Journal of Cancer2011，30，9： | 18 |
| 7 | Characterization of a bioflocculant from a newly isolated Vagococcus sp. W31显示文摘Screening of microorganisms producing flocculating substances was carried out. A strain secreting a large amount of bioflocculant was isolated from wastewater samples collected from the Little Moon River in Beijing. Based on the morphological properties and 16S rDNA sequence analysis, the isolate (designated W31) was classified as Vagococcus sp. A bioflocculant (named MBFW31) produced by W31 was extracted from the culture broth by ethanol precipitation and purified by gel chroma-tography. MBFW31 was heat-stable and had strong flocculating activity in a wide range of pH with relatively low dosage re-quirement. MBFW31 was identified as a polysaccharide with molecular weight over 2×106. It contained neutral sugar and uronic acid as its major and minor components, respectively. Infrared spectra showed the presence of hydroxyl, carboxyl and methoxyl group in its molecules. The present results suggested that MBFW31 had potential application in wastewater treatment. | GAO Jie BAO Hua-ying XIN Ming-xiu LIU Yuan-xia LI Qian ZHANG Yan-fen | 2006 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2006，7，3： | 16 |
| 8 | Estimation of soil reinforcement by the roots of four postdam prevailing grass species in the riparian zone of Three Gorges Reservoir, China显示文摘Soil erosion and bank degradation is a major post-dam concern regarding the riparian zone of the Three Gorges Reservoir. The development and succession of vegetation is a main countermeasure,especially to enhance bank stability and mitigate soil erosion by the root system. In this study, the roots of four prevailing grass species, namely, Cynodon dactylon, Hemarthria altissima, Hemarthria compressa, and Paspalum paspaloides, in the riparian zone were investigated in relation to additional soil cohesion. Roots were sampled using a single root auger. Root length density(RLD) and root area ratio(RAR) were measured by using the Win RHIZO image analysis system. Root tensile strength(TR) was performed using a manualdynamometer, and the soil reinforcement caused by the roots was estimated using the simple Wu's perpendicular model. Results showed that RLD values of the studied species ranged from 0.24 cm/cm3 to20.89 cm/cm3 at different soil layers, and RLD were significantly greater at 0–10 cm depth in comparison to the deeper soil layers(>10 cm). RAR measurements revealed that on average 0.21% of the reference soil area was occupied by grass roots for all the investigated species. The measured root tensile strength was the highest for P. paspaloides(62.26MPa) followed by C. dactylon(51.49 MPa), H.compressa(50.66 MPa), and H. altissima(48.81MPa). Nevertheless, the estimated maximum root reinforcement in this investigation was 22.5 k Pa for H.altissima followed by H. compressa(21.1 k Pa), P.paspaloides(19.5 k Pa), and C. dactylon(15.4 k Pa) at0–5 cm depth soil layer. The root cohesion values estimated for all species were generally distributed at the 0–10 cm depth and decreased with the increment of soil depth. The higher root cohesion associated with H. altissima and H. compressa implies their suitability for revegetation purposes to strengthen the shallow soil in the riparian zone of the Three Gorges Reservoir. Although the soil reinforcement induced by roots is only assessed from indirect indicators, the present results still useful for species selection in the framework of implementing and future vegetation recovery actions in the riparian zone of the Three Gorges Reservoir and similar areas in the Yangtze River Basin. | ZHONG Rong-hua HE Xiu-bin BAO Yu-hai TANG Qiang GAO Jin-zhang YAN Dan-dan WANG Ming-feng LI Yu | 2016 | Journal of Mountain Science2016，13，3： | 15 |
| 9 | Microsatellite instability,MMR gene expression and proliferation kinetics in colorectal cancer with famillial predisposition显示文摘INTRODUCTIONGenetic instability is a conunon property of manyhuman cancers,including those of HNPCC.A novel form of genetic instability involving somaticalterations,such as deletions and insertions insimple repeated sequences,has been found.Microsatellitcs are relatively short runs of tandemlyrepeated sequences scattered throughout | Bao Ping Wu Ya Li Zhang Dian Yuan Zhou Chun Fang Gao Zhuo Sheng Lai | 2000 | World Journal of Gastroenterology2000，6，6： | 14 |
| 10 | Efficient generation of transgenic chickens using the spermatogonial stem cells in vivo and ex vivo transfection显示文摘The highly efficient novel methods to produce transgenic chickens were established by directly in-jecting the recombinant plasmid containing green fluorescent protein (GFP) gene into the cock's testis termed as testis-medianted gene transfer (TMGT), and transplanting transfected spermatogonial stem cells (TTSSCs). For the TMGT approach,four dosages of pEGFP-N1 DNA/cationic polymer complex were injected intratesticularly. The results showed: (1) 48 h after the injection,the percentages of testis cells expressing GFP were 4.0%, 8.7%, 10.2% and 13.6% in the 50, 100, 150 and 200 μg/mL group, re-spectively. The difference from the four dosage groups was significant (P<0.05). On day 25 after the injection, a dosage-dependent and time-dependent increase in the number of transgenic sperm was observed. The percentages of gene expression reached the summit and became stable from day 70 to 160, being 12.7%, 12.8%, 15.9% and 19.1%, respectively. The difference from the four dosage groups was also significant (P<0.05). (2) 70 d after the injection, strong green fluorescent could be observed in the seminiferous tubules by whole-mount in-situ hybridization. (3) 70 d after the injection, the semen was collected and used to artificially inseminate wild-type females. The blastoderms of F1 and F2 transgenic chicken expressed GFP were 56.2% (254/452) and 53.2% (275/517), respectively. The detec-tion of polymerase chain reaction (PCR) of F1 and F2 transgenic chicken blood genomic DNA showed that 56.5% (3/23) of F1 and 52.9% (9/17) of F2 were positive. Southern blot showed GFP DNA was in-serted in their genomic DNAs. (4) Frozen whole mount tissue sections of F1 and F2 transgenic chicken liver, heart, kidney and muscle showed that the rates of green fluorescent positive were between 50.0% and 66.7%. (5) With the TTSSCs method, SSCs ex vivo transfected with GFP were transplanted into recipient roosters whose endogenic SSCs had been resoluted. The donor SSCs settled and GFP ex-pression became readily detectable in the frozen whole mount tissue sections of recepient testes. Moreover, sperms carrying GFP could be produced normally. The results of artificially inseminating wild-type females with these sperms showed 12.5% (8/64) of offspring embryo expressed GFP and 11.1% (2/18) hatched chicks were tested transgenic. Our data therefore suggest TMGT and TTSSCs are the feasible methods for the generation of transgenic chickens. | LI BiChun SUN GuoBo SUN HuaiChang XU Qi GAO Bo ZHOU GuanYue ZHAO WenMing WU XinSheng BAO WenBin YU Fei WANG KeHua CHEN GuoHong | 2008 | Science China(Life Sciences)2008，51，8： | 13 |
| 11 | B to O erythrocyte conversion by the recombinant α-galactosidase显示文摘背景人的组 O 红血房间在象武装冲突和自然灾祸那样的专业化输送区域有大利益。组 B 抗原不同从仅仅由一个终端的增加的组 O 抗原的在结构上连接了半乳糖残余。在我们试图把终端半乳糖从组 B 红血房间移开得到的这研究组织 O 红血 cell.Methods 牛乳糖 cDNA 被 RT-PCR 从在 China.The 的海南岛上种的 Catimor 咖啡豆子克隆为牛乳糖 cDNA 表示的向量被构造并且由 electroporation 转了进 Pichia pastoris 房间。转基因的房间被发酵克隆, recombinant 牛乳糖被离子交换层析净化。在学习 -galactosidase, 的生物化学的人物以后,我们在从组 B 变换人的红血球组织 recombinant 牛乳糖的纯净是的 O.Results 使用了它比 96% 高,它被认为对血的使用合适变换。酶地变换的人的组 O 红血房间(ECHORBC ) 展出了膜正直,新陈代谢的正直,正常房间变丑和形态学。在 ECHORBC 和任何组人的血之间没有凝结。ECHORBC 将在 monoammoniumphosphate 营养素答案在 4 点为 21 天的一个句号使结构和函数正常。有恒河猴和长臂猿的实验证明酶地变换的红血球的那输送是 safe.Conclusion ECHORBC 能被牛乳糖容易从组 B 红血房间获得消化。这研究建议 ECHORBC 能安全地并且高效地被输到病人。 | ZHANG Yang-pei GONG Feng BAO Guo-qiang GAO Hong-wei JI Shou-ping TAN Ying-xia LI Su-bo LI Li-li WANG Ying-li XU Hua XU Li-juan TIAN Shu-guang ZHANG Zhi-xin LU Qiu-shuang QIU Yan BAI Jian-shi CHEN Ji-ting | 2007 | Chinese Medical Journal2007，，13： | 13 |
| 12 | A comprehensive generic-level phylogeny of the sunflower family: Implications for the systematics of Chinese Asteraceae显示文摘葵花家庭(Asteraceae ) 最大并且最多样的 flowering 植物家庭,包括 24 000-30 000 种类和 1600-1700 类。在中国, Asteraceae 也是最大的家庭,与在 248 个类的约 2336 土生土长的种类。在过去的二十年,分子的种系发生的分析极大地作出贡献到我们 Asteraceae 的 systematics 的理解。不过,关于在整个的通用水平的中国 Asteraceae 的关系的大规模分析和知识由于在采样的困难是远非完全的。在这研究,我们介绍了一三标记(rbcL, ndhF,和 matK ) Asteraceae 的发展史,包括 506 个类(即,约三分之一个个 Asteraceae 类) 。学习取样了 200 个中国类(即,约 80% 中国 Asteraceae 类) 。新发展史的脊梁与更早的研究大部分适合,与认出的 13 个亚科和 45 个部落。中国 Asteraceae 在 7 个亚科( Mutisioideae , Wunderlichioideae , Carduoideae , Pertyoideae , Gymnarrhenoideae , Cichorioideae ,和 Asteroideae )和 22 个部落被散布( Mutiseae , Hyalideae , Cardueae , Pertyeae , Gymnarrheneae , Vernonieae , Cichorieae , Doroniceae , Senecioneae , Astereae , Anthemideae , Gnaphalieae , Calenduleae , Inuleae , Athroismeae , Helenieae , Coreopsideae , Neurolaeneae , Tageteae , Millieae , Eupatorieae ,和 Heliantheae )。中国 Asteraceae 缺乏 6 个基础亚科和 23 个部落。几种以前模糊的关系被澄清。我们的分析也在中国 Asteraceae 以内解决了一些未受到安置的类。最后,我们的种系发生的树被用来为中国 Asteraceae 的所有类修订分类。总共,在中国的 255 个类, 22 个部落,和 7 个亚科被认出。 | Zhi-Xi Fu Bo-Han Jiao Bao Nie Guo-Jin Zhang Tian-Gang Gao | 2016 | Journal of Systematics and Evolution2016，54，4： | 12 |
| 13 | Study on the spatial differences and its time lag effect on climatic factors of the vegetation in the Longitudinal Range-Gorge Region显示文摘这篇文章包括温度和降水分析 NDVI 和二个气象学的数据的关联,并且探查回答植被的敏感到温度和降水变化的空间模式。由构造 NDVIr 索引,在在纵的范围峡区域(LRGR ) 的植被盖子和陆地使用之间的关系被揭示。结论如下:(1 ) 时间落后那植被回答到温度和降水变化的效果被证明。不同区域有相应于最大的关联系数的不同延期时间。根据降水和温度联合的反应时间,也就是,三种温度降水形式被定义在一样的时间的降水和温度,在温度以前的降水和在降水以前的温度。(2 ) 敏感的空间分发,哪个对温度的植被回答,被几个高、低的散布关联中心描绘。与温度,二个感觉迟钝的区域和二条敏感的带不同被形成介绍植被的反应给降水。(3 ) NDVIr 被构造,它能完美地在 LRGR 反映在气象学的因素和陆地使用状况之间的相应关系。 | BAO YaJing SONG GuoBao LI ZhengHai GAO JiXi LU HaiYan WANG HaiMei CHENG Yan XU Tian | 2007 | Chinese Science Bulletin2007，52，A02： | 12 |
| 14 | NLRP3-dependent pyroptosis is required for HIV-1 gp120- induced neuropathology显示文摘The human immunodeficiency virus-1(HIV-1)envelope protein gp120 is the major contributor to the pathogenesis of HIVassociated neurocognitive disorder(HAND).Neuroinflammation plays a pivotal role in gp120-induced neuropathology,but how gp120 triggers neuroinflammatory processes and subsequent neuronal death remains unknown.Here,we provide evidence that NLRP3 is required for gp120-induced neuroinflammation and neuropathy.Our results showed that gp120-induced NLRP3-dependent pyroptosis and IL-1βproduction in microglia.Inhibition of microglial NLRP3 inflammasome activation alleviated gp120-mediated neuroinflammatory factor release and neuronal injury.Importantly,we showed that chronic administration of MCC950,a novel selective NLRP3 inhibitor,to gp120 transgenic mice not only attenuated neuroinflammation and neuronal death but also promoted neuronal regeneration and restored the impaired neurocognitive function.In conclusion,our data revealed that the NLRP3 inflammasome is important for gp120-induced neuroinflammation and neuropathology and suggest that NLRP3 is a potential novel target for the treatment of HAND. | Xiaolong He Weijun Yang Zhijie Zeng Yi Wei Jie Gao Bao Zhang Li Li Liqun Liu Yu Wan Qing Zeng Zelong Gong Liting Liu Hanyun Zhang Yubin Li Shaojie Yang Tongtong Hu Lixian Wu Eliezer Masliah Shenghe Huang Hong Cao | 2020 | Cellular & Molecular Immunology2020，17，3： | 11 |
| 15 | Economic burden and its associated factors of hospitalized patients infected with A (H7N9) virus: a retrospective study in Eastern China, 2013–2014显示文摘Background:H7N9 continues to cause human infections and remains a pandemic concern.Understanding the economic impacts of this novel disease is important for making decisions on health resource allocation,including infectious disease prevention and control investment.However,there are limited data on such impacts.Methods:Hospitalized laboratory-confirmed H7N9 patients or their families in Jiangsu Province of China were interviewed.Patients’direct medical costs of hospitalization were derived from their hospital bills.A generalized linear model was employed to estimate the mean direct medical costs of patients with different characteristics.Results:The mean direct cost of hospitalization for H7N9 was estimated to be¥71060(95%CI,48180–104820),i.e.,US$10996(95%CI,7455–16220),and was¥12060(US$1861),¥136120(US$21001)and¥218610(US$33728)for those who had mild or severe symptoms or who died,respectively.The principal components of the total fees differed among patients with different disease severity,although medication fees were always the largest contributors.Disease severity,proportion of reimbursement and family member monthly average income were identified as the key factors that contributed to a patient’s direct medical cost of hospitalization.Conclusions:The direct medical costs of hospitalized patients with H7N9 are significant,and far surpass the annual per capita income of Jiangsu Province,China.The influencing factors identified should be taken into account when developing related health insurance policies and making health resource allocation.Trial registration:Not applicable.This is a survey study with no health care intervention implemented on human participants. | Xiang Huo Li-Ling Chen Lei Hong Lun-Hui Xiang Fen-Yang Tang Shan-Hui Chen Qiang Gao Cong Chen Qi-gang Dai Chuan-Wu Sun Ke Xu Wen-Jun Dai Xian Qi Chang-Cheng Li Hui-Yan Yu Yin Zhou Hao-Di Huang Xing-Yang Pan Chang-sha Xu Ming-Hao Zhou Chang-Jun Bao | 2016 | Infectious Diseases of Poverty2016，5，1： | 10 |
| 16 | Wheat genomic study for genetic improvement of traits in China显示文摘Bread wheat(Triticum aestivum L.)is a major crop that feeds 40%of the world’s population.Over the past several decades,advances in genomics have led to tremendous achievements in understanding the origin and domestication of wheat,and the genetic basis of agronomically important traits,which promote the breeding of elite varieties.In this review,we focus on progress that has been made in genomic research and genetic improvement of traits such as grain yield,end-use traits,flowering regulation,nutrient use efficiency,and biotic and abiotic stress responses,and various breeding strategies that contributed mainly by Chinese scientists.Functional genomic research in wheat is entering a new era with the availability of multiple reference wheat genome assemblies and the development of cutting-edge technologies such as precise genome editing tools,highthroughput phenotyping platforms,sequencing-based cloning strategies,high-efficiency genetic transformation systems,and speed-breeding facilities.These insights will further extend our understanding of the molecular mechanisms and regulatory networks underlying agronomic traits and facilitate the breeding process,ultimately contributing to more sustainable agriculture in China and throughout the world. | Jun Xiao Bao Liu Yingyin Yao Zifeng Guo Haiyan Jia Lingrang Kong Aimin Zhang Wujun Ma Zhongfu Ni Shengbao Xu Fei Lu Yuannian Jiao Wuyun Yang Xuelei Lin Silong Sun Zefu Lu Lifeng Gao Guangyao Zhao Shuanghe Cao Qian Chen Kunpu Zhang Mengcheng Wang Meng Wang Zhaorong Hu Weilong Guo Guoqiang Li Xin Ma Junming Li Fangpu Han Xiangdong Fu Zhengqiang Ma Daowen Wang Xueyong Zhang Hong-Qing Ling Guangmin Xia Yiping Tong Zhiyong Liu Zhonghu He Jizeng Jia Kang Chong | 2022 | Science China(Life Sciences)2022，65，9： | 9 |
| 17 | Tribological properties of copper matrix composites reinforced with homogeneously dispersed graphene nanosheets显示文摘Graphene reinforced copper matrix composites(Gr/Cu) were fabricated by electrostatic self-assembly and powder metallurgy. The morphology and structure of graphene oxide, graphene oxide-Cu powders and Gr/Cu composites were characterized by scanning electronic microscopy, transmission electronic microscopy, X-ray diffraction and Raman spectroscopy, respectively. The effects of graphene contents,applied loads and sliding speeds on the tribological behavior of the composites were investigated. The results indicate that the coefficient of friction of the composites decreases first and then increases with increasing the graphene content. The lowest friction coefficient is achieved in 0.3 wt% Gr/Cu composite,which decreases by 65% compared to that of pure copper. The coefficient of friction of the composite does not have significant change with increasing the applied load, however, it increases with increasing the sliding speed. The tribological mechanisms of the composite under different conditions were also investigated. | Xin Gao Hongyan Yue Erjun Guo Shaolin Zhang Longhui Yao Xuanyu Lin Bao Wang Enhao Guan | 2018 | Journal of Materials Science & Technology2018，34，10： | 9 |
| 18 | Serum uric acid as an index of impaired renal function in congestive heart failure显示文摘BackgroundHyperuricemia 经常是在有心失败的病人的现在。许多病理学的条件例如织物局部缺血,肾的功能缺陷,心脏的功能缺陷,新陈代谢的症候群,和煽动性的地位,可以影响尿酸(UA ) 新陈代谢。这研究是回顾地在心 failure.MethodsWe 估计他们的潜在的关系到 UA 新陈代谢估计的临床的特征, echocardiological ,肾,与充血的心失败在随机选择的成年人的一个大队在心血管的疾病和 UA 新陈代谢根据他们的参与的以前的证据选择的新陈代谢、煽动性的变量( n = 553 )。由索引聚类,那些变量用因素 analysis.ResultsIn 因素分析被探索,尿酸(SUA ) 形成了的浆液包括了浆液 creatinine (SCr ) 和血脲氮(甜面包) 的肾的功能的变量的主要的簇的部分。在有充血的心失败的病人的变量之间的 Univariate 关联系数证明为 SUA 的最强壮的关联与甜面包(r = 0.48, P <0.001 ) 并且 SCr (r = 0.47, P <0.001 ).ConclusionsThere 是在 SUA 层次和在有充血的心失败的病人的肾的功能的措施之间的一种反的关系。在 SUA 和 SCr 和甜面包层次之间的强壮的关联建议提高的 SUA 集中在心失败反映肾的功能的一个缺陷。 | Yu Tian Ying Chen Bao Deng Gang Liu Zhen-Guo Ji Qing-Zhen Zhao Yu-Zhi Zhen Yan-Qiu Gao Li Tian Le Wang Li-Shuang Ji Guo-Ping Ma Kun-Shen Liu Chao Liu | 2012 | Journal of Geriatric Cardiology2012，9，2： | 9 |
| 19 | Regulatory Effect of E2,IL-6 and IL-8 on the Growth of Epithelial Ovarian Cancer Cells显示文摘To determine the regulatory effects of estrogen and cytokine IL-6 and IL-8 on the growth of epithelial ovarian cancer (OVCA), we first examined the status of estrogen receptors (ERα and ERβ), IL-6 receptor (IL-6Rα and gp130), and IL-8 receptor (IL-8RA and IL-8RB) on five epithelial OVCA cell lines by semiquantitative RT-PCR and Western blot analysis. Results showed that the expressions of these receptors were variable on the five cells.Those OVCA cells expressing the receptors were selected to study related molecular mechanism. MTT assay was performed to observe the effects of 17β-estradiol (E2), IL-6 and IL-8 on cell proliferation. We discovered that E2 markedly promoted the proliferation of CAOV-3 and OVCAR-3 cell in a time- and dose-dependent manner.Tamoxifen (Txf), an ER inhibitor, completely blocked the proliferation of the E2-induced cells, and IL-6- or/and IL-8-neutralizing antibody only showed partially blocking activity. IL-6 and IL-8 were able to significantly stimulate CAOV-3 and OVCAR-3 cell proliferation in a time- and dose-dependent manner, which had a potential synergistic effect on CAOV-3 cells but not on OVCAR-3 cells. The cell proliferation induced by these two cytokines was abolished completely by their specific neutralizing antibodies, partially by Txf, but not by unrelated goat IgG.Taken together, our results suggested that estrogen, IL-6 and IL-8 could modulate OVCA growth by forming a reciprocal cascade with amplifying effect. Cellular & Molecular Immunology. | Yue Wang Jie Yang Yan Gao Yongrui Du Leyuan Bao Wenyan Niu Zhi Yao | 2005 | Cellular & Molecular Immunology2005，2，5： | 9 |
| 20 | Dynamics and Control of a Novel 3-DOF Parallel Manipulator with Actuation Redundancy显示文摘This paper deals with the dynamics and control of a novel 3-degrees-of-freedom(DOF)parallel manipulator with actuation redundancy.According to the kinematics of the redundant manipulator,the inverse dynamic equation is formulated in the task space by using the Lagrangian formalism,and the driving force is optimized by utilizing the minimal 2-norm method.Based on the dynamic model,a synchronized sliding mode control scheme based on contour error is proposed to implement accurate motion tracking control.Additionally,an adaptive method is introduced to approximate the lumped uncertainty of the system and provide a chattering-free control.The simulation results indicate the efectiveness of the proposed approaches and demonstrate the satisfactory tracking performance compared to the conventional controller in the presence of the parameter uncertainties and un-modelled dynamics for the motion control of manipulators. | Xue-Mei Niu Guo-Qin Gao Xin-Jun Liu Zhi-Da Bao | 2013 | International Journal of Automation and computing2013，10，6： | 8 |
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