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| 1 | A Chromosome-Level Genome Assembly of Garlic (Allium sativum) Provides Insights into Genome Evolution and Allicin Biosynthesis显示文摘Garlic,an economically important vegetable,spice,and medicinal crop,produces highly enlarged bulbs and unique organosulfur compounds.Here,we report a chromosome-level genome assembly for garlic,with a total size of approximately 16.24 Gb,as well as the annotation of 57561 predicted protein-coding genes,making garlic the first Allium species with a sequenced genome.Analysis of this garlic genome assembly reveals a recent burst of transposable elements,explaining the substantial expansion of the garlic genome.We examined the evolution of certain genes associated with the biosynthesis of allicin and inulin neoseries-type fructans,and provided new insights into the biosynthesis of these two compounds.Furthermore,a large-scale transcriptome was produced to characterize the expression patterns of garlic genes in different tissues and at various growth stages of enlarged bulbs.The reference genome and large-scale transcriptome data generated in this study provide valuable new resources for research on garlic biology and breeding. | Xiudong Sun Siyuan Zhu Ningyang Li Yi Cheng Jing Zhao Xuguang Qiao Li Lu Shiqi Liu Yanzhou Wang Chan Liu Benping Li Wu Guo Shuang Gao Zemao Yang Fu Li Zheng Zeng Qing Tang Yupeng Pan Mengjiao Guan Jian Zhao Xiaomi ng Lu Huanwe n Meng Zhenlin Han Chun she ng Gao Wenkai Jiang Xing Zhao Shilin Tian Jianguang Su Zhihui Cheng Touming Liu | 2020 | Molecular Plant2020，13，9： | 14 |
| 2 | Roles of a sustained activation of NCED3 and the synergistic regulation of ABA biosynthesis and catabolism in ABA signal production in Arabidopsis显示文摘ABA, acting as a stress signal, plays crucial roles in plant resistance to water stress. Because ABA signal production is based on ABA biosynthesis, the regulation of NCED, a key enzyme in the ABA biosynthesis pathway, is normally thought of as the sole factor controlling ABA signal production. Here we demonstrate that ABA catabolism in combination with a synergistic regulation of ABA biosynthesis plays a crucial role in governing ABA signal production. Water stress induced a significant accumulation of ABA, which exhibited different patterns in detached and attached leaves. ABA catabolism followed a temporal trend of exponential decay for both basic and stress ABA, and there was little difference in the catabolic half-lives of basic ABA and stress ABA. Thus, the absolute rate of ABA catabolism, i.e. the amount of ABA catabolized per unit time, increases with increased ABA accumulation. From the dynamic processes of ABA biosynthesis and catabolism, it can be inferred that stress ABA accumulation may be governed by a synergistic regulation of all the steps in the ABA biosynthesis pathway. Moreover, to maintain an elevated level of stress ABA sustained activation of NCED3 should be required. This inference was supported by further findings that the genes encoding major enzymes in the ABA biosynthesis pathway, e.g. NCED3, AAO3 and ABA3 were all activated by water stress, and with ABA accumulation progressing, the expressions of NCED3, AAO3 and ABA3 remained activated. Data on ABA catabolism and gene expression jointly indicate that ABA signal production is controlled by a sustained activation of NCED3 and the synergistic regulation of ABA biosynthesis and catabolism. | REN HuiBo FAN YiJian GAO ZhiHui WEI KaiFa LI GuiFen LIU Jing CHEN Lin LI BingBing HU JianFang JIA WenSuo | 2007 | Chinese Science Bulletin2007，52，4： | 12 |
| 3 | Long-and short-chain AHLs affect AOA and AOB microbial community composition and ammonia oxidation rate in activated sludge显示文摘Quorum sensing(QS)regulation of the composition of ammonia-oxidising archaea(AOA)and ammonia-oxidising bacteria(AOB)communities and functions in wastewater treatment was investigated.Specifically,we explored the role of N-acyl-L-homoserine lactones(AHLs)in microbial community dynamics in activated sludge.On average,the specific ammoniaoxidising-rate increased from 1.6 to 2.8 mg NH_4^+-N/g MLSS/hr after treatment with long-chain AHLs for 16 days,and the addition of AHLs to sludge resulted in an increased number of AOA/AOB amoA genes.Significant differences were observed in the AOA communities of control and AHL-treated cultures,but not the AOB community.Furthermore,the dominant functional AOA strains of the Crenarchaeota altered their ecological niche in response to AHL addition.These results provide evidence that AHLs play an important role in mediating AOA/AOB microbial community parameters and demonstrate the potential for application of QS to the regulation of nitrogen compound metabolism in wastewater treatment. | Jie Gao Yu Duan Ying Liu Xuliang Zhuang Yichen Liu Zhihui Bai Wenlin Ma Guoqiang Zhuang | 2019 | Journal of Environmental Sciences2019，31，4： | 11 |
| 4 | Designing and Optimization of an Off-line Programming System for Robotic Belt Grinding Process显示文摘Off-line programming (OLP) system becomes one of the most important programming modules for the robotic belt grinding process, however there lacks research on increasing the grinding dexterous space depending on the OLP system. A new type of grinding robot and a novel robotic belt grinding workcell are forwarded, and their features are briefly introduced. An open and object-oriented off-line programming system is developed for this robotic belt grinding system. The parameters of the trimmed surface are read from the initial graphics exchange specification (IGES) file of the CAD model of the workpiece. The deBoor-Cox basis function is used to sample the grinding target with local contact frame on the workpiece. The numerical formula of inverse kinematics is set up based on Newton's iterative procedure, to calculate the grinding robot configurations corresponding to the grinding targets. After the grinding path is obtained, the OLP system turns to be more effective than the teach-by-showing system. In order to improve the grinding workspace, an optimization algorithm for dynamic tool frame is proposed and performed on the special robotic belt grinding system. The initial tool frame and the interval of neighboring tool frames are defined as the preparation of the algorithm. An optimized tool local frame can be selected to grind the complex surface for a maximum dexterity index of the robot. Under the optimization algorithm, a simulation of grinding a vane is included and comparison of grinding workspace is done before and after the tool frame optimization. By the algorithm, the grinding workspace can be enlarged. Moreover the dynamic tool frame can be considered to add one degree-of-freedom to the grinding kinematical chain, which provides the theoretical support for the improvement of robotic dexterity for the complex surface grinding. | WANG Wei YUN Chao ZHANG Ling GAO Zhihui | 2011 | Chinese Journal of Mechanical Engineering2011，24，4： | 11 |
| 5 | Structural Dimension Optimization of Robotic Belt Grinding System for Grinding Workpieces with Complex Shaped Surfaces Based on Dexterity Grinding Space显示文摘为了改进机器的带磨擦的磨擦质量,为有建筑群的细工品的系统塑造了表面,磨点的灵巧的新概念和磨空格的灵巧被建议,他们的数学描述被定义。影响磨空间的灵巧的因素被分析。并且决定磨空间的必要灵巧的一个方法被建议。把方法基于粒子群优化(PSO ) ,优化磨擦机器人的策略关于磨擦车轮的结构的尺寸和位置被提出获得磨空间的必要灵巧。最后,磨天线引擎片,奉献 PPPRRR (P:棱柱的 R:旋转) 磨擦机器人关于磨擦车轮的结构的尺寸和位置用上述策略被优化。根据模拟结果,如果片被放在磨空间的灵巧以内,仅仅一 gripper 和一磨擦机器被需要磨它的建筑群塑造的表面。 | GAO Zhihui LAN Xiaodong BIAN Yushu | 2011 | Chinese Journal of Aeronautics2011，24，3： | 9 |
| 6 | Research progress of gut flora in improving human wellness显示文摘Human wellness is the ultimate goal of our efforts in improving the human life.Special foods are undoubtedly important in achieving human wellness.However,overeating significantly leads to obesity and diabetes.These chronic diseases will in turn affect the human wellness.Therefore,“dietary restriction and proper exercise”were introduced in the human daily life.Different foods cause various effects on the human health.The diversification of diet is a priority for nutritionists to keep our body healthy.To avoid diabetes mellitus,special foods for ketogenic diet,low-carbon diet,and low-calorie intake are also gradually attracting attention.In addition,the hypothesis that“hunger sensation comes from gut flora”brings new light to the research on the biological motivation for humans to eat food.This hypothesis has been gradually demonstrated using the flexible fasting technology by providing special foods,such as plant polysaccharides and dietary fibers.The response to food-needing signals from the gut flora to these foods demonstrates the importance of the gut flora in improving human wellness.The gut flora is probably an essential factor for translating the food-eating signals and converting the nutrition to our body.Therefore,“gut flora priority principle”is developed to guarantee human wellness.The 16S rRNA sequencing and mass spectrometric techniques can be used to identify the gut flora,which may guide us to a new era of human wellness based on gut flora wellness. | Chenggang Zhang Wenjing Gong Zhihui Li Dawen Gao Yan Gao | 2019 | Food Science and Human Wellness2019，8，2： | 8 |
| 7 | An individualized immune signature of pretreatment biopsies predicts pathological complete response to neoadjuvant chemoradiotherapy and outcomes in patients with esophageal squamous cell carcinoma显示文摘No clinically available biomarkers can predict pathological complete response(pCR)for esophageal squamous cell carcinomas(ESCCs)with neoadjuvant chemoradiotherapy(nCRT).Considering that antitumor immunity status is an important determinant for nCRT,we performed an integrative analysis of immune-related gene profiles from pretreatment biopsies and constructed the first individualized immune signature for pCR and outcome prediction of ESCCs through a multicenter analysis.During the discovery phase,14 differentially expressed immune-related genes(DEIGs)with greater than a twofold change between pCRs and less than pCRs( | Chaoqi Zhang Guochao Zhang Nan Sun Zhen Zhang Liyan Xue Zhihui Zhang Haijun Yang Yuejun Luo Xiaoli Zheng Yonglei Zhang Yufen Yuan Ruixue Lei Zhaoyang Yang Bo Zheng Le Wang Yun Che Feng Wang Sihui Wang Shugeng Gao Qi Xue Yi Zhang Jie He | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 7 |
| 8 | QTL Mapping for Cucumber Fruit Size and Shape with Populations from Long and Round Fruited Inbred Lines显示文摘To gain insight into the molecular and genetic basis of fruit size and shape in cucumber,we conducted Quantitative Trait Locus(QTL)mapping with F2 and BC1F1 populations derived froma cross between the Northern-China type inbred line CNS21 and the Southern-China type inbred line RNS7.Populations were evaluated during two developmental stages,ovary at anthesis and commercial fruit(immature fruit).A total of 13 major-effect QTLs(R2>10%)were detected for six traits,and one of them,fruit shape index 2.1,explained more than 50%of phenotypic variation.All QTLs distributed on chromosome(chr)1 and 2.We constructed a physical map containing almost all of the QTLs with their physical location from previous studies.For fruit size and shape,the highest number of QTLs were mapped on chr1 and chr6,and the fewest number were mapped on chr2 and chr7.At least one consensus region was presented on each chromosome.In addition,three candidate genes were predicted between the long-fruited and round-fruited inbred lines by comparing the sequences of the consensus region of chr3,where many QTLs for marketable fruit length had been detected.Our results provide a base for additional QTLs and molecular markers for fruit size and shape in cucumber breeding. | Zhihui Gao Haiyang Zhang Chenxing Cao Jing Han Hao Li Zhonghai Ren | 2020 | Horticultural Plant Journal2020，6，3： | 7 |
| 9 | Restudy of the storage and migration model of the Quaternary groundwater in Beijing Plain area显示文摘Through a wide-spread groundwater sampling mainly at nested monitoring wells in the Beijing Plain area,combined with data collection,the study analyzes water level,hydrochemistry,temperature,tritium,deuterium,18O,14C and other aspects,and indicates that there exits an obvious stratification phenomenon of the groundwater in the alluvial plain area down in the middle part of alluvial-pluvial fans,and the hydraulic connection between layers is very weak.The analysis of the tritium concentration suggests that the average influence depth of the modern precipitation is approximately 120m.Based on the analysis of the 22 paleowater samples through the D18O method and 14C isotopic dating,the deep groundwater circulation in the fine sediments area of Beijing Plain down in the fringe part of alluvial-pluvial fans is relatively slow.On average the paleowater point occurs approximately below the 180m at these points.The main reasons for the formation of stratification and paleowater points are the water-blocking effect of the clay type strata and the compaction effect during the sedimentary process,especially the differential compaction,which could form closed or relatively closed stagnant aquifers.Groundwater in this kind of stagnant aquifers to some degree belongs to non-renewable resource,and should be reconsidered and re-arranged in the water resources management strategy. | LIU YuanZhang WU Qiang LIN Pei LIU JiuRong XING LiTing GAO ZhiHui | 2012 | Science China Earth Sciences2012，55，7： | 7 |
| 10 | COUPLING EFFECT OF FLEXIBLE JOINT AND FLEXIBLE LINK ON DYNAMIC SINGULARITY OF FLEXIBLE MANIPULATOR显示文摘The coupling effect of the flexible joint and the flexible link on the dynamic singularity of the flexible manipulator is addressed. Firstly,the dynamic equations of a flexible manipulator with a flexible joint and a flexible link are derived. Secondly,the relationship and property between the flexible joint and the flexible link are analyzed. It shows that the flexible joint's amplitude will increase abruptly,thereby the dynamic singularity occurs if the frequency of a flexible joint is near or equal to some natural frequency of a flexible link. Finally,some numerical simulations which will verify the correctness of the theoretical analysis,are carried out. The results are fundamental for the design of a flexible manipulator and for the avoidance of the dynamic singularity. | GAO Zhihui YUN Chao BIAN Yushu | 2008 | Chinese Journal of Mechanical Engineering2008，21，1： | 6 |
| 11 | Effects of Bionic Units in Different Scales on the Wear Behavior of Bionic Impregnated Diamond Bits显示文摘 | Zhaozhi Wang Ke Gao Youhong Sun Zhihui Zhang Shiyu Zhang Yunhong Liang Xiujuan Li Luquan Ren | 2016 | Journal of Bionic Engineering2016，13，4： | 4 |
| 12 | Microstructures and high-temperature self-lubricating wearresistance mechanisms of graphene-modified WC–12Co coatings显示文摘To reduce the friction coefficient of cobalt-cemented tungsten carbide(WC–12Co)wear-resistant coatings,graphene was compounded into WC–12Co powder via wet ball milling and spray granulation.Selflubricating and wear-resistant graphene coatings were prepared via detonation gun spraying.The presence,morphologies,and phase compositions of graphene in the powders and coatings that are obtained through different powder preparation processes were analyzed.The analysis was performed using the following technologies:energy-dispersive X-ray-spectroscopy(EDXS),scanning electron microscopy(SEM),transmission electron microscopy(TEM),and Raman spectroscopy.The mechanical properties of the coatings were studied using a microhardness tester and a universal drawing machine.The friction and wear properties of the coatings were studied using an SRV-4 friction and wear tester.The results showed that the graphene content in the WC–12Co coating modified with graphene was higher than that without modification;graphene was embedded in the structure in a transparent and thin-layer state.The adhesive strength of this coating at approximately 25°C was approximately 60.33 MPa,and the hardness was approximately 984 HV0.3.After high-temperature treatment,the adhesive strength and hardness of the graphene oxide(GO)/WC–12Co coating decreased slightly(the lowest adhesive strength of 53.16 MPa was observed after treatment at 400°C,and the lowest hardness of approximately 837 HV0.3 was observed after treatment at 300°C).Compared to the friction coefficient(0.6)of the WC–12Co coating obtained at room temperature,the friction coefficient of the GO/WC–12Co coating was decreased by approximately 50%of that value.The graphene-modified coating was continuously exposed to the wear tracks on the surface of the contacting materials during friction,and a lubricating film was formed in the microareas in which the wear tracks were present.The coating exhibited improved self-lubricating and wear-resistant effects compared to the unmodified WC–12Co coating.The results of this study demonstrated that graphene could be effective in self-lubrication and wear-reduction in a temperature range of 100–200°C,as a friction coefficient of 0.3 was maintained. | Haoliang TIAN Changliang WANG Mengqiu GUO Yongjing CUI Junguo GAO Zhihui TANG | 2021 | Friction2021，9，2： | 4 |
| 13 | Coupling Effect of Morphology and Mechanical Properties Contributes to the Tribological Behaviors of Snake Scales显示文摘 | Long Zheng Yinghui Zhong Yihang Gao Jiayi Li Zhihui Zhang Zhenning Liu Luquan Ren | 2018 | Journal of Bionic Engineering2018，15，3： | 4 |
| 14 | Swelling and thermal properties of porous PNIPAM/PEG hydrogels prepared by radiation polymerization显示文摘In this study,a series of porous intelligent hydrogels were synthesized by radiation exhibiting the lower critical solution temperature(LCST) and fast response involving a combination of A’-isopropyl acrylamideas monomer, polyethylene glycol(PEG) as pore-forming agent and N,N-methylene-bis-acrylamide as crosslinking agent.The hydrogels were analyzed by Fourier transform infrared spectroscopy,and the influence of radiation doses on their swelling and thermal behaviors were studied.Their surface morphologies were examined by scanning electron microscopy.The results showed that PEG molecules only acted as pore-forming agent in the cross-linked polymerization.Their swelling ratios reduced with increasing radiation doses.The LCST was around 37℃,and varied little with the radiation doses.The frozen water content of PNIPAM/PEG6000 hydrogel reduced with increasing the radiation dose,and was greater than that of PN1PAM hydrogel at 15 kGy.Hydrogel macropores were prepared by PEG agent,and the hydrogels without PEG had a dense surface.The porous hydrogels are expected to be applied in the field of artificial intelligence material. | LI Zhihui LIU Wentao LI Zhongyuan YANG Mingcheng GAO Xujing CUI Haitao HE Suqin ZHU Chengshen | 2013 | Nuclear Science and Techniques2013，24，2： | 3 |
| 15 | OPTIMAL CONTROL OF THE FLEXI-BLE LINK MANIPULATOR WITH CONTROLLABLE LOCAL DEGREES OF FREEDOM显示文摘Although flexible manipulators own many potential advantages, one of their major disadvantages is the deterioration of the end-effector accuracy due to the flexibility. Therefore, how to reduce vibration is a significant problem. Inspired by the observation on the motion behaviors of animals, a new idea of decreasing motion deflection of the flexible manipulator is suggested. The concept of controllable local degrees of freedom is proposed and analyzed. By way of optimizing local motion provided by the controllable local degrees of freedom, the end-effector deflection of the flexible manipulator can be effectively decreased through dynamic coupling. The corresponding optimal method for vibration control of the flexible manipulator is put forward. The kinematic simulation is carried ant on a three-link flexible manipulator The corresponding results verify the feasibility of this method. | BIAN Yushu YUN Chao GAO Zhihui | 2008 | Chinese Journal of Mechanical Engineering2008，21，4： | 3 |
| 16 | Hepatocytes in a normal adult liver are derived solely from the embryonic hepatocytes显示文摘In vertebrates,body weight increases many folds as a consequence of body growth from the childhood to adulthood(e.g.,~20 folds for a mouse).Considering the fact that the liver-to-body weight ratio(LBR)stays relatively constant within species(Weglarz and Sandgren,2000;Kan et al.,2009),the cell number in a liver must therefore keep increasing along with the | Ce Gao Zhihui Zhu Yuqi Gao Li Jan Lo Jun Chen Lingfei Luo Jinrong Peng | 2018 | Journal of Genetics and Genomics2018，45，3： | 2 |
| 17 | MULTI-SCALE DUAL-PHASE CYCLIC PLASTICITY WITH QUANTITATIVE TRANSITIONS AND SIZE EFFECTS OF LAYERED STRUCTURES显示文摘A method is developed for cyclic elastoplastic analysis across micro/meso/macro scales whichis effective for the quantitative transition of physical variables and for evaluating the size effects of microstruc-tures.By using the improved self-consistent seheme proposed by Fan and carrying out a delicate mesoscop-ic analysis based on a shear-lag model,the size effects including the thickness of hard and soft layers relativeto the inclusion dimension are obtained on the overall elastoplastic responses of materials up to 50 cycles.The dominant characteristics of the analysis rare that the characteristic dimensions of a microstructure such asthe thickness of the layers and the inclusion dimension can be explicitly incorporated into the formulation.Results of numerical analysis using only 4 plastic constants show that the thicker the layer relative to the in-clusion size,the softer the material in producing more plastic strain values for a given applied stress ampli-tude.This is in agreement with the well-known experimental rule that the yield strength of layered structuresis inversely proportionul to the square root of the spacing between layers.It is found that ratcheting dependsvery much on the size of the layered-structure and that the thinner the relative thickness of the layer the lessthe ratchetiug displacement.This finding may be used to explain why phenomenological models on ratchetingare not quite successful so far,indicating the significance of aeross scale analysis in understanding issueswhich have existed for a long time. | Fan Jinghong Gao Zhihui Zeng Xiangguo | 2002 | Acta Mechanica Solida Sinica2002，15，1： | 2 |
| 18 | Restricted peri-operative fluid administration adjusted by serum lactate level improved outcome after major elective surgery for gastrointestinal malignancy显示文摘 | Yu WenKui Li Ning Gong JianFeng Li WeiQin Tang ShaoQiu Tong Zhihui Gao Tao Zhang JuanJuan Xi FengChan Shi Hui Zhu WeiMing Li Jie-Shou | 2010 | Surgery2010，，4： | 2 |
| 19 | Synthesis and kinetics of 2,5-dicyanofuran in the presence of hydroxylamine ionic liquid salts显示文摘2,5-Dicyanofuran(DCF)is an important biomass-derived platform compound primarily used to prepare bio-based adiponitrile,which is the key precursor for the synthesis of nylon 66 and 1,6-hexanediisocyanate(HDI).In this study,one-pot,green and safe synthesis of DCF from 2,5-diformylfuran(DFF)and hydroxylamine ionic liquid salts was proposed.Eco-friendly hydroxylamine ionic liquid salts were used as the nitrogen source.Ionic liquid exhibited three-fold function of cosolvent,catalysis and phase separation.The conversion of DFF and yield of DCF reached 100%under the following optimum reaction conditions:temperature of 120℃ for 70 min,volume ratio of paraxylene:[HSO_(3)-b-Py]HSO4 of 2:1,and molar ratio of DFF:(NH_(2)OH)_(2)[HSO_(3)-b-Py]HSO4 of 1:1.5.The reaction mechanism for the synthesis of DCF was proposed,and the kinetic model was established.The reaction order with respect to DFF and intermediate product 2,5-diformylfuran dioxime(DFFD)was 1.06 and 0.16,and the reaction activation energy was 64.07 kJ·mol^(-1) and 59.37 kJ·mol^(-1) respectively.After the reaction,the ionic liquid was easy to separate,recover and recycle. | Xuan Gao Zhihui Li Dongsheng Zhang Xinqiang Zhao Yanji Wang | 2023 | Chinese Journal of Chemical Engineering2023，53，1： | 2 |
| 20 | Polymorphism analysis of microsatellites and construction of linkage map in part regions of four chromosomes in chicken显示文摘Based on chicken' consensus map issued in 2000,17 microsatellites near 4 candidate genes such as IGF2,OBR,GDF8 and APOA1 in 4 chromosomes(chromosome 5,7,8 and 24)were chosen for polymorphism analysis and construction of linkage map.Combining the technique of PCR and the fluorescent semi-automated detection,genome scanning was performed for 440 chickens,which was derived from China Agricultural University chicken resource families within three generations.The individuals of this resource families were genotyped.The results showed that the number of alleles ranged from 4 to 14;heterozygosity(H) of markers was between 0.3116 and 0.9148.Polymorphic information content(PIC)varied from 0.2672 to 0.8679.Microsatellites along with above-mentioned 4 candidate genes doing as general markers were used to construct linkage map.The spans of 4 linkage maps constructed in the part region of chromosome 5,7,8 and 24 were 263.5,79.9,206.2 and 104.2 cM,respectively.The order of markers was consistent with that of counterpart of reported consensus map.However,The spans of linkage map were larger than that of consensus map.The constructed linkage maps laid the foundation for mapping quantitative trait loci(QTL)responsible for economically important traits in chicken. | WANG Shouzhi LI Hui LI Ning GAO Yu DU Zhiqiang GU Zhiliang WANG Qigui LI Zhihui WANG Ying | 2007 | Journal of Northeast Agricultural University(English Edition)2007，14，2： | 1 |
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