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| 1 | Association of polymorphism of tumor necrosis factor-alpha gene promoter region with outcome of hepatitis B virus infection显示文摘AIM: To determine whether -238G/A and -857C/T polymorphisms of tumor necrosis factor-alpha (TNF-α), gene promoter and hepatitis B (HB) viral genotypes were associated with outcomes of HBV infection.METHODS: A total of 244 HBV self-limited infected subjects, 208 asymptomatic carriers, and 443 chronic HB patients were recruited to conduct a case-control study.TNF-α -238G/A and -857C/T gene promoter polymorphisms were examined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP), and HBV genotypes were examined by nested PCR.RESULTS: The positive rate of HBV DNA in asymptomatic carrier group and chronic HB group was 46.6% and 49.9%,respectively. HBV genotype proportion among the asymptomatic carriers was 2.1% for genotype A, 25.8% for genotype B, 68.0% for genotype C, and 4.1% for genotype B+C mixed infection, and 0.9% for genotype A,21.7% for genotype B, 71.5% for genotype C, 5.9% for genotype B+C mixed infection in chronic HB group. There was no significant difference in genotype distribution between the asymptomatic carrier group and chronic HB group (x2 = 1.66, P = 0.647). The frequency of -238GG genotype in self-limited group was 95.1%, significantly higher than 90.7% in chronic HB group and 89.0% in asymptomatic carrier group (P = 0.041 and P = 0.016,respectively).The frequency of TNF-α-857 CC in chronic HB group was 79.7%, significantly higher than 64.4% in asymptomatic carrier group and 70.9% in self-limited group (P<0.001 and P = 0.023, respectively). A multiple logistic regression analysis revealed that TNF-α-238GA and -857CC were independently associated with chronic HB after gender and age were adjusted.CONCLUSION: TNF-α promoter variants are likely to play a substantial role in the outcome of HBV infection. | Hong-Quan Li Zhuo Li Ying Liu Jun-Hong Li Jian-Qun Dong Ji-Rong Gao Chun-Yan Gou Hui Li | 2005 | World Journal of Gastroenterology2005，11，33： | 15 |
| 2 | WAVE-CURRENT INTERACTIONS WITH THREE-DIMENSIONAL FLOATING BODIES显示文摘A Time-domain Higher-Order Boundary Element Method(THOBEM) is developed for simulating wave-current interactions with 3-D floating bodies.Through a Taylor series expansion and a perturbation procedure,the model is formulated to the first-order in the wave steepness and in the current velocity,respectively.The boundary value problem is decomposed into a steady double-body flow problem and an unsteady wave problem.Higher-order boundary integral equation methods are then used to solve the proposed problems with a fourth-order Runge-Kutta method for the time marching.An artificial damping layer is adopted to dissipate the scattering waves.Different from the other time-domain numerical models,which are often focused on the wave-current interaction with restrained bodies,the present model deals with a floating hemisphere.The numerical results of wave forces,wave run-up and body response are all in a close agreement with those obtained by frequency-domain methods.The proposed numerical model is further applied to investigate wave-current interactions with a floating body of complicated geometry.In this work,the regular and focused wave combined with current interacting with a truss-spar platform is investigated. | LIU Zhen TENG Bin NING De-zhi GOU Ying | 2010 | Journal of Hydrodynamics2010，22，2： | 14 |
| 3 | Association of-238G/A and -857C/T Polymorphisms of Tumor Necrosis Factor-Alpha Gene Promoter Region With Outcomes of Hepatitis B Virus Infection显示文摘Objectives To determine whether -238G/A and -857C/T polymorphisms of tumor necrosis factor-alpha (TNF-α) gene promoter were associated with outcomes of hepatitis B virus infection. Methods A total of 246 HBV self-limited infected subjects and 443 chronic hepatitis B (HB) patients were recruited in this case-control study. TNF-α-238G/A and -857C/T gene promoter polymorphisms were examined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Results The frequency of TNF-α-238 GG (90.7%) in chronic HB group was significantly lower than that (95.1%) in self-limited group (P=0.041). The frequency of TNF-α-857 CC (79.7%) in chronic HB patients was significantly higher than that (70.9%) in self-limited infected subjects (P=0.021). Multiple logistic regression analysis revealed that both TNF-α-238GA and -857CC were independently associated with chronic HB. Conclusions TNF-α promoter variants are likely to play a substantial role in influencing the outcomes of HBV infection. | HONG-QUAN LI ZHUO LI YING LIU JUN-HONG LI JIAN-QUN DONG JI-RONG GAO CHUN-YAN GOU AND HUI LI | 2006 | Biomedical and Environmental Sciences2006，19，2： | 7 |
| 4 | SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation显示文摘Coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is the ongoing global pandemic that poses substantial challenges to public health worldwide.A subset of COVID-19 patients experience systemic inflammatory response,known as cytokine storm,which may lead to death.Receptor-interacting serine/threonine-protein kinase 1(RIPK1)is an important mediator of inflammation and cell death.Here,we examined the interaction of RIPK1-mediated innate immunity with SARS-CoV-2 infection.We found evidence of RIPK1 activation in human COVID-19 lung pathological samples,and cultured human lung organoids and ACE2 transgenic mice infected by SARS-CoV-2.Inhibition of RIPK1 using multiple smallmolecule inhibitors reduced the viral load of SARS-CoV-2 in human lung organoids.Furthermore,therapeutic dosing of the RIPK1 inhibitor Nec-1s reduced mortality and lung viral load,and blocked the CNS manifestation of SARS-CoV-2 in ACE2 transgenic mice.Mechanistically,we found that the RNA-dependent RNA polymerase of SARS-CoV-2,NSP12,a highly conserved central component of coronaviral replication and transcription machinery,promoted the activation of RIPK1.Furthermore,NSP12323L variant,encoded by the SARS-CoV-2 C14408T variant first detected in Lombardy,Italy,that carries a Pro323Leu amino acid substitution in NSP12,showed increased ability to activate RIPK1.Inhibition of RIPK1 downregulated the transcriptional induction of proinflammatory cytokines and host factors including ACE2 and EGFR that promote viral entry into cells.Our results suggest that SARS-CoV-2 may have an unexpected and unusual ability to hijack the RIPK1-mediated host defense response to promote its own propagation and that inhibition of RIPK1 may provide a therapeutic option for the treatment of COVID-19. | Gang Xu Ying Li Shengyuan Zhang Haoran Peng Yunyun Wang Dekang Li Taijie Jin Zhuohao He Yilun Tong Chunting Qi Guowei Wu Kangyun Dong Jizhou Gou Yang Liu Tongyang Xiao Jing Qu Liang Li Liang Liu Ping Zhao Zheng Zhang Junying Yuan | 2021 | Cell Research2021，31，12： | 6 |
| 5 | Draft effect on wave action with a semi-infinite elastic plate显示文摘A method for analyzing reflection and transmission of ocean waves from a semi-infinite elastic plate with a draft is developed. The relation of energy conservation for plates with three different edge conditions (free, simply supported and built-in) is also derived. It is found that the present method satisfies the energy relation very well. The effects of draft on wave reflection and transmission coefficients as well as on the vertical vibration of the plates are examined through numerical tests. It is demonstrated that the zero draft assumption works well for low wave frequencies, but the effect of plate draft becomes significant for high wave frequencies. | TENG Bin GOU Ying CHENG Liang LIU Shuxue | 2006 | Acta Oceanologica Sinica2006，25，6： | 4 |
| 6 | Multi-responsive nanotheranostics with enhanced tumor penetration and oxygen self-producing capacities for multimodal synergistic cancer therapy显示文摘Incorporation of multiple functions into one nanoplatform can improve cancer diagnostic efficacy and enhance anti-cancer outcomes. Here, we constructed doxorubicin(DOX)-loaded silk fibroinbased nanoparticles(NPs) with surface functionalization by photosensitizer(N770). The obtained nanotheranostics(N770-DOX@NPs) had desirable particle size(157 nm) and negative surface charge(-25 m V). These NPs presented excellent oxygen-generating capacity and responded to a quadruple of stimuli(acidic solution, reactive oxygen species, glutathione, and hyperthermia). Surface functionalization of DOX@NPs with N770 could endow them with active internalization by cancerous cell lines, but not by normal cells. Furthermore, the intracellular NPs were found to be preferentially retained in mitochondria, which were also efficient for near-infrared(NIR) fluorescence imaging, photothermal imaging,and photoacoustic imaging. Meanwhile, DOX could spontaneously accumulate in the nucleus. Importantly, a mouse test group treated with N770-DOX@NPs plus NIR irradiation achieved the best tumorretardation effect among all treatment groups based on tumor-bearing mouse models and a patientderived xenograft model, demonstrating the unprecedented therapeutic effects of trimodal imagingguided mitochondrial phototherapy(photothermal therapy and photodynamic therapy) and chemotherapy.Therefore, the present study brings new insight into the exploitation of an easy-to-use, versatile, and robust nanoplatform for programmable targeting, imaging, and applying synergistic therapy to tumors. | Shuangquan Gou Nanxi Chen Xiaoai Wu Menghang Zu Shixiong Yi Binwu Ying Fangyin Dai Bowen Ke Bo Xiao | 2022 | Acta Pharmaceutica Sinica B2022，12，1： | 2 |
| 7 | Catalytic degradation of lomefloxacin by photo-assisted persulfate activation on natural hematite:Performance and mechanism显示文摘The natural hematite(α-Fe_(2)O_(3)) is stable and abundant on the earth,as well as with strange electronic band structure and good visible light absorption properties.However,the composition and catalytic performance of natural hematite should be explored.In this study,the photo-assisted hematite nanoparticles activated persulfate(H-NPs/PS/vis)system was constructed.As detected,H-NPs had an irregular agglomerate structure with abundant internal pore and were mainly composed of Fe_(2)O_(3),SiO_(2) and TiO_(2).The system was applied to removing various antibiotic(i.e.,lomefloxacin,ciprofloxacin and enrofloxacin with initial concentration of 10 mg/L),achieving high degradation performance of 82.0%,81.2%and 82.2%after120,330 and 240 min,respectively.Moreover,H-NPs had excellent reusability with low metal leaching(Ti leaching percentage lower than 0.01%,Fe dissolution percentage was 0.48%)and stable structure.At last,a possible reaction mechanism of H-NPs/PS/vis system was proposed that lomefloxacin(LOM)was efficiently removed via the synergistic process of components contained in H-NPs with PS and light,involving the generation of·O_(2)^(-),·OH and SO_(4)^(·-).Above all,this paper provided a novel application scheme of natural hematite through in-depth and comprehensive experimental exploration. | Ruonan Guo Ying Chen Bingrui Liu Ying Han Jianfeng Gou Xiuwen Cheng | 2022 | Chinese Chemical Letters2022，33，8： | 1 |
| 8 | Alterations of high-density lipoprotein subclasses in endogenous hypertriglyceridemia显示文摘 | Lantu Gou Mingde Fu Yanhua Xu Ying Tian Bingyu Yan Luchuan Yang | 2005 | American Heart Journal2005，，5： | 1 |
| 9 | Ana- lytical Solution of a Wave Diffraction Problem on a Sub- merged Cylinder显示文摘 | JIANG Sheng-chao GOU Ying TENG Bin | 2014 | Journal of Engineering Mechanics2014，140，1： | 1 |
| 10 | Construction of high-efficient visible photoelectrocatalytic system for carbamazepine degradation:Kinetics,degradation pathway and mechanism显示文摘This study aimed to construct a photoelectrocatalytic(PEC)reaction system based on the self-made reduced TiO_(2) NTAs(r-TNAs)photoanode and activated carbon/Polytetrafluoroethylene(AC/PTFE)cathode.It would be observed clearly that the degradation rate constant of carbamazepine(CBZ)over r-TNAs(photoanode)-AC/PTFE(cathode)PEC system(0.04961 min^(-1))was even higher than that of r-TNAs(photoanode)-Pt(cathode)PEC system(0.04602 min^(-1))with the assistance of visible light irradiation and+0.4 V external potential.Besides,in order to obtain optimized conditions,the influence of key parameters such as pH value,electric current density and electrolyte concentration were studied.Most impo rtantly,photoelectrochemical(PECH)properties,reactive oxide species contribution.OH formation rate and CBZ degradation pathway were determined.The results illustrated that the excellent PEC degradation performance depended on the excellent photocatalytic property of r-TNAs photoanode and electron transfer prope rty of photoelectrodes in r-TNAs(photoanode)-AC/PTFE(cathode)PEC system.Therefo re,the study demonstrated that the r-TNAs(photoanode)-AC/PTFE(cathode)PEC system could be expected to replace metal-catalyzed cathodes depending on its excellent PEC performance activity and low cost as well as the reaction system possessed objective and practical application prospect. | Ruonan Guo Li-Chao Nengzi Ying Chen Qingqing Song Jianfeng Gou Xiuwen Cheng | 2020 | Chinese Chemical Letters2020，31，10： | 1 |
| 11 | The Cultural Ecology Protection and Management of Urban Forests in China显示文摘Forests have economic,ecological,social and cultural functions.Forests Cultural ecology,the counterpart of forest ecology,is the integration of human spirit formed on the basis of natural forest and living systems.In recent years,China's urbanization rate has increased from 28%in 1993 to 45.68%in 2008,and ecological protection of urban forest has made great progress,but insufficient attention was paid to the forest cultural ecology protection and the relevant regulatory was not well performed.In order to strengthen the protection of forest cultural ecology and the management,the study showed that the social economic development of China has become mature and entered the consumption phase,besides,cultural ecology protection of forest will be the essence of urban forestry development in the future,so more and more attention will be paid to the protection of urban forest cultural ecology,especially with the enhancement of urbanization in China.The study suggests that protection of urban forest cultural ecology should be included into the forest legislation and management.The development planning of urban forest development should be strengthened to highlight the organic combination of material wealth production and spiritual wealth production,and finally promote protection of urban forest culture and the development of green culture. | Ying ZHANG Weiming SONG Ke CHEN Chunjing GOU | 2013 | Asian Agricultural Research2013，5，9： | 1 |
| 12 | Integrative Analyses of Lung Squamous Cell Carcinoma in Ten Chinese Patients with Transcriptome Sequencing显示文摘Few effective therapies have been developed for the treatment of lung squamous cell carcinoma(SQCC), in part due to a lack of understanding regarding the mechanisms underlying the initiation and development of this disease. Whole transcriptome sequencing not only provides insight into the expression of all transcribed genes, but offers an efficient approach for identifying genetic variations,including gene fusions, mutations and alternative splicing. In this study, we performed whole transcriptome sequencing of 10 patients with stage IIIA lung SQCC, and discovered a large number of single nucleotide variants(SNVs; mean of 12.2 SNVs/Mb), with C>T/G>A and A>G/T>C transitions being the most frequently observed. Additionally, a total of 132 gene fusions were identified based upon Top Hat alignments, 70.5%(93/132) of which occurred as a result of intra-chromosomal rearrangements. Based on the number of supporting reads for each fusion, we further validated 20 of the 26 top gene fusions by RT-PCR and Sanger sequencing. Taken together, these data provide an in-depth view of transcriptional alterations in lung SQCC patients, and may be useful for identification of new therapeutic targets. | Lu-Lu Yang Xu-Chao Zhang Shao-Kun Chuai Zhi-Hong Chen Zhi Xie Wei-Bang Guo Shi-Liang Chen Yuan-Yuan Lei Long-Hua Guo Lan Ying Gou Hui-Wen Sun Qi Zhang Jin-Ji Yang Hai-Yan Tu Jian Su Yi-Long Wu | 2015 | Journal of Genetics and Genomics2015，42，10： | 1 |
| 13 | Alterations of high-density lipoprotein subclasses in hypercholesterolemia and combined hyperlipidemia显示文摘 | Lianqun Jia Mingde Fu Ying Tian Yanhua Xu Lantu Gou Haoming Tian Li Tian | 2006 | International Journal of Cardiology2006，，3： | 1 |
| 14 | A 3D time-domain method for predicting the wave-induced forces and motions of a floating body显示文摘 | LIU Chenfeng TENG Bing GOU Ying | 2011 | Ocean Engineering2011，38，： | 1 |
| 15 | The F-box pro- tein CPR1/CPR30 negatively regulates R protein SNC1 accu- mulation 显示文摘 | Gou Mingyue Shi Zhenying Zhu Ying et at | 2012 | Plant Journal2012，69，3： | 1 |
| 16 | Effect of pontoons on free surface elevation around a TLP platform显示文摘Tension leg platform(TLP)is a typical compliant offshore structure for oil/gas resources exploitation.In the design process,the prediction of the free surface elevation is of great importance for the determination of the air gap.So far,the existing researches for predicting the air gap of the TLPs focus on the supporting columns while pay little attention to the horizontal pontoons.For the second order diffraction problem or long incident wave condition,the velocity potential decays slowly with water depth and the effect of pontoons should not be neglected.Herein the effect of pontoons on the diffracted wave field in the vicinity of a TLP platform is investigated in this study.The diffraction of regular waves by a square array of truncated cylinders and a whole TLP structure is studied in detail by using both the linear and the second-order diffraction theory.Numerical calculation is performed for the free surface elevation and wave run up.Numerical results show that the near-trapping phenomenon can occur inside the TLP and leads to significantly increased wave height.To study the effect of pontoons on the free surface elevation comparisons are carried out between the results of these two structures with and without pontoons.It is found that pontoons have an appreciable effect on the diffracted wave field for long incident regular waves and increase the largest response notably when the near-trapping phenomenon occurs at the second-order. | CONG PeiWen GOU Ying TENG Bin | 2014 | Science China(Technological Sciences)2014，57，1： | 1 |
| 17 | An Overview of Structural Design,Analysis and Common Monitoring Technologies for Floating Platform and Flexible Cable and Riser显示文摘Offshore oil and gas development plays an important part in the global energy sector.Offshore platforms and flexible pipes are the key equipments in the whole offshore oil and gas development system.Because of the randomness and uncertainty of wave and current loads in the ocean environment,the structural design and mechanical analysis of the marine equipment can be highly complicated.Therefore,this paper reviews the recent works of the theoretical model,numerical simulation,and experimental test in three research areas:hydrodynamic analysis of offshore platforms,structural mechanics analysis of flexible pipe and cable,and monitoring technology of offshore floating structures under marine loads.By analyzing their main research methods and key technical difficulties,this paper provides theoretical basis and technical support for the reliability engineering application of offshore platforms and flexible pipelines.Also,China is relatively backward in the design of marine floating platform,the design,analysis and testing of flexible pipeline and cable,as well as the marine equipment prototype monitoring technology research.Calling for breakthroughs at the earliest possible stage in the above fields,prime research should be focused on and strategic planning should be made to deal with“key areas and stranglehold problems”.It is of great significance for the development of China's deep-sea energy and resource development of independent technology and on time to achieve the“carbon peak”national strategic objectives. | WU Wen-hua ZHAO Yan GOU Ying LYU Bai-cheng LU Qing-zhen LU Zhao-kuan YAN Jun | 2022 | China Ocean Engineering2022，36，4： | 1 |
| 18 | CoFe_(2)O_(4)nanoparticles anchored on waste eggshell for catalytic oxidation of florfenicol via activating peroxymonosulfate显示文摘Eggshell-loaded CoFe_(2)O_(4) catalyst was synthesized via a convenient hydrothermal method during our work,then the surface morphology and elemental composition of the composites were systematically investigated.Performance of CoFe_(2)O_(4)/eggshell-activated peroxymonosulfate(PMS)system was evaluated by selecting florfenicol(FF)as the model pollutant,and effects of operating parameters and water matrices on the FF removal efficiency in this system were investigated.In addition,main radicals involved in FF degradation were identified by EPR tests and radical quenching experiments,and possible mechanism was proposed.The reduction of toxicity during FF degradation was confirmed,and in combination with HP-LC tests,it was found that dehalogenation and defluorination were effectively carried out during FF degradation.In addition,the prepared CoFe_(2)O_(4)polyvinylidene fluoride(PVDF)membrane effectively improved the stability of the material and reduced the precipitation of metals. | Yingjie Gao Ying Han Bingrui Liu Jianfeng Gou Dan Feng Xiuwen Cheng | 2022 | Chinese Chemical Letters2022，33，8： | 1 |
| 19 | Study of Thermal Treatment on Properties of Polycrystalline Silicon显示文摘The effects of thermal annealing on oxygen behavior and carrier lifetimes of mc-Si wafers were investigated by means of FTIR and QSSPCD during single step and two step heat treatments in N2 and O2 ambient. It reveals that interstitial oxygen concentration of mc-Si and CZ-Si has a slighter decrease in N2 and O2 ambient during single-step annealing, which means oxygen precipitates are not generated. But oxygen concentration greatly decreases and generates a number of oxygen precipitates during two-step annealing. Bulk lifetime of mc-Si increases in N2 ambient at 850, 950, 1150 ℃ respectively, and annealing in O2 shows better results than that in N2 and annealing in two-step reflected better consequence than annealing in single-step. But lifetime of CZ-Si annealed in N2 or O2 decreases rapidly. The reason of lifetime increase is probably considered due to the fact that interstitial Si atoms of Si/SiO2 interface fill vacancies or some recombination centers at high temperature annealing. Moreover, a number of impurities in mc-Si probably diffuse to grain boundaries so that greatly reduce recombination centers result to lifetime rising. | Ren Bingyan Gou Xianfang Ma Lifen Li Xudong Xu Ying Wang Wenjing | 2006 | Journal of Rare Earths2006，24，z1： | 0 |
| 20 | Methods of Mental Health Education for Chinese College Students in the New Era显示文摘Mental health education is an important part of China's college education,and colleges should promote and improve the work on college students'mental health education.In the new era,with the rapid development of society,college students will face various temptations and difficulties,which will have a serious negative impact on their mental health.This article starts from the current situation of college students'mental health,and puts forward targeted suggestions for the difficulties of college students'mental health at this stage,and strives to make more college students maintain a good and positive attitude. | Ying Gou | 2021 | 教育研究前沿(中英文版)2021，11，2： | 0 |
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