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| 1 | Lightweight and Manageable Digital Evidence Preservation System on Bitcoin显示文摘为证据保藏使用的一个有效、安全的系统是必要的拥有反损失,反伪造品,反捣弄和完美的可证实性的性质。依靠集中的云存储的传统的建筑学被象不完全的信心和不可靠的规定那样的安全问题抑压地困绕。而且,一个昂贵、低效、不兼容的图案阻碍证据的努力保藏。相反,分散的 blockchain 网络为它的安全匿名,不可改变的承诺,和透明可描绘作为完美的代替被限制。在 blockchain 与阈下的隧道结合,我们与最新设计的证据编织了办理网络审计网络。在这份报纸,我们介绍了并且实现拥有隐私匿名,审计透明性,功能可伸缩性和操作无足轻重的人的特征的小数字证据保藏体系结构。匿名自然地从密码的设计被形成,自从在到公众的加密 cryptosystem 和基于回锅肉丁的功能漏没有东西下面的零证据。秘密隧道高效地被挖掘优化框架的费用,连接和安全,转变到信用的价值的 Bitcoin 网络的大计算力量。为审计使用的透明性,联系到存在的证明,在成熟 blockchain 网络来自立刻的时间标记和不可逆的哈希函数。可伸缩性被证据链代表与原版交往了 blockchain,和在 mainchain 上的扩大的链将在不同机构盖住听者的大多数。并且无足轻重的人,它等于便宜,从我们的有细密纹理的层次服务被导出。最后,效率,安全,和可获得性的分析显示出我们的系统的完全的成就。 | Mingming Wang Qianhong Wu Bo Qin Qin Wang Jianwei Liu Zhenyu Guan | 2018 | Journal of Computer Science & Technology2018，33，3： | 5 |
| 2 | A wheat integrative regulatory network from large-scale complementary functional datasets enables trait-associated gene discovery for crop improvement显示文摘Gene regulation is central to all aspects of organism growth,and understanding it using large-scale functional datasets can provide a whole view of biological processes controlling complex phenotypic traits in crops.However,the connection between massive functional datasets and trait-associated gene discovery for crop improvement is still lacking.In this study,we constructed a wheat integrative gene regulatory network(wGRN)by combining an updated genome annotation and diverse complementary functional datasets,including gene expression,sequence motif,transcription factor(TF)binding,chromatin accessibility,and evolutionarily conserved regulation.wGRN contains 7.2 million genome-wide interactions covering 5947 TFs and 127439 target genes,which were further verified using known regulatory relationships,condition-specific expression,gene functional information,and experiments.We used wGRN to assign genome-wide genes to 3891 specific biological pathways and accurately prioritize candidate genes associated with complex phenotypic traits in genome-wide association studies.In addition,wGRN was used to enhance the interpretation of a spike temporal transcriptome dataset to construct high-resolution networks.We further unveiled novel regulators that enhance the power of spike phenotypic trait prediction using machine learning and contribute to the spike phenotypic differences among modern wheat accessions.Finally,we developed an interactive webserver,wGRN(http://gffzzaeec8df70e7c4b21hnn0o9wwwfqk666un.ffgz.tsg.suse.edu.cn/wGRN),for the community to explore gene regulation and discover trait-associated genes.Collectively,this community resource establishes the foundation for using large-scale functional datasets to guide trait-associated gene discovery for crop improvement. | Yongming Chen Yiwen Guo Panfeng Guan Yongfa Wang Xiaobo Wang Zihao Wang Zhen Qin Shengwei Ma Mingming Xin Zhaorong Hu Yingyin Yao Zhongfu Ni Qixin Sun Weilong Guo Huiru Peng | 2023 | Molecular Plant2023，16，2： | 1 |
| 3 | Antimold effect of\sultrasonic treatment on Chinese moso bamboo显示文摘 | Guan Mingjie Zhou Mingming Yong Cheng | 2013 | Forest Products\sJournal2013，63，78： | 1 |
| 4 | A novel glucose colorimetric sensor based on intrinsic peroxidase-like activity of Cso-carboxyfullerenes显示文摘 | Li Ruimin Zhen Mingming Guan Mirong | 2013 | Biosens Bioelectron2013，47，1： | 1 |
| 5 | The SACT Template:A Human Brain Diffusion Tensor Template for School-age Children显示文摘School-age children are in a specific development stage corresponding to juvenility,when the white matter of the brain experiences ongoing maturation.Dffusion-weighted magnetic resonance imaging(DWI),especially diffusion tensor imaging(DTI),is extensively used to characterize the maturation by assessing white matter properties in vivo.In the analysis of DWI data,spatial normalization is crucial for conducting inter-subject analyses or linking the individual space with the reference space.Using tensor-based registration with an appropriate diffusion tensor template presents high accuracy regarding spatial normalization.However,there is a lack of a standardized diffusion tensor template dedicated to school-age children with ongoing brain development.Here,we established the school-age children diffusion tensor(SACT)template by optimizing tensor reorientation on high-quality DTI data from a large sample of cognitively normal participants aged 6-12 years.With an age-balanced design,the SACT template represented the entire age range well by showing high similarity to the age-specific templates.Compared with the tensor template of adults,the SACT template revealed significantly higher spatial normalization accuracy and inter-subject coherence upon evaluation of subjects in two different datasets of schoolage children.A practical application regarding the age associations with the normalized DTI-derived data was conducted to further compare the SACT template and the adult template.Although similar spatial patterns were found,the SACT template showed significant effects on the distributions of the statistical results,which may be related to the performance of spatial normalization.Looking forward,the SACT template could contribute to future studies of white matter development in both healthy and clinical populations.The SACT template is publicly available now(tp://igshare com/aricles/dataseu'SACT_.template/14071283). | Congying Chu Haoran Guan Sangma Xie Yanpei Wang Jie Luo Gai Zhao Zhiying Pan Mingming Hu Weiwei Men Shuping Tan Jia-Hong Gao Shaozheng Qin Yong He Lingzhong Fan Qi Dong Sha Tao | 2022 | Neuroscience Bulletin2022，38，6： | 1 |
| 6 | A novel glucose colorimetric sensor based on intrinsic peroxidase-like activity of C60-carboxyfullerenes 显示文摘 | Li Ruimin Zhen Mingming Guan Mirong | 2013 | Biosens Bioelectron2013，47，： | 1 |
| 7 | TMEM16A inhibits angiotensin Ⅱ-induced basilar artery smooth muscle cell migration in a WNK1-dependent manner显示文摘Vascular smooth muscle cell(VSMC) migration plays a critical role in the pathogenesis of many cardiovascular diseases.We recently showed that TMEM16 A is involved in hypertensioninduced cerebrovascular remodeling.However,it is unclear whether this effect is related to the regulation of VSMC migration.Here,we investigated whether and how TMEM16 A contributes to migration in basilar artery smooth muscle cells(BASMCs).We observed that AngⅡ increased the migration of cultured BASMCs,which was markedly inhibited by overexpression of TMEM16 A.TMEM16 A overexpression inhibited AngⅡ-induced RhoA/ROCK2 activation,and myosin light chain phosphatase(MLCP)and myosin light chain(MLC20) phosphorylation.But AnsⅡ-induced myosin light chain kinase(MLCK)activation was not affected by TMEM16 A.Furthermore,a suppressed activation of integrinβ3/FAK pathway,determined by reduced integrinβ3 expression,FAK phosphorylation and F-actin rearrangement,was observed in TMEM16 A-overexpressing BASMCs upon AngⅡ stimulation.Contrary to the results of TMEM16 A overexpression,silencing of TMEM16 A showed the opposite effects.These in vitro results were further demonstrated in vivo in basilar arteries from VSMC-specific TMEM10 A transgenic mice during AngⅡ-induced hypertension.Moreover,we observed that the inhibitory effect of TMEM16 A on BASMC migration was mediated by decreasing the activation of WNK1,a Cl^(-)-sensitive serine/threonine kinase.In conclusion,this study demonstrated that TMEM16 A suppressed AnsⅡ-induced BASMC migration,thus contributing to the protection against cerebrovascular remodeling during AngⅡ-infused hypertension.TMEM16 A may exert this effect by suppressing the RhoA/ROCK2/MLCP/MLC20 and integrinβ3/FAK signaling pathways via inhibiting WNK1.Our results suggest that TMEM16 A may serve as a novel therapeutic target for VSMC migration-related diseases,such as vascular remodeling. | Huaqing Zheng Xiaolong Li Xin Zeng Chengcui Huang Mingming Ma Xiaofei Lv Yajuan Zhang Lu Sun Guanlei Wang Yanhua Du Yongyuan Guan | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 1 |
| 8 | Design, Synthesis and Antitumor Activity of Pyrrolopyrazinone-chalcone Hybrids显示文摘 | MENG Ying ZHANG Hongwei LIU Zehua ZENG Shanchao SUN Chiyu ZHANG Lijuan ZHAO Mingming WANG Guan JIANG Mengying SHI Wei SONG Hongrui | 2014 | Chemical Research in Chinese Universities2014，30，4： | 0 |
| 9 | Advances in Diagnosis and Treatment of Neuropsychiatric Systemic Lupus Erythematosus显示文摘1 Introduction Neuropsychiatric systemic lupus erythematosus(NPSLE)is a serious complication of systemic lupus erythematosus(SLE),with an incidence of about 30%to 40%[1].No matter early or late SLE patients are prone to concurrent,so early diagnosis and treatment of NPSLE is extremely important. | Shufei Zeng Yangyang Zang Dezhen Chen Baozhang Guan Fanna Liu Mingming Ma Yu Mong Huiyuan Zheng Aiyun Cha Xiangnan Dong Huanhuan Liu Taksui Wong Shuang Cui Tong Liu Yongpin Lu Chen Yun Hongwei Hu B.Hocher W.Pommer Zuhui Chen Lianghong Yin | 2017 | 临床医学工程2017，24，S1： | 0 |
| 10 | Peritoneal Dialysis: Prospects and Challenges显示文摘There are 3 kinds of Renal Replacement Therapy:hemodialysis,peritoneal dialysis and kidney transplantation.Although a kidney transplant would be the best solution,organ donations are limited and the transplanted organs can be rejected by the body.Hemodialysis is a widely recognized and near-universally available treatment method,however,the patient must make at least 3 weekly visits to a hospital to undergo treatment,with each session lasting on average around 4 hours.Consequently this can have an impact on the patients’life,including work and travel.Since the clinical populariza- | Lifeng Yang Jun Ke Jie Huang Hongwei Hu Shaofeng Huang Jie Shu Bo Hu Aiyun Cha Xiangnan Dong Guanmin Wu Fanna Liu Yu Chen Huanhuan Liu Mingming Ma Taksui Wong Lianghong Yin Chen Yun Shufei Zeng Baozhang Guan Zuhui Chen | 2017 | 临床医学工程2017，24，S1： | 0 |
| 11 | Genome-wide linkage mapping of QTL for root hair length in a Chinese common wheat population显示文摘Root hairs are fast growing,ephemeral tubular extensions of the root epidermis that aid nutrient and water uptake.The aim of the present study was to identify QTL for root hair length(RHL)using 227 F8 recombinant inbred lines(RILs)derived from a cross of Zhou 8425 B(Z8425 B)and Chinese Spring(CS),and to develop convenient molecular markers for markerassisted breeding in wheat.Analysis of variance of root hair length showed significant differences(P<0.01)among RILs.The genetic map for QTL analysis consisted of 3389 unique SNP markers.Using composite interval mapping,four major QTL(LOD>2.5)for RHL were identified on chromosomes 1 B(2),2 D and 6 D and four putative QTL(2≤LOD≤2.5)were detected on chromosomes 1 A,3 A,6 B,and 7 B,explaining 3.32%–6.52%of the phenotypic variance.The positive alleles for increased RHL of QTL on chromosomes 2 D,6 B and 6 D(QRhl.cau-2 D,q Rhl.cau-6 B,and QRhl.cau-6 D)were contributed by Z8425 B,and CS contributed positive QTL alleles on chromosomes 1 A(q Rhl.cau-1 A),1 B(QRhl.cau-1 B.1 and QRhl.cau-1 B.2),3 A(q Rhl.cau-3 A)and 7 B(q Rhl.cau-7 B).STARP markers were developed for QRhl.cau-1 B.1,QRhl.cau-2 D,QRhl.cau-6 D,and q Rhl.cau-7 B.Haplotype and association analysis indicated that the positive allele of QRhl.cau-6 D had been strongly selected in Chinese wheat breeding programs.Collectively,the identified QTL for root hair length are likely to be useful for marker-assisted selection. | Feng Huang Zhaoyan Chen Dejie Du Panfeng Guan Lingling Chai Weilong Guo Zhaorong Hu Mingming Xin Huiru Peng Yingyin Yao Zhongfu Ni | 2020 | The Crop Journal2020，8，6： | 0 |
| 12 | Roles of effective stabilizers in improving oral bioavailability of naringenin nanocrystals:Maintenance of supersaturation generated upon dissolution by inhibition of drug dimerization显示文摘Nanocrystals(NCs),a colloidal dispersion system formulated with stabilizers,have attracted widespread interest due to their ability to effectively improve the oral bioavailability of poorly water-soluble drugs.The stabilizer plays a key role because it can affect the physical stability and even the oral bioavailability of NCs.However,how stabilizers affect the bioavailability of NCs remains unknown.In this study,F68,F127,HPMC,and PVP were each used as a stabilizer to formulate naringenin NCs.The NCs formulated with PVP exhibited excellent release behaviors,cellular uptake,permeability,oral bioavailability,and anti-inflammatory effects.The underlying mechanism is that PVP effectively inhibits the formation of naringenin dimer,which in turn improves the physical stability of the supersaturated solution generated when NC is dissolved.This finding provides insights into the effects of stabilizers on the in vivo performances of NCs and supplies valuable knowledge for the development of poorly water-soluble drugs. | Guangshuai Zhang Haishan Guan Jianfeng Li Mo Li Xiaofan Sui Baocheng Tian Huiming Dong Bingyang Liu Zhonggui He Ning Li Mingming Zhao Qiang Fu | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，5： | 0 |
| 13 | Melatonin restores normal Bax and Bcl-2 protein expression in the subgranular zone of the dentate gyrus in pinealectomized rats显示文摘In this study, we sought to elucidate the effects of melatonin on learning and memory as well as apoptosis and expression of the Bax or Bcl-2 proteins in the subgranular zone of the dentate gyrus in pinealectomized rats. Using the Morris water maze and the olfactory memory tests, we found that the average escape latency in pinealectomized rats was clearly increased compared with sham-operated rats. Moreover, the average escape latency in the melatonin-treated and pinealectomized rats was longer than that in the sham-operated rats and shorter than that in the pinealectomized and untreated rats. Immunohistochemistry and terminal-deoxynucleoitidyl transferase mediated nick end labeling (TUNEL) showed that there were fewer Bax immunoreactive cells and TUNEL-positive (apoptotic) cells but more Bcl-2 immunoreactive cells in the melatonin-treated rats compared with the pinealectomized rats. The sham-operated rats showed numbers of these cells similar to the melatonin-treated rats. These experimental findings demonstrate that melatonin treatment may reduce abnormal apoptosis by promoting gene expression of Bax and suppressing gene expression of Bcl-2 in the subgranular zone of the dentate gyrus in pinealectomized rats. These effects appear to result in the inhibition of cellular apoptosis and the improvement of spatial learning and memory in pinealectomized rats. | Shengchang Zhang Shuang Zhao Lu Bai Mingming Guan Jielin Mo Ling Lan | 2011 | Neural Regeneration Research2011，6，27： | 0 |
| 14 | Author correction to‘TMEM16A inhibits angiotensin II-induced basilar artery smooth muscle cell migration in a WNK1-dependent manner'[Acta Pharmaceutica Sinica B 11(2021)3994-4007]显示文摘The authors regret that picture errors were found in the Fig.II,Fig.4L and Fig.6C owing to copy and paste mistakes during the process of using AI tools to check published images.Due to the large number of original images,these errors were not detected by manual inspection when preparing the corrected representative images previously. | Huaqing Zheng Xiaolong Li Xin Zeng Chengcui Huang Mingming Ma Xiaofei Lv Yajuan Zhang Lu Sun Guanlei Wang Yanhua Du Yongyuan Guan | 2023 | Acta Pharmaceutica Sinica B2023，13，9： | 0 |
| 15 | A comparison of the distributions of carbazoles and dibenzothiophenes in western Qaidam Basin, Northwest China显示文摘Variations in the distributions of carbazoles and dibenzothiophenes were investigated in a set of source rocks, which differ mainly in their maturity levels during immature-mature stages. A comparison of the distributions of carbazoles and dibenzothiophenes has revealed the main results as follows: variations in the relative amounts ①of C0-, C1-, C2-dibenzothiophenes show a low correlation with that of the corresponding carbazoles, with the former's being much higher than the latter's; variations in the relative amounts of methyldibe② nzothiophene isomers also display a low correlation with that of the corresponding methylcarbazoles, with 4-/4- +1-methyldibenzothiophene ratio ranging from 0.52 to 0.96, while the corresponding carbazole ratio of 1-/1- +4-methylcarbazole only being 0.71±0.05; the mat③ urity parameter for 4,6-/4,6- +1,4-dimethyldibenzothiohene, ranging from 0.34 to 0.75, shows a remarkable linear correlation with the corresponding ratio of 1,8-/1,8- +1,4-dimethylcarbazole(R2>0.84). The un-correlation may indicate some different geological-geochemical fates for some isomers of dibenzothiophenes and carbazoles. The high correlation may reveal a strong maturation dependence on the dimethylcarbazole distributions, indicating that attention should be paid when 1,8-/1,8- +1,4-dimethylcarbazole is used as a petroleum migration indicator. | GUAN Mingming ZHANG Chunming | 2014 | Chinese Journal Of Geochemistry2014，33，2： | 0 |
| 16 | Author correction to“TMEM16A inhibits angiotensin Ⅱ-induced basilar artery smooth muscle cell migration in a WNK1-dependent manner”[Acta Pharm Sin B 11(12)(2021)3994–4007]显示文摘The authors regret that there were some picture errors in the Fig.1D,G,I,Fig.4L,Fig.6C,H and Supporting Information Fig.S1A owing to copy and paste mistakes when preparing the representative images.The revisions do not affect the data value,significant difference,and conclusions of the current work and the description of the whole article.The original data of this figure have been provided to the Editorial Office,and the Editorial Office or the corresponding authors can be contacted for original data access. | Huaqing Zheng Xiaolong Li Xin Zeng Chengcui Huang Mingming Ma Xiaofei Lv Yajuan Zhang Lu Sun Guanlei Wang Yanhua Du Yongyuan Guan | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 0 |
| 17 | Analysis of Performance Stability and Clinical Efficacy of OBERS - 3000 Hemodialysis Machine显示文摘Objective To explore the method of safety and efficacy validation of hemodialysis machine,and observe the clinical efficacy of OBERS-3000 multifunctional hemodialysis machine.Methods Randomized,open,two-phase crossover and positive control design,a total of 72 patients from two hospitals were included.OBERS-3000 multifunctional hemodialysis machine was the test machine,and the Fresenius 4008 series hemodialysis machine was as the control machine,indicators of blood routine test,serum electrolytes,liver and kidney function test,blood gas analysis,CRP were compared,body weight before and after hemodialysis,ultrafiltration volume were recorded,urea clearance index,urea reduction ratio were calculated.The XL90 conductivity meter was connected in series in the test machine,to monitor the temperature,conductance,venous pressure and arterial pressure during the dialysis in real time,and the measured value were compared with the machine monitoring value.Results Both of the test machine and the control machine could effectively eliminate creatinine,urea nitrogen and other uremic toxins,could continuously supply qualified dialysate,and precisely control the ultrafiltration volume.There were no significant differences in temperature,conductance,venous pressure and arterial pressure monitoring with the real time measured value by XL90 conductivity meter.Conclusions OBERS-3000 multifunctional hemodialysis machine can effectively eliminate uremic toxins,maintain electrolyte and acid-base balance,and can accurately display the monitoring parameters. | Lianghong Yin Bo Hu Lihua Luo Lifeng Yang Guanmin Wu Liangyong Hu Fanna Liu Yu Chen Peitian Yang Long Xiao Huiyuan Zheng Tong Liu Hongwei Hu Chen Yun Ying Huang Xia Yu Folan Li Aiyun Cha Xiangnan Dong Huanhuan Liu Mingming Ma Yongpin Lu Taksui Wong Baozhang Guan Yingming Gu Zuhui Chen | 2017 | 临床医学工程2017，24，S1： | 0 |
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