|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Recombinant rabies virus expressing IL-15 enhances immunogenicity through promoting the activation of dendritic cells in mice显示文摘Rabies remains a public health threat that kills approximately 59,000 people worldwide each year,most of which are from the developing countries of Africa and Asia where dog rabies are endemic.Therefore, developing an affordable and efficacious vaccine is crucial for rabies control in these countries. Interleukin(IL)-15, an immunoregulatory cytokine, is a pluripotent molecule with therapeutic potential, which targets many cell types and links the innate and adaptive immune system. In this study, IL-15 gene was cloned and inserted into the genome of a recombinant rabies virus(RABV) strain LBNSE(designated as LBNSE-IL15), and the effect of over-expression of IL-15 on the immunogenicity of RABV was investigated. It was found that mice vaccinated with LBNSEIL15 could induce significantly higher level of virus-neutralizing antibody(VNA) than those immunized with LBNSE, resulting in the higher protection after challenge. Further investigation was performed to find out the possible role of IL-15 plays in the process of antibody induction, and it was found that LBNSE-IL15 could enhance the maturation of dendritic cells(DCs) in immunized mice. Furthermore, the mice immunized with LBNSE-IL15 could promote the T_(FH) cells differentiation and the generation of germinal center B cells and plasma cells. Together, these data indicated that IL-15 could be a potential adjuvant in enhancing the immunogenicity of RABV, contributing to the development of more-efficacious rabies vaccines. | Tiange Chen Yajing Zhang Zhao Wang Jie Yang Mingming Li Kunlun Wang Min Cui Zhen F.Fu Ling Zhao Ming Zhou | 2017 | Virologica Sinica2017，32，4： | 5 |
| 2 | Preferential CTL targeting of Gag is associated with relative viral control in long-term surviving HIV-1 infected former plasma donors from China显示文摘它通常被相信细胞毒素的 T 淋巴细胞(CTL ) 玩的那 CD8 + 在限制人的免疫不全病毒类型 1 的复制(HIV-1 ) 并且在决定感染的结果,和这效果可以部分优先地取决于产品是哪个 HIV 的一个关键角色指向了。在以前的血浆施主(FPD ) 的一个队探讨在 HIV-1-specific CTL 回答和病毒复制之间的关联,天真的 FPD 与 HIV-1 clade B' 紧张感染了的 143 antiretroviral 治疗与 IFN-γ 为 HIV-1-specific CTL 回答被估计;在由使用盖住整个一致 clade B proteome 的重叠的肽(OLP ) 的单个肽水平的 Elispot 试金。由使用一个枪兵的等级关联分析,当是断然相关到 CD4 计数时,我们发现在全部的病毒特定的 CTL 活动之中的作呕特定的 CTL 回答的比例相反地与病毒的负担被相关,与与增加的病毒的负担被联系并且减少的Pol特定、Env特定的回答对比, CD4 数。另外, Vpr-specifc CTL 回答显示出类似的保护的效果与作呕回答,但是与识别的低得多的频率。显著地,我们也观察了在 HLA 之间的一个协会 --*30/B*13/Cw*06 haplotype 和可能由于的更低的病毒的负担限制了作呕特定的 CTL 回答。因此,我们的数据在疾病控制表明作呕特定的 CTL 回答的突出的角色。HLA 的优点 -- 在病毒的控制的 *30/B*13/Cw*06 haplotype 可以在学习个人与作呕特定的 CTL 回答的贡献被联系。 | Mingming Jia Kunxue Hong Jianping Chen Yuhua Ruan Zhe Wang Bing Su Guoliang Ren Xiaoqing Zhang Zhen Liu Quanbi Zhao Dan Li Hong Peng Marcus Altfeld Bruce D Walker Xu G Yu Yiming Shao | 2012 | Cell Research2012，22，5： | 3 |
| 3 | Production sharing contract: An analysis based on an oil price stochastic process显示文摘Assuming that oil price follows the stochastic processes of Geometric Brownian Motion (GBM) or the Mean-Reverting Process (MRP), this paper takes the net present value (NPV) as an economic index and models the PSC in 11 different scenarios by changing the value of each contract element (i.e. royalty, cost oil, profit oil as well as income tax). Then the NPVs are shown in probability density graphs to investigate the effect of different elements on contract economics. The results show that under oil price uncertainty the influence of profit oil and income tax on NPV are more significant than those of royalty and cost oil, while a tax holiday could improve the contractor's financial status remarkably. Results also show that MRP is more appropriate for cases with low future oil price volatility, and GBM is best for high future oil price volatility. | Liu Mingming Wang Zhen Zhao Lin Pan Yanni Xiao Fei | 2012 | Petroleum Science2012，9，3： | 3 |
| 4 | A Recombinant Rabies Virus Expressing Fms-like Tyrosine Kinase 3 Ligand(Flt3L) Induces Enhanced Immunogenicity in Mice显示文摘Rabies is a zoonotic disease that still causes 59,000 human deaths each year,and rabies vaccine is the most effective way to control the disease.Our previous studies suggested that the maturation of DC plays an important role in enhancing the immunogenicity of rabies vaccine.Flt3L has been reported to own the ability to accelerate the DC maturation,therefore,in this study,a recombinant rabies virus expressing mouse Flt3L,designated as LBNSE-Flt3L,was constructed,and its immunogenicity was characterized.It was found that LBNSE-FU3L could enhance the maturation of DC both in vitro and in vivo,and significantly more TFH cells and Germinal Center B(GC B)cells were generated in mice immunized with LBNSE-FU3L than those immunized with the parent virus LBNSE.Consequently,expressing of Flt3L could elevate the level of virus-neutralizing antibodies(VNA)in immunized mice which provides a better protection from a lethal rabies virus challenge.Taken together,our study extends the potential of Flt3L as a good adjuvant to develop novel rabies vaccine by enhancing the VNA production through activating the DC—Tfh^GC B axis in immunized mice. | Yachun Zhang Jie Yang Mingming Li Min Cui Zhen FFu Ling Zhao Ming Zhou | 2019 | Virologica Sinica2019，34，6： | 3 |
| 5 | A wheat integrative regulatory network from large-scale complementary functional datasets enables trait-associated gene discovery for crop improvement显示文摘Gene regulation is central to all aspects of organism growth,and understanding it using large-scale functional datasets can provide a whole view of biological processes controlling complex phenotypic traits in crops.However,the connection between massive functional datasets and trait-associated gene discovery for crop improvement is still lacking.In this study,we constructed a wheat integrative gene regulatory network(wGRN)by combining an updated genome annotation and diverse complementary functional datasets,including gene expression,sequence motif,transcription factor(TF)binding,chromatin accessibility,and evolutionarily conserved regulation.wGRN contains 7.2 million genome-wide interactions covering 5947 TFs and 127439 target genes,which were further verified using known regulatory relationships,condition-specific expression,gene functional information,and experiments.We used wGRN to assign genome-wide genes to 3891 specific biological pathways and accurately prioritize candidate genes associated with complex phenotypic traits in genome-wide association studies.In addition,wGRN was used to enhance the interpretation of a spike temporal transcriptome dataset to construct high-resolution networks.We further unveiled novel regulators that enhance the power of spike phenotypic trait prediction using machine learning and contribute to the spike phenotypic differences among modern wheat accessions.Finally,we developed an interactive webserver,wGRN(http://gffzzaeec8df70e7c4b21hvkp9cffwp5b66fvf.ffgz.tsg.suse.edu.cn/wGRN),for the community to explore gene regulation and discover trait-associated genes.Collectively,this community resource establishes the foundation for using large-scale functional datasets to guide trait-associated gene discovery for crop improvement. | Yongming Chen Yiwen Guo Panfeng Guan Yongfa Wang Xiaobo Wang Zihao Wang Zhen Qin Shengwei Ma Mingming Xin Zhaorong Hu Yingyin Yao Zhongfu Ni Qixin Sun Weilong Guo Huiru Peng | 2023 | Molecular Plant2023，16，2： | 1 |
| 6 | Cellular antioxidant activity and cytotoxicity assay of canolol显示文摘To better understand canolol as an efficient intracellular antioxidant agent in food related fields, potential cellular antioxidant activity and cytotoxicity were evaluated using multiple assays, including cellular antioxidant activity(CAA), 3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-di-phenytetrazoliumromide(MTT) and methylene blue assay. CAA assay was used to identify the half maximal effective concentration of canolol and other bioactive components, such as sinapic acid, resveratrol and sesamol in oil crops. Results showed that antioxidant capacity(without PBS wash) varies between different compounds. Capacity variation followed the order: sinapic acid > canolol > resveratrol > sesamol. While with PBS wash, the order changed to sinapic acid > resveratrol > canolol > sesamol. Half maximal inhibitory concentration of canolol measured by MTT was 1887.08±1.22 μmol/L, implying that cytotoxicity of canolol was greatly lower than that of resveratrol, sesamol and sinapic acid. Methylene blue assay showed that cell viability was still up to 90% exposed to canolol at a high concentration of 4444 μmol/L. It suggested that canolol had desired antioxidant activity in organism with low cellular cytotoxicity. | Xiaoyang Xia Xia Xiang Fenghong Huang Ling Han Zhen Zhang Mingming Zheng Chang Zheng | 2018 | Oil Crop Science2018，3，2： | 1 |
| 7 | A novel glucose colorimetric sensor based on intrinsic peroxidase-like activity of Cso-carboxyfullerenes显示文摘 | Li Ruimin Zhen Mingming Guan Mirong | 2013 | Biosens Bioelectron2013，47，1： | 1 |
| 8 | Oral nano-antioxidants improve sleep by restoring intestinal barrier integrity and preventing systemic inflammation显示文摘Sleep deprivation(SD)is a severe public health threat that can cause systemic inflammation and nerve damage.Few effective and side-effect-free drugs are available to address SD.However,the bidirectional communications between the brain and gut provide new strategies for anti-SD therapeutics.Here we explored oral delivery of fullerene nano-antioxidants(FNAO)in the SD model to improve sleep by regulating abnormal intestinal barrier and systemic inflammation via the brain-gut axis.SD caused excessive reactive oxygen species(ROS)production and hyperactive inflammatory responses in the intestines of zebrafish and mouse models,leading to disturbed sleep patterns and reduced brain nerve activity.Of note,based on the property of the conjugatedπbond of the C_(60)structure to absorb unpaired electrons,oral FNAO efficiently reduced the excessive ROS in the intestines,maintained redox homeostasis and intestinal barrier integrity,and ameliorated intestinal and systemic inflammation,resulting in superior sleep improvement.Our findings suggest that maintaining intestinal homeostasis may be a promising avenue for SD-related nerve injury therapy. | Zhanfeng Wu Lei Liu Lei Li Xinran Cao Wang Jia Xiaodan Liao Zhongpu Zhao Hedong Qi Guoqiang Fan Huiqiang Lu Chunying Shu Mingming Zhen Chunru Wang Chunli Bai | 2023 | National Science Review2023，10，12： | 1 |
| 9 | A novel glucose colorimetric sensor based on intrinsic peroxidase-like activity of C60-carboxyfullerenes 显示文摘 | Li Ruimin Zhen Mingming Guan Mirong | 2013 | Biosens Bioelectron2013，47，： | 1 |
| 10 | China Crude Oil Imports and Oil Market-oriented Reform显示文摘Crude oil imports in China are mainly carried out by state-owned entities with non state-owned entities as compliment. Crude imported by 5 state-owned entities accounts for 90% of the total imports, while non state-owned entities are about given more freedom in using and importing crude. In 2015 only, there were 13 companies granted with access to imported crude oil and 6 were qualified to import rights. Currently, there are 29 non-state-owned companies engaging in crude import business. China oil market is faced with severe challenges. The growth rate of oil demand declined, and dependence upon imported oil increased and reached as high as 61.26% in 2015. Refined oil demand growth also slowed down, and oil refining overcapacity got prominent and completion would become fiercer in future. Overcapacity was about 140 million tons per year in 2015. Consumption ratio of diesel to gasoline went on declining, and the task of product structure adjustment was heavy. China oil market is undergoing great transformation, and institutional mechanism will go ahead, on the basis of centering on orderly release of limitations on crude oil and refined oil import and export, orderly release of competitive business and government pricing of oil/gas downstream links, vigorous resolving of overcapacity, strengthening low-carbon development, and laying a solid foundation for guarantee. | Wang Zhen Zhang An Liu Mingming | 2016 | China Oil & Gas2016，23，2： | 1 |
| 11 | SP2509, an inhibitor of LSD1, exerts potential antitumor effects by targeting the JAK/STAT3 signaling显示文摘Hyperactivation of Janus kinase(JAK)/signal transducer and activator of transcription(STAT)signaling promotes tumorigenesis and cancer progression.STAT3 participates in the essential processes of cell proliferation,survival,and differentiation in many types of tumors.In the present study,SP2509 was identified as a potent inhibitor of the JAK/STAT3 signaling pathway by high-throughput drug screening based on a STAT3-driven luciferase expression system.Our results indicated that SP2509 inhibits constitutive STAT3 activation and the expression of STAT3-driven downstream genes.Bcl-xL,c-Myc,and Cyclin D1 were downregulated after treatment with SP2509.In addition,SP2509 specifically inhibits JAK activity,which could cause cell cycle arrest,inhibit cell growth,and induce apoptosis of various cancer cells.These results confirmed that SP2509 inhibits tumor progression by suppressing the expression of JAK/STAT3 signaling and STAT3-related downstream genes.Moreover,we demonstrated that SP2509 inhibits tumor growth in vivo and induces cell death in vitro.SP2509-mediated inhibition of STAT3 phosphorylation is dependent on its original target lysine-specific demethylase 1 in cancer cells.In summary,our results indicate that SP2509 is a novel inhibitor of JAK/STAT3 signaling. | Huiyan Zhen Xinxin Zhang Lei Zhang Mingming Zhou Liangliang Lu Lihong Wu Na He Juan Wang Rui Li Yan Guo | 2021 | Acta Biochimica et Biophysica Sinica2021，53，8： | 0 |
| 12 | Cancer Cell:我国科学家有望开发出治疗急性髓性白血病的新疗法显示文摘近日,刊登在国际杂志Cancer Cell上的一项研究报告中,来自上海交通大学医学院等机构的研究人员通过研究发现了治疗急性髓性白血病(AML)的新型治疗靶点和新型疗法,急性髓性白血病是一种血液骨髓癌症,通常需要及时且积极的疗法对这种癌症进行治疗。 | Chen, Wen-Lian Wang, Yue-Ying Zhao, Aihua Xia, Li Xie, Guoxiang Su, Mingming Zhao, Linjing Liu, Jiajian Qu, Chun Wei, Runmin Rajani, Cynthia Ni, Yan Cheng, Zhen Chen, Zhu Chen, Sai-Juan Jia, Wei | 2017 | 现代生物医学进展2017，17，6： | 0 |
| 13 | Mass spectrometry analysis of intact protein N-glycosylation signatures of cells and sera in pancreatic adenocarcinomas显示文摘Pancreatic cancer is among the most malignant cancers,and thus early intervention is the key to better survival outcomes.However,no methods have been derived that can reliably identify early precursors of development into malignancy.Therefore,it is urgent to discover early molecular changes during pancreatic tumorigenesis.As aberrant glycosylation is closely associated with cancer progression,numerous efforts have been made to mine glycosylation changes as biomarkers for diagnosis;however,detailed glycoproteomic information,especially site-specific N-glycosylation changes in pancreatic cancer with and without drug treatment,needs to be further explored.Herein,we used comprehensive solid-phase chemoenzymatic glycoproteomics to analyze glycans,glycosites,and intact glycopeptides in pancreatic cancer cells and patient sera.The profiling of N-glycans in cancer cells revealed an increase in the secreted glycoproteins from the primary tumor of MIA PaCa-2 cells,whereas human sera,which contain many secreted glycoproteins,had significant changes of glycans at their specific glycosites.These results indicated the potential role for tumor-specific glycosylation as disease biomarkers.We also found that AMG-510,a small molecule inhibitor against Kirsten rat sarcoma viral oncogene homolog(KRAS)G12C mutation,profoundly reduced the glycosylation level in MIA PaCa-2 cells,suggesting that KRAS plays a role in the cellular glycosylation process,and thus glycosylation inhibition contributes to the anti-tumor effect of AMG-510. | Mingming XU Zhaoliang LIU Wenhua HU Ying HAN Zhen WU Sufeng CHEN Peng XIA Jing DU Xumin ZHANG Piliang HAO Jun XIA Shuang YANG | 2024 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2024，25，1： | 0 |
| 14 | SLC2A5介导的果糖利用增强是急性髓系白血病的独特代谢特征并具有潜在治疗价值显示文摘快速增殖的白血病前体细胞需消耗大量的葡萄糖,这会导致骨髓中葡萄糖不足。为对抗葡萄糖不足,急性髓系白血病(AML)细胞可上调果糖转运子GLUT5表达而利用果糖。 | wen-lian chen yue-ying wang aihua zhao li xia guoxiang xie mingming su linjing zhao jiajian liu chun qu runmin wei cynthia rajani yan ni zhen cheng zhu chen 陈赛娟 贾伟 | 2017 | 科学新闻2017，0，4： | 0 |
| 15 | Rapid characterization of non-volatile phenolic compounds reveals the reliable chemical markers for authentication of traditional Chinese medicine Xiang-ru among confusing Elsholtzia species显示文摘The aerial parts of Mosla chinensis Maxim.and Mosla chinensis cv.'Jiangxiangru'(MCJ)are widely utilized in traditional Chinese medicine(TCM),known collectively as Xiang-ru.However,due to clinical effectiveness concerns and frequent misidentification,the original plants have increasingly been substituted by various species within the genera Elsholtzia and Mosla.The challenge in distinguishing between these genera arises from their similar morphological and metabolic profiles.To address this issue,our study introduced a rapid method for metabolic characterization,employing high-resolution mass spectrometry-based metabolomics.Through detailed biosynthetic and chemometric analyses,we pinpointed five phenolic compounds—salviaflaside,cynaroside,scutellarein-7-O-D-glucoside,rutin,and vicenin-2—among 203 identified compounds,as reliable chemical markers for distinguishing Xiang-ru from closely related Elsholtzia species.This methodology holds promise for broad application in the analysis of plant aerial parts,especially in verifying the authenticity of aromatic traditional medicinal plants.Our findings underscore the importance of non-volatile compounds as dependable chemical markers in the authentication process of aromatic traditional medicinal plants. | ZENG Zhen ZHANG Chen HU Jiadong WANG Feiyan WU Ziding WANG Jing ZHANG Jun YANG Shuda CHEN Junfeng LI Mingming TONG Qi QIU Shi CHEN Wansheng | 2024 | Chinese Journal of Natural Medicines2024，22，4： | 0 |
| 16 | Current Situation and Ideas of Protection and Restoration of Aquatic Ecosystems in Rivers and Lakes of China显示文摘Based on the investigation and analysis of protection and restoration of aquatic ecosystems in rivers and lakes of China,the ideas and measures of restoring aquatic ecosystems were proposed to build healthy aquatic ecosystems of rivers and lakes in China,such as setting scientific and clear goals,improving the standard adopted by wastewater treatment plants,controlling sources of pollutants and intercepting pollutants,collection of blue-green algae,water transfer,dredging,reducing the quantity of blue-green algae,restoring reed wetlands on a large scale,combing dredging and base raise of restored reed wetlands,making full use of microorganisms,and implementing effective management,technology integration and innovation. | Zhang Yaohua Hu Mingming Zhu Xi Wang Zhen | 2016 | Meteorological and Environmental Research2016，7，3： | 0 |
| 17 | Application of mannose-modified fullerene immunomodulator selectively polarizes tumor-associated macrophages potentiating antitumor immunity显示文摘Polarization of tumor associated macrophages(TAMs)has been a promising therapeutic paradigm for tumor.However,how to achieve precise regulation of TAMs and high efficiency of tumor immunotherapy is still a huge challenge.Here,we report dicarboxy fullerene modified with mannose(DCFM)as an immunomodulator to selectively polarize TAMs and prominently boost anti-tumor immunity.The dicarboxy fullerene molecule was synthesized through the Prato reaction and further covalently bonded with mannose,obtaining the DCFM with well-defined structure.Due to the exist of mannose in DCFM,it could accurately recognize mannose receptor in TAMs.Our cellular experiment results showed that mannose modification could notably promote the uptake of DCFM by the immunosuppressive M2-type macrophages that effectively reprogrammed M2-type macrophages into anti-tumor M1-type macrophages,leading to enhance the phagocytosis of tumor cells by macrophages and inhibiting tumor cells migration.Subsequently,we observed that DCFM could significantly distribute into tumor tissues by in vivo fluorescence imaging.Importantly,DCFM exhibited a superior anti-tumor efficiency in the subcutaneous colorectal tumor model.In addition,it showed that DCFM precisely polarized TAMs into M1-type macrophages and actively increased the infiltration of cytotoxic T lymphocytes(CTLs),inducing profound tumor growth inhibition. | Haoyu Wang Lei Li Xinran Cao Mingming Zhen Chunru Wang Chunli Bai | 2023 | Nano Research2023，16，11： | 0 |
| 18 | Study of MRPC technology for BESIII endcap-TOF upgrade显示文摘Purpose In order to improve the charged particle identi-fication capability,end-cap time-of-flight(ETOF)detector of the Beijing Spectrometer(BESIII)has been upgraded with multi-gap resistive plate chamber(MRPC)technology,aiming at an overall time resolution of 80 ps for minimum-ionization particles to extend the K/πseparation(2σ)momentum range to 1.4 GeV/c.Methods The previous version of ETOF in BESIII consisted of plastic scintillators.The multi-hit events distort both shape and amplitude of the output signals.MRPC technique was chosen for the BESIII ETOF upgrade as it provides high time resolution and high detection efficiency,is of relatively low cost and is insensitive to neutral particles.Most importantly,the fine segmentation of the MRPC readout stripes can suppress multi-hit events effectively.Results The final design of MRPC module for ETOF is characterized by double-stack(2×6)structure,dual-end readout mode and precision electronics.To batch-produce and test these MRPC modules,a series of tools and production procedures as well as related performance simulation and test methods were developed.Results showed that each MRPC module’s intrinsic time resolution(including the electronics contribution)is around 50 ps and the efficiency is better than 97%.The overall performance of the upgraded ETOF is better than the designed index.The new ETOF has been successfully installed at BESIII and run in 2016. | Xin Li Yongjie Sun Cheng Li Zhen Liu Yuekun Heng Ming Shao Xiaozhuang Wang Zhi Wu Ping Cao Mingming Chen Hongliang Dai Shubing Liu Xiaolan Luo Xiaoshan Jiang Shengsen Sun Zebo Tang Weijia Sun Siyu Wang Meihang Xu Rongxing Yang Kejun Zhu | 2017 | Radiation Detection Technology and Methods2017，1，2： | 0 |
| 19 | Oxidants and Anti-Oxidants in Turbot Seminal Plasma and Their Effects on Sperm Quality显示文摘In this research, the concentration and activity of oxidants and anti-oxidants in turbot semen, and their effects on sperm quality were studied. The results showed that superoxide dismutase(SOD), catalase, glutathione reductase(GR), uric acid, vitamin E(VE) and vitamin C(VC) were more abundant in seminal plasma than in spermatozoa. The variation for each of them was specific. In seminal plasma, the activity of SOD and GR increased from November 15, November 30 to December 15, and then decreased on December 30. The concentrations of both VC and uric acid decreased during the first 3 sampling times and increased on December 30. The oxidants in seminal plasma accumulated to the highest on December 30. Lactic acid(LA) and ATP levels decreased to the lowest on December 30. The correlation analysis showed that GR had the significant positive relevance to sperm motility and VSL/VCL, while ·OH had negative relevance to them. | HAN Mingming DING Fuhong MENG Zhen LEI Jilin | 2015 | Journal of Ocean University of China2015，14，4： | 0 |
| 20 | Prospective study on observations of γ-ray sources in the Galaxy using the HADAR experiment显示文摘The High Altitude Detection of Astronomical Radiation(HADAR)experiment is a refracting terrestrial telescope array based on the atmospheric Cherenkov imaging technique.It focuses the Cherenkov light emitted by extensive air showers through a large aperture water-lens system for observing very-high-energyγ-rays and cosmic rays.With the advantages of a large field-of-view(FOV)and low energy threshold,the HADAR experiment operates in a large-scale sky scanning mode to observe galactic sources.This study presents the prospects of using the HADAR experiment for the sky survey of TeVγ-ray sources from TeVCat and provids a one-year survey of statistical significance.Results from the simulation show that a total of 23 galactic point sources,including five supernova remnant sources and superbubbles,four pulsar wind nebula sources,and 14 unidentified sources,were detected in the HADAR FOV with a significance greater than 5 standard deviations(σ).The statistical significance for the Crab Nebula during one year of operation reached 346.0σand the one-year integral sensitivity of HADAR above 1 TeV was~1.3%–2.4%of the flux from the Crab Nebula. | Xiangli Qian Huiying Sun Tianlu Chen Danzengluobu Youliang Feng Qi Gao Quanbu Gou Yiqing Guo Hongbo Hu Mingming Kang Haijin Li Cheng Liu Maoyuan Liu Wei Liu Bingqiang Qiao Xu Wang Zhen Wang Guangguang Xin Yuhua Yao Qiang Yuan Yi Zhang | 2022 | Frontiers of physics2022，17，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员