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| 1 | IL-17 response mediates acute lung injury induced by the 2009 Pandemic Influenza A (HIN1) Virus显示文摘 | Chenggang Li Penghui Yang Yang Sun Taisheng Li Chen Wang Zhong Wang Zhen Zou Yiwu Yan Wei Wang Chen Wang Zhongwei Chen Li Xing Chong Tang Xiangwu Ju Feng Guo Jiejie Deng Yan Zhao Peng Yang Jun Tang Huanling Wang Zhongpeng Zhao Zhinan Yin Bin Cao Xiliang Wang Chengyu Jiang | 2012 | Cell Research2012，22，3： | 22 |
| 2 | PRMT5 regulates Golgi apparatus structure through methylation of the golgin GM130显示文摘Golgi 仪器(GA ) 的维护结构和功能取决于 Golgi 矩阵蛋白质。象 golgin 和掌握家庭的成员的 phosphorylation 那样的 Golgi 蛋白质的 posttranslational 修正为决定 Golgi 建筑学是重要的。包括 golgin-84 的一些 Golgi 蛋白质也被知道是 methylated,但是 golgin methylation 的功能仍然保持不清楚。这里,我们证明蛋白质精氨酸 methyltransferase (PRMT5 ) 5 本地化到 GA 和形式建筑群,几个部件在拴住的 GA 带子形成和泡包含了。PRMT5 在 Golgi 带子形成与 PRMT5 原因缺点的 golgin GM130,和弄空交往。而且,在 GM130 的 PRMT5 甲醇化物 N 终端精氨酸,和如此的精氨酸 methylation 为 GA 显得批评带子形成。我们的调查结果揭示 GM130 的 PRMT5 依赖的精氨酸 methylation 由控制 GA 建筑学的维护的分子的机制。 | Zhongwei Zhou Xiaotian Sun Zhenhua Zou Litao Sun Tao Zhang Shaoshi Guo Ya Wen Lin Liu Yi Wang Jun Qin Lei Li Weimin Gong Shilai Bao | 2010 | Cell Research2010，20，9： | 16 |
| 3 | Theoretical and experimental study of the pulling force of jet bits in radial drilling technology显示文摘Radial drilling technology,of which the jet bit is the key device,is a research focus in the field of oil drilling and production.This paper establishes mechanical equations for jet bits and analyzes the hydroseal of backward jets in bottom holes.Meanwhile this paper establishes a mechanical equation for a high pressure hose and analyzes the axial force distribution.Laboratory experiments indicate that the flow rate,the angle between the backward nozzle axis and the jet bit axis,and the hole diameter are the major influencing factors;the generation of the pulling force is mainly due to the inlet pressure of the jet bit;the backward jets can significantly increase not only the pulling force but also the stability of jet bits.The pulling force would reach 8,376 N under experimental conditions,which can steadily pull the high-pressure hose forward. | Ruichang Guo Gensheng Li Zhongwei Huang Shouceng Tian Xiaoning Zhang Wei Wu | 2009 | Petroleum Science2009，6，4： | 5 |
| 4 | Autophagy receptor CCDC50 tunes the STING-mediated interferon response in viral infections and autoimmune diseases显示文摘DNA sensing and timely activation of interferon(IFN)-mediated innate immunity are crucial for the defense against DNA virus infections and the clearance of abnormal cells.However,overactivation of immune responses may lead to tissue damage and autoimmune diseases;therefore,these processes must be intricately regulated.STING is the key adaptor protein,which is activated by cyclic GMP-AMP,the second messenger derived from cGAS-mediated DNA sensing.Here,we report that CCDC50,a newly identified autophagy receptor,tunes STING-directed type I IFN signaling activity by delivering K63-polyubiquitinated STING to autolysosomes for degradation.Knockout of CCDC50 significantly increases herpes simplex virus 1(HSV-1)-or DNA ligand-induced production of type I IFN and proinflammatory cytokines.Ccdc50-deficient mice show increased production of IFN,decreased viral replication,reduced cell infiltration,and improved survival rates compared with their wild-type littermates when challenged with HSV-1.Remarkably,the expression of CCDC50 is downregulated in systemic lupus erythematosus(SLE),a chronic autoimmune disease.CCDC50 levels are negatively correlated with IFN signaling pathway activation and disease severity in human SLE patients.CCDC50 deficiency potentiates the cGAS-STING-mediated immune response triggered by SLE serum.Thus,our findings reveal the critical role of CCDC50 in the immune regulation of viral infections and autoimmune diseases and provide insights into the therapeutic implications of CCDC50 manipulation. | Panpan Hou Yuxin Lin Zibo Li Ruiqing Lu Yicheng Wang Tian Tian Penghui Jia Xi Zhang Liu Cao Zhongwei Zhou Chunmei Li Jieruo Gu Deyin Guo | 2021 | Cellular & Molecular Immunology2021，18，10： | 3 |
| 5 | Ecosystem functions, services and their values – a case study in Xingshan County of China显示文摘 | Zhongwei Guo Xiangming Xiao Yaling Gan Yuejun Zheng | 2001 | Ecological Economics2001，，1： | 2 |
| 6 | Biomarkers of aging显示文摘Aging biomarkers are a combination of biological parameters to(i)assess age-related changes,(ii)track the physiological aging process,and(iii)predict the transition into a pathological status.Although a broad spectrum of aging biomarkers has been developed,their potential uses and limitations remain poorly characterized.An immediate goal of biomarkers is to help us answer the following three fundamental questions in aging research:How old are we?Why do we get old?And how can we age slower?This review aims to address this need.Here,we summarize our current knowledge of biomarkers developed for cellular,organ,and organismal levels of aging,comprising six pillars:physiological characteristics,medical imaging,histological features,cellular alterations,molecular changes,and secretory factors.To fulfill all these requisites,we propose that aging biomarkers should qualify for being specific,systemic,and clinically relevant. | Aging Biomarker Consortium Hainan Bao Jiani Cao Mengting Chen Min Chen Wei Chen Xiao Chen Yanhao Chen Yu Chen Yutian Chen Zhiyang Chen Jagadish K Chhetri Yingjie Ding Junlin Feng Jun Guo Mengmeng Guo Chuting He Yujuan Jia Haiping Jiang Ying Jing Dingfeng Li Jiaming Li Jingyi Li Qinhao Liang Rui Liang Feng Liu Xiaoqian Liu Zuojun Liu Oscar Junhong Luo Jianwei Lv Jingyi Ma Kehang Mao Jiawei Nie Xinhua Qiao Xinpei Sun Xiaoqiang Tang Jianfang Wang Qiaoran Wang Siyuan Wang Xuan Wang Yaning Wang Yuhan Wang Rimo Wu Kai Xia Fu-Hui Xiao Lingyan Xu Yingying Xu Haoteng Yan Liang Yang Ruici Yang Yuanxin Yang Yilin Ying Le Zhang Weiwei Zhang Wenwan Zhang Xing Zhang Zhuo Zhang Min Zhou Rui Zhou Qingchen Zhu Zhengmao Zhu Feng Cao Zhongwei Cao Piu Chan Chang Chen Guobing Chen Hou-Zao Chen Jun Chen Weimin Ci Bi-Sen Ding Qiurong Ding Feng Gao Jing-Dong JHan Kai Huang Zhenyu Ju Qing-Peng Kong Ji Li Jian Li Xin Li Baohua Liu Feng Liu Lin Liu Qiang Liu Qiang Liu Xingguo Liu Yong Liu Xianghang Luo Shuai Ma Xinran Ma Zhiyong Mao Jing Nie Yaojin Peng Jing Qu Jie Ren Ruibao Ren Moshi Song Zhou Songyang Yi Eve Sun Yu Sun Mei Tian Shusen Wang Si Wang Xia Wang Xiaoning Wang Yan-Jiang Wang Yunfang Wang Catherine CL Wong Andy Peng Xiang Yichuan Xiao Zhengwei Xie Daichao Xu Jing Ye Rui Yue Cuntai Zhang Hongbo Zhang Liang Zhang Weiqi Zhang Yong Zhang Yun-Wu Zhang Zhuohua Zhang Tongbiao Zhao Yuzheng Zhao Dahai Zhu Weiguo Zou Gang Pei Guang-Hui Liu | 2023 | Science China(Life Sciences)2023，66，5： | 2 |
| 7 | Applying aresting operation to alleviate bioclogging in vertical flow constructedwetlands : an experimental lab evaluation 显示文摘 | GUO Fenhua ZENG Yitao ZHAO Zhongwei | 2014 | Journal ofEnvironmental Management2014，136，1： | 1 |
| 8 | Landscape planning for a rural ecosystem: case study of a resettlement area for residents from land submerged by the Three Gorges Reservoir, China显示文摘 | Guo Zhongwei Xiao Xiangming Gan Yaling | 2003 | Landscape Ecology2003，18，5： | 1 |
| 9 | The C_(6)D_(6)detector system on the Back-n beam line of CSNS显示文摘Introduction The neutron capture cross sections are very important in the field of nuclear device design and basic physics research.Hydrogen-free liquid scintillator such as C_(6)D_(6)detectors are widely used in the neutron capture cross-sectional measurements for the low neutron sensitivity and fast time response.The Back-n white neutron source at China Spallation Neutron Source is the first spallation white neutron source in China,and it is suitable for neutron capture cross-sectional measurement.Materials and methods A C_(6)D_(6)detector system was built in the Back-n experimental station.The pulse height weighting technique was used to determine the system’s detection efficiency.The response to gamma rays of the C_(6)D_(6)detector was measured,and the energy resolution function was determined.Monte Carlo simulation with Geant4 code was carried out to get the weighting function of this C_(6)D_(6)detector system.Additionally,the systematic uncertainty of the weighting function was also determined.Conclusion According to the experimental and simulation results,this C_(6)D_(6)detector system can be used to measure neutron capture cross section. | Jie Ren Xichao Ruan Jie Bao Guangyuan Luan Wei Jiang Qi An Huaiyong Bai Ping Cao Qiping Chen Yonghao Chen Pinjing Cheng Zengqi Cui Ruirui Fan Changqing Feng Minhao Gu Fengqin Guo Changcai Han Zijie Han Guozhu He Yongcheng He Yuefeng He Hanxiong Huang Weiling Huang Xiru Huang Xiaolu Ji Xuyang Ji Haoyu Jiang Hantao Jing Ling Kang Mingtao Kang Bo Li Lun Li Qiang Li Xiao Li Yang Li Yang Li Rong Liu Shubin Liu Xingyan Liu Yinglin Ma Changjun Ning Binbin Qi Zhaohui Song Hong Sun Xiaoyang Sun Zhijia Sun Zhixin Tan Hongqing Tang Jingyu Tang Pengcheng Wang Qi Wang Taofeng Wang Yanfeng Wang Zhaohui Wang Zheng Wang Jie Wen Zhongwei Wen Qingbiao Wu Xiaoguang Wu Xuan Wu Likun Xie Yiwei Yang Han Yi Li Yu Tao Yu Yongji Yu Guohui Zhang Jing Zhang Linhao Zhang Liying Zhang Qingmin Zhang Qiwei Zhang Xianpeng Zhang Yuliang Zhang Zhiyong Zhang Yingtan Zhao Liang Zhou Zuying Zhou Danyang Zhu Kejun Zhu Peng Zhu | 2019 | Radiation Detection Technology and Methods2019，3，3： | 1 |
| 10 | Ecosystem functions and their values-a case study in Xingshan County of China显示文摘 | Zhongwei Guo | 2001 | Ecol-Econ2001，38，： | 1 |
| 11 | The Scraping Test and Adhesion Measurements of Diamond and Nickel Electroless Coatings显示文摘 | Xie Zhongwei Zhu Jing Guo Wei | 2000 | Materials Characterization2000，44，45： | 1 |
| 12 | Ecosystem functions, services and their values – a case study in Xingshan County of China显示文摘 | Zhongwei Guo Xiangming Xiao Yaling Gan Yuejun Zheng | 2001 | Ecological Economics2001，，1： | 1 |
| 13 | Observation analysis of land-atmosphere interactions over the Loess Plateau of northwest China显示文摘 | Wang Guoyin Huang Jianping Guo Weidong Zuo Jinqing Wang Jiemin Bi Jianrong Huang Zhongwei Shi Jinsen | 2010 | Atmospheres2010，，： | 1 |
| 14 | An assessment of ecosystem services: water flow regulation and hydroelectric power production 显示文摘 | Guo Zhongwei Xiao Xiangming Li Dianmo | 2000 | Ecological Application2000，10，3： | 1 |
| 15 | Ecosystem functions, services and their values-a case study in Xingshan Country of China 显示文摘 | Zhongwei Guo etc | 2001 | Ecological Economics2001，38，： | 1 |
| 16 | Highly Sensitive and Selective Butanone Sensors Based oil Cerimn-Doped SnO2 Thin Fihns显示文摘 | Jiang Zhongwei Guo Zheng Sun Bai | 2010 | Sensors and Actuators B2010，145，： | 1 |
| 17 | The Scraping Test and Adhesion Measurements of Diamond and Nickel Electroless Coatings 显示文摘 | Zhongwei Xie Jing Zhu Wei Guo | 2000 | Materials characterization2000，44，： | 1 |
| 18 | Ecosystem functions and their values--a case study in Xingshan County of China显示文摘 | Zhongwei Guo | 2001 | Eeol--Econ2001，38，： | 1 |
| 19 | Some Aspects of Ecological Modeling Developments in China显示文摘 | Li Dianmo Guo Zhongwei | | 0，，1： | 1 |
| 20 | Landscape planning for a rural ecosystem: case study of a resettlement area for residents from land submerged by the Three Gorges Reservoir, China显示文摘 | Zhongwei Guo Xiangming Xiao Yaling Gan Yuejun Zheng | | Landscape Ecology0，，： | 1 |
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