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| 1 | Prevalence of Nontraumatic Osteonecrosis of the Femoral Head and its Associated Risk Factors in the Chinese Population: Results from a Nationally Representative Survey显示文摘 | De-Wei Zhao Mang Yu Kai Hu Wei Wang Lei Yang Ben-Jie Wang Xiao-Hong Gao Yong-Ming Guo Yong-Qing Xu Yu-Shan Wei Si-Miao Tian Fan Yang Nan Wang Shi-Bo Huang Hui Xie Xiao-Wei Wei Hai-Shen Jiang Yu-Qiang Zang Jun Ai Yuan-Liang Chen Guang-Hua Lei Yu-Jin Li Geng Tia Zong-Sheng Li Yong Cao Li Ma | 2015 | Chinese Medical Journal2015，，21： | 151 |
| 2 | Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer's disease progression显示文摘Recently,increasing evidence has suggested the association between gut dysbiosis and Alzheimer's disease(AD)progression,yet the role of gut microbiota in AD pathogenesis remains obscure.Herein,we provide a potential mechanistic link between gut microbiota dysbiosis and neuroinflammation in AD progression.Using AD mouse models,we discovered that,during AD progression,the alteration of gut microbiota composition leads to the peripheral accumulation of phenylalanine and isoleucine,which stimulates the differentiation and proliferation of pro-inflammatory T helper 1(Thl)cells.The brain-infiltrated peripheral Th1 immune cells are associated with the Ml microglia aaivation,contributing to AD-associated neuroinflammation.Importantly,the elevation of phenylalanine and isoleucine concentrations and the increase of Th1 cell frequency in the blood were also observed in two small independent cohorts of patients with mild cognitive impairment(MCI)due to AD.Furthermore,GV-971,a sodium oligomannate that has demonstrated solid and consistent cognition improvement in a phase 3 clinical trial in China,suppresses gut dysbiosis and the associated phenylalanine/isoleucine accumulation,harnesses neuroinflammation and reverses the cognition impairment.Together,our findings highlight the role of gut dysbiosis-promoted neuroinflammation in AD progression and suggest a novel strategy for AD therapy by remodelling the gut microbiota. | Xinyi Wang Guangqiang Sun Teng Feng Jing Zhang Xun Huang Tao Wang Zuoquan Xie Xingkun Chu Jun Yang Huan Wang Shuaishuai Chang Yanxue Gong Lingfei Ruan Guanqun Zhang Siyuan Yan Wen Lian Chen Du Dabing Yang Qingli Zhang Feifei Lin Jia Liu Haiyan Zhang Changrong Ge Shifu Xiao Jian Ding Meiyu Geng | 2019 | Cell Research2019，29，10： | 192 |
| 3 | Targeting ERK,an Achilles' Heel of the MAPK pathway,in cancer therapy显示文摘The mitogen-activated protein kinases(MAPK) pathway, often known as the RAS-RAFMEK-ERK signal cascade, functions to transmit upstream signals to its downstream effectors to regulate physiological process such as cell proliferation, differentiation, survival and death. As the most frequently mutated signaling pathway in human cancer, targeting the MAPK pathway has long been considered a promising strategy for cancer therapy. Substantial efforts in the past decades have led to the clinical success of BRAF and MEK inhibitors. However, the clinical benefits of these inhibitors are compromised by the frequently occurring acquired resistance due to cancer heterogeneity and genomic instability. This review briefly introduces the key protein kinases involved in this pathway as well as their activation mechanisms. We also generalize the correlations between mutations of MAPK members and human cancers, followed by a summarization of progress made on the development of small molecule MAPK kinases inhibitors. In particular, this review highlights the potential advantages of ERK inhibitors in overcoming resistance to upstream targets and proposes that targeting ERK kinase may hold a promising prospect for cancer therapy. | Feifei Liu Xiaotong Yang Meiyu Geng Min Huang | 2018 | Acta Pharmaceutica Sinica B2018，8，4： | 40 |
| 4 | Anti-hepatoma activity and mechanism of ursolic acid and its derivatives isolated from Aralia decaisneana显示文摘瞄准:为了调查 ursolic (UA ) 和它的衍生物的反肿瘤活动,在肝细胞癌上从美┦木孤立 decaisneana 在试管内和在活体内。方法:在活体内细胞毒性被 3- 首先屏蔽[4,5-dimethylthiazol-2-yl ]-2, 5-diphenyltetrazolium 溴化物(MTT ) 试金。词法观察, DNA 梯子,流动血细胞计数分析,西方的污点和实时 PCR 被采用阐明 UA 的细胞毒素的机制。植入的老鼠肝细胞瘤 H22 被用来评估生长 UA 的禁止的效果在活体内。结果:UA 能显著地禁止 HepG2 和它的药抵抗的增长紧张, R-HepG2 房间,而是首先有教养的正常老鼠 hepatocytes 上的有的不禁止的效果而 UA 的所有六衍生物不能禁止所有的生长,测试房间排队。机制上的进一步的学习证明那 apoptosis 和 G0/G1 拘捕涉及多(自动数据处理核糖) 的细胞毒性和劈开聚合酶(PARP ) 。cyclooxygenase-2 (COX-2 ) 的 Downregulation 蛋白质并且在热吃惊蛋白质(HSP ) 的规定上面, 105 mRNA 相关到与 UA 对待的 HepG2 房间的 apoptosis。另外, UA 能也禁止 H22 肝细胞瘤在活体内的生长。结论:UA 是一个有希望的反肿瘤代理人,但是推进工作需要被做改进它的溶解度。 | Ze Tian Geng Lin Rui-Xia Zheng Feng Huang Meng-Su Yang Pei-Gen Xiao | 2006 | World Journal of Gastroenterology2006，12，6： | 31 |
| 5 | Natural Variation in the Promoter of GSE5 Contributes to Grain Size Diversity in Rice显示文摘自然基因变化的利用极大地在庄稼贡献重要农学的特点的改进。为谷物尺寸的自然变化理解基因基础能帮助 breeders 开发产量很高的米饭变化。在这研究,我们识别以前未被认出的基因,命名 GSE5,与功能的分析在由联合染色体宽的协会控制米饭谷物尺寸的 qSW5/GW5 地点学习。GSE5 编码血浆有 IQ 领域的联系膜的蛋白质,与米饭 calmodulin 蛋白质交往, OsCaM1-1。我们发现 GSE5 功能的损失引起了宽、重的谷物,当 GSE5 的 overexpression 导致了狭窄的谷物时。我们证明 GSE5 由在小穗状花小穗壳影响房间增长主要调整谷物尺寸。GSE5 的三主要 haplotypes (GSE5, GSE5 DEL1+IN1 , 和 GSE5 在栽培米饭的 DEL2 ) 在它的倡导者区域基于删除 / 插入类型被识别。我们表明了那在带 GSE5 在带 GSE5 haplotype 和 1212-bp 删除(DEL2 )> 与 GSE5 的减少的表示联系的 DEL2 haplotype,导致宽谷物。进一步的分析显示野米饭就职包含 GSE5 的所有三 haplotypes,建议在栽培米饭在场的 GSE5 haplotypes 是可能的从在米饭驯服期间的不同野米饭就职发源。一起拿,我们的结果显示在 qSW5/GW5 地点的以前未被认出的 GSE5 基因,被米饭 breeders 广泛地利用,控制谷物缩放,并且表明在 GSE5 的倡导者区域的那个自然变化在米饭贡献谷物尺寸差异。 | Penggen Duan Jinsong Xu Dali Zeng Baolan Zhang Mufan Geng Guozheng Zhang Ke Huang Luojiang Huang Ran Xu Song Ge Qian Qian Yunhai Li | 2017 | Molecular Plant2017，10，5： | 31 |
| 6 | The structural and accessory proteins M,ORF 4a,ORF 4b,and ORF 5 of Middle East respiratory syndrome coronavirus(MERS-CoV)are potent interferon antagonists显示文摘The newly emerged Middle East respiratory syndrome coronavirus(MERS-CoV)is a highly pathogenic respira-tory virus with pathogenic mechanisms that may be driven by innate immune pathways.The goal of this study is to characterize the expression of the structural(S,E,M,N)and accessory(ORF 3,ORF 4a,ORF 4b,ORF 5)proteins of MERS-CoV and to determine whether any of these pro-teins acts as an interferon antagonist.Individual structural and accessory protein-coding plasmids with an N-terminal HA tag were constructed and transiently transfected into cells,and their native expression and subcellular localiza-tion were assessed using Wes tern blotting and indirect immunofl uorescence.While ORF 4b demonstrated majorly nuclear localization,all of the other proteins demonstrated cytoplasmic localization.In addition,for the fi rst time,our experiments revealed that the M,ORF 4a,ORF 4b,and ORF 5 proteins are potent interferon antagonists.Further exami-nation revealed that the ORF 4a protein of MERS-CoV has the most potential to counteract the antiviral effects of IFN via the inhibition of both the interferon production(IFN-βpromoter activity,IRF-3/7 and NF-κB activation)and ISRE promoter element signaling pathways.Together,our re-sults provide new insights into the function and pathogenic role of the structural and accessory proteins of MERS-CoV. | Yang Yang Ling Zhang Heyuan Geng Yao Deng Baoying Huang Yin Guo Zhengdong Zhao Wenjie Tan | 2013 | Protein & Cell2013，4，12： | 25 |
| 7 | Characteristics and Performance of Novel Water-Absorbent Slow Release Nitrogen Fertilizers显示文摘In this article, a research on the characteristics and performance of water-absorbent slow release nitrogen fertilizer (WASRNF) using infrared spectroscopy (IR), scanning electronic microscopy (SEM), differential scanning calorimetry (DSC), and thermogravimetry analysis (TGA), was present. The results indicate that the water absorbency and nitrogen analysis of WASRNF is 103 g g-1 and 30%, respectively, and WASRNF exhibits approximately neutral pH and very low salt index. WASRNF is a copolymer of nitrogen fertilizer and super absorbent polymer (SAP) monomers which is formed through hydrogen bond interaction, and the molecule contains hydrophilic groups, which is responsible for the absorption and water retention capacity of the molecule. WASRNF is a gel that exhibits the ability to swell, but does not dissolve in water. WASRNF shows non-homogenous nature as a whole, but in local zone it is homogenous, the copolymer molecule shows chain network that is the physical structure responsible for absorption and retention of water in WASRNF. The water retained in WASRNF exists as free and nonfreezing bound and freezing bound water states, with the free and the nonfreezing water accounting for more than 95% of water retained in WASRNF, and the nonfreezing bound water for less than 5%. WASRNF functions in delaying the release of nitrogen from it, thereby serving a novel slow release nitrogenous fertilizer. | HE Xu-sheng LIAO Zong-wen HUANG Pei-zhao DUAN Ji-xian GE Ren-shan LI Hong-bo GENG Zeng-chao | 2007 | Agricultural Sciences in China2007，6，3： | 24 |
| 8 | Genome Editing and Double-Fluorescence Proteins Enable Robust Maternal Haploid Induction and Identification in Maize显示文摘 | Le Dong Lina Li Changlin Liu Chenxu Liu Shuaifeng Geng Xinhai Li Changling Huang Long Mao Shaojiang Chen Chuanxiao Xie | 2018 | Molecular Plant2018，11，9： | 22 |
| 9 | Chemokines and hepatocellular carcinoma显示文摘Chemokines play a paramount role in tumor progres-sion. In hepatocellular carcinoma (HCC) progression, chemokines and their receptors play an intricate role. Currently, chemokines and their receptors such as the CXCL12-CXCR4 axis, CX3CL1-CX3CR1 axis and the CCL20-CCR6 axis have received much research attention. Although a large number of studies show that these axes are strongly associated with HCC, the exact mechanism by which these axes promote the growth and progression of HCC remains unknown. In this paper, several chemokines and their receptor interactions in HCC progression, growth and metastasis and immune response to HCC are reviewed. | Huang, Fan Geng, Xiao-Ping | 2010 | World Journal of Gastroenterology2010，16，15： | 19 |
| 10 | Chemotherapy-induced intestinal inflammatory responses are mediated by exosome secretion of double-strand DNA via AIM2 inflammasome activation显示文摘化疗经常被知道导致严重的胃肠的道毒性,但是内在的机制仍然保持不清楚。这研究作为一个代表性的代理人认为广泛地应用的细胞毒素的代理人是 irinotecan (CPT-11 ) 并且证明治疗从说明混合物的限制剂量的肠的毒性的肠导致双海滨 DNA 的巨大的版本。明确地,通过 exosome 分泌物释放的 self-DNA 进入天生的有免疫力的房间的 cytosol 并且激活 AIM2 (在黑瘤 2 不在) inflammasome。这导致成熟 IL-1 和 IL-18 分泌物并且导致肠的 mucositis 和迟了发作的腹泻。有趣地,在 AIM2 缺乏的老鼠或由象镇静药那样的一个药理学禁止者,没有影响 CPT-11 的 anticancer 功效, AIM2 发信号的废除显著地减少导致药的腹泻的发生。这些调查结果提供化疗怎么触发引起肠的毒性的天生的有免疫力的回答的机械学的卓见,并且揭示维持反瘤效果,但是围绕联系不利煽动性的反应的新化疗政体。 | Lian, Qiaoshi Xu, Jun Yan, Shanshan Huang, Min Ding, Honghua Sun, Xiaoyu Bi, Aiwei Ding, Jian Sun, Bing Geng, Meiyu | 2017 | Cell Research2017，27，6： | 18 |
| 11 | Combination of serum inhibin B and follicle-stimulating hormone levels can not improve the diagnostic accuracy on testicular sperm extraction outcomes in Chinese non-obstructive azoospermic men显示文摘 | HUANG Xiang BAI Quan YAN Li-ying ZHANG Qiu-fang GENG Li QIAO Jie | 2012 | Chinese Medical Journal2012，，16： | 17 |
| 12 | Recurrent gain-of-function USP8 mutations in Cushing's disease显示文摘库欣的疾病,引起过量皮质醇生产的也已知的同样促肾上腺皮质的荷尔蒙(ACTH )-secreting 垂体腺瘤(舞步) ,占多达 85%corticotrophin 依赖的库欣的症候群盒子。然而,在这疾病的基因改变是不清楚的。这里,我们执行了从 12 秘密 ACTH 舞步导出并且匹配血样品的 DNA 定序的 whole-exome,它在候选人基因揭示了体的变化的三种类型, USP8 (编码 ubiquitin 特定的朊酶 8 ) ,专门在 exon 14 在 12 秘密 ACTH 舞步中的 8 个。我们进一步评估了体的 USP8 变化在另外由定序的 Sanger 的 258 舞步。进一步定序指向在 108 秘密 ACTH 舞步(62.04%) 中的 67 个识别了 USP8 变体的 17 种类型的一个总数。然而,任何一个都没在舞步的另外的类型这些变化被检测(n = 150 ) 。这些变化在 USP8 的 14-3-3 绑定主题以内聚集并且破坏在 USP8 和 14-3-3 蛋白质之间的相互作用,导致保护 EGFR 免受 lysosomal 降级的伤害的一个提高的能力。因此,有 EGFR 表示,提高的 EGFR 蛋白质丰富和 mRNA 表示的更高的发生 POMC 铺平的变异的 USP8 显示的舞步,它编码 ACTH 的先锋。有变异的 USP8 的舞步在尺寸是显著地更小的并且比野类型的舞步有更高的 ACTH 生产。在里面通过手术 resected 主要变异 USP8 的肿瘤房间, USP8 击倒或堵住的 EGFR 有效地稀释 ACTH 分泌物。一起拿,体的 gain-of-function USP8 变化是普通的并且在库欣的疾病贡献 ACTH 生产过剩。USP8 或 EGFR 的抑制为对待变异 USP8 的 corticotrophin 腺瘤是有希望的。我们的学习在库欣的疾病加亮潜在地功能的变异的基因并且提供卓见进这疾病的治疗学。 | Zeng-Yi Ma Zhi-Jian Song Jian-Hua Chen Yong-Fei Wang Shi-Qi Li Liang-Fu Zhou Ying Mao Yi-Ming Li Rong-Gui Hu Zhao-Yun Zhang Hong-Ying Ye Ming Shen Xue-Fei Shou Zhi-Qiang Li Hong Peng Qing-Zhong Wang Dai-Zhan Zhou Xiao-Lan Qin Jue Ji Jie Zheng Hong Chen Yin Wang Dao-Ying Geng Wei-Jun Tang Chao-Wei Fu Zhi-Feng Shi Yi-Chao Zhang Zhao Ye Wen-Qiang He Qi-Lin Zhang Qi-Sheng Tang Rong Xie Jia-Wei Shen Zu-Jia Wen Juan Zhou Tao Wang Shan Huang Hui-Jia Qiu Ni-Dan Qiao Yi Zhang Li Pan Wei-Min Bao Ying-Chao Liu Chuan-Xin Huang Yong-Yong Shi Yao Zhao | 2015 | Cell Research2015，25，3： | 16 |
| 13 | Soliton bursts and deterministic dissipative Kerr soliton generation in auxiliary-assisted microcavities显示文摘Dissipative Kerr solitons in resonant frequency combs offer a promising route for ultrafast mode-locking,precision spectroscopy and time-frequency standards.The dynamics for the dissipative soliton generation,however,are intrinsically intertwined with thermal nonlinearities,limiting the soliton generation parameter map and statistical success probabilities of the solitary state.Here,via use of an auxiliary laser heating approach to suppress thermal dragging dynamics in dissipative soliton comb formation,we demonstrate stable Kerr soliton singlet formation and soliton bursts.First,we access a new soliton existence range with an inverse-sloped Kerr soliton evolution—diminishing soliton energy with increasing pump detuning.Second,we achieve deterministic transitions from Turinglike comb patterns directly into the dissipative Kerr soliton singlet pulse bypassing the chaotic states.This is achieved by avoiding subcomb overlaps at lower pump power,with near-identical singlet soliton comb generation over twenty instances.Third,with the red-detuned pump entrance route enabled,we uncover unique spontaneous soliton bursts in the direct formation of low-noise optical frequency combs from continuum background noise.The burst dynamics are due to the rapid entry and mutual attraction of the pump laser into the cavity mode,aided by the auxiliary laser and matching well with our numerical simulations.Enabled by the auxiliary-assisted frequency comb dynamics,we demonstrate an application of automatic soliton comb recovery and long-term stabilization against strong external perturbations.Our findings hold potential to expand the parameter space for ultrafast nonlinear dynamics and precision optical frequency comb stabilization. | Heng Zhou Yong Geng Wenwen Cui Shu-Wei Huang Qiang Zhou Kun Qiu Chee Wei Wong | 2019 | Light(Science & Applications)2019，8，1： | 16 |
| 14 | Binding Activity Difference of Anti-CD20 scFv-Fc Fusion Protein Derived from Variable Domain Exchange显示文摘Two novel engineered antibody fragments binding to antigen CD20 were generated by fusing a murine IgM-type anti-CD20 single-chain Fv fragment (scFv) to the human IgG1 CH2 (i.e., Cγ2) and CH3 (i.e., Cγ3) domains with the human IgG1 hinge (i.e. Hγ). Given the relationship between structure and function of protein, the 3-D structures of the two engineered antibody fragments were modeled using computer-aided homology modeling method. Furthermore, the relationship between 3-D conformation and their binding activity was evaluated theoretically. Due to the change of active pocket formed by CDRs, the HL23 (VH-Linker-VL-Hγ-Cγ2-Cγ3) remained its activity because of its preserved conformation, while the binding activity of the LH23 (VL-Linker-VH-Hγ-Cγ2-Cγ3) was impaired severely. Experimental studies by flow cytometry and fluorescence microscopy showed that HL23 possessed significantly superior binding activity to CD20-expressing target cells than LH23. That is to say, the order of variable regions could influence the binding activity of the fusion protein to CD20+ cell lines, which was in accordance with the theoretical results. The study highlights the potential relationship between the antibody binding activity and their 3-D conformation, which appears to be worthwhile in providing direction for future antibody design of recombinant antibody. | Shusheng Geng Jiannan Feng Yan Li Yingxun Sun Xin Gu Ying Huang Yugang Wang Xianjiang Kang Hong Chang Beifen Shen | 2006 | Cellular & Molecular Immunology2006，3，6： | 13 |
| 15 | Soil respiration is driven by fine root biomass along a forest chronosequence in subtropical China显示文摘Aims Soil respiration(Rs)is a major process controlling soil carbon loss in forest ecosystems.However,the underlying mechanisms leading to variation in Rs along forest successional gradients are not well understood.In this study,we investigated the effects of biotic and abiotic factors on Rs along a forest successional gradient in southeast China.Methods We selected 16 plots stratified by forest age,ranging from 20 to 120 years.In each plot,six shallow collars and six deep collars were permanently inserted into the soil.Shallow and deep collars were used to measure Rs and heterotrophic respiration(Rh),respectively.Autotrophic soil respiration(Ra)was estimated as the difference between Rs and Rh.Litter layer respiration(R_(L))was calculated by subtracting soil respiration measured in collars without leaf litter layer(R_(NL))from Rs.Rs was measured every 2 months,and soil temperature(ST)and soil volumetric water content(SVWC)were recorded every hour for 19 months.We calculated daily Rs using an exponential model dependent on ST.Daily Rs was summed to obtain cumulative annual Rs estimates.Structural equation modelling(SEM)was applied to identify the drivers of Rs during forest succession.Important Findings Rs showed significant differences among three successive stages,and it was the highest in the young stage.Ra was higher in the young stage than in the medium stage.Cumulative annual Rs and Ra peaked in the young and old stages,respectively.Cumulative annual Rh and respiration measured from soil organic matter(R_(SOM))decreased,whereas R_(L)increased with forest age.The SEM revealed that cumulative annual Rs was influenced by fine root biomass and SVWC.Our results indicated that the dominant force regulating Rs on a seasonal scale is ST;however,on a successional scale,belowground carbon emerges as the dominant influential factor. | Chao Wang Yinlei Ma Stefan Trogisch Yuanyuan Huang Yan Geng Michael Scherer-Lorenzen Jin-Sheng He | 2017 | Journal of Plant Ecology2017，10，1： | 13 |
| 16 | Lichong decoction reduces Matrix Metalloproteinases-2 expression but increases Tissue Inhibitors of Matrix Metalloproteinases-2 ex-pression in a rat model of uterine leiomyoma显示文摘OBJECTIVE:To study the effect of Lichong decoction(LD) on expression of matrix metalloproteinase-2(MMP-2) and metalloproteinase-2(TIMP-2) in a rat model of uterine leiomyoma(UL).METHODS:UL was induced in rats using exogenous estrogen and progesterone.LD was administered(p.o.) for 4 weeks,and mifepristone(RU-486)used as a control.To observe the effect of LD on the uterine coefficient and uterine transverse diameter,a radioimmunoassay method was used to detect serum levels of sex hormones.Light microscopic analyses of pathologic changes in the tissues of UL rats were evaluated.Expression of the proteins of matrix metalloproteinases(MMPs) and tissue inhibitors of metalloproteinases(TIMPs) in uterine tissues was assessed by immunohistochemical staining and western blotting.RESULTS:A UL model in rats was established successfully.LD reduced uterine weight,uterine coefficient,and uterine transverse diameter compared with untreated controls.LD reduced levels of estradiol,progesterone,follicle-stimulating hormone,and luteinizing hormone in our UL models.LD improved the pathologic condition of uterine muscle.Expression of MMP-2 protein decreased to varying extents in LD-treated groups,but TIMP-2 levels were enhanced.LD appears to reduce MMP-2 expression and increase TIMP-2 expression in UL tissue.CONCLUSION:These data suggest that the mechanism of action of LD on ULs may involve reduction of MMP-2 expression and increase in TIMP-2 expression in rats. | Wang Yasong Li Donghua Xu Xin Qian Ruiya Zhang Yalan Huang Yuhua Geng Jianguo Zou Xiaoli Han Hon-gjuan Zhang Wufang | 2016 | Journal of Traditional Chinese Medicine2016，36，4： | 12 |
| 17 | Pharmacokinetic and metabolomic analyses of the neuroprotective effects of salvianolic acid A in a rat ischemic stroke model显示文摘 | Si-qi FENG Nan AA Jian-liang GENG Jing-qiu HUANG Run-bin SUN Chun GE Zhi-jian YANG Lian-sheng WANG Ji-ye AA Guang-ji WANG | 2017 | Acta Pharmacologica Sinica2017，38，11： | 12 |
| 18 | Diagnosis and Differential Diagnosis of Desmoplastic Fibroblastoma by Clinical, Radiological, and Histopathological Analyses显示文摘 | Li-Hua Gong Wei-Feng Liu Yi Ding Yue-Hang Geng Xiao-Qi Sun Xiao-Yuan Huang | 2018 | Chinese Medical Journal2018，，1： | 12 |
| 19 | OsRFPH2-10, a RING-H2 Finger E3 Ubiquitin Ligase, Is Involved in Rice Antiviral Defense in the Early Stages of Rice dwarf virus Infection显示文摘 | Lifang Liu Lian Jin Xiahe Huang Yongtao Geng Feng Li Qingqing Qin Rui Wang Shaoyi Ji Shanshan Zhao Qi Xie Chunhong Wei Can Xie Biao Ding Yi Li | 2014 | Molecular Plant2014，7，6： | 11 |
| 20 | First mass measurement of short-lived nuclides at HIRFL-CSR显示文摘Recent commissioning of the HIRFL-CSR has demonstrated its ability to perform direct mass measurement for short-lived nuclides. Projectile fragments produced by the 78Kr ions at 481.88 MeV/u were separated with the new radioactive beam line in Lanzhou (RIBLL2), and injected into and stored in the experimental storage ring (CSRe). By operating the CSRe as an isochronous mass spectrometry, a typical mass resolution around 2.0×10?5 has been achieved. The masses for 63Ge, 65As and 67Se were measured for the first time. The measured masses are compared with theoretical predictions and the location of the proton drip-line for As isotopes is discussed. The implication of the 65As mass in the astrophysical rapid proton capture process has also been addressed. | XU HuShan TU XiaoLin YUAN YouJin XIA JiaWen ZANG YongDong WANG Meng MAO RuiShi HU ZhengGuo MEI Bo SHUAI Peng ZHU ZhiChao TANG ShuWen GENG Peng LIU Yong ZHAO TieCheng ZHANG XueYing YANG JianCheng MAO LiJun ZHANG YuHu ZHOU XiaoHong HUANG WenXue XIAO GuoQing ZHAO HongWei ZHAN WenLong | 2009 | Chinese Science Bulletin2009，54，24： | 11 |
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