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| 1 | The adult human testis transcriptional cell atlas显示文摘Human adult spermatogenesis balances spermatogonial stem cell (SSC) self-renewal and differentiation,alongside complex germ cell-niche interactions,to ensure long-term fertility and faithful genome propagation. Here,we performed single-cell RNA sequencing of -6500 testicular cells from young adults. We found five niche/somatic cell types (Leydig,myoid,Sertoli,endothelial,macrophage),and observed germline-niche interactions and key human-mouse differences. Spermatogenesis,including meiosis,was reconstructed computationally,revealing sequential coding,non-coding,and repeat-element transcriptional signatures. Interestingly,we identified five discrete transcriptional/developmental spermatogonial states,including a novel early SSC state,termed State 0. Epigenetic features and nascent transcription analyses suggested developmental plasticity within spermatogonial States. To understand the or丨gin of State 0,we profiled testicular cells from infants,and identified distinct similarities between adult State 0 and infant SSCs. Overall,our datasets describe key transcriptional and epigenetic signatures of the normal adult human testis,and provide new insights into germ cell developmental transitions and plasticity. | Jingtao Guo Edward J. Grow Hana Mlcochova Geoffrey J. Maher Cecilia Lindskog Xichen Nie Yixuan Guo Yodai Takei Jina Yun Long Cai Robin Kim Douglas T. Carrell Anne Goriely James M. Hotaling Bradley R. Cairns | 2018 | Cell Research2018，28，12： | 12 |
| 2 | Primary energy congestion of power systems显示文摘Primary energy has the potential to bring challenges to the reliability,economic,and eco-friendliness of global electric power systems.The concept of electric power security are proposed,including many factors that are not considered in power system reliability analysis,such as coal supply for power system,fuel price for electricity power market,carbon emissions of power generation,and so on.It is broader than power system reliability and security,which means that providing energy in the form of reliable,economical,and eco-friendly electric power.Following an account of existing blackout defence methods and systems,the processes of transforming various kinds of primary energy into electric power and the interactions between them are described,particularly with regard to flows of energy,capital,and information.Factors that limit the liquidity of these flows are defined as“generalized congestion”,and the challenges presented by primary energy are named“primary energy congestion”.China’s dilemma on coal supply for power generation is presented in some detail as an example of primary energy congestion.To cope with impacts of the primary energy on electric power systems,an idea is introduced to extend the scope of existing coordinated blackout defence systems to account for primary energy,which would lead to an integrated tool to provide decision support to power system operators accounting for primary energy congestion. | Yusheng XUE Bin CAI Geoffrey JAMES Zhaoyang DONG Fushuan WEN Feng XUE | 2014 | Journal of Modern Power Systems and Clean Energy2014，2，1： | 6 |
| 3 | Low virological response and high relapse rates in hepatitis C genotype 1 patients with advanced fibrosis despite adequate therapeutic dosing显示文摘 | Wendy S.C. Cheng Stuart K. Roberts Geoffrey McCaughan William Sievert Martin Weltman Darrell Crawford William Rawlinson Philippa S. Marks James Thommes Bishoy Rizkalla Motoko Yoshihara Gregory J Dore | 2010 | Journal of Hepatology2010，，4： | 2 |
| 4 | Targeting the Human Microbiome With Antibiotics, Probiotics, and Prebiotics: Gastroenterology Enters the Metagenomics Era显示文摘 | Geoffrey A. Preidis James Versalovic | 2009 | Gastroenterology2009，，6： | 2 |
| 5 | A multicenter, double-blind, one-year study comparing safety and efficacy of atorvastatin versus simvastatin in patients witb hypercholesterolemia显示文摘 | Anthony Dart George Jerums Geoffrey Nicholson Michael d’Emden Ian Hamilton-Craig George Tallis James Best Malcolm West David Sullivan Peter Braes Donald Black | 1997 | The American Journal of Cardiology1997，，： | 2 |
| 6 | Insulin resistance is associated with chronic hepatitis C and virus infection fibrosis progression显示文摘 | Jason M Hui Archana Sud Geoffrey C Farrell Priyanka Bandara Karen Byth James G Kench Geoffrey W McCaughan Jacob George | 2003 | Gastroenterology2003，，6： | 2 |
| 7 | Reporting standards for endovascular aortic aneurysm repair显示文摘 | Elliot L. Chaikof Jan D. Blankensteijn Peter L. Harris Geoffrey H. White Christopher K. Zarins Victor M. Bernhard Jon S. Matsumura James May Frank J. Veith Mark F. Fillinger Robert B. Rutherford K.Craig Kent | 2002 | Journal of Vascular Surgery2002，，： | 2 |
| 8 | An interna for the determination of puri fled microcystin-LR and microcystins in cyanobacterial field material显示文摘 | JUTTA F GEOFFREY A C tional intercomparison exercise JAMES S | 2002 | Anal Bioanal Chem2002，374，： | 1 |
| 9 | Association of fibrinogen with cardlo-vasocular risk factors and cardiovascular disease in the framingham off- spring population显示文摘 | James JS Halit S Geoffrey HT et el | 2000 | Circulation2000，102，： | 1 |
| 10 | The impact of uterine artery emboli- zation on ovarian function显示文摘 | Geoffrey RK James BS | 2013 | Journal of Vascular and Iner- ventional Radiology2013，4，24： | 1 |
| 11 | Trends in worker hearing loss by industry sector, 1981–2010显示文摘 | Elizabeth A. Masterson James A. Deddens Christa L. Themann Stephen Bertke Geoffrey M. Calvert | 2015 | Am. J. Ind. Med2015，，4： | 1 |
| 12 | Association of fibrinogen with cardio-vascular risk factors and cardiovascular disease in the framingham off- spring populatlon显示文摘 | James JS Halit S Geoffrey HT | 2000 | Circulation2000，102，： | 1 |
| 13 | ACCF/SCCT/ACR/AHA/ASE/ASNC/NASCI/SCAI/SCMR 2010 Appropriate Use Criteria for Cardiac Computed Tomography显示文摘 | Allen J. Taylor Manuel Cerqueira John McB. Hodgson Daniel Mark James Min Patrick O’Gara Geoffrey D. Rubin | 2010 | Journal of the American College of Cardiology2010，，22： | 1 |
| 14 | A Mitochondria-Targeted Macrocyclic Mn(II) Superoxide Dismutase Mimetic显示文摘 | Geoffrey F. Kelso Andrej Maroz Helena M. Cochemé Angela Logan Tracy A. Prime Alexander V. Peskin Christine C. Winterbourn Andrew M. James Meredith F. Ross Sally Brooker Carolyn M. Porteous Robert F. Anderson Michael P. Murphy Robin A.J. Smith | 2012 | Chemistry & Biology2012，，10： | 1 |
| 15 | Cyanobacterial toxins: risk management for health protection显示文摘 | Geoffrey A. Codd Louise F. Morrison James S. Metcalf | 2004 | Toxicology and Applied Pharmacology2004，，3： | 1 |
| 16 | Obesitygene variant and elite endurance performance显示文摘 | Moore Geoffrey E Shuldiner Alan R Zmuda J0seph M Ferrell Robert E Mccole Steve D Hagberg James M | 2001 | Metabolism Clinical and Experimental2001，50，12： | 1 |
| 17 | Biomedical applications of diamond-like carbon (DLC) coatings: A review显示文摘 | Geoffrey Dearnaley James H Arps | 2005 | Surface & Coatings Technology2005，200，7： | 1 |
| 18 | Lubricating Acrylic Syntans A Review of the Technology and Practical Applications显示文摘 | Anton EL A'mma James J Hodder Geoffrey J Ward | 2002 | JALACA2002，，： | 1 |
| 19 | Unusual complication after laser in situ keratomileusis: Eyelash under the flap显示文摘 | James Chuan-Hsin Pan Geoffrey James Crawford | 2007 | Journal of Cataract & Refractive Surgery2007，，3： | 1 |
| 20 | Association of fibrinogen with ardiovascular risk factors and cardiovascular disease in the framing am offspring-population显示文摘 | James JS Halit S Geoffrey HT | 2000 | Circulation2000，102，： | 1 |
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