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| 1 | Assessment of disease progression in patients with transfusion-associated chronic hepatitis C using transient elastography显示文摘AIM:To evaluate the relationship between liver stiffness and duration of infection in blood transfusion-associated hepatitis C virus (HCV) patients with or without hepatocellular carcinoma (HCC).METHODS:Between December 2006 and June 2008,a total of 524 transfusion-associated HCV-RNA positive patients with or without HCC were enrolled.Liver stiffness was obtained noninvasively by using Fibroscan (Echosens,Paris,France).The date of blood transfusion was obtained by interview.Duration of infection was derived from the interval between the date of bloodtransfusion and the date of liver stiffness measurement (LSM).Patients were stratified into four groups based on the duration of infection (17-29 years;30-39 years;40-49 years;and 50-70 years).The difference in liver stiffness between patients with and without HCC was assessed in each group.Multiple linear regression analysis was used to determine the factors associated with liver stiffness.RESULTS:A total of 524 patients underwent LSM.Eight patients were excluded because of unsuccessful measurements.Thus 516 patients were included in the current analysis (225 with HCC and 291 without).The patients were 244 men and 272 women,with a mean age of 67.8 ± 9.5 years.The median liver stiffness was 14.3 kPa (25.8 in HCC group and 7.6 in nonHCC group).The patients who developed HCC in short duration of infection were male dominant,having lower platelet count,with a history of heavier alcohol consumption,showing higher liver stiffness,and receiving blood transfusion at an old age.Liver stiffness was positively correlated with duration of infection in patients without HCC (r=0.132,P=0.024) but not in patients with HCC (r=-0.103,P=0.123).Liver stiffness was significantly higher in patients with HCC than in those without in each duration group (P < 0.0001).The factors significantly associated with high liver stiffness in multiple regression were age at blood transfusion (P < 0.0001),duration of infection (P=0.0015),and heavy alcohol consumption (P=0.043) CONCLUSION:Although liver stiffness gradually increases over time,HCC develops in patients with high stiffness value regardless of the duration of infection. | Ryota Masuzaki Ryosuke Tateishi Haruhiko Yoshida Toru Arano Koji Uchino Kenichiro Enooku Eriko Goto Hayato Nakagawa Yoshinari Asaoka Yuji Kondo Tadashi Goto Hitoshi Ikeda Shuichiro Shiina Masao Omata Kazuhiko Koike | 2012 | World Journal of Gastroenterology2012，18，12： | 4 |
| 2 | Stronger inhibition of gastric acid secretion by lafutidine, a novel H_2 receptor antagonist, than by the proton pump inhibitor lansoprazole显示文摘AIM: To compare the antisecretory activity and plasma drug concentrations of a single oral dose of 10 mg lafutidine, a novel H2 receptor antagonist, with those of the proton pump inhibitor lansoprazole (LPZ) 30 mg. METHODS: Ten volunteers without H pylori infection participated in this crossover study comparing lafutidine 10 mg with LPZ 30 mg. Intragastric pH was monitored for 6 h in all participants, and blood samples were collected from four randomly selected individuals after single-dose administration of each drug. RESULTS: The median intragastric pH was significantly higher in individuals who received lafutidine 10 mg than in those who received LPZ 30 mg 2, 3, 4, 5, and 6 h after administration. Maximal plasma drug concentration was reached more promptly with lafutidine 10 mg than with LPZ 30 mg. CONCLUSION: In H pylori-negative individuals, gastric acid secretion is more markedly inhibited by lafutidinethan by LPZ. | Hatsushi Yamagishi Tomoyuki Koike Shuichi Ohara Toru Horii Ryousuke Kikuchi Shigeyuki Kobayashi Yasuhiko Abe Katsunori Iijima Akira Imatani Kaori Suzuki Takanori Hishinuma Junichi Goto Tooru Shimosegawa | 2008 | World Journal of Gastroenterology2008，14，15： | 3 |
| 3 | A phase I study of adoptive immunotherapy for recurrent non-small-cell lung cancer patients with autologous γδ T cells <sup>☆</sup> , <sup>☆☆</sup>显示文摘 | Jun Nakajima Tomohiro Murakawa Takeshi Fukami Shigenori Goto Toru Kaneko Yukihiro Yoshida Shinichi Takamoto Kazuhiro Kakimi | 2010 | European Journal of Cardio-Thoracic Surgery2010，，5： | 2 |
| 4 | Early effects of Lansoprazole orally disintegrating tablets on intragastric pH in CYP2C19 extensive metabolizers显示文摘AIM: To compare rabeprazole (RPZ; 10 mg) with Lansoprazole orally disintegrating tablets (LPZ; 30 mg OD) in terms of antisecretory activity and blood drug concentration after a single dose. METHODS: Eight H pylori-negative cytochrome P450 (CYP) 2C19 extensive metabolizers were assigned to receive a single oral dose of RPZ 10 mg or LPZ 30 mg OD. Twelve hour intragastric pH monitoring was perform- ed on the day of treatment. Blood samples were also collected after the administration of each drug. RESULTS: LPZ 30 mg OD induced a significantly earlier rise in blood drug concentration than RPZ 10 mg; consequently, LPZ 30 mg OD induced a significantly earlier rise in median pH in the third and fourth hours of the study. CONCLUSION: In H pylori-negative CYP2C19 extensive metabolizers, LPZ 30 mg OD induced a significantly faster inhibition of gastric acid secretion than RPZ 10 mg. | Hatsushi Yamagishi Tomoyuki Koike Shuichi Ohara Toru Horii Ryousuke Kikuchi Shigeyuki Kobayashi Yasuhiko Abe Katsunori Iijima Akira Imatani Kaori Suzuki Takanori Hishinuma Junichi Goto Tooru Shimosegawa | 2008 | World Journal of Gastroenterology2008，14，13： | 2 |
| 5 | Nondestructive evaluation of temper embrittlement in Cr-Mo-V rotor steels显示文摘 | Yoshikuni Kadoya Toru Goto Mao Takei | 1992 | JSME International Journal1992，35，2： | 1 |
| 6 | No - ndestructive evaluation of temper embrittlement in Cr- Mo - V rotor steel显示文摘 | Kadoya Yoshikuni Goto Toru Takei Mao | 1991 | American Society of Mechanical Engineers Power Division (Publication) PWR v13 Design Repair and Refurbishment of Steam Turbines1991，1991，： | 1 |
| 7 | Pathogenesis of lipid metabolism disorder in hepatitis C: Polyunsaturated fatty acids counteract lipid alterations induced by the core protein显示文摘 | Hideyuki Miyoshi Kyoji Moriya Takeya Tsutsumi Seiko Shinzawa Hajime Fujie Yoshizumi Shintani Hidetake Fujinaga Koji Goto Toru Todoroki Tetsuro Suzuki Tatsuo Miyamura Yoshiharu Matsuura Hiroshi Yotsuyanagi Kazuhiko Koike | 2010 | Journal of Hepatology2010，，3： | 1 |
| 8 | A study on NDE method of thermal aging of cast duplex stainless steels 显示文摘 | Toru Goto Takeshi Naito Takasi Yamaoka | 1998 | Nuclear Engineering and Design1998，182，2： | 1 |
| 9 | Nondestructive evaluation of temper embrittlement in Cr-Mo-V rotor steels 显示文摘 | Yoshikuni Kadoya Toru Goto Mao Takei | 1992 | JSME International Journal1992，35，2： | 1 |
| 10 | Nondestructive Evaluation of Temper Embrittlement in Cr-Mo-V Rotor Steels显示文摘 | Yoshikuni Kadoya Toru Goto Mao Takei | 1992 | JSME International Journal1992，35，2： | 1 |
| 11 | Methylene blue sensitized dichromated gelatin holograms:influence of the moisture on their exposure and diffraction efficiency显示文摘 | Toru Mizuno Tsukasa Goto Masayuki Goto | 1990 | Appl Opt1990，29，32： | 1 |
| 12 | Impaired and imbalanced cellular immunological status assessed in advanced cancer patients and restoration of the T cell immune status by adoptive T-cell immunotherapy显示文摘 | Atsutaka Noguchi Toru Kaneko Keiko Naitoh Masashi Saito Kazuro Iwai Ryuji Maekawa Takashi Kamigaki Shigenori Goto | 2014 | International Immunopharmacology2014，，1： | 1 |
| 13 | A study on NDE method of thermal aging of cast duplex stainless steels显示文摘 | Toru Goto Takeshi Naito Takasi Yamaoka | 1998 | Nuclear Engineering and Design1998，182，： | 1 |
| 14 | Extended survival observed in adoptive activated T lymphocyte immunotherapy for advanced lung cancer: results of a multicenter historical cohort study显示文摘 | Kazuro Iwai Kenzo Soejima Shoji Kudoh Yoshimasa Umezato Toru Kaneko Kouji Yoshimori Hitoshi Tokuda Tetsuo Yamaguchi Akira Mizoo Yasuhiro Setoguchi Takashi Kamigaki Katsunada Fujimoto Shigenori Goto | 2012 | Cancer Immunology Immunotherapy2012，，10： | 1 |
| 15 | Nondestructive evaluation of temper embrittlement in Cr-Mo-V rotor steel显示文摘 | Yoshikuni KADOYA Toru GOTO Mao TAKEI | 1992 | JSME International Journal1992，35，2： | 1 |
| 16 | Highly efficient electro-gene therapy of solid tumor by using an expression plasmid for the herpes simplex virus thymidine kinase gene显示文摘 | Tomoaki Goto Toru Nishi Takahiko Tamura | 2000 | Proc Natl Acad Sci U S A2000，97，1： | 1 |
| 17 | Development of the aluminium alloy bearing with higher wear resistance显示文摘 | Toru Desaki Yesauaki Goto | 2000 | JSAE Review2000，，21： | 1 |
| 18 | A high efficiency thin film silicon solar cell and module显示文摘 | Kenji Yamamoto Akihiko Nakajima Masashi Yoshimi Toru Sawada Susumu Fukuda Takashi Suezaki Mitsuru Ichikawa Yohei Koi Masahiro Goto Tomomi Meguro Takahiro Matsuda Masataka Kondo Toshiaki Sasaki Yuko Tawada | 2004 | Solar Energy2004，，6： | 1 |
| 19 | Zoledronate-activated Vγ9γδ T cell-based immunotherapy is feasible and restores the impairment of γδ T cells in patients with solid tumors显示文摘 | Atsutaka Noguchi Toru Kaneko Takashi Kamigaki Katsunada Fujimoto Masanori Ozawa Masashi Saito Naoko Ariyoshi Shigenori Goto | 2011 | Cytotherapy2011，，1： | 1 |
| 20 | No - nde - structive Evaluation of Temper Embrittlement in Cr - · Mo - · V Rotor Steel显示文摘 | KadoyaYoshikuni Goto Toru Takei Mao et aL | 1991 | American Society of Mechanical Engi - neers Power Division (Publication) PWR v13 Design Repair and Refurbishment of Steam Turbines1991，，： | 1 |
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