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| 1 | CT-maximum intensity projection is a clinically useful modality for the detection of gastric varices显示文摘AIM: To evaluate the efficacy of CT-maximum intensity projection (CT-MIP) in the detection of gastric varicesand their inflowing and outflowing vessels in patientswith gastric varices scheduled to undergo balloonoccluded retrograde transvenous obliteration (B-RTO). METHODS: Sixteen patients with endoscopicallyconfirmed gastric varices were included in this study. All patients were evaluated with CT-MIP using threedimensional reconstructions, before and after B-RTO. RESULTS: CT-MIP clearly depicted gastric varices in 16 patients (100%), the left gastric vein in 6 (32.5%),the posterior gastric vein in 12 (75.0%), the short gastric veins in 13 (81.3%), gastrorenal shunts in 16 (100%), the hemiazygos vein (HAZV) in 4 (25.0%), the pericardiophrenic vein (PCPV) in 9 (56.3%), and the left inferior phrenic vein in 9 patients (56.3%). Although flow direction itself cannot be determined from CT-MIP,this modality provided clear images of the inflowing and the outflowing vessels. Moreover, in one patient, short gastric veins were not seen on conventional angiographic portography images of the spleen, but were clearly revealed on CT-MIP,CONCLUSION: We suggest that CT-MIP should be considered as a routine method for detecting and diagnosing collateral veins in patients with gastric varices scheduled for B-RTO. Furthermore, CT-MIP is more useful than endoscopy in verifying the early therapeutic effects of B-RTO. | Toru Ishikawa Takashi Ushiki Ken-ichi Mizuno Tadayuki Togashi Kouji Watanabe Kei-ichi Seki Hironobu Ohta Toshiaki Yoshida Keiko Takeda Tomoteru Kamimura | 2005 | World Journal of Gastroenterology2005，11，47： | 13 |
| 2 | Factors correlating with acoustic radiation force impulse elastography in chronic hepatitis C显示文摘AIM: To investigate the factors other than fibrosis stage correlating with acoustic radiation force impulse(ARFI) elastograpy in chronic hepatitis C. METHODS: ARFI elastograpy was performed in 108 consecutive patients with chronic hepatitis C who underwent a liver biopsy. The proportion of fibrosis area in the biopsy specimens was measured by computerassisted morphometric image analysis. RESULTS: ARFI correlated significantly with fibrosis stage(β = 0.1865, P < 0.0001) and hyaluronic acid levels(β = 0.0008, P = 0.0039) in all patients by multiple regression analysis. Fibrosis area correlated significantly with ARFI by Spearman's rank correlation test but not by multiple regression analysis. ARFI correlated significantly with body mass index(BMI)(β =-0.0334, P = 0.0001) in F 0 or F 1, with γ-glutamyltranspeptidase levels(β = 0.0048, P = 0.0012) in F 2, and with fibrosis stage(β = 0.2921, P = 0.0044) and hyaluronic acid levels(β = 0.0012, P = 0.0025) in F 3 or F 4. The ARFI cutoff value was 1.28 m/s for F ≥ 2, 1.44 m/s for F ≥ 3, and 1.73 m/s for F 4. CONCLUSION: ARFI correlated with fibrosis stage and hyaluronic acid but not with inflammation. ARFI was affected by BMI, γ-glutamyltranspeptidase, and hyaluronic acid in each fibrosis stage. | Toru Nishikawa Senju Hashimoto Naoto Kawabe Masao Harata Yoshifumi Nitta Michihito Murao Takuji Nakano Yuko Mizuno Hiroaki Shimazaki Toshiki Kan Kazunori Nakaoka Yuka Takagawa Masashi Ohki Naohiro Ichino Keisuke Osakabe Kentaro Yoshioka | 2014 | World Journal of Gastroenterology2014，20，5： | 7 |
| 3 | Familial pancreatic cancer: Concept, management and issues显示文摘Familial pancreatic cancer (FPC) is broadly defined as two first-degree-relatives with pancreatic cancer (PC) and accounts for 4%-10% of PC. Several genetic syndromes, including Peutz-Jeghers syndrome, hereditary pancreatitis, hereditary breast-ovarian cancer syndrome(HBOC), Lynch syndrome, and familial adenomatous polyposis (FAP), also have increased risks of PC, but the narrowest definition of FPC excludes these known syndromes. When compared with other familial tumors, proven genetic alterations are limited to a small proportion (<20%) and the familial aggregation is usually modest. However, an ethnic deviation (Ashkenazi Jewish>Caucasian) and a younger onset are common also in FPC. In European countries, 'anticipation' is reported in FPC families, as with other hereditary syndromes; a trend toward younger age and worse prognosis is recognized in the late years. The resected pancreases of FPC kindred often show multiple pancreatic intraepithelial neoplasia (Pan IN) foci, with various K-ras mutations, similar to colorectal polyposis seen in the FAP patients. As with HBOC patients, a patient who is a BRCA mutation carrier with unresectable pancreatic cancer (accounting for 0%-19% of FPC patients) demonstrated better outcome following platinum and Poly (ADP-ribose) polymerase inhibitor treatment. Western countries have established FPC registries since the 1990 s and several surveillance projects for highrisk individuals are now ongoing to detect early PCs. Improvement in lifestyle habits, including non-smoking, is recommended for individuals at risk. In Japan, the FPC study group was initiated in 2013 and the Japanese FPC registry was established in 2014 by the Japan Pancreas Society. | Hiroyuki Matsubayashi Kyoichi Takaori Chigusa Morizane Hiroyuki Maguchi Masamichi Mizuma Hideaki Takahashi Keita Wada Hiroko Hosoi Shinichi Yachida Masami Suzuki Risa Usui Toru Furukawa Junji Furuse Takamitsu Sato Makoto Ueno Yoshimi Kiyozumi Susumu Hijioka Nobumasa Mizuno Takeshi Terashima Masaki Mizumoto Yuzo Kodama Masako Torishima Takahisa Kawaguchi Reiko Ashida Masayuki Kitano Keiji Hanada Masayuki Furukawa Ken Kawabe Yoshiyuki Majima Toru Shimosegawa | 2017 | World Journal of Gastroenterology2017，23，6： | 5 |
| 4 | Isolation and multilineage differentiation of bovine bone marrow mesenchymal stem cells显示文摘 | Darko Bosnakovski Morimichi Mizuno Gonhyung Kim Satoshi Takagi Masahiro Okumura Toru Fujinaga | 2005 | Cell and Tissue Research2005，，2： | 2 |
| 5 | Fabrication of nanostructured tool steel layer by combination of laser cladding and friction stir processing显示文摘 | Yoshiaki Morisada Hidetoshi Fujii Tadashi Mizuno Genryu Abe Toru Nagaoka Masao Fukusumi | 2010 | Surface & Coatings Technology2010，，11： | 1 |
| 6 | miR-210 promotes osteoblastic differentiation through inhibition of AcvR1b显示文摘 | Yosuke Mizuno Yoshimi Tokuzawa Yuichi Ninomiya Ken Yagi Yukiko Yatsuka-Kanesaki Tatsuo Suda Toru Fukuda Takenobu Katagiri Yasumitsu Kondoh Tomoyuki Amemiya Hideo Tashiro Yasushi Okazaki | 2009 | FEBS Letters2009，，13： | 1 |
| 7 | The possibility of delayed arterial healing 5 years after implantation of sirolimus-eluting stents: Serial observations by coronary angioscopy显示文摘 | Masanori Yamamoto Masamichi Takano Daisuke Murakami Toru Inami Nobuaki Kobayashi Sigenobu Inami Kentaro Okamatsu Takayoshi Ohba Chikao Ibuki Noritake Hata Yoshihiko Seino Ik-Kyung Jang Kyoichi Mizuno | 2011 | American Heart Journal2011，，6： | 1 |
| 8 | Methylene blue sensitized dichromated gelatin holograms:influence of the moisture on their exposure and diffraction efficiency显示文摘 | Toru Mizuno Tsukasa Goto Masayuki Goto | 1990 | Appl Opt1990，29，32： | 1 |
| 9 | Comparison of mesenchymal stem cells from adipose tissue and bone marrow for ischemic stroke therapy显示文摘 | Yuka Ikegame Kentaro Yamashita Shin-Ichiro Hayashi Hiroshi Mizuno Masahiro Tawada Fukka You Kiyofumi Yamada Yoshitaka Tanaka Yusuke Egashira Shigeru Nakashima Shin-Ichi Yoshimura Toru Iwama | 2011 | Cytotherapy2011，，6： | 1 |
| 10 | Isolation and multilineage differentiation of bovine bone marrow mesenchymal stem cells显示文摘 | Darko Bosnakovski Morimichi Mizuno Gonhyung Kim Satoshi Takagi Masahiro Okumura Toru Fujinaga | 2005 | Cell and Tissue Research2005，，2： | 1 |
| 11 | Prevalence of H elicobacter pylori Infection by Birth Year and Geographic Area in Japan显示文摘 | Junko Ueda Masahiko Gosho Yoshikatsu Inui Toru Matsuda Masatoshi Sakakibara Katsuhiro Mabe Shigemi Nakajima Tadashi Shimoyama Mitsugi Yasuda Takashi Kawai Kazunari Murakami Tomoari Kamada Motowo Mizuno Shogo Kikuchi Yingsong Lin Mototsugu Kato | 2014 | Helicobacter2014，，2： | 1 |
| 12 | Carbon dioxide insufflation is useful for obtaining clear images of the bile duct during peroral cholangioscopy (with video)显示文摘 | Toru Ueki Motowo Mizuno Shigeru Ota Tsuneyoshi Ogawa Hiroshi Matsushita Daisuke Uchida Norifumi Numata Asuka Ueda Yuuki Morimoto Yoko Kominami Shintaro Nanba Manabu Kurome Hirotoki Ohe Masahiro Nakagawa Yasuyuki Araki | 2010 | Gastrointestinal Endoscopy2010，，6： | 1 |
| 13 | High doses of dextromethorphan induced shock and convulsions in a 19-year-old female:A case report显示文摘BACKGROUND Dextromethorphan is a prevalent antitussive agent that can be easily obtained as an over-the-counter medication.There has been a growing number of reported cases of toxicity in recent years.Generally,there are numerous instances of mild symptoms,with only a limited number of reports of severe cases necessitating intensive care.We presented the case of a female who ingested 111 tablets of dextromethorphan,leading to shock and convulsions and requiring intensive care that ultimately saved her life.CASE SUMMARY A 19-year-old female was admitted to our hospital via ambulance,having overdosed on 111 tablets of dextromethorphan(15 mg)obtained through an online importer in a suicide attempt.The patient had a history of drug abuse and multiple self-inflicted injuries.At the time of admission,she exhibited symptoms of shock and altered consciousness.However,upon arrival at the hospital,the patient experienced recurrent generalized clonic convulsions and status epilepticus,necessitating tracheal intubation.The convulsions were determined to have been caused by decreased cerebral perfusion pressure secondary to shock,and noradrenaline was administered as a vasopressor.Gastric lavage and activated charcoal were also administered after intubation.Through systemic management in the intensive care unit,the patient’s condition stabilized,and the need for vasopressors ceased.The patient regained consciousness and was extubated.The patient was subsequently transferred to a psychiatric facility,as suicidal ideation persisted.CONCLUSION We report the first case of shock caused by an overdose of dextromethorphan. | Shintaro Shimozawa Daisuke Usuda Toru Sasaki Shiho Tsuge Riki Sakurai Kenji Kawai Shun Matsubara Risa Tanaka Makoto Suzuki Yuta Hotchi Shungo Tokunaga Ippei Osugi Risa Katou Sakurako Ito Suguru Asako Kentaro Mishima Akihiko Kondo Keiko Mizuno Hiroki Takami Takayuki Komatsu Jiro Oba Tomohisa Nomura Manabu Sugita | 2023 | World Journal of Clinical Cases2023，11，16： | 0 |
| 14 | Regression of hepatocellular carcinoma during vitamin K administration显示文摘An 85-year-old man with HCV infection and diabetes mellitus was diagnosed as having hepatocellular carcinoma (HCC, 13 cm in diameter) based on high serum alpha-fetoprotein (AFP),AFP-L3,and des-γ-carboxy prothrombin levels as well as typical enhancement pattern on contrast-enhanced CT. The patient did not receive any interventional treatments because of advanced age and the advanced stage of HCC.He chose to take vitamin K,which was reported to suppress the growth of HCC in vitro. Three months after starting vitamin K, all three tumor markers were normalized and HCC was markedly regressed, showing no enhancement in the early arterial phase on CT. Here we present the report describing the regression of HCC during the administration of vitamin K. | Kazuhiro Nouso Shuji Uematsu Kunihiro Shiraga Ryoichi Okamoto Ryo Harada Shoko Takayama Wakako Kawai Shigeru Kimura Toru Ueki Nobuaki Okano Masahiro Nakagawa Motowo Mizuno Yasuyuki Araki Yasushi Shiratori | 2005 | World Journal of Gastroenterology2005，11，42： | 0 |
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