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| 1 | Efficacy and safety of a novel anti-HER2 therapeutic antibody RC48 in patients with HER2-overexpressing,locally advanced or metastatic gastric or gastroesophageal junction cancer:a single-arm phase II study显示文摘Background:Current treatment options for human epidermal growth factor receptor 2(HER2)-overexpressing gastric cancer at third-line have shown limited clinical benefit.Further,there is no specific treatment for HER2 immunohistochemistry(IHC)2+and fluorescence in-situ hybridization-negative patients.Here,we report the efficacy and safety of a novel anti-HER2 antibody RC48 for patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer.Methods:Patients with HER2-overexpressing(IHC 2+or 3+),locally advanced or metastatic gastric or gastroesophageal junction cancer who were under at least second-line therapy were eligible and received RC482.5 mg/kg alone every 2 weeks.The primary endpoint was the objective response rate(ORR)assessed by an independent review committee.Secondary endpoints included progressionfree survival(PFS),overall survival(OS),duration of response,time to progression,disease control rate,and safety.Results:Of 179 patients screened,125 were eligible and received RC48 treatment.The ORR was 24.8%(95%confidence interval[CI]:17.5%-33.3%).The median PFS and OS were 4.1 months(95%CI:3.7-4.9 months)and 7.9 months(95%CI:6.7-9.9 months),respectively.The most frequently reported adverse events were decreased white blood cell count(53.6%),asthenia(53.6%),hair loss(53.6%),decreased neutrophil count(52.0%),anemia(49.6%),and increased aspartate aminotransferase level(43.2%).Serious adverse events(SAEs)occurred in 45(36.0%)patients,and RC48-related SAEs were mainly decreased neutrophil count(3.2%).Seven patients had adverse events that led to death were not RC48-related.Conclusions:RC48 showed promising activity with manageable safety,suggesting potential application in patients with HER2-overexpressing,advanced gastric or gastroesophageal junction cancer who have previously received at least two lines of chemotherapy. | Zhi Peng Tianshu Liu Jia Wei Airong Wang Yifu He Liuzhong Yang Xizhi Zhang Nanfeng Fan Suxia Luo Zhen Li Kangsheng Gu Jianwei Lu Jianming Xu Qingxia Fan Ruihua Xu Liangming Zhang Enxiao Li Yuping Sun Guohua Yu Chunmei Bai Yong Liu Jiangzheng Zeng Jieer Ying Xinjun Liang Nong Xu Chao Gao Yongqian Shu Dong Ma Guanghai Dai Shengmian Li Ting Deng Yuehong Cui Jianmin Fang Yi Ba Lin Shen | 2021 | Cancer Communications2021，41，11： | 29 |
| 2 | Cloning and functional characterization of Rht8,a“Green Revolution”replacement gene in wheat显示文摘Dear Editor,Wheat(Triticum aestivum)is a major staple crop in the world and provides~20%of the food calories for human consumption(Appels et al.,2018).During the 1960s and 1970s,the introduction of two semi-dwarfing genes Rht-B1b and Rht-D1b in wheat varieties strikingly improved lodging resistance and harvest index,and therefore substantially increased grain yield,resulting in the well-known'Green Revolution'(Peng et al.,1999).However,plants carrying Rht-B1b and Rht-D1b suffer from several drawbacks. | Hongchun Xiong Chunyun Zhou Meiyu Fu Huijun Guo Yongdun Xie Linshu Zhao Jiayu Gu Shirong Zhao Yuping Ding Yuting Li Jiazi Zhang Ke Wang Xuejun Li Luxiang Liu | 2022 | Molecular Plant2022，15，3： | 7 |
| 3 | Cooling effect of ballast revetment on the roadbed of Qinghai-Tibetan Railway显示文摘The data obtained through the roadbed surface thermal regime experiment (ROBSTREX), which was carried out at Beiluhe test section of Qinghai-Tibetan Railway from October to December in 2002, were used to estimate the cooling effect of ballast revetment on the roadbed. The results show that both riprap rock ballast revetment and crushed stone ballast revetment can reduce the temperature of the roadbed. But the cooling effect of riprap rock ballast revetment is better than that of crushed stone ballast revetment when the temperature of roadbed is higher. The cooling effect of crushed stone ballast revetment is better than that of riprap rock ballast revetment when the temperature of the roadbed is lower, especially at deeper roadbed layers. In the frozen season, the heat release from the roadbed also shows that the cooling effect of ballast revetment on the roadbed is obvious, and the cooling effect of crushed stone-ballast revetment on the roadbed is much evident than that of riprap rock ballast revetment. | HU Zeyong CHENG Guodong QIAN Zeyu WANG Jiemin WEI Guoan HOU Xuhong GU Lianglei YAN Yuping | 2004 | Science China Earth Sciences2004，47，z1： | 2 |
| 4 | Evaluation of the anti-inflammatory and analgesic properties of individual and combined extracts from Commiphora myrrha , and Boswellia carterii显示文摘 | Shulan Su Yongqing Hua Yanyan Wang Wei Gu Wei Zhou Jin-ao Duan Haifeng Jiang Ting Chen Yuping Tang | 2011 | Journal of Ethnopharmacology2011，，2： | 1 |
| 5 | Hydraulic considerations for compressed subsurface drip-tape 显示文摘 | Hills D J Tajrishy M Gu Yuping | 1989 | Transactions of the ASAE1989，32，4： | 1 |
| 6 | Lateral move water application uniformity relative to machine speed显示文摘 | David J H Gu Yuping James W | 1988 | Transactions of the ASAE1988，31，2： | 1 |
| 7 | Paclitaxel liposome for injection (Lipusu) plus cisplatin versus gemcitabine plus cisplatin in the first-line treatment of locally advanced or metastatic lung squamous cell carcinoma: A multicenter, randomized, open-label, parallel controlled clinical study显示文摘Background:Lipusu is the first commercialized liposomal formulation of pacli-taxel and has demonstrated promising efficacy against locally advanced lung squamous cell carcinoma(LSCC)in a small-scale study.Here,we conducted a multicenter,randomized,phase 3 study to compare the efficacy and safety of cis-platin plus Lipusu(LP)versus cisplatin plus gemcitabine(GP)as first-line treat-ment in locally advanced or metastatic LSCC.Methods:Patients enrolled were aged between 18 to 75 years,had locally advanced(clinical stage IIIB,ineligible for concurrent chemoradiation or surgery)or metastatic(Stage IV)LSCC,had no previous systemic chemother-apy and at least one measurable lesion as per the Response Evaluation Criteria in Solid Tumors(version 1.1)before administration of the trial drug.The primary endpoint was progression-free survival(PFS).The secondary endpoints included objective response rate(ORR),disease control rate(DCR),overall survival(OS),and safety profiles.To explore the possible predictive value of plasma cytokines for LP treatment,plasma samples were collected from the LP group at baseline and first efficacy evaluation time and were then subjected to analysis by 45-Plex ProcartaPlex Panel 1 to detect the presence of 45 cytokines using the Luminex xMAP technology.The correlation between treatment outcomes and dynamic changes in the levels of cytokines were evaluated in preliminary analyses.Results:The median duration of follow-up was 15.4 months.237 patients in the LP group and 253 patients in the GP group were included in the per protocol set(PPS).In the PPS,the median PFS was 5.2 months versus 5.5 months in the LP and GP group(hazard rtio[HR]:1.03,P=0.742)respectively.The median OS was 14.6 months versus 12.5 months in the LP and GP group(HR:0.83,P=0.215).The ORR(41.8%versus 45.9%,P=0.412)and DCR(90.3%versus 88.1%,P=0.443)were also similar between the LP and GP group.A significantly lower proportion of patients in the LP group experienced adverse events(AEs)leading to treatment interruptions(10.9%versus 26.4%,P<0.001)or treatment termination(14.3%versus 23.1%,P=0.011).The analysis of cytokine levels in the LP group showed that low baseline levels of 27 cytokines were associated with an increased ORR,and 15 cytokines were associated with improved PFS,with 14 cytokines,including TNF-a,IFN-y,IL-6,and IL-8,demonstrating an overlapping trend.Conclusion:The LP regimen demonstrated similar PFS,OS,ORR and DCR as the GP regimen for patients with locally advanced or metastatic LSCC but had more favorable toxicity profiles.The study also identified a spectrum of different cytokines that could be potentially associated with the clinical benefit in patients who received the LP regimen. | Jie Zhang Yueyin Pan Qin Shi Guojun Zhang Liyan Jiang Xiaorong Dong Kangsheng Gu Huijuan Wang Xiaochun Zhang Nong Yang Yuping Li Jianping Xiong Tienan Yi Min Peng Yong Song Yun Fan Jiuwei Cui Gongyan Chen Wei Tan Aimin Zang Qisen Guo Guangqiang Zhao Ziping Wang Jianxing He Wenxiu Yao Xiaohong Wu Kai Chen Xiaohua Hu Chunhong Hu Lu Yue Da Jiang Guangfa Wang Junfeng Liu Guohua Yu Junling Li Jianling Bai Wenmin Xie Weihong Zhao Lihong Wu Caicun Zhou | 2022 | Cancer Communications2022，42，1： | 1 |
| 8 | B7-H3 and B7-H4 expression in non-small-cell lung cancer显示文摘 | Yuping Sun Yunshan Wang Jianqiang Zhao Ming Gu Ricardo Giscombe Ann Kari Lefvert Xiongbiao Wang | 2006 | Lung Cancer2006，，2： | 1 |
| 9 | Preparation and properties of transparent zinc oxide /silicone nanocompos- ites for the packaging of high-power light-emitting diodes 显示文摘 | SUN Yuping GU Aijuan LIANG Guozheng | 2011 | Journal of Applied Polymer Science2011，121，4： | 1 |
| 10 | Study on microwave absorbing properties of carbonyl-iron composite coating based on PVC and AI sheet显示文摘 | Duan Yuping Wu Guangli Gu shucha e al | 2012 | Applied Surface Science2012，258，15： | 1 |
| 11 | Hydraulic considerations for compressed subsurface drip-tape显示文摘 | Hills David J Tajrishy Masoud A M Gu Yuping | 1989 | Transactions of the ASAE1989，32，4： | 1 |
| 12 | Network Modeling and Operation Optimization of Electricity-HCNG-Integrated Energy System显示文摘Hydrogen-enriched compressed natural gas(HCNG)has great potential for renewable energy and hydrogen utilization.However,injecting hydrogen into the natural gas network will change original fluid dynamics and complicate compressed gas's physical properties,threatening operational safety of the electricity-HCNG-integrated energy system(E-HCNG-IES).To resolve such problem,this paper investigates effect of HCNG on gas network dynamics and presents an improved HCNG network model,which embodies the influence of blending hydrogen on the pressure drop equation and line pack equation.In addition,an optimal dispatch model for the E-HCNG-IES,considering the“production-storage-blending-transportation-utilization”link of the HCNG supply chain,is also proposed.The dispatch model is converted into a mixed-integer second-order conic programming(MISOCP)problem using the second-order cone(SOC)relaxation and piecewise linearization techniques.An iterative algorithm is proposed based on the convex-concave procedure and bound-tightening method to obtain a tight solution.Finally,the proposed methodology is evaluated through two E-HCNGIES numerical testbeds with different hydrogen volume fractions.Detailed operation analysis reveals that E-HCNG-IES can benefit from economic and environmental improvement with increased hydrogen volume fraction,despite declining energy delivery capacityand line pack flexibility. | Yue Qiu Suyang Zhou Wei Gu Yuping Lu Xiao-Ping Zhang Gaoyan Han Kang Zhang Hongkun Lyu | 2023 | CSEE Journal of Power and Energy Systems2023，9，4： | 0 |
| 13 | 微灌周期对盐碱地西葫芦产量的影响显示文摘一、试验步骤 该项试验在加利福尼亚的戴维斯进行。时间是1985~1987年。试区面积500m^2。土质为较好的壤土,这种土壤的水分特性(体积含水量)是:凋萎系数16%,田间持水率36%,饱和含水率59%。土层厚,排水条件较好。 | David J Hills Amir Mansoubi Yuping Gu James W Rumsey 王力刚 郑跃泉 | 1990 | 灌溉排水1990，9，3： | 0 |
| 14 | Multi-stage Co-planning Model for Power Distribution System and Hydrogen Energy System Under Uncertainties显示文摘The increased deployment of electricity-based hydrogen production strengthens the coupling of power distribution system(PDS)and hydrogen energy system(HES).Considering that power to hydrogen(PtH)has great potential to facilitate the usage of renewable energy sources(RESs),the coordination of PDS and HES is important for planning purposes under high RES penetration.To this end,this paper proposes a multi-stage co-planning model for the PDS and HES.For the PDS,investment decisions on network assets and RES are optimized to supply the growing electric load and PtHs.For the HES,capacities of PtHs and hydrogen storages(HSs)are optimally determined to satisfy hydrogen load considering the hydrogen production,tube trailer transportation,and storage constraints.The overall planning problem is formulated as a multistage stochastic optimization model,in which the investment decisions are sequentially made as the uncertainties of electric and hydrogen load growth states are revealed gradually over periods.Case studies validate that the proposed co-planning model can reduce the total planning cost,promote RES consumption,and obtain more flexible decisions under long-term load growth uncertainties. | Qirun Sun Zhi Wu Wei Gu Pengxiang Liu Jingxuan Wang Yuping Lu Shu Zheng Jingtao Zhao | 2023 | Journal of Modern Power Systems and Clean Energy2023，11，1： | 0 |
| 15 | Discovery of Cladonema multiramosum sp.nov.(Cnidaria:Hydrozoa:Cladonematidae)using DNA barcoding and life cycle analyses显示文摘In contrast to typical planktonic hydromedusae,Cladonema medusae are mostly benthic,with specialised adhesive branches to adhere to the substrate.In this study,a Cladonema species discovered in a laboratory aquarium in Fuzhou,China,was confirmed as a new species,based on morphological and molecular analyses.The species was named Cladonema multiramosum sp.nov.Its medusa is distinct from that of congeners possessing substantially more adhesive branches(8-24,rarely 5-7),and tiny branches on the upper radial canals.The validity of C.multiramosumum sp.nov.was also supported by molecular phylogenetic analyses based on the mitochondrial 16S rDNA sequence.However,C.multiramosum sp.nov.medusa also displayed considerable phenotypic plasticity with respect to its radial canals,tentacles,stinging branches per tentacle,oral tentacles,manubrium,and gonads,hindering species identification based solely on morphology.Although some morphological characteristics of hydroids(filiform tentacles and medusa buds)and nematocysts could also be used as diagnostic characters in the genus Cladonema,this information is unavailable for some Cladonema species.Thus,the taxonomy within the genus Cladonema was re-evaluated based mainly on the morphological characteristics of the medusa.Further revision of the genus Cladonema should be made when supplementary information on the life cycle and DNA barcoding are updated. | Konglin Zhou Yuping Gu Lu Wang Jianming Chen | 2022 | Acta Oceanologica Sinica2022，41，3： | 0 |
| 16 | Effect of bilayer number on the photoluminescent property of TPE-based self-assembled film显示文摘Tetraphenylethylene (TPE) derivatives have been proved to be typical aggregation-induced emission (AIE) luminogens when they were aggregated in the free three-dimensional space. In order to reveal the effect of the dimensional degree on AIE property of TPEs, we utilized tetra(4-hydroxyphenyl)ethylene (TPE-4OH) and 1,4-benzenediamine diazonium salt (BD) to fabricate the ultrathin films (TPE-4OH/BD LBL SA film) through layer-by-layer self-assembled technique. The interaction between TPE-4OH and BD in the films was converted from electrostatic force and hydrogen-bond to covalent bonds through photodecomposition of diazonium groups under UV irradiation. Fluorescence emission spectroscopy, UV-Vis absorption spectroscopy and atomic force microscope were carried out to evaluate the relationship between bilayer number and photoluminescence of the TPE-based self-assembled films. The experimental results showed that the TPE-based film with three bilayers only displayed AIE character, whereas the fluorescence of the film became randomly changed if the bilayer number was above three. It is supposed that the fluorescence property of the TPE-4OH/BD LBL SA film with limited molecular length in z-axis and infinite aggregation space in x-and y-axis is dominated by two competitive effects, one is the partial restriction of intramolecular rotation through short inter-molecular interactions in cross-linked structure of TPE-4OH/BD, and the other is deactivation of its excited state through unrestricted intramolecular rotations or π-π interactions. | CHEN DiDi FENG Xiao GU ShangZhi TONG Bin SHI JianBing ZHI JunGe DONG YuPing | 2013 | Chinese Science Bulletin2013，58，22： | 0 |
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