|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Programmed Death Ligand-1 on Microglia Regulates Th1 Differentiation via Nitric Oxide in Experimental Autoimmune Encephalomyelitis显示文摘Microglia are considered to be potential antigen-presenting cells and have the ability to present antigen under pathological conditions. Nevertheless, whether and how microglia are involved in immune regulation are largely unknown. Here, we investigated the suppressive activity of microglia during experimental autoimmune encephalomyelitis(EAE) induced by myelin oligodendrocyte glycoprotein, with the goal of understanding their role in regulating the T cell reaction. Using flow cytometric analysis, we found that microglia were characterized by increased cell number and up-regulated programmed death ligand-1(PD-L1) at the peak phase of EAE. Meanwhile,both the CD^(4+)T cells and microglia that infiltrated the central nervous system expressed higher levels of PD1, the receptor for PD-L1, accompanied by a decline of Th1 cells.In an ex vivo co-culture system, microglia from EAE mice inhibited the proliferation of antigen-specific CD^(4+)T cells and the differentiation of Th1 cells, and this was significantly inhibited by PD-L1 blockade. Further,microglia suppressed Th1 cells via nitric oxide(NO), the production of which was dependent on PD-L1. Thus, these data suggest a scenario in which microglia are involved in the regulation of EAE by suppressing Th1-cell differentiation via the PD-L1-NO pathway. | Jingxia Hu Hao He Zhengang Yang Guangming Zhu Li Kang Xiuli Jing Hai Lu Wengang Song Bo Bai Hua Tang | 2016 | Neuroscience Bulletin2016，32，1： | 9 |
| 2 | Chinese expert consensus on conversion therapy for hepatocellular carcinoma(2021 edition)显示文摘Recent advances in systemic and locoregional treatments for patients with unresectable or advanced hepatocellular carcinoma(HCC)have resulted in improved response rates.This has provided an opportunity for selected patients with initially unresectable HCC to achieve adequate tumor downstaging to undergo surgical resection,a‘conversion therapy’strategy.However,conversion therapy is a new approach to the treatment of HCC and its practice and treatment protocols are still being developed.Review the evidence for conversion therapy in HCC and develop consensus statements to guide clinical practice.Evidence review:Many research centers in China have accumulated significant experience implementing HCC conversion therapy.Preliminary findings and data have shown that conversion therapy represents an important strategy to maximize the survival of selected patients with intermediate stage to advanced HCC;however,there are still many urgent clinical and scientific challenges for this therapeutic strategy and its related fields.In order to summarize and learn from past experience and review current challenges,the Chinese Expert Consensus on Conversion Therapy for Hepatocellular Carcinoma(2021 Edition)was developed based on a review of preliminary experience and clinical data from Chinese and non-Chinese studies in this field and combined with recommendations for clinical practice.Sixteen consensus statements on the implementation of conversion therapy for HCC were developed.The statements generated in this review are based on a review of clinical evidence and real clinical experience and will help guide future progress in conversion therapy for patients with HCC. | Hui-Chuan Sun Jian Zhou Zheng Wang Xiufeng Liu Qing Xie Weidong Jia Ming Zhao Xinyu Bi Gong Li Xueli Bai Yuan Ji Li Xu Xiao-Dong Zhu Dousheng Bai Yajin Chen Yongjun Chen Chaoliu Dai Rongping Guo Wenzhi Guo Chunyi Hao Tao Huang Zhiyong Huang Deyu Li Gang Li Tao Li Xiangcheng Li Guangming Li Xiao Liang Jingfeng Liu Fubao Liu Shichun Lu Zheng Lu Weifu Lv Yilei Mao Guoliang Shao Yinghong Shi Tianqiang Song Guang Tan Yunqiang Tang Kaishan Tao Chidan Wan Guangyi Wang Lu Wang Shunxiang Wang Tianfu Wen Baocai Xing Bangde Xiang Sheng Yan Dinghua Yang Guowen Yin Tao Yin Zhenyu Yin Zhengping Yu Bixiang Zhang Jialin Zhang Shuijun Zhang Ti Zhang Yamin Zhang Yubao Zhang Aibin Zhang Haitao Zhao Ledu Zhou Wu Zhang Zhenyu Zhu Shukui Qin Feng Shen Xiujun Cai Gaojun Teng Jianqiang Cai Minshan Chen Qiang Li Lianxin Liu Weilin Wang Tingbo Liang Jiahong Dong Xiaoping Chen Xuehao Wang Shusen Zheng Jia Fan 无 | 2022 | Hepatobiliary Surgery and Nutrition2022，11，2： | 4 |
| 3 | Subcellular distribution and chemical forms of cadmium in Bechmeria nivea (L.) Gaud.显示文摘 | Xin Wang Yunguo Liu Guangming Zeng Liyuan Chai Xiaochen Song Zongyi Min Xin Xiao | 2007 | Environmental and Experimental Botany2007，，3： | 2 |
| 4 | The analysis of genetic diversity and differentiation of six Chinese cattle populations using microsatellite markers显示文摘A total of 321 individuals from six cattle populations of four species in a bovine subfamily in China were studied using 12 pairs of mi- crosatellite markers. The genetic diversities within and between populations were calculated. The phylogenetic trees were constructed by (δμ) 2 and DA distances, and the divergence times between populations were estimated by (δμ) 2. Altogether, 144 microsatellite alleles were detected including 24 private alleles and nine shared alleles. Chinese Holstein had the largest number of private alleles (10), whereas, Bohai black and Buffalo had the smallest number of private alleles (2). Chinese Holstein showed the highest genetic variability. Its ob- served number of alleles (Na), mean effective number of alleles (MNA), and mean heterozygosity (He) were 7.7500, 4.9722, and 0.7719, respectively, whereas, the Buffalo and Yak showed low genetic variability. In the phylogenetic trees, Luxi and Holstein grouped first, followed by Bohai and Minnan. Yak branched next and buffalo emerged as the most divergent population from other cattle populations. Luxi and Bohai were estimated to have diverged 0.039-0.105 million years ago (MYA), however, buffalo and Holstein diverged 0.501-1.337 MYA. The divergence time of Yak versus Minnan, Holstein and buffalo was 0.136-0.363, 0.273-0.729, and 0.326-0.600 MYA, respectively. | Yongjiang Mao Hong Chang Zhangping Yang Liu Zhang Ming Xu Guobin Chang Wei Sun Guangming Song Dejun Ji | 2008 | Journal of Genetics and Genomics2008，35，1： | 2 |
| 5 | A Wireless Power Outlet System for Smart Homes 显示文摘 | SONG Guangming DING Fei ZHANG Weijuan | 2008 | IEEE Transactions on Consumer Electronics2008，54，4： | 1 |
| 6 | Anovel three - axis force sensor for advanced training ofshot - put athletes 显示文摘 | Guangming Song Hongyan Yuan Yi Tang | 2006 | Sensors and Actuators2006，，： | 1 |
| 7 | A wireless power outlet system for smart homes显示文摘 | Song Guangming Ding Fei Zhang Weijuan | 2008 | IEEE Transactions on Consumer Electronics2008，54，4： | 1 |
| 8 | Asmart node architecture for adding mobility to wireless sensornetworks显示文摘 | SONG Guangming ZHOU Yaoxin WEI Zhigang | 2008 | Sensors and Actuators A:Physical2008，147，1： | 1 |
| 9 | A GPS-enabled wireless sensor network for monitoring radioactive materials显示文摘 | Fei Ding Guangming Song Kaijian Yin | | 0，，： | 1 |
| 10 | A wireless power outlet system for smart homes显示文摘 | Guangming Song Fei Ding Weijuan Zhang | 2008 | IEEE transactions on consumer electronics2008，54，5： | 1 |
| 11 | Simultaneous Cr(VI) reduction and phenol degradation in pure cultures of Pseudomonas aeruginosa CCTCC AB91095显示文摘 | Huaxiao Song Yunguo Liu Weihua Xu Guangming Zeng Nuzaaiti Aibibu Li Xu Beibei Chen | 2009 | Bioresource Technology2009，，21： | 1 |
| 12 | Pedological characteristics of Mn mine tailings and metal accumulation by native plants显示文摘 | Xin Wang Yunguo Liu Guangming Zeng Liyuan Chai Xin Xiao Xiaochen Song Zongyi Min | 2008 | Chemosphere2008，，9： | 1 |
| 13 | Awire-less Power Outlet System for Smart Homes显示文摘 | Guangming song Fei Ding Weijuan Zhang | 2008 | IEEETransactions on Consumer Electronics2008，54，4： | 1 |
| 14 | Volatiles from Ficus hispida and their attractiveness to fig wasps显示文摘 | QISHI SONG DARONG YANG GUANGMING ZHANG | 2001 | Journal of Chemical Ecology2001，27，10： | 1 |
| 15 | Fabrication of Bi-Bi3O4Cl plasmon photocatalysts for removal of aqueous emerging contaminants under visible light显示文摘Photocatalytic oxidation of emerging contaminants(ECs) in water has recently gained extensive attentions. In this study, bismuth oxychloride-based plasmon photocatalysts(BiBiOCl) exhibiting high performance were successfully developed by reducing Bion the surface of BiOCl. Consequently, the photocatalysts were used to remove ECs from water.The effects of developmental process and Bi metal plasmon resonance on the photoelectric performances of Bi-BiOCl were investigated through a series of characterizations. The UV-vis diffuse reflection and photoluminescence spectra revealed that the light absorption range of the photocatalyst gradually increased and the electron recombination rate gradually decreased with the introduction of Bi metals. The optimal removal rates of ciprofloxacin and tetrabromobisphenol A by Bi-BiOCl were 93.8% and 96.4%;the respective reaction rate constants were 5.48 and 4.93 times higher than that of BiOCl. The mechanism study indicated that main reactants in the photocatalytic system were ·O-2radicals and photogenerated holes, and the existence of oxygen vacancies and Bi metals promoted electron transfer in photocatalyst. In conclusion, this research produces a novel, green, highly efficient, and stable visible light photocatalyst for the removal of ECs from water. | Zeqing Long Hui Song Guangming Zhang Jingsi Gao Jia Zhu | 2022 | Journal of Environmental Sciences2022，34，8： | 1 |
| 16 | A mobile sensor network system for monitoring of unfriendly environments显示文摘 | SONG Guangming ZHOU Yaoxin DING Fei | 2008 | Sensors2008，8，11： | 1 |
| 17 | Subcellular distribution and chemical forms of cadmium in Bechmeria nivea (L.) Gaud.显示文摘 | Xin Wang Yunguo Liu Guangming Zeng Liyuan Chai Xiaochen Song Zongyi Min Xin Xiao | 2007 | Environmental and Experimental Botany2007，，3： | 1 |
| 18 | Automation docking system for recharging home surveillance robots 显示文摘 | Guangming Song Hui Wang Jun Zhang | 2011 | IEEE Transaction Consumer Electronics2011，57，4： | 1 |
| 19 | In vivo skin penetration and metabolic path of quantum dots显示文摘The skin is the largest organ of the body and is a potential route of exposure to sunscreens and cosmetics containing nanoparticles;however,the permeability of the skin to these nanoparticles is currently unknown.In this paper,we studied the transdermal delivery capacity through mouse skin of water-soluble CdSeS quantum dots(QDs) and the deposition of these QDs in the body.QD solution was coated onto the dorsal hairless skin of male ICR mice.Fluorescence microscopy and transmission electron microscopy(TEM) were used to observe the distribution of QDs in the skin and organs,and inductively coupled plasma-mass spectrometry(ICP-MS) was used to measure the 111Cd content to indicate the concentration of QDs in plasma and organs.Experimental results indicate that QDs can penetrate into the dermal layer and are limited to the uppermost stratum corneum layers and the hair follicles.Through blood circulation,QDs deposit mostly in liver and kidney and are difficult to clear.111Cd concentration was greater than 14 ng g-1 in kidney after 120 h after 0.32 nmol QDs was applied to a mouse.These results suggest that QDs have in vivo transdermal delivery capacity through mouse skin and are harmful to the liver and kidney. | TANG Lei ZHANG ChunLing SONG GuangMing JIN Xun XU ZhongWei | 2013 | Science China(Life Sciences)2013，56，2： | 1 |
| 20 | A wireless power outlet system for smart homes显示文摘 | SONG Guangming DING Fei ZHANG Wei-juan | 2011 | IEEE Transactions on Consumer Electronics2011，54，4： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员