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| 1 | How is mRNA expression predictive for protein expression? A correlation study on human circulating monocytes显示文摘在学习 mRNA 表示的一个关键假设是它在蛋白质表示的预言是增进知识的。然而,仅仅有限的研究在酵母探索了 mRNA 蛋白质表示关联或人的纸巾和结果是相对不一致的。我们从 30 个无关的女人在刚孤立的人的传播单核白血球在 mRNA 蛋白质表情上执行了关联分析。为 71 基因的表示蛋白质被确定并且由结合的 2-D 电气泳动识别了集体 spectrometry。相应 mRNA 表达式被 Affymetrix 基因芯片确定。重要关联(r=0.235, P < 0.0001 ) 包括所有学习基因和所有样品为整个数据集被观察。关联在基因本体论的不同生物范畴变化了。例如,最高的关联以细胞的部件为细胞外的区域的基因被完成(r=0.643, P < 0.0001 ) 并且最低关联为规定的基因被获得(r=0.099, P=0.213 ) 以生物过程。在染色体,样品的一半证明为 71 基因的重要积极关联和重要关联在所有样品在平均 mRNA 和平均蛋白质表示层次之间被发现(r=0.296, P < 0.01 ) 。在学习组水平,然而,仅仅五学习基因越过所有样品有重要积极关联。我们的结果显示出在 mRNA 和蛋白质表示层次之间的全面积极关联。然而,中等、变化的关联建议那 mRNA 表情可能有时是有用的,但是远非当然在预言蛋白质表示层次完善。 | Yanfang Guo Peng Xiao Shufeng Lei Feiyan Deng Gary Guishan Xiao Yaozhong Liu Xiangding Chen Liming Li Shan Wu Yuan Chen Hui Jiang Lijun Tan Jingyun Xie Xuezhen Zhu Songping Liang Hongwen Deng | 2008 | Acta Biochimica et Biophysica Sinica2008，40，5： | 7 |
| 2 | Macrophages in immunoregulation and therapeutics显示文摘Macrophages exist in various tissues,several body cavities,and around mucosal surfaces and are a vital part of the innate immune system for host defense against many pathogens and cancers.Macrophages possess binary M1/M2 macrophage polarization settings,which perform a central role in an array of immune tasks via intrinsic signal cascades and,therefore,must be precisely regulated.Many crucial questions about macrophage signaling and immune modulation are yet to be uncovered.In addition,the clinical importance of tumor-associated macrophages is becoming more widely recognized as significant progress has been made in understanding their biology.Moreover,they are an integral part of the tumor microenvironment,playing a part in the regulation of a wide variety of processes including angiogenesis,extracellular matrix transformation,cancer cell proliferation,metastasis,immunosuppression,and resistance to chemotherapeutic and checkpoint blockade immunotherapies.Herein,we discuss immune regulation in macrophage polarization and signaling,mechanical stresses and modulation,metabolic signaling pathways,mitochondrial and transcriptional,and epigenetic regulation.Furthermore,we have broadly extended the understanding of macrophages in extracellular traps and the essential roles of autophagy and aging in regulating macrophage functions.Moreover,we discussed recent advances in macrophages-mediated immune regulation of autoimmune diseases and tumorigenesis.Lastly,we discussed targeted macrophage therapy to portray prospective targets for therapeutic strategies in health and diseases. | Shanze Chen Abdullah F.U.H.Saeed Quan Liu Qiong Jiang Haizhao Xu Gary Guishan Xiao Lang Rao Yanhong Duo | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 2 |
| 3 | Application of SrAl_2O_4:Eu^(2+) Down–conversion Powder in Flexible Dye–Sensitized Solar Cells显示文摘TiO2 nanotube(NT) was firstly prepared on titanium foil by an electrochemical anodization method, and then modified via subsequent deposition of a layer of SrAl2O4:Eu2+ phosphor embedded within TiO2 nanoparticles to fabricate photoanodes of dye–sensitized solar cells(DSSCs). The effect of doping down–conversion Sr Al2O4:Eu2+ phosphor in DSSCs was investigated. SrAl2O4:Eu2+ can effectively convert ultraviolet light to visible light within the range of the dye commonly used in DSSC to increase the photocurrent of DSSC, and enhance the open–circuit voltage by a p–type doping effect. When the ratio of Sr Al2O4:Eu2+ in the doping layer is optimized to be 1wt.%, the photoelectric conversion efficiency of the DSSC reaches 3.09%, which is increased by 38.6%, compared to that of the DSSC without Sr Al2O4:Eu2+ doping. | WANG Lijun LI Yueying HAO Hongshun GUO Weihua SU Qing JIN Shanshan QIN Lei GAO Wenyuan LIU Guishan HU Zhiqiang | 2015 | Journal of the Chinese Ceramic Society2015，，2： | 1 |
| 4 | Prediction of soluble solids content of jujube fruit using hyperspectral reflectance imaging 显示文摘 | He Jianguo Luo Yang Liu Guishan | 2012 | Advanced Materials Research2012，，： | 1 |
| 5 | Ran binding protein 9(RanBPM) binds IFN-λR1 in the IFN-λsignaling pathway显示文摘Like the type I interferons(IFNs),the recently discovered cytokine IFN-λ displays antiviral,antiproliferative,and proapoptotic activities,mediated by a heterodimeric IFN-λ receptor complex composed of a unique IFN-λR1 chain and the IL-10R2 chain.However,the molecular mechanism of the IFN-λ-regulated pathway remains unclear.In this study,we newly identified RAN-binding protein M(RanBPM) as a binding partner of IFN-λR1.The interaction between RanBPM and IFN-λRl was identified with a glutathione S-transferase pull-down assay and coimmunoprecipitation experiments.IFN-λ1 stimulates this interaction and affects the cellular distribution of RanBPM.However,the interaction between RanBPM and IFN-λR1 does not correlate with their conserved TRAF6-binding sites.Furthermore,we also found that RanBPM is a scaffolding protein with a modulatory function that regulates the activities of IFN-stimulated response elements.Therefore,RanBPM plays a novel role in the IFN-λ-regulated signaling pathway. | Junwen Zhang XiaojieCong Jiajie Zhaoqiao Xia Yang Meng Li Hong Chen Ruifang Mi Guishan Jin Fusheng Liu Bing-Ren Huang | 2017 | Science China(Life Sciences)2017，60，9： | 1 |
| 6 | Optical absorption and photoluminescence in Sm 3+ - and Eu 3+ -doped rare-earth borate glasses显示文摘 | Hai Lin Dianlai Yang Guishan Liu Tiecheng Ma Bin Zhai Qingda An Jiayou Yu Xiaojun Wang Xingren Liu Edwin Yue-Bun Pun | 2004 | Journal of Luminescence2004，，1： | 1 |
| 7 | Naringenin inhibits lipid accumulation by activating the AMPK pathway in vivo and in vitro显示文摘The aim of this study was to explore the lipid-lowering effect of naringenin and the underlying mechanism in high-fat-diet-fed SD rats and 3T3-L1 cells.In this study,SD rats were divided into the normal chow diet group(NCD),high fat diet group(HFD),three treatment groups feeding high-fat diet with naringenin(100,200,400 mg/kg)for 12 weeks.Results indicated that naringenin treatment decreased total cholesterol(TC),triglyceride(TG)and the non-high-density lipoprotein cholesterol(non-HDL-C)levels in serum.Naringenin also alleviated hepatic steatosis and reduced the adipocyte size in the epididymis in high-fat-diet-induced SD rats.In addition,naringenin(25−75μg/mL)decrease TG and TC levels in 3T3 mature adipocytes.The molecular mechanism of naringenin in the treatment of obesity were predicted by using network pharmacology.Real-time PCR analysis results showed that naringenin regulated the expression of lipid metabolism genes.Meanwhile,naringenin increased the AMPK(AMP-activated protein kinase)activity and the expression of AMPK phosphorylated protein in 3T3 mature adipocytes.And the inhibitory effect of naringenin on lipid accumulation in 3T3 adipocytes was abolished by Compound C.Molecular docking results indicated that naringenin could bind to AMPK protein.These results indicated naringenin reduced lipid accumulation through AMPK pathway. | Xiaoyu Cai Songxue Wang Huali Wang Suwen Liu Guishan Liu Huibin Chen Ji Kang Hao Wang | 2023 | Food Science and Human Wellness2023，12，4： | 0 |
| 8 | Berberine inhibits the proliferation of pancreatic cancer cells by targeting pancreatic cancer stem cells through regulating EMT signaling pathway显示文摘Pancreatic ductal adenocarcinoma(PDAC)is universally acknowledged as the cancer with the highest mortality rate.Berberine has high medicinal value and has been used as an anti-cancer agent.Hence the purpose of this study was to investigate the anti-cancer effect of berberine in PDAC.Berberine was shown to have a selective anti-cancer effect on PDAC by MTT assay in vitro.Pancreatic cancer stem cells(PCSCs),regulated by epithelial-mesenchymal transition(EMT),could promote the proliferation of PDAC cells.However,berberine suppressed the proliferation and stemness of PCSCs through immunofluorescence staining,stem cell sphere assays and so forth in vitro.In vivo,berberine reduced tumor size and decreased the expression levels of Ki67,a marker of cellular proliferation,in orthotopic pancreatic tumors.In addition,berberine inhibited the EMT signaling pathway by RT-PCR and Western blotting methods both in vitro and in vivo.Our study indicates that berberine inhibits the proliferation of PDAC cells both in vivo and in vitro.The mechanism of the anti-cancer effect of berberine likely involves the inhibition of EMT.Therefore,berberine may be a novel antineoplastic drug with clinical efficacy in PDAC. | MENGMENG LIU YUE PAN XUFENG TAO WENLI KANG YINGJIE LIU YONGJIE YANG GARY GUISHAN XIAO | 2022 | BIOCELL2022，46，10： | 0 |
| 9 | Synthesis of Copillar[5]arenes and Their Host-Guest Complexation with Two Types of Guests显示文摘A series of novel copillar[5]arenes 1a-1f containing different substituents were synthesized.And their com-plexation with two types of guests was investigated.For symmetrical guests,1,4-dibromobutane(DBB)could thread in the cavity of copillar[5]arenes to form inclusion complexes.But for the unsymmetrical guests,copillar-[5]arene 1f bearing 4-(naphthalen-1-yloxy)butoxy could not complex with sec-butyl iodide(SBI)and sec-butyl bromide(SBB)at all,while 1f showed weak interaction with sec-butylamine•HCl(SBA)outside the cavity.These results indicated that the modified group of copillar[5]arene and the symmetry of guest played an important role in the complexation model and selectivity. | Hongfei Huang Luzhi Liu Wengui Duan Yan Huang Guishan Lin | 2015 | Chinese Journal of Chemistry2015，33，3： | 0 |
| 10 | WC/Co_(7)Fe_(3)heterojunction embedded in N,P co-doped hierarchical carbon enables rechargeable/flexible Zn-air battery显示文摘Rational design and synthesis of bifunctional oxygen electrocatalysts with high activity and stability are key challenges in the development of rechargeable Zn-air batteries(ZABs).In this paper,tungsten carbide(WC)and Co_(7)Fe_(3)embedded in N,P co-doped hierarchical carbon(WC/Co_(7)Fe_(3)-NPHC)was prepared by using zeolite imidazolate frameworks as precursor.Density functional theory demonstrates that the mutual adjustment among the WC,Co_(7)Fe_(3),and N,P co-doped carbon at the three-phase heterojunction interface makes the catalyst possess moderate adsorption strength,and greatly improves the conductivity and electron transfer rate of the catalyst.As a result,the WC/Co_(7)Fe_(3)-NPHC exhibits a low overall oxygen redox potential difference of 0.72 V,while the ZAB assembled by WC/Co_(7)Fe_(3)-NPHC as an air cathode exhibits ultra-long cycle stability of over 550 h.Futhermore,WC/Co_(7)Fe_(3)-NPHC can keep good charge and discharge stability at different bending angles when applied to flexible solid ZAB. | Huimin Mao Xiaobin Liu Siqi Wu Yixin Fu Guishan Liu Guizhong Zhou Lei Wang | 2023 | Nano Research2023，16，2： | 0 |
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