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| 1 | Timing of the formation of the Tianhuashan Basin in northern Wuyi as constrained by geochronology of volcanic and plutonic rocks显示文摘The Tianhuashan Basin is one of the most important volcanic basins in the northern Wuyi,southeastern China,comprising two successive volcanic units,the Daguding Formation and the overlying Ehuling Formation,along with several small associated igneous intrusions.The Lengshuikeng super-large-scale Ag-Pb-Zn deposit,which is closely related to these volcanic-intrusive rocks,is located in the northwestern part of the basin.In order to understand the basin evolution and magmatism,we determined LA-ICP-MS U-Pb zircon ages for the volcanic successions and associated intrusive rocks.U-Pb zircon dating of volcanic units yielded precise ages of 144±1 Ma for crystal tuff in the lower member of the Daguding Formation,142±1 Ma for andesite within the upper member of the Daguding Formation,140±1 Ma for tuffite of the first(i.e.,lowermost) member of the Ehuling Formation,and 137±1 Ma for rhyolitic ignimbrite within the third volcano-stratigraphic member of the Ehuling Formation.Three types of intrusive igneous rocks(quartz syenite porphyry,K-feldspar granite porphyry,and rhyolite porphyry) yielded precise weighted mean 206 Pb/238 U ages of 144±1,140±1,and 140±1 Ma,respectively,suggesting that these intrusions along with the aforementioned volcanics were all emplaced during the Early Cretaceous.In addition,the weighted mean 206 Pb/238 U ages determined on zircon from two samples of a granite porphyry intrusion,which hosts ore mineralization of the Lengshuikeng Ag-Pb-Zn deposit,are 158±1 and 157±1 Ma,indicating emplacement in the Late Jurassic.These new geochronological results for igneous rocks of the Tianhuashan Basin constrain the timing of volcanic and plutonic activity in the basin,and have important implications for our understanding the tectonic history of the region,and for identifying metallogenic types and the timing of ore deposition of the Lengshuikeng deposit. | SU HuiMin MAO JingWen HE XiRong LU Ran | 2013 | Science China Earth Sciences2013，56，6： | 16 |
| 2 | TALEN-based generation of a cynomolgus monkey disease model for human microcephaly显示文摘基因在非人类的首领编辑可以为在人探索病原学和遗传上基于的神经病学的混乱的治疗学的策略导致珍贵模型。然而,仔细在人模仿病理学、行为的赤字的神经病学的混乱的一个猴子模型成功地还没被产生了。Microcephalin 1 (MCPH1 ) 在人的大脑,和智力迟钝伴随的 MCPH1 变化原因头小畸型的进化被含有。这里,我们产生了用抄写带 biallelic MCPH1 变化的一只 cynomolgus 猴子(Macaca fascicularis ) 像使活跃之物的受动器核酸酶。猴子概括了大多数在病人观察的重要临床的特征,包括在头圆周,早熟的染色体冷凝作用(PCC ) ,语料库 callosum 的发育不全和上面的手足 spasticity 的显著减小。而且,在变异的真皮的成纤维细胞的 MCPH1 的 overexpression 救了 PCC 症候群。这个猴子模型可以帮助我们阐明在人的头小畸型并且更好的致病的 MCPH1 的角色在首领大脑尺寸的进化理解这蛋白质的功能。 | Qiong Ke Weiqiang Li Xingqiang Lai Hong Chen Lihua Huang Zhuang Kang Kai Li Jie Ren Xiaofeng Lin Haiqing Zheng Weijun Huang Yunhan Ma Dongdong Xu Zheng Chen Xinming Song Xinyi Lin Min Zhuang Tao Wang Fengfeng Zhuang Jianzhong Xi Frank Fuxiang Mao Huimin Xia Bruce T Lahn Qi Zhou Shihua Yang Andy Peng Xiang | 2016 | Cell Research2016，26，9： | 13 |
| 3 | Polyethyleneimine modified AuPd@PdAu alloy nanocrystals as advanced electrocatalysts towards the oxygen reduction reaction显示文摘Designing the low cost, active, durable, and alcohol-tolerant cathode catalysts towards the oxygen reduction reaction(ORR) is significant for the large-scale commercialization of direct alcohol fuel cells.Recently, Pd-based nanocrystals have attracted attention as Pt-alternative cathode catalysts towards the ORR in the alkaline electrolyte. Unfortunately, the pristine Pd-based nanocrystals lack the selectivity towards the ORR due to their inherent activity for the alcohol molecule oxidation reaction in the alkaline electrolyte. In this work, polyethyleneimine(PEI) modified Au Pd alloy nanocrystals with Au-rich Au Pd alloy cores and Pd-rich Pd Au alloy shells(AuPd@PdAu-PEI) are successfully synthesized using a traditional chemical reduction method in presence of PEI. The rotating disk electrode(RDE) technique is applied to evaluate the ORR performance of AuPd@PdAu-PEI nanocrystals. Compared with commercial Pd black,AuPd@PdAu-PEI nanocrystals show significantly enhanced activity and durability towards the ORR, and simultaneously exhibit particular alcohol tolerance towards the ORR in the alkaline electrolyte. | Qi Xue Guangrui Xu Rundong Mao Huimin Liu Jinghui Zeng Jiaxing Jiang Yu Chen | 2017 | Journal of Energy Chemistry2017，26，6： | 5 |
| 4 | miR-20a Promotes the Axon Regeneration of DRG Neurons by Targeting Nr4a3显示文摘Dear Editor,The peripheral nervous system(PNS)regenerates more easily after injury than the central nervous system(CNS)[1].Sensory neurons in the L4–L6 dorsal root ganglia(DRGs)extend axons to form the sciatic nerve along with motor axons.The DRG neuron is one of the exceptional mature neurons whose axons can regenerate after injury. | Lili Zhao Leilei Gong Ping Li Jing Qin Lingchi Xu Qiyao Wei Huimin Xie Susu Mao Bin Yu Xiaosong Gu Songlin Zhou | 2021 | Neuroscience Bulletin2021，37，4： | 3 |
| 5 | Plant multiscale networks:charting plant connectivity by multi-level analysis and imaging techniques显示文摘In multicellular and even single-celled organisms,individual components are interconnected at multiscale levels to produce enormously complex biological networks that help these systems maintain homeostasis for development and environmental adaptation.Systems biology studies initially adopted network analysis to explore how relationships between individual components give rise to complex biological processes.Network analysis has been applied to dissect the complex connectivity of mammalian brains across different scales in time and space in The Human Brain Project.In plant science,network analysis has similarly been applied to study the connectivity of plant components at the molecular,subcellular,cellular,organic,and organism levels.Analysis of these multiscale networks contributes to our understanding of how genotype determines phenotype.In this review,we summarized the theoretical framework of plant multiscale networks and introduced studies investigating plant networks by various experimental and computational modalities.We next discussed the currently available analytic methodologies and multi-level imaging techniques used to map multiscale networks in plants.Finally,we highlighted some of the technical challenges and key questions remaining to be addressed in this emerging field. | Xi Zhang Yi Man Xiaohong Zhuang Jinbo Shen Yi Zhang Yaning Cui Meng Yu Jingjing Xing Guangchao Wang Na Lian Zijian Hu Lingyu Ma Weiwei Shen Shunyao Yang Huimin Xu Jiahui Bian Yanping Jing Xiaojuan Li Ruili Li Tonglin Mao Yuling Jiao Sodmergen Haiyun Ren Jinxing Lin | 2021 | Science China(Life Sciences)2021，64，9： | 3 |
| 6 | Experimentai Research on Saturated-Gain for Soft X-Ray Laser from Neon-Like Germanium Plasma显示文摘AmpliHcation of spontaneous emissions at 19.6,23.2 and 23.6 nm have been observed by a “ultiple-Target Series Coupling”design in Ge plasma,.The combined length for four targets is up to 56mm.The gain length product(GL)of small signal is up to 18 for both lines at 23.2 and 23.6 nmt and the effective GL is 16.4 and 15.7 for these two lines respectively.This two lines are obviously tending to saturation.The divergence of x-ray laser beam is about 4 mrad. | WANG Shiji GU Yuan ZHOU GuanUn NI Yuanlong YU Songyu FU Sizu MAO Chusheng TAO Zucong CHEN Wannian LIN Zunqi FAN Dianyuan ZHANG Guoping SHENG Jiatian YANG Minglun ZHANG Tanxin SHAO Yunfeng PENG Huimin HE Xiantu YU Min | 1991 | Chinese Physics Letters1991，8，12： | 3 |
| 7 | Polymer-/Ceramic-based Dielectric Composites for Energy Storage and Conversion显示文摘Dielectric composites boost the family of energy storage and conversion materials as they can take full advantage of both the matrix and filler.This review aims at summarizing the recent progress in developing highperformance polymer-and ceramic-based dielectric composites,and emphases are placed on capacitive energy storage and harvesting,solid-state cooling,temperature stability,electromechanical energy interconversion,and high-power applications.Emerging fabrication techniques of dielectric composites such as 3D printing,electrospinning,and cold sintering are addressed,following by highlighted challenges and future research opportunities.The advantages and limitations of the typical theoretical calculation methods,such as finite-element,phase-field model,and machine learning methods,for designing high-performance dielectric composites are discussed.This review is concluded by providing a brief perspective on the future development of composite dielectrics toward energy and electronic devices. | Honghui Wu Fangping Zhuo Huimin Qiao Lalitha Kodumudi Venkataraman Mupeng Zheng Shuize Wang He Huang Bo Li Xinping Mao Qiaobao Zhang | 2022 | Energy & Environmental Materials2022，5，2： | 2 |
| 8 | CRISPR/dCas-mediated gene activation toolkit development and its application for parthenogenesis induction in maize显示文摘Clustered regularly interspaced short palindromic repeats(CRISPR)-Cas systems can be engineered as programmable transcription factors to either activate(CRISPRa)or inhibit transcription.Apomixis is extremely valuable for the seed industry in breeding clonal seeds with pure genetic backgrounds.We report here a CRISPR/dCas9-based toolkit equippedwith dCas9-VP64 andMS2-p65-HSF1 effectors that may specifically target genes with high activation capability.We explored the application of in vivo CRISPRa targeting of maize BABY BOOM2(ZmBBM2),acting as a fertilization checkpoint,as a means to engineer parthenogenesis.We detected ZmBBM2 transcripts only in egg cells but not in other maternal gametic cells.Activation of ZmBBM2 in egg cells in vivo caused maternal cell-autonomous parthenogenesis to produce haploid seeds.Our work provides a highly specific gene-activation CRISPRa technology for target cells and verifies its application for parthenogenesis induction in maize. | Xiantao Qi Huimin Gao Renyao Lv Wenbo Mao Jinjie Zhu Changling Liu Long Mao Xinhai Li Chuanxiao Xie | 2023 | Plant Communications2023，4，2： | 1 |
| 9 | Porphyry Cu–Au–Mo–epithermal Ag–Pb–Zn–distal hydrothermal Au deposits in the Dexing area, Jiangxi province, East China—A linked ore system显示文摘 | Jingwen Mao Jiandong Zhang Franco Pirajno Daizo Ishiyama Huimin Su Chunli Guo Yuchuan Chen | 2011 | Ore Geology Reviews2011，，1： | 1 |
| 10 | Recog- nition of human activities using SVM multi-classifier 显示文摘 | Qian Huimin Mao Yao Bin Xiang Wen Bo | 2010 | Pattern Recognition Letters2010，31，2： | 1 |
| 11 | Fractional derivative multivariable grey model for nonstationary sequence and its application显示文摘Most of the existing multivariable grey models are based on the 1-order derivative and 1-order accumulation, which makes the parameters unable to be adjusted according to the data characteristics of the actual problems. The results about fractional derivative multivariable grey models are very few at present. In this paper, a multivariable Caputo fractional derivative grey model with convolution integral CFGMC(q, N) is proposed. First, the Caputo fractional difference is used to discretize the model, and the least square method is used to solve the parameters. The orders of accumulations and differential equations are determined by using particle swarm optimization(PSO). Then, the analytical solution of the model is obtained by using the Laplace transform, and the convergence and divergence of series in analytical solutions are also discussed. Finally, the CFGMC(q, N) model is used to predict the municipal solid waste(MSW). Compared with other competition models, the model has the best prediction effect. This study enriches the model form of the multivariable grey model, expands the scope of application, and provides a new idea for the development of fractional derivative grey model. | KANG Yuxiao MAO Shuhua ZHANG Yonghong ZHU Huimin | 2020 | Journal of Systems Engineering and Electronics2020，31，5： | 1 |
| 12 | Monte Carlo simulation study of SEM images of rough surfaces显示文摘 | Li Yonggang Mao Shifeng Li Huimin | 2008 | Journal of Applied Physics2008，104，064901： | 1 |
| 13 | Tunable and sustained-release characteristics of venlafaxine hydrochloride from chitosan–carbomer matrix tablets based on in situ formed polyelectrolyte complex film coating显示文摘The objective of this study is to design sustained-release tablets using matrix technology, which can well control the release of highly water-soluble drugs with good system robustness and simple preparation process. Taking venlafaxine hydrochloride(VH) as a drug model, the feasibility of using chitosan(CS), carbomer(CBM) combination system to achieve this goal was studied. Formulation and process variables influencing drug release from CS–CBM matrix tablets were investigated. It was found that CS–CBM combination system weakened the potential influence of CS, CBM material properties and gastric emptying time on drug release profile. Demonstrated by direct observation, differential scanning calorimetry(DSC) and Fourier transform infrared spectroscopy(FTIR), in situ self-assembled polyelectrolyte complex(PEC) film was formed on the tablet surface during gastrointestinal tract transition, which contributed to the tunable and robust control of drug release. The sustained drug release behavior was further demonstrated in vivo in Beagle dogs, with level A in vitro and in vivo correlation(IVIVC) established successfully. In conclusion, CS–CBM matrix tablets are promising system to tune and control the release of highly water-soluble drugs with good system robustness. | Xiaofei Zhang Xiangqin Gu Xiaodan Wang Huimin Wang Shirui Mao | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，6： | 1 |
| 14 | Porphyry Cu–Au–Mo–epithermal Ag–Pb–Zn–distal hydrothermal Au deposits in the Dexing area, Jiangxi province, East China—A linked ore system显示文摘 | Jingwen Mao Jiandong Zhang Franco Pirajno Daizo Ishiyama Huimin Su Chunli Guo Yuchuan Chen | 2011 | Ore Geology Reviews2011，，1： | 1 |
| 15 | Perspective on antiferroelectrics for energy storage and conversion applications显示文摘As a close relative of ferroelectricity,antiferroelectricity has received a recent resurgence of interest driven by technological aspirations in energy-efficient applications,such as energy storage capacitors,solid-state cooling devices,explosive energy conversion,and displacement transducers.Though prolonged efforts in this area have led to certain progress and the discovery of more than 100 antiferroelectric materials over the last 70 years,some scientific and technological issues remain unresolved.Herein,we provide perspectives on the development of antiferroelectrics for energy storage and conversion applications,as well as a comprehensive understanding of the structural origin of antiferroelectricity and field-induced phase transitions,followed by design strategies for new lead-free antiferroelectrics.We also envision unprecedented challenges in the development of promising antiferroelectric materials that bridge materials design and real applications.Future research in these directions will open up new possibilities in resolving the mystery of antiferroelectricity,provide opportunities for comprehending structure-property correlation and developing antiferroelectric/ferroelectric theories,and suggest an approach to the manipulation of phase transitions for real-world applications. | Fangping Zhuo Huimin Qiao Jiaming Zhu Shuize Wang Yang Bai Xinping Mao Hong-Hui Wu | 2021 | Chinese Chemical Letters2021，32，7： | 0 |
| 16 | Schisandrin B protects PC12 cells by decreasing the expression of amyloid precursor protein and vacuolar protein sorting 35显示文摘PC12 cell injury was induced using 20 μM amyloid β-protein 25-35 to establish a model of Alzheimer's disease. The cells were then treated with 5, 10, and 25 μM Schisandrin B. Methylthiazolyldiphenyl-tetrazolium bromide assays and Hoechst 33342 staining results showed that with increasing Schisandrin B concentration, the survival rate of PC12 cells injured by amyloid β-protein 25-35 gradually increased and the rate of apoptosis gradually decreased. Reverse transcription-PCR, immunocytochemical staining and western blot results showed that with increasing Schisandrin B concentration, the mRNA and protein expression of vacuolar protein sorting 35 and amyloid precursor protein were gradually decreased. Vacuolar protein sorting 35 and amyloid precursor protein showed a consistent trend for change. These findings suggest that 5, 10, and 25 μM Schisandrin B antagonizes the cellular injury induced by amyloid β-protein 25-35 in a dose-dependent manner. This may be caused by decreasing the expression of vacuolar protein sorting 35 and amyloid precursor protein. | Mingmin Yan Shanping Mao Huimin Dong Baohui Liu Qian Zhang Gaofeng Pan Zhiping Fu | 2012 | Neural Regeneration Research2012，7，9： | 0 |
| 17 | Intrinsic Zero-Linear and Zero-Area Compressibilities over an Ultrawide Pressure Range within a Gear-Spring Structure显示文摘Materials with zero-linear compressibility(ZLC)and zero-area compressibility(ZAC)have great promise for specific applications retaining constancy in specific directions or planes under external impaction.To date,no more than 10 ZLC/ZAC materials have been reported,most of which have very limited working pressure ranges(<10 GPa).Herein,we report the observation of ZLC and ZAC in Li2Ti(IO3)6 with a gear-spring type structure over an ultrawide pressure range(0–40 GPa). | Dequan Jiang Ting Wen Huimin Song Zimin Jiang Chen Li Ke Liu Wenge Yang Ho-kwang Mao Yonggang Wang | 2022 | CCS Chemistry2022，4，10： | 0 |
| 18 | WC/Co_(7)Fe_(3)heterojunction embedded in N,P co-doped hierarchical carbon enables rechargeable/flexible Zn-air battery显示文摘Rational design and synthesis of bifunctional oxygen electrocatalysts with high activity and stability are key challenges in the development of rechargeable Zn-air batteries(ZABs).In this paper,tungsten carbide(WC)and Co_(7)Fe_(3)embedded in N,P co-doped hierarchical carbon(WC/Co_(7)Fe_(3)-NPHC)was prepared by using zeolite imidazolate frameworks as precursor.Density functional theory demonstrates that the mutual adjustment among the WC,Co_(7)Fe_(3),and N,P co-doped carbon at the three-phase heterojunction interface makes the catalyst possess moderate adsorption strength,and greatly improves the conductivity and electron transfer rate of the catalyst.As a result,the WC/Co_(7)Fe_(3)-NPHC exhibits a low overall oxygen redox potential difference of 0.72 V,while the ZAB assembled by WC/Co_(7)Fe_(3)-NPHC as an air cathode exhibits ultra-long cycle stability of over 550 h.Futhermore,WC/Co_(7)Fe_(3)-NPHC can keep good charge and discharge stability at different bending angles when applied to flexible solid ZAB. | Huimin Mao Xiaobin Liu Siqi Wu Yixin Fu Guishan Liu Guizhong Zhou Lei Wang | 2023 | Nano Research2023，16，2： | 0 |
| 19 | Stress sensitivity of coal reservoir and its impact on coalbed methane production in the southern Qinshui Basin, north China显示文摘Stress sensitivity has significant negative effects on the permeability and production of coalbed methane(CBM)reservoirs.To effectively minimize these negative effects,the degree of stress sensitivity during the CBM production process should be carefully studied.In this work,the curvature of the stress-sensitivity curve was adopted to explore the degree of stress sensitivity,dividing the stress-sensitivity curve and the drainage process into five stress stages:sharp decrease,rapid decrease,low-speed decrease,slower decrease and harmless with four critical stress points—transition,sensitivity,relief and harmless.The actual stages were determined by the initial permeability,stress-sensitivity coefficient and difference between the reservoir pressure and desorption pressure.The four critical stress points did not completely exist in the stress-sensitivity curve.With an increase in the initial permeability of coal,the number of existing critical stresses increases,leading to different gas-water drainage strategies for CBM wells.For reservoirs with a certain stress-sensitivity coefficient,the permeability at the sensitive stress point was successively greater than that at the transition,relief and the harmless stresses.When the stress-sensitivity coefficient is different,the stage is different at the beginning of drainage,and with an increase in the stress-sensitivity coefficient,the decrease rate of the permeability increases.Therefore,the stress-sensitivity coefficient determines the ability to maintain stable CBM production.For well-fractured CBM reservoirs,with a high stress-sensitivity coefficient,permeability damage mainly occurs when the reservoir pressure is less than the relief stress;therefore,the depressurization rate should be slow.For CBM reservoirs with fewer natural fractures,the reverse applies,and the depressurization rate can be much faster.The higher the difference between the reservoir and desorption pressures,the higher the effective stress and permeability damage after desorption,resulting in a much longer drainage time and many difficulties for the desorption of coalbed methane.The findings of this study can help better understand and minimize the negative effects of stress sensitivity during the CBM production process. | Huimin JIA Yidong CAI Qiujia HU Cong ZHANG Feng QIU Bin FAN Chonghao MAO | 2023 | Frontiers of Earth Science2023，17，1： | 0 |
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