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| 1 | Species-dependent neuropathology in transgenic SOD' aigs显示文摘 | Huaqiang Yang Guohao Wang Haitao Sun Runzhe Shu Tao Liu Chuan-En Wang Zhaoming Liu Yu Zhao Bentian Zhao Zhen Ouyang Dongshan Yang Jiao Huang Yueling Zhou Shihua Li Xiaodan Jiang Zhicheng Xiao Xiao-Jiang Li Liangxue Lai | 2014 | Cell Research2014，24，4： | 13 |
| 2 | The study on the mechanical properties of PU/MF double shell self-healing microcapsules显示文摘The self-healing microcapsules can be buried in the coating to improve the anticorrosive ability.In this paper,self-healing microcapsules of polyurea(PU)/melamine resin(MF)double shell were prepared by in-situ polymerization and interfacial polymerization with isocyanate as the core material.Scanning electron microscope was used to observe the microcapsule morphology.The structures of microcapsules prepared with different chain extenders were characterized by Fourier transform infrared spectroscopy.The micromanipulation system was used to loading–holding,loading–unloading and loading to rupture individual microcapsules,so as to explore the mechanical properties of microcapsules.The Young’s modulus corresponding to microcapsules was calculated by mathematical model fitting.The self-healing properties of microcapsule coating were characterized by optical microscope.The experimental results showed that the microcapsule shell prepared under optimized conditions had a complete morphology and good mechanical properties.The microcapsule was in the elastic deformation stage under small deformation,and the plastic deformation stage under large deformation.The Young’s modulus range of microcapsules was 9.29–14.51 MPa,and the corresponding Young’s modulus could be prepared by adjusting the process.The surface crack of the coating containing microcapsule could heal itself after48 h in a humid environment. | Guohao Du Jianfeng Hu Jianhui Zhou Guangwu Wang Shengli Guan Hailing Liu Man Geng Chuang Lv Yaoqiang Ming Jinqing Qu | 2020 | Chinese Journal of Chemical Engineering2020，28，5： | 4 |
| 3 | Dietary nano-selenium alleviated intestinal damage of juvenile grass carp(Ctenopharyngodon idella)induced by high-fat diet:Insight from intestinal morphology,tight junction,inflammation,anti-oxidization and intestinal microbiota显示文摘In recent years,high-fat diet(HFD)has been widely applied in aquaculture,which reduces the intestinal health of cultured fish.The current study evaluated the protective effects of nano-selenium(nano-Se)on intestinal health of juvenile grass carp(Ctenopharyngodon idella)fed with HFD.A total of 135 experimental fish were fed with a regular diet(Con),a HFD(HFD)and a HFD containing nano-Se at 0.6 mg/kg(HSe)for 10 weeks.The results showed that dietary nano-Se significantly improved the survival rate and feed efficiency which were reduced by HFD in juvenile grass carp(P<0.05).Also,nano-Se(0.6 mg/kg)supplement alleviated intestinal damage caused by the HFD,thus maintaining the integrity of the intestine.Moreover,it significantly up-regulated the expression of genes related to tight junction(ZO-1,claudin-3 and occludin),anti-oxidization(GPx4a and GPx4b),and the protein of ZO-1 in the intestine of juvenile grass carp,which were depressed by the HFD(P<0.05).Furthermore,nano-Se supplementation significantly suppressed the expressions of genes related to the inflammation,including inflammatory cytokines(IL-8,IL-1β,IFN-γ,TNF-αand IL-6),signaling molecules(TLR4,p38 MAPK and NF-kB p65),and protein expression of NF-kB p65 and TNF-αin the intestine of juvenile grass carp which were induced by the HFD(P<0.05).Besides,dietary nano-Se normalized the intestinal microbiota imbalance of juvenile grass carp caused by the HFD through increasing the abundance of the beneficial bacteria,e.g.,Fusobacteria.Finally,dietary nano-Se increased the production of short chain fatty acids(SCFA)in the intestine,especially for butyric acid and caproic acid,which were negatively related to the increase of intestinal permeability and inflammation.In summary,supply of nano-Se(0.6 mg/kg)in HFD could effectively alleviate intestinal injury of juvenile grass carp by improving intestinal barrier function and reducing intestinal inflammation and oxidative stress.These positive effects may be due to the regulation of nano-Se on intestinal microbiota and the subsequently increased beneficial SCFA levels. | Sha Liu Haibo Yu Pengju Li Chi Wang Guohao Liu Xiaotian Zhang Cheng Zhang Meng Qi Hong Ji | 2022 | Animal Nutrition2022，，1： | 4 |
| 4 | Luminescence and energy transfer processes in Lu 2 SiO 5 :Ce 3+ scintillator显示文摘 | Bo Liu Chaoshu Shi Min Yin Yibin Fu Guobin Zhang Guohao Ren | 2005 | Journal of Luminescence2005，，2： | 1 |
| 5 | One-step supramolecular preorganization constructed crinkly graphitic carbon nitride nanosheets with enhanced photocatalytic activity显示文摘Here we report a new one-step thermal polycondensation process to form crinkly graphitic carbon nitride nanosheets(CGCNNs)via supramolecular preorganization,using a mixture of urea and melamine as the starting material.Systematical studies reveal that the newly developed CGCNNs significantly strengthen the optical absorption,widen the bandgap,and increase the Hall mobility and carrier density compared to that of its bulk counterpart,regardless of the similar chemical composition and structure.As a result,the photocatalytic hydrogen production rate is improved by 7 times.Moreover,Na doping of CGCNNs can further promote its photocatalytic activity,leading to an excellent photocatalytic hydrogen production rate of 250.9μmol h^(–1),which is approximately 10.5 times higher than its bulk counterpart.Moreover,an impressive apparent quantum efficiency of 19.12%is achieved at 420 nm.This study provides a facile strategy for the design of efficient low-cost carbon-nitride-based photocatalysts for solar fuel production. | Songcan Wang Yuelin Li Xin Wang Guohao Zi Chenyang Zhou Boyan Liu Gang Liu Lianzhou Wang Wei Huang | 2022 | Journal of Materials Science & Technology2022，，9： | 1 |
| 6 | Electronic and optical properties analysis on Bi/N-codoped anatase TiO 2显示文摘 | Guohao Wu S.K. Zheng Pengfei Wu Jie Su Lei Liu | 2013 | Solid State Communications2013，，： | 1 |
| 7 | Nanoparticle enhanced combination therapy for stem-like progenitors defined by single-cell transcriptomics in chemotherapy-resistant osteosarcoma显示文摘The adaptation of osteosarcoma cells to therapeutic pressure impedes the efficacy of chemotherapy for osteosarcoma.However,the characteristics and cellular organization of therapy-resistant cells in osteosarcoma tumors remain elusive.Here,we utilized single-cell transcriptomics to systematically map the cell-type-specific gene expression in a chemotherapy-resistant osteosarcoma tumor.Our data demonstrated the VEGFR2-JMJD3-abundant subsets as quiescent stem-like cells,thereby establishing the hierarchy of therapy-resistant actively cycling progenitor pools(JMJD3-abundant)in osteosarcoma.VEGFR2 inhibitor and JMJD3 inhibitor synergistically impeded osteosarcoma cell propagation and tumor growth.Although osteosarcoma cells are predisposed to apoptosis induced by the synergistic therapy through activation of the CHOP pro-apoptotic factor via the endoplasmic reticulum(ER)stress,the stem-like/progenitor cells exhibit an adaptive response,leading to their survival.Reduction in cellular glutathione levels in stem-like/progenitor cells caused by the treatment with a glutathione synthesis inhibitor increases ER stress-induced apoptosis.Importantly,the marked therapeutic improvement of synergistic therapy against stem-like/progenitor cells was achieved by using glutathione-scavenging nanoparticles,which can load and release the drug pair effectively.Overall,our study provides a framework for understanding glutathione signaling as one of the therapeutic vulnerabilities of stem-like/progenitor cells.Broadly,these findings revealed a promising arsenal by encapsulating glutathione-scavenging nanoparticles with co-targeting VEGFR2 and JMJD3 to eradicate chemotherapy-resistant osteosarcoma. | Li Wang Xiaojia Huang Xinru You Tianqi Yi Bing Lu Jiali Liu Guohao Lu Minglin Ma Changye Zou Jun Wu Wei Zhao | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 1 |
| 8 | Transparent and Mechanically High-Performance Soft Materials Consisting of Colloidal Building Blocks显示文摘CONSPECTUS:Soft materials,which are optically transparent and exhibit high mechanical performance,will be key materials in important research areas in our future lives,such as highly advanced medicine,soft robotics,and wearable displays.When soft materials are transparent,objects underneath the soft material can be observed by the naked eye.Additionally,because they allow light to pass through,such materials can be used in optical applications such as lenses and displays.Therefore,transparent materials make it possible to transmit light information.Such transparent soft materials have been widely used in our daily life,but their applications will be directed to higher value-added products in the future.One example of a great transparent and flexible soft material is transparent silicone rubber,but even this material is not without drawbacks.Silicone rubber has the property of not adhering to most materials.This feature can be an advantage,but it can also be a disadvantage in some applications.Moreover,its tensile strength,tear strength,and friction resistance are not always strong.The ability to develop transparent soft materials whose surface and mechanical properties differ from those of silicone rubber will lead to the development of various technologies that will enrich our lives.By use of colloid-sized molecules and materials as building blocks to form soft materials,the properties and functions of the resulting soft materials are expected to reflect those of the building blocks.In addition,if the soft material is formed such that the building blocks have a characteristic order,the physical properties derived from the ordered structure can be manifested in the soft material.If the size of the order is as large as the wavelength of light,it is possible to develop materials that can manipulate light.The authors have been working for many years on soft materials in which building blocks of various colloidal sizes are obtained in an ordered state.As a result,we have reported that we can obtain soft materials that are optically transparent and exhibit a variety of mechanical properties.In this Account,we introduce our various works on optically transparent soft materials consisting of colloidal building blocks that exhibit high mechanical performance.To help you understand our research,a basic description of the optical transparency of the materials and the mechanical properties of the materials is given in the Supporting Information,which you are invited to read if necessary. | Yukikazu Takeoka Fumio Asai Guohao Gao Jialei He Sizhe Liu | 2022 | Accounts of Materials Research2022，3，8： | 0 |
| 9 | The establishment of Boron nitride@sodium alginate foam/polyethyleneglycol composite phase change materials with high thermal conductivity, shape stability, and reusability显示文摘Adopting organic phase change materials(PCMs) for the management of electronic devices is restricted by low thermal conductivity. In this paper, the composite PCMs are established by freeze-drying and vacuum impregnation. Herein, polyethylene glycol(PEG) is induced as heat storage materials, boron nitride(BN) is embedded as filler stacking in an orderly fashion on the foam walls to improve thermal conductivity and sodium alginate(SA) is formed as supporting material to keep the shape of the composite stable. X-ray diffractometry, scanning electron microscopy-energy dispersive spectrometer, thermal gravimetric analysis, thermal conductivity meter, differential scanning calorimeter, and Fourier transform infrared were used to characterize the samples and thermal cycles were employed to measure the shape stability. The results exhibit the BN@SA/PEG composite PCMs have good chemical compatibility, stable morphology, and thermal stability. Due to the high porosity of foam, PEG endows the composite PCMs with high latent heat(149.11 and 141.59 J·g^(-1)). Simultaneously, BN@SA/PEG shows an excellent heat performance with high thermal conductivity(0.99 W·m^(-1)·K^(-1)), reusability, and shape stability, contributing the composite PCMs to application in the energy storage field. This study provides a strategy to manufacture flexible, long-serving, and shape-stable PCMs via introducing BN@SA foam as a storage framework, and these PCMs have great potential in thermal management in the electronic field. | Jianhui Zhou Guohao Du Jianfeng Hu Xin Lai Shan Liu Zhengguo Zhang | 2023 | Chinese Journal of Chemical Engineering2023，54，2： | 0 |
| 10 | Alkylation of benzene with carbon dioxide to low-carbon aromatic hydrocarbons over bifunctional Zn-Ti/HZSM-5 catalyst显示文摘Alkylation of benzene to value-added,high octane number and low toxic toluene and xylenes provides a way to lower benzene content in gasoline pool,and is hence a method to promote fuel quality.On the other hand,CO_(2) accumulation in the atmosphere causes global warming and requires effective route for its valorization.Utilization of CO_(2) as a carbon source for benzene alkylation could achieve both goals.Herein,alkylation of benzene with CO_(2) and H2 was realized by a series of low-cost bifunctional catalysts containing zinc/titanium oxides(Zn/Ti oxides)and HZSM-5 molecular sieves in a fixed-bed reactor.By regulating and controlling oxygen vacancies of Zn/Ti oxides and the acidities of HZSM-5,benzene conversion and CO_(2) conversion reached 28.7%and 29.9%respectively,along with a total selectivity of toluene and xylene higher than 90%.In this process,more than 25%CO_(2) was effectively utilized and incorporated into the target products.Moreover,the mechanism of the reaction was analyzed and the course was simultaneously traced.CO_(2) was transformed into methanol firstly,and then methanol reacted with benzene generating toluene and xylene.The innovation provides a new method for upgrading of fuels and upcycling the emissions of CO_(2),which is of great environmental and economic benefits. | Xiangyu Liu Yanling Pan Peng Zhang Yilin Wang Guohao Xu Zhaojie Su Xuedong Zhu Fan Yang | 2022 | Frontiers of Chemical Science and Engineering2022，16，3： | 0 |
| 11 | 3D direct printing of mechanical and biocompatible hydrogel meta-structures显示文摘Direct Ink Writing(DIW)has demonstrated great potential as a versatile method to 3D print multifunctional structures.In this work,we report the implementation of hydrogel meta-structures using DIW at room temperature,which seamlessly integrate large specific surface areas,interconnected porous characteristics,mechanical toughness,biocompatibility,and water absorption and retention capabilities.Robust but hydrophobic polymers and weakly crosslinked nature-origin hydrogels form a balance in the self-supporting ink,allowing us to directly print complex meta-structures without sacrificial materials and heating extrusion.Mechanically,the mixed bending or stretching of symmetrical re-entrant cellular lattices and the unique curvature patterns are combined to provide little lateral expansion and large compressive energy absorbance when external forces are applied on the printed meta-structures.In addition,we have successfully demonstrated ear,aortic valve conduits and hierarchical architectures.We anticipate that the reported 3D meta-structured hydrogel would offer a new strategy to develop functional biomaterials for tissue engineering applications in the future. | Lei Zhang Wenhan Lee Xinhao Li Yanhui Jiang Nicholas Xuanlai Fang Guohao Dai Yongmin Liu | 2022 | Bioactive Materials2022，7，4： | 0 |
| 12 | A neuron-immune circuit regulates neurodegeneration in the hindbrain and spinal cord of Arf1-ablated mice显示文摘Neuroimmune connections have been revealed to play a central role in neurodegenerative diseases(NDs).However,the mechanisms that link the central nervous system(CNS)and peripheral immune cells are still mostly unknown.We recently found that specific ablation of the Arf1 gene in hindbrain and spinal cord neurons promoted NDs through activating the NLRP3 inflammasome in microglia via peroxided lipids and adenosine triphosphate(ATP)releasing.Here,we demonstrate that IL-1βwith elevated chemokines in the neuronal Arf1-ablated mouse hindbrain and spinal cord recruited and activatedγδT cells in meninges.The activatedγδT cells then secreted IFN-γthat entered into parenchyma to activate the microglia-A1astrocyte-C3-neuronal C3a R neurotoxic pathway.Remarkably,the neurodegenerative phenotypes of the neuronal Arf1-ablated mice were strongly ameliorated by IFN-γor C3 knockout.Finally,we show that the Arf1-reduction-induced neuroimmune-IFN-γ-gliosis pathway exists in human NDs,particularly in amyotrophic lateral sclerosis and multiple sclerosis.Together,our results uncover a previously unknown mechanism that links the CNS and peripheral immune cells to promote neurodegeneration. | Guohao Wang Shuhan Jin Jiaqi Liu Xu Li Peng Dai Yuetong Wang Steven X.Hou | 2023 | National Science Review2023，10，12： | 0 |
| 13 | Aerosol-radiation interaction and its variation in North China within 2015–2019 period under continuous PM_(2.5)improvements显示文摘A study was conducted on aerosol-radiation interactions over six cities in this region within the 2015–2019 period.WRF-Chem simulations on 2017 showed that based on the six-city average,the aerosol load(PM_(2.5)concentrations)of 121.9,49.6,43.3,and 66.3μg/m^(3)in January,April,July,and October,mainly lowered the level of downward shortwave radiation by 38.9,24.0,59.1,and 24.4 W/m~2and reduced the boundary layer height by 79.9,40.8,87.4,and 31.0 m,via scattering and absorbing solar radiation.The sensitivity of meteorological changes to identical aerosol loads varied in the order July>January>October and April.Then,the cooling and stabilizing effects of aerosols further led to increases in PM_(2.5),by23.0,3.4,4.6,and 7.3μg/m^(3)respectively in the four months.The sensitivity of the effect of aerosols on PM_(2.5)was greatest in January rather than in July,contrary to the effect on meteorology.Moreover,a negative linear relation was observed between daily BLH reductions and aerosol loads in fall and winter,and between PM_(2.5)increases and aerosol loads in all seasons.With the PM_(2.5)pollution improvements in this region,the aerosol radiative forcing was effectively reduced.This should result in daily BLH increases of 10–24 m in fall and winter,and the estimates in Beijing agreed well with the corresponding results based on AMDAR data.Additionally,the reduction in aerosol radiation effects brought about daily PM_(2.5)decreases of 1.6-2.8μg/m^(3),accounting for 7.0%–17.7%in PM_(2.5)improvements. | Zhe Lv Xiaoqi Wang Wei Wei Huahua Bai Xiaoyu Liu Guohao Li Shuiyuan Cheng | 2024 | Journal of Environmental Sciences2024，，2： | 0 |
| 14 | Experimental study on the invasiveness inhibition of bladder cancer cells by nuclear factor-κB decoy——circular dumbbell oligodeoxynucleotides显示文摘Objective:To determine whether NF-κB is constitutively activated in human bladder cancer cell and,if so,to deter-mine the invasiveness inhibition of bladder cancer cells by nuclear factor-κB decoy—circular dumbbell oligodeoxynucleotides(CD-ODN).Methods:NF-κBp65 activation was determined by immunohistochemical analysis of formalin-fixed,paraffin-embed-ded specimens from 38 cases of bladder transitional cell carcinoma patients.We quantified nuclear staining of RelA as a marker of NF-κBp65 activation.CD-ODN were transfected into human bladder cancer cell line BIU87 by lipofectamine.Luciferase reporter were applied to detecting NF-κB DNA binding activity.The expression levels of uPA were detected by RT-PCR and the cells’ invasion ability by transwell cell culture chamber.Results:P65 excessive activation existed in tumor cell(P<0.01),the activation degree correlated significantly with the expression of uPA(r=0.89,P<0.01),as well as related to tumor invasion-related clinicopathological features such as lymphatic metastasis(P<0.01)and pathological ranking(P<0.05);After transfection with CD-ODN,the activation of NF-κB in BIU87 cell line was suppressed remarkably,the expression level of uPA was decreased and the cells’ invasiveness was weakened as well.Conclusion:Excessively activated NF-κB is related to tumor progression pos-sibly due to its transcriptional regulation of invasion-related factors such as uPA.CD-ODN can efficiently suppress DNA binding activity of NF-κB to reduce the invasive potency of tumor. | Bo Wen Siwei Zhou Weimin Yang Guohao Li Zhen Liu Huifang Liang | 2006 | The Chinese-German Journal of Clinical Oncology2006，5，6： | 0 |
| 15 | Earthquake-triggered landslide interpretation model of high resolution remote sensing imageries based on bag of visual word显示文摘Traditional visual interpretation is often inefficient due to its excessively workload professional knowledge and strong subjectivity.Therefore,building an automatic interpretation model on high spatial resolution remote sensing images is the key to the quick and efficient interpretation of earthquake-triggered landslides.Aiming at addressing this problem,a landslide interpretation model of high-resolution images based on bag of visual word(BoVW)feature was proposed.The high-resolution images were pre-processed,and then BoVW feature and support vector machine(SVM)was adopted to establish an automatic landslide interpretation model.This model was further compared with the currently widely used Histogram of Oriented Gradient(HoG)feature extraction model.In order to test the effectiveness of the method,typical landslide images were selected to construct a landslide sample library,which was subsequently utilized as the foundation for conducting an experimental study.The results show that the accuracy of landslide extraction using this method reaches as high as 89%,indicating that the method can be used for the automatic interpretation of landslides in disaster-prone areas,and has high practical value for regional disaster prevention and damage reduction. | Ruyue Bai Zegen Wang Heng Lu Chen Chen Xiuju Liu Guohao Deng Qiang He Zhiming Ren Bin Ding Xin Ye | 2023 | Earthquake Research Advances2023，3，2： | 0 |
| 16 | Development and identification of two novel wheat-rye 6R derivative lines with adult-plant resistance to powdery mildew and high-yielding potential显示文摘Powdery mildew,caused by Blumeria graminis f.sp.tritici(Bgt),is a devastating disease that seriously threatens wheat yield and quality.To control this disease,host resistance is the most effective measure.Compared with the resistance genes from common wheat,alien resistance genes can better withstand infection of this highly variable pathogen.Development of elite alien germplasm resources with powdery mildew resistance and other key breeding traits is an attractive strategy in wheat breeding.In this study,three wheat-rye germplasm lines YT4-1,YT4-2,and YT4-3 were developed through hybridization between octoploid triticale and common wheat,out of which the lines YT4-1 and YT4-2 conferred adult-plant resistance(APR)to powdery mildew while the line YT4-3 was susceptible to powdery mildew during all of its growth stages.Using genomic in situ hybridization,multi-color fluorescence in situ hybridization,multi-color GISH,and molecular marker analysis,YT4-1,YT4-2,and YT4-3 were shown to be cytogenetically stable wheat-rye 6R addition and T1RS.1BL translocation line,6RL ditelosomic addition and T1RS.1BL translocation line,and T1RS.1BL translocation line,respectively.Compared with previously reported wheat-rye derivative lines carrying chromosome 6R,YT4-1 and YT4-2 showed stable APR without undesirable pleiotropic effects on agronomic traits.Therefore,these novel wheat-rye 6R derivative lines are expected to be promising bridge resources in wheat disease breeding. | Guohao Han Jing Wang Hanwen Yan Tiantian Gu Lijun Cao Shiyu Liu Xiuquan Li Yilin Zhou Jieru Fan Zhipeng Shi Hong Liu Lihui Li Diaoguo An | 2024 | The Crop Journal2024，12，1： | 0 |
| 17 | NIR-Ⅱ-absorbing conjugated polymer-based theranostic agent for NIR-Ⅱfluorescence imaging-guided photothermal therapy acting synergistically with tumor microenvironment-responsive nitric oxide therapy显示文摘Despite tremendous advances in gas therapy,there are major concerns about the inevitable concentration of toxicity and the ability to perform real-time tracking of drug delivery.Second near-infrared(NIR-Ⅱ)window absorbing nanoplatforms hold great promise for precision medicine because of their excellent tissue penetration of light and non-invasive nature.In this study,we engineered an NIR-Ⅱlaser-activated theranostic agent(named CP-bF@PEG)that was composed of amphiphilic polymers(Pluronic F127,with polyethylene glycol,PEG,moieties)coated with an NIR-Ⅱ-absorbing conjugated polymer(PTTBBT,CP)and nitric oxide(NO)donor(benzofuroxan,bF),which served as an NIR-Ⅱphotothermal inducer and NO nanogenerator.Under deep tissue penetration of NIR-Ⅱlaser irradiation,CP-bF@PEG was found to possess fluorescence imaging ability to accurately identify tumor and excellent photothermal effect.Moreover,CP-bF@PEG could generate NO via glutathione activation in the tumor microenvironment in a controllable manner.This NIR-Ⅱ-absorbing polymer for high-contrast NIR-Ⅱfluorescence imaging-guided precision photothermal therapy achieved synergistic effects with NO therapy,as evidenced by pronounced tumor therapeutic efficacy and few side effects.This nanotheranostic agent is a highly promising candidate for high-contrast NIR-Ⅱimaging-guided precision photothermal therapy combined with gas therapy against cancer. | Jie Li Lisi Xie Wei Sang Wenxi Li Guohao Wang Hao Tian Zhan Zhang Jianhua Liu Quli Fan Yunlu Dai | 2022 | ChemPhysMater2022，1，1： | 0 |
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