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| 1 | Bevacizumab biosimilar LY01008 compared with bevacizumab(Avastin)as first-line treatment for Chinese patients with unresectable,metastatic,or recurrent non-squamous non-small-cell lung cancer:A multicenter,randomized,double-blinded,phase Ⅲ trial显示文摘Background:Previous studies have demonstrated the preclinical pharmacological and toxicological consistency,and clinical pharmacokinetic equivalence of bevacizumab biosimilar LY01008 with reference bevacizumab(Avastin).This randomized controlled trial aimed to compare the efficacy and safety of LY01008 with Avastin in first-line treatment of Chinese patients with advanced or recurrent non-squamous non-small cell lung cancer(NSCLC).Methods:StageⅢB-ⅣNSCLC patients with evaluable lesions,good physical status,and adequate organ functions from 67 centers across China were randomized in a ratio of 1:1 to receive LY01008 or Avastin 15 mg/kg intravenously in combination with paclitaxel/carboplatin(combined treatment)for 4-6 cycles,followed by maintenance monotherapy with LY01008 until disease progression,intolerable toxicity,or death.The primary endpoint was objective response rate(ORR)in accordance with Response Evaluation Criteria in Solid Tumors(RECIST)version 1.1 confirmed by independent radiological review committees(IRRC).Secondary endpoints included disease control rate(DCR),duration of response(DoR),progression-free survival(PFS),overall survival(OS),and safety.This study was registered in Clinical Trials.gov(NCT03533127).Results:Between December 15^(th),2017,and May 15^(th),2019,a total of 649 patients were randomized to the LY01008(n=324)or Avastin(n=325)group.As of September 25th,2019 for primary endpoint analysis,589 patients received ORR evaluation,with a median number of combined treatment cycles of 5(range 1-6)andmedian duration of treatment of 3.0(range 0.0-5.1)months.ORRof responseevaluable patients in the LY01008 and Avastin groups were 48.5% and 53.0%,respectively.The stratified ORR ratio was 0.91(90%CI 0.80-1.04,within the prespecified equivalence margin of 0.75-1.33).Up to May 15^(th),2020,with a median follow-up of 13.6(range 0.8-28.4)months,no notable differences in DCR,median DoR,median PFS,median OS,and 1-year OS rate were observed between the LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,LY01008 and Avastin groups.There were no clinically meaningful differences in safety and immunogenicity across treatment groups.Conclusions:LY01008 demonstrated similarity to Avastin in terms of efficacy and safety in Chinese patients with advanced or recurrent non-squamous NSCLC.LY01008 combined with paclitaxel/carboplatin is expected to become a new treatment option for unresectable,metastatic,or recurrent non-squamous NSCLC patients in the first-line setting. | Yuankai Shi Kaijian Lei Yuming Jia Bingqiang Ni Zhiyong He Minghong Bi Xicheng Wang Jianhua Shi Ming Zhou Qian Sun Guolei Wang Dongji Chen Yongqian Shu Lianke Liu Zhongliang Guo Yong Liu Junquan Yang Ke Wang Ke Xiao LinWu Tienan Yi Debin Sun Mafei Kang Tianjiang Ma Yimin Mao Jinsheng Shi Tiegang Tang Yan Wang Puyuan Xing Dongqing Lv Wangjun Liao Zhiguo Luo Bin Wang Xiaohong Wu Xiaoli Zhu Shuhua Han Qisen Guo Rongyu Liu Zhiwei Lu Jianyong Zhang Jian Fang Changlu Hu Yinghua Ji Guolong Liu Hong Lu Dedong Wu Junhong Zhang Shuyang Zhu Zheng Liu Wensheng Qiu Feng Ye Yan Yu Yanqiu Zhao Qinhong Zheng Jun Chen Zhanyu Pan Yiping Zhang Wenjuan Lian Bo Jiang Bo Qiu Guojun Zhang Hua Zhang Yanju Chen Yuan Chen Hongbing Duan Manxiang Li Shengming Liu Lijun Ma Hongming Pan Xia Yuan Xueli Yuan Yulong Zheng Emei Gao Li Zhao Shumin Wang Can Wu | 2021 | Cancer Communications2021，41，9： | 5 |
| 2 | Preparation of β-SiC/AI2O3 composite from kaolinite gangue by carbthermal reduction显示文摘 | HAN Bingqiang LI Nan | 2005 | Ceram In2005，31，2： | 1 |
| 3 | An investigation on slag resistance of castable refractories containing porous spinel aggregates 显示文摘 | Yan Wen Li Nan Han Bingqiang | 2009 | InterCeram: Refractories Manual2009，2528，： | 1 |
| 4 | Influence of microsilica content on the slag resistance of castables containing porous corundum-spinel aggregates 显示文摘 | Yan Wen Li Nan Han Bingqiang | 2008 | International Journal of Applied Ceramic Technology2008，5，6： | 1 |
| 5 | Influence of Microporous Magnesia-rich Spinel Aggregates on Properties of Low Carbon MgO-C Refractories显示文摘Two types of low carbon MgO-C refractories with 6% graphite were prepared using microporous magnesia-rich spinel(5-3 and 3-1 mm)and fused magnesia(5-3 and 3-1 mm)as coarse aggregates,respectively,fused magnesia(≤1 mm)as fine aggregate,magnesia powder(≤0.088 mm),flake graphite powder(≤0.088 mm),metal Al powder(<0.074 mm)as matrix,and phenol resin as binder.After curing at 220 ℃ and coke-embedded firing at 1 500 ℃,the apparent porosity,cold crushing strength,cold modulus of rupture,permanent linear change on heating,thermal shock resistance and slag resistance of the specimens were studied comparatively.The results indicate that:(1)after curing at 220 ℃ and coke-embedded firing at 1 500 ℃,the specimen with microporous magnesia-rich spinel replacing fused magnesia has lower bulk density and higher apparent porosity than the common low carbon MgO-C specimen.After curing at 220 ℃,the specimen with microporous aggregate has lower strength than common low carbon MgO-C specimen,but after coke-embedded firing at 1 500 ℃,it has higher strength and lower permanent linear change on heating;(2)low carbon MgO-C specimen using microporous magnesia-rich spinel to replace fused magnesia aggregate has better thermal shock resistance but worse slag resistance. | PENG Conghua LI Nan HAN Bingqiang | 2010 | China's Refractories2010，19，1： | 1 |
| 6 | Highly efficient generation of biallelic reporter gene knock-in mice via CRISPR-mediated genome editing of ESCs显示文摘 | Yanliang Wang Junhong Li Jinzhu Xiang Bingqiang Wen sHaiyuan Mu Wei Zhang Jianyong Han | 2016 | Protein & Cell2016，7，2： | 1 |
| 7 | Pluripotent stem cells secrete Activin A to improve their epiblast competency after injection into recipient embryos显示文摘 | Jinzhu Xiang Suying Cao Liang Zhong Hanning Wang Yangli Pei Qingqing Wei Bingqiang Wen Haiyuan Mu Shaopeng Zhang Liang Yue Genhua Yue Bing Lim Jianyong Han | 2018 | Protein & Cell2018，9，8： | 0 |
| 8 | Pollution of Chrome Bearing Materials and the Solutions显示文摘This paper summarizes the pollution, situation and solutions of chrome bearing materials used in high temperature industry. Hexavalent chromium compounds are readily soluble in water and associated with carcinogen. Therefore, serious environmental problems appeal for the study and application of chrome free materials. Chrome free products include: magnesia based materials, dolomite based materials, magnesia spinel materials, magnesia hercynite or magnesia galaxite materials and zirconia containing materials,and other substitutes. Although any product has its advantages and disadvantages, the trend to development of chrome free products is inevitable. | HAN Bingqiang LI Nan | 2007 | China's Refractories2007，16，1： | 0 |
| 9 | Effect of Andalusite on Properties of Homogenized Bauxite Based Al2O3-SiC-C Castables显示文摘In this study,in order to evaluate the performance of homogenized bauxite,two Al_2O_3-SiC-C castables were prepared using homogenized bauxite and brown fused corundum as aggregates,respectively. 5 mass%andalusite was introduced into the two castables so as to research the effect and mechanism of andalusite in Al_2O_3-SiC-C castables. The results showed that:(1) compared with the brown fused corundum based castables,the homogenized bauxite based castables had higher cold strength after heat treatment,but lower hot modulus of rupture;(2) addition of 5 mass% andalusite could enhance the cold and hot modulus of rupture,improve the thermal shock resistance,and optimize the microstructure of specimens;( 3) the mullitization of andalusite was not obvious in the castables fired at 1100-1400℃. | ZHANG Ting HAN Bingqiang LI Nan | 2017 | China's Refractories2017，26，2： | 0 |
| 10 | Effects of Electro-fused Magnesia on Properties of Al_2O_3-SiC-C Castable显示文摘Al2O3-SiC-C castables for iron trough with fused magnesia powder (0, 3%, 6%, 9% and 12%) were prepared with brown fused corundum particles (5-3 mm, 3-1 mm, ≤1 mm), white fused corundum powder (≤0.088 mm), SiC particle (≤1 mm) and powder (≤0.088 mm), fused magnesia powder (≤0.088 mm), reactive α-Al2O3 micropowder, ultrafine SiO2, Si powder and sphere pitch as main starting materials and calcium aluminate cement as binder. The specimens were fired at 1 100 ℃ and 1 450 ℃ for 3 h after vibrating moulding, curing, demoulding and drying at 110 ℃ for 24 h. Bulk density, apparent porosity, linear change rate, modulus of rupture, resistance to blast furnace slag, oxidation resistance, phase composition and microstructure of the specimens were analyzed. The results show that: (1) With fused magnesia addition increasing, apparent porosity increases, while bulk density, modulus of rupture and oxidation resistance decline, slag resistance varies slightly; (2) The main crystal phases in the specimens fired at 1 450 ℃ for 3 h are 3C-SiC, 6H-SiC, corundum, periclase, reaction-synthesized spinel and mullite; the quantity of the formed spinel and mullite increases with the increase of fused magnesite addition; (3) Along the corroded side, spinel layer with about 80 μm thickness forms at the corundum particles boundary. | HAN Bingqiang LI Yousheng LI Nan | 2008 | China's Refractories2008，17，3： | 0 |
| 11 | Effect of La_2O_3 Addition on Hydration Properties of CaO Clinker显示文摘To obtain CaO clinker with high density,low porosity,and good hydration resistance,the effect of the La_-2O_3 content on physical properties,such as sintering property and hydration resistance of CaO clinker was researched in this paper. Apparent porosity and bulk density were measured by Archimedes principle with kerosene as the medium. Two methods were used to test hydration resistance of CaO clinker. One was carried out in a humidity cabinet at 20 ℃ with 90% of relative humidity.Another was the boiling method. SEM and EDS characterization analyses of CaO clinker were performed to observe the microstructural information and the hydration mechanism was put forward. The results show that:(1)the specimen with 0. 79 mass% of La_2O_3 addition has lower apparent porosity,and higher bulk density;(2)the hydration mass gain of CaO clinker with 0.79 mass% La_2O_3 addition is lower,which is less than 1% after 20 days;(3) La_2O_3 mainly distributes in the grain boundary,and a small amount of La_2O_3 dissolves in grains. The average grain size of CaO specimens with 0.79 mass% La_2O_3 addition sintered at 1450℃,1550℃,and 1650℃,is 44.5 μm,48.6 μm,and 63.5 μm,respectively;(4) solid solution is formed due to the similar ionic radius of La^(3+)and Ca^(2+),which promotes the sintering of CaO clinker and improves the hydration resistance simultaneously. | YU Hui HAN Bingqiang ZHANG Tao WEI Yaowu LI Nan | 2018 | China's Refractories2018，27，1： | 0 |
| 12 | Effect of Temperature Schedule on the Morphology of SiC Made From Graphite and Silicon Powder显示文摘SiC whiskers were synthesized in a coke bed using a two-step heat treatment process.The temperature was held for 3 h at 1 200 ℃ before heating to 1 430 ℃ and holding for 3 h.The morphologies of SiC synthesized by the two-step heat treatment method were much more different from those produced by direct heating to 1 430 ℃.SiC whiskers formed at 1 200 ℃ firstly and grew at1 430 ℃ to obtain a mean diameter about 326 nm,while the SiC grains with a size range from 0.70 to2.30 μm were obtained by direct heating to the target temperature of 1 430 ℃.This was explained by the different formation mechanisms.The result proposes a promising alternative technical process for whisker-reinforced ceramic/refractory composites in-situ during sintering. | CHEN Junfeng LI Nan YAN Wen WEI Yaowu HAN Bingqiang | 2016 | China's Refractories2016，25，4： | 0 |
| 13 | Effect of CeO2 and Calcination Temperature on Hydration Resistance of CaO Aggregates显示文摘Active lime was used to produce Ca(OH)_2fine powder.And then Ca(OH)_2fine powder with analytically pure CeO_2fine powder(0,0.2%,0.4%,0.6%,0.8%and1.0%by mass,respectively)were mixed via wet mixing.After drying and ball milling,the specimens were pressed and fired at 1 450℃,1 500℃,1 550℃,1 600℃and1 650℃,respectively.The hydration resistance of the specimens was evaluated by measuring the mass gain after soaking the specimens in a chamber kept at 20℃and90%relative humidity.The influences of CeO_2and calcination temperature on the hydration resistance of CaO aggregates were investigated by determination of bulk density,apparent porosity,and XRD,SEM and EDS analysis.The results show that:(1)the sintering of CaO aggregates is promoted by CeO_2addition and the hydration resistance of CaO aggregates is improved;(2)CeO_2mainly locates in CaO grain boundary,some CeO_2is solved in the CaO grains which improves CaO sintering;(3)the appropriate calcination temperature is 1 550℃.When the calcination temperature is below 1 550℃,the specimens are sintered inadequately.The density and hydration resistance of CaO aggregates are nearly stable when the calcination temperature is above 1 550℃. | ZHANG Tao WEI Yaowu YU Hui HAN Bingqiang LI Nan | 2017 | China's Refractories2017，26，1： | 0 |
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