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| 1 | Genome analysis of Taraxacum kok-saghyz Rodin provides new insights into rubber biosynthesis显示文摘The Russian dandelion Taraxacum kok-saghyz Rodin(TKS), a member of the Composite family and a potential alternative source of natural rubber(NR) and inulin, is an ideal model system for studying rubber biosynthesis. Here we present the draft genome of TKS, the first assembled NR-producing weed plant. The draft TKS genome assembly has a length of 1.29 Gb, containing 46 731 predicted protein-coding genes and68.56% repeats, in which the LTR-RT elements predominantly contribute to the genome enlargement. We analyzed the heterozygous regions/genes, suggesting its possible involvement in inbreeding depression.Through comparative studies between rubber-producing and non-rubber-producing plants, we found that enzymes of the mevalonate(MVA) pathway and rubber elongation might be critical for rubber biosynthesis, and several key isoforms have been isolated and shown to be predominantly expressed in the latex, indicating their crucial functions in rubber biosynthesis. Moreover, for two important families in rubber elongation, the CPT/CPTL and REF/SRPP families, diverse evolutionary tracks have been revealed. These results provide valuable resources and new insights into the mechanism of NR biosynthesis,and facilitate the development of alternative NR-producing crops. | Tao Lin Xia Xu Jue Ruan Shizhong Liu Shigang Wu Xiujuan Shao Xiaobo Wang Lin Gan Bi Qin Yushuang Yang Zhukuan Cheng Suhua Yang Zhonghua Zhang Guosheng Xiong Sanwen Huang Hong Yu Jiayang Li | 2018 | National Science Review2018，5，1： | 22 |
| 2 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 3 | The effects of coal blending on the formation and properties of particulate matter during combustion显示文摘The control of particulate matter (PM) emissions from coal combustion becomes an urgent work due to their adverse effects on human health. Coal blending is a promising option for submicron particulate (PM1) reduction. This study addressed the effects of coal blending on the formation and properties of particulate matter in combustion process. Coal blends from lignite and bituminous coal,with different blend ratios (9:1,7:3,5:5,3:7 and 1:9),were combusted in a drop tube furnace. The mass size distribution,concentration,elemental composition and morphology of the particulate matter generated under O2/N2 and O2/CO2 conditions were characterized. Particulate matter was collected by a low pressure impactor (LPI),which aerodynamically segregated particulates into thirteen fractions with sizes ranging from 0.03 to 9.8 μm. The results showed that coal blending reduced PM1 generation,compared with the calculated average values from the combustion of constituent coals. This indicated that the mineral interactions had a great effect on PM1 reduction. The blend ratio also played an important role in the suppression of PM1 genera-tion. In this experimental study,PM1 generation suffered a maximum suppression at the blend ratio of 7:3. The O2/CO2 atmos-phere affected the formation and properties of the PM1 during coal blends combustion. Compared with the O2/N2 combustion,the interaction of minerals was weakened under O2/CO2 combustion,thus the suppression of PM1 generation decreased after coal blending. Compared with the calculated values,the concentrations and percentages of Ca,Fe in PM1 decreased,but the concentra-tions of Ca,Fe,Si and Al in coarse particulates (PM10+) increased after coal blends combustion. The interactions between the aluminosilicates in the bituminous coal and volatile elements Ca,Fe in the lignite were thought to contribute to the suppression of PM1 generation during the combustion of coal blends. | ZHOU Ke XU MingHou YU DunXi WEN Chang ZHAN ZhongHua YAO Hong | 2010 | Chinese Science Bulletin2010，55，30： | 7 |
| 4 | Characteristics and composition of particulate matter from coal-fired power plants显示文摘Measurements of the characteristics of particulate matter(PM)were performed at the inlet and outlet of the electrostatic precipitators(ESP)of four boilers in two full-scale pulverized coal power plants.PM was collected with a 13-stages low-pressure-impactor(LPI)having aerodynamic cut-off diameter ranging from 10.0 to 0.03μm for a size-segregated collection.The properties of PM including its con-centration,mass size distribution,emission characteristics,percent penetration of PM through ESP and elemental composition were investigated.The experimental results indicate that,in all the cases the mass size distribution of PM10 had typical bimodal.PM1 contained up to 1.15wt% of the total particle(TP)generated in the boilers.PM2.5 contained about 2wt%―7wt% of the TP and PM10 contained about 4wt%―19wt% of the TP.When additive limestone used for desulphurization as sorbent besides PM generated from coal combustion,there was new PM generated from limestone.Penetration as a func-tion of particle diameter had a clear peak in particle size ranging from 0.2 to 0.6μm.Particles in the submicrometer size range were much more difficult to be collected with ESP than larger particles.Dis-tributions of individual elements within PM10 were different. | LIU XiaoWei XU MingHou YAO Hong YU DunXi ZHANG ZhongHua LüDangZhen | 2009 | Science China(Technological Sciences)2009，52，6： | 7 |
| 5 | Study on ultrasonic spray technology for the coating of vascular stent显示文摘The ultrasonic spray technology is studied by the method of theoretical derivation,CFD simulation,spray particle diameter detection and analysis,and experimental analysis. And the ultrasonic spray process for the coating of vascular stent is also optimized. Firstly,the ultrasonic atomization physical model is established and the equation of atomization particle diameter is derived. Secondly,the ultrasonic atomization process is simulated by the CFD method,and shows three atomization patterns:incomplete atomization pattern,critical atomization pattern and jet atomization pattern. The critical amplitude and power equation for ultrasonic atomization is derived. Thirdly,experiment is conducted to study the influence of parameters including power,gas pressure,and surface tension. The results show that the spray is stable though few particles are likely to collide each other during spray moving,and the droplet diameter is about 10-m. The Rosin-Rammler distribution equation for ultrasonic spray is created,and the uniform index number is between 7.11 and 11.48. The uniformity of spray particle diameter,the efficiency of adjustment and the energy consumption are better than traditional spray technology. Lastly,the ultrasonic spray process parameters for stent coating are optimized to eliminate the common defects and obtain fine coating. | YI Hong HUANG Jie GU XingZhong NI ZhongHua | 2011 | Science China(Technological Sciences)2011，54，12： | 5 |
| 6 | Separation of nanocolloids driven by dielectrophoresis:A molecular dynamics simulation显示文摘The nonequilibrium molecular dynamics (MD) method was used to model the nanocolloids and the solvent particles. By introducing a non-uniform electric field, colloids were polarized to have opposite polarities. Separation of colloids driven by dielectrophoresis (DEP) could be seen clearly under a strong electric field at low temperatures. Analyzing the ratio of DEP velocities of colloids to thermal velocities of neutral solvent particles showed that when the ratio was correspondingly big, collision between colloids and solvent particles would be intense, making the DEP velocity of colloids fluctuate frequently. By changing the electric field strength, it was found that the enhancement of electric field strength would quicken the separation of colloids. But when the electric field strength increased to a certain degree, the separation motion would be slow because of the strong friction resistance of the solvent particles to the colloids. Moreover, studying the separation reason of colloids based on the potential energy showed that after colloids were polarized, the attractive potential energy among the colloids would be weaker than before, while the increase of temperature would reduce the attractive potential energy and increase the repulsive potential energy, which accorded with the DLVO theory. | NI ZhongHua ZHANG XinJie YI Hong | 2009 | Science China(Technological Sciences)2009，52，7： | 5 |
| 7 | First results on ^(76)Ge neutrinoless double beta decay from CDEX-1 experiment显示文摘We report the first results on ^(76)Ge neutrinoless double beta decay from stage one of the China dark-matter experiment(CDEX).A p-type point-contact high-purity germanium detector with a mass of 994 g has been installed to detect neutrinoless double beta decay events, as well as to directly detect dark matter particles. An exposure of 304 kg d has been analyzed over a wide spectral band from 500 keV to 3 MeV. The average event rate obtained was about 0.012 counts per keV per kg per day over the 2.039 MeV energy range. The half-life of ^(76)Ge neutrinoless double beta decay derived based on this result is T^(0ν)1/2>6.4×10^(22) yr(90% C.L.). An upper limit on the effective Majorana-neutrino mass of 5.0 eV has been achieved. | Li Wang Qian Yue KeJun Kang JianPing Cheng YuanJing Li TszKing Henry Wong ShinTed Lin JianPing Chang JingHan Chen QingHao Chen YunHua Chen Zhi Deng Qiang Du Hui Gong Li He QingJu He JinWei Hu HanXiong Huang TengRui Huang LiPing Jia Hao Jiang HauBin Li Hong Li JianMin Li Jin Li Jun Li Xia Li XueQian Li YuLan Li FongKay Lin ShuKui Liu Hao Ma JingLu Ma XingYu Pan Jie Ren XiChao Ruan ManBin Shen Vivek Sharma Lakhwinder Singh Manoj Kumar Singh Manoj Kumar Singh Arun Kumar Soma ChangJian Tang WeiYou Tang ChaoHsiung Tseng JiMin Wang Qing Wang ShiYong Wu YuCheng Wu HaoYang Xing Yin Xu Tao Xue LiTao Yang SongWei Yang Nan Yi ChunXu Yu HaiJun Yu WeiHe Zeng XiongHui Zeng Zhi Zeng Lan Zhang YunHua Zhang MingGang Zhao Wei Zhao JiFang Zhou ZuYing Zhou JingJun Zhu WeiBin Zhu ZhongHua Zhu | 2017 | Science China(Physics,Mechanics & Astronomy)2017，60，7： | 3 |
| 8 | Research on critical technology of micro/nano bioparticles manipulation platform based on light-induced dielectrophoresis显示文摘On the basis of the research on the status and problems of micro/nano bio-particles manipulation using dielectrophoresis, the theoretical basis and the model simulation of micro/nano bio-particles manipu-lation using light-induced dielectrophoresis were discussed. The space distribution of electric field and dielectrophoresis forces in different heights were also obtained. On this basis, the core component of the micro manipulation system, that is, photoconductive layer of the chip, was completed in the mate-rial selection, fabricating process and performance analysis testing. Then the voltage drop of the sus-pension and the effective voltage frequency spectrum were obtained. Finally, by combining the machine vision detection with real-time tracking system, the micro/nano bio-particles manipulation platform based on the light-induced dielectrophoreisis was established, and then the manipulations for micro/nano bio-particles, such as quick collection, transport, separation, were implemented. This provided a basis for rapid, accurate, and low-cost detection of serious diseases based on the micro-fluidic biochip and early diagnosis. | NI ZhongHua YI Hong ZHU ShuCun SONG ChunFeng | 2009 | Science China(Technological Sciences)2009，52，10： | 3 |
| 9 | Exosomes secreted from cardiomyocytes suppress the sensitivity of tumor ferroptosis in ischemic heart failure显示文摘Heart failure(HF)patients in general have a higher risk of developing cancer.Several animal studies have indicated that cardiac remodeling and HF remarkably accelerate tumor progression,highlighting a cause-and-effect relationship between these two disease entities.Targeting ferroptosis,a prevailing form of non-apoptotic cell death,has been considered a promising therapeutic strategy for human cancers.Exosomes critically contribute to proximal and distant organ-organ communications and play crucial roles in regulating diseases in a paracrine manner.However,whether exosomes control the sensitivity of cancer to ferroptosis via regulating the cardiomyocyte-tumor cell crosstalk in ischemic HF has not yet been explored.Here,we demonstrate that myocardial infarction(MI)decreased the sensitivity of cancer cells to the canonical ferroptosis activator erastin or imidazole ketone erastin in a mouse model of xenograft tumor.Post-MI plasma exosomes potently blunted the sensitivity of tumor cells to ferroptosis inducers both in vitro in mouse Lewis lung carcinoma cell line LLC and osteosarcoma cell line K7M2 and in vivo with xenograft tumorigenesis model.The expression of miR-22-3p in cardiomyocytes and plasma-exosomes was significantly upregulated in the failing hearts of mice with chronic MI and of HF patients as well.Incubation of tumor cells with the exosomes isolated from post-MI mouse plasma or overexpression of miR-22-3p alone abrogated erastin-induced ferroptotic cell death in vitro.Cardiomyocyte-enriched miR-22-3p was packaged in exosomes and transferred into tumor cells.Inhibition of cardiomyocyte-specific miR-22-3p by AAV9 sponge increased the sensitivity of cancer cells to ferroptosis.ACSL4,a pro-ferroptotic gene,was experimentally established as a target of miR-22-3p in tumor cells.Taken together,our findings uncovered for the first time that MI suppresses erastin-induced ferroptosis through releasing miR-22-3p-enriched exosomes derived from cardiomyocytes.Therefore,targeting exosome-mediated cardiomyocyte/tumor pathological communication may offer a novel approach for the ferroptosis-based antitumor therapy. | Ye Yuan Zhongting Mei Zhezhe Qu Guanghui Li Shuting Yu Yingqi Liu Kuiwu Liu Zhihua Shen Jiaying Pu Yanquan Wang Changhao Wang Zhiyong Sun Qian Liu Xiaochen Pang Ao Wang Zijing Ren Tong Wang Ying Liu Jinhuan Hong Jiajie Xie Xin Li Zhonghua Wang Weijie Du Baofeng Yang | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 2 |
| 10 | Silicon substrate-integrated hollow waveguide for miniaturized optical gas sensing显示文摘Gas sensors have a wide variety of applications.Among various existing gas sensing technologies,optical gas sensors have outstanding advantages.The development of the Internet of Things and consumer electronics has put stringent requirements on miniaturized gas sensing technology.Here,we demonstrate a chip-scale silicon substrate-integrated hollow waveguide(Si-iHWG) to serve as an optical channel and gas cell in an optical gas sensor.It is fabricated through silicon wafer etching and wafer bonding.The Si-i HWG chip is further assembled with an off-chip light source and detector to build a fully functional compact nondispersive infrared(NDIR) CO_(2) sensor.The chip size is 10 mm × 9 mm,and the dimension of the sensor excluding the microcontroller board is 50 mm × 25 mm × 16 mm.This chip solution with compactness,versatility,robustness,and low cost provides a cost-effective platform for miniaturized optical sensing applications ranging from air quality monitoring to con-sumer electronics. | SHAONAN ZHENG HONG CAI LINFANG XU NANXI LI ZHONGHUA GU YAO ZHANG WEIGUO CHEN YANYAN ZHOU QINGXIN ZHANG LENNON YAO TING LEE | 2022 | Photonics Research2022，10，1： | 2 |
| 11 | OPTIMIZATION OF CORONARY STENT STRUCTURE DESIGN FOR MAXIMIZING THE ANTICOMPRESSION MECHANICAL PROPERTY显示文摘Excellent mechanical property of the anti-compression or high collapse pressure has become an essential feature of new coronary stents.How to determine the design parameters of stent becomes the key to improve the stent quality.An integrated approach using radial basis function neural network (RBFNN) and genetic algorithm (GA) for the optimization of anti-compression mechanical property of stent is presented in this paper.First,finite element simulation and RBFNN are used to map the complex non-linear relationship between the collapse pressure and stent design parameters.Then GA is employed with the fitness function based on an RBFNN model for arriving at optimum configuration of the stent by maximizing the collapse pressure.The results of numerical experiment demonstrate that the combination of RBFNN and GA is an effective approach for the mechanical properties optimization of stent. | SHEN Xiang YI Hong NI Zhonghua GU Xingzhong | 2008 | Chinese Journal of Mechanical Engineering2008，21，6： | 2 |
| 12 | Clean Synthesis of adipic acid by direct oxidation of cyclohexene in the absence of phase transfer agents显示文摘 | Heng Jiang Hong Gong Zhonghua Yang Xiaotong Zhang Zhaolin Sun | 2002 | Reaction Kinetics and Catalysis Letters2002，，2： | 1 |
| 13 | Novel nanocrystalline PdNi alloy catalyst for methanol and ethanol electro-oxidation in alkaline media显示文摘 | Zhen Qi Haoran Geng Xiaoguang Wang Changchun Zhao Hong Ji Chi Zhang Junling Xu Zhonghua Zhang | 2011 | Journal of Power Sources2011，，： | 1 |
| 14 | 24-h residual urine volume at hemodialysis initiation: A possible predictor for acute ischemic stroke incurrence in hemodialyis patients显示文摘 | Yuemei Chen Hong Liu Jianzhou Zou Yuxing Ge Jie Teng ShaoWei Xu WenLv Lv Zhonghua Liu Yan Xu XueSen Cao Bo Shen XiaoQiang Ding | 2012 | Clinical Neurology and Neurosurgery2012，，： | 1 |
| 15 | pUGTdb:A comprehensive database of plant UDP-dependent glycosyltransferases显示文摘Dear Editor,Plant UDP-dependent glycosyltransferases(UGTs),belonging to the carbohydrate-active enzyme glycosyltransferase 1 family(Louveau and Osbourn,2019),not only play important roles in adaptation to various environments(Cai et al.,2020;Pastorczyk-Szlenkier and Bednarek,2021)but also endow plant natural products with great pharmaceutical and ecological significance(Margolin et al.,2020).In recent years,an increasing number of plant UGTs have been characterized to function in the biosynthesis of many bioactive compounds such as ginsenosides(Wei et al.,2015),breviscapine(Liu et al.,2018),and rubusoside(Xu et al.,2022). | Yuqian Liu Qian Wang Xiaonan Liu Jian Chengi Lei Zhang Huanyu Chu Ruoyu Wang Haoran Li Hong Chang Nida Ahmed Zhonghua Wang Xiaoping Liao Huifeng Jiang | 2023 | Molecular Plant2023，16，4： | 1 |
| 16 | The phase transition and optical synthesis temperature of LiNiO2显示文摘 | Lu Zhonghua Huang Xuejie Huang Hong | 1999 | Solid State Ionics1999，118，： | 1 |
| 17 | A robust structure-adaptive hy- brid vector filter for color image restoration显示文摘 | Zhonghua M Hong R W Bin Q | 2005 | lEEE Transac- tions on Image Processing2005，14，12： | 1 |
| 18 | Novel Raney-like nanoporous Pd catalyst with superior electrocatalytic activity towards ethanol electro-oxidation显示文摘 | Xiaoguang Wang Weimin Wang Zhen Qi Changchun Zhao Hong Ji Zhonghua Zhang | 2011 | International Journal of Hydrogen Energy2011，，3： | 1 |
| 19 | Clean Synthesis of adipic acid by direct oxidation of cyclohexene in the absence of phase transfer agents显示文摘 | Heng Jiang Hong Gong Zhonghua Yang Xiaotong Zhang Zhaolin Sun | 2002 | Reaction Kinetics and Catalysis Letters2002，，2： | 1 |
| 20 | A harlequin ichthyosis pig model with a novel ABCA12 mutation can be rescued by acitretin treatment显示文摘Harlequin ichthyosis (HI) is a severe genetic skin disorder and caused by mutation in the ATP-binding cassette A12 (ABCA12) gene. The retinoid administration has dramatically improved long-term survival of HI, but improvements are still needed. However, the ABCA12 null mice failed to respond to retinoid treatment, which impedes the development of novel cure strategies for HI. Here we generated an ethylnitrosourea mutagenic HI pig model (named Z9), which carries a novel deep intronic mutation IVS49-727 A>G in the ABCA12 gene, resulting in abnormal mRNA splicing and truncated protein production. Z9 pigs exhibit significant clinical symptom as human patients with HI. Most importantly, systemic retinoid treatment significantly prolonged the life span of the mutant pigs via improving epidermal maturation, decreasing epidermal apoptosis, and triggering the expression of ABCA6. Taken together, this pig model perfectly resembles the clinical symptom and molecular pathology of patients with HI and will be useful for understanding mechanistic insight and developing therapeutic strategies. | Xiao Wang Chunwei Cao Yongshun Li Tang Hai Qitao Jia Ying Zhang Qiantao Zheng Jing Yao Guosong Qin Hongyong Zhang Ruigao Song Yanfang Wang Guanghou Shui Sin Man Lam Zhonghua Liu Hong Wei Anming Meng Qi Zhou Jianguo Zhao | 2019 | Journal of Molecular Cell Biology2019，11，12： | 1 |
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