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| 1 | H7N9 virulent mutants detected in chickens in China pose an increased threat to humans显示文摘 | Jianzhong Shi Guohua Deng Huihui Kong Chunyang Gu Shujie Ma Xin Yin Xianying Zeng Pengfei Cui Yan Chen Huanliang Yang Xiaopeng Wan Xiurong Wang Liling Liu Pucheng Chen Yongping Jiang Jinxiong Liu Yuntao Guan Yasuo Suzuki Mei Li Zhiyuan Qu Lizheng Guan Jinkai Zang Wenli Gu Shuyu Han Yangming Song Yuzhen Hu Zeng Wang Linlin Gu Wenyu Yang Libin Liang Hongmei Bao Guobin Tian Yanbing Li Chuanling Qiao Li Jiang Chengjun Li Zhigao Bu Hualan Chen | 2017 | Cell Research2017，27，12： | 70 |
| 2 | Neuroprotective effects of Buyang Huanwu decoction on cerebral ischemia-induced neuronal damage显示文摘Among the various treatment methods for stroke, increasing attention has been paid to traditional Chinese medicines. Buyang Huanwu decoction is a commonly used traditional Chinese medicine for the treatment of stroke. This paper summarizes the active components of the Chinese herb, which is composed of Huangqi(Radix Astragali seu Hedysari), Danggui(Radix Angelica sinensis), Chishao(Radix Paeoniae Rubra), Chuanxiong(Rhizoma Ligustici Chuanxiong), Honghua(Flos Carthami), Taoren(Semen Persicae) and Dilong(Pheretima), and identifies the therapeutic targets and underlying mechanisms that contribute to the neuroprotective properties of Buyang Huanwu decoction. | Qingchun Mu Pengfei Liu Xitong Hu Haijun Gao Xu Zheng Haiyan Huang | 2014 | Neural Regeneration Research2014，9，17： | 32 |
| 3 | The China Alzheimer Report 2022显示文摘China’s population has rapidly aged over the recent decades of social and economic development as neurodegenerative disorders have proliferated,especially Alzheimer’s disease(AD)and related dementias(ADRD).AD’s incidence rate,morbidity,and mortality have steadily increased to make it presently the fifth leading cause of death among urban and rural residents in China and magnify the resulting financial burdens on individuals,families and society.The‘Healthy China Action’plan of 2019-2030 promotes the transition from disease treatment to health maintenance for this expanding population with ADRD.This report describes related epidemiological trends,evaluates the economic burden of the disease,outlines current clinical diagnosis and treatment status and delineates existing available public health resources.More specifically,it examines the public health impact of ADRD,including prevalence,mortality,costs,usage of care,and the overall effect on caregivers and society.In addition,this special report presents technical guidance and supports for the prevention and treatment of AD,provides expertise to guide relevant governmental healthcare policy development and suggests an information platform for international exchange and cooperation. | Rujing Ren Jinlei Qi Shaohui Lin Xinya Liu Peng Yin Zhihui Wang Ran Tang Jintao Wang Qiang Huang Jianping Li Xinyi Xie Yongbo Hu Shishuang Cui Yuan Zhu Xiaoping Yu Pengfei Wang Yikang Zhu Yiran Wang Yanyan Huang Yisong Hu Ying Wang Chunbo Li Maigeng Zhou Gang Wang | 2022 | General Psychiatry2022，35，1： | 20 |
| 4 | Neutrophil extracellular traps mediate the crosstalk between glioma progression and the tumor microenvironment via the HMGB1/RAGE/IL-8 axis显示文摘Objective:Neutrophil extracellular traps(NETs)produced by tumor-infiltrating neutrophils(TINs)are associated with poor prognosis in patients with several types of cancer.However,the mechanisms underlying the involvement of NETs in glioma progression remain largely unknown.This study aimed to elucidate the roles of NETs in biological processes that drive the crosstalk between glioma progression and the tumor microenvironment.Methods:Neutrophil infiltration and NETs formation were investigated in glioma tissue through immunohistochemistry,and their relationships with clinicopathological features and outcomes were statistically evaluated.The effects of NETs on glioma cell progression were studied in a co-culture system.In vivo and in vitro experiments validated the reactive oxygen species activity and cytokine production of TINs,as well as the ERK signaling pathway activation and the metastasis of gliomas.Results:Neutrophil infiltration and NETs formation were induced in high-grade glioma compared with low-grade glioma.NETs induced by TINs were determined to be an oncogenic marker of high-grade gliomas and to be involved in cell proliferation and invasion.NETs overproduction promoted glioma cell proliferation,migration,and invasion.Furthermore,HMGB1 was found to bind to RAGE and activate the NF-κB signaling pathway in vitro.In addition,NETs stimulated the NF-κB signaling pathway,thus promoting IL-8 secretion in glioblastoma.Subsequently,IL-8 recruited neutrophils which in turn mediated NETs formation via the PI3 K/AKT/ROS axis in TINs.Conclusions:Our results suggest that NETs produced by TINs mediate the crosstalk between glioma progression and the tumor microenvironment by regulating the HMGB1/RAGE/IL-8 axis.Targeting NETs formation or IL-8 secretion may be an effective approach to inhibit glioma progression. | Caijun Zha Xiangqi Meng Lulu Li Shan Mi Da Qian Ziwei Li Pengfei Wu Shaoshan Hu Shihong Zhao Jinquan Cai Yanhong Liu | 2020 | Cancer Biology & Medicine2020，17，1： | 19 |
| 5 | γ-secretase inhibitor DAPT prevents neuronal death and memory impairment in sepsis associated encephalopathy in septic rats显示文摘 | Huang Man Liu chunhui Hu Yueyu Wang Pengfei Ding Meiping | 2014 | Chinese Medical Journal2014，，5： | 12 |
| 6 | Effect of slurry conditioning on flocculant-aided filtration of coal tailings studied by low-field nuclear magnetic resonance and X-ray micro-tomography显示文摘The present work aimed to study the effect of slurry conditioning on flocculant-aided filtration of coal tailings by the analysis of filtration kinetics and filter cake structure.Laboratory filtration tests of the coal tailings showed that both the shear rate and agitation time have significant effects on filtration rate and cake moisture.Moderate agitation at the shear rate of 92 s^-1 was favorable for fast filtration,but high cake moisture was encountered.The low-field 1H nuclear magnetic resonance(NMR)measurements of the filter cake showed that the slurry conditioning has a significant effect on the residual water in large pores and a negligible effect on the residual water in small pores.The X-ray micro-tomography(XRM)measurements indicated that the filter cake formed at the shear rate of 92 s^-1 has more macro-pores and higher porosity than that formed at the shear rate of 53 s1,hence more residual water was entrapped in filter cake.The slurry conditioning in the presence of flocculant will change the structure of filter cake and affect the filtration performance.There was a paradox between fast filtration rate and low filter cake moisture.The findings enable better understanding of the effect of slurry conditioning on flocculant-aided filtration of coal tailings. | Pengfei Hu Long Liang Guangyuan Xie Shaoqi Zhou Yaoli Peng | 2020 | International Journal of Mining Science and Technology2020，30，6： | 12 |
| 7 | Yolk-shell Si/C composites with multiple Si nanoparticles encapsulated into double carbon shells as lithium-ion battery anodes显示文摘The conceptual design of yolk-shell structured Si/C composites is considered to be an effective way to improve the recyclability and conductivity of Si-based anode materials. Herein, a new type of yolk-shell structured Si/C composite (denoted as TSC-PDA-B) has been intelligently designed by rational engineering and precise control. In the novel structure, the multiple Si nanoparticles with small size are successfully encapsulated into the porous carbon shells with double layers benefiting from the strong etching effect of HF. The TSC-PDA-B product prepared is evaluated as anode materials for lithium-ion batteries (LIBs). The TSC-PDA-B product exhibits an excellent lithium storage performance with a high initial capacity of 2108 mAh g^-1 at a current density of 100 mA g^-1 and superior cycling performance of 1113 mAh g^-1 over 200 cycles. The enhancement of lithium storage performance may be attributed to the construction of hybrid structure including small Si nanoparticles, high surface area, and double carbon shells, which can not only increase electrical conductiv让y and intimate electrical contact with Si nanoparticles, but also provide built-in buffer voids for Si nanoparticles to expand freely without damaging the carbon layer. The present findings can provide some scientific insights into the design and the application of advanced Si-based anode materials in energy storage fields. | Le Hu Bin Luo Chenghao Wu Pengfei Hu Lianzhou Wang Haijiao Zhang | 2019 | Journal of Energy Chemistry2019，28，5： | 10 |
| 8 | The seismic reflecting characteristics of gas hydrate bearing strata and its possible distribution in the South China Sea显示文摘关于煤气的水合物的研究是对精力资源和环境的地的一般兴趣的话题之一。华南海为煤气的水合物的出现和形成有有利条件。煤气的水合物的存在在模仿反射镜的底部的出现改变沉积阶层和结果的声学的性质,它使多信道的地震调查成为一个重要方法识别煤气的水合物。首先,基于地震思考成像的结果,论文分析包含煤气的水合物的沉积阶层的质的地震思考特征。一些关键地震成像技术也被讨论。下次,一口伪井被构造执行阻抗倒置自从在学习区域没有井,得到阶层的量的速度结构。最后,从地球物理的倒置的速度领域与在钻程序 184 巡航的海洋上获得的 geochemical 和地球物理的数据是综合的。所有信息证实煤气的水合物的存在并且显示出它的空间分发。 | Xu Huaning Li Liqing Shu Hu Wen Pengfei Zhang Baojin | 2006 | Applied Geophysics2006，3，1： | 10 |
| 9 | High power all-fiberized and narrow-bandwidth MOPA system by tandem pumping strategy for thermally induced mode instability suppression显示文摘An all-fiberized and narrow-bandwidth master oscillator power amplification(MOPA) system with record output power of 4 kW level and slope efficiency of 78% is demonstrated. Tandem pumping strategy is tentatively introduced into the narrow-bandwidth MOPA system for thermally induced mode instability(TMI) suppression. The stimulated Brillouin scattering(SBS) effect is balanced by simply using one-stage phase modulation technique. With different phase modulation signals, SBS limited output powers of 336 W, 1.2 kW and 3.94 kW are respectively achieved with spectral bandwidths accounting for 90% power of ~0.025, 0.17 and ~0.89 nm. Compared with our previous 976 nm pumping system, TMI threshold is overall boosted to be >5 times in which tandem pumping increases the TMI threshold of >3times. The beam quality(M~2 factor) of the output laser is well within 1.5 below the TMI threshold while it is ultimately saturated to be 1.86 with the influence of TMI at maximal output power. Except for SBS and TMI, stimulated Raman scattering(SRS) effect will be another challenge for further power scaling. In such a high power MOPA system, multidetrimental effects(SBS, SRS and TMI) will coexist and may be mutual-coupled, which could provide a well platform for further comprehensively investigating and optimizing the high power, narrow-bandwidth fiber amplifiers. | Pengfei Ma Hu Xiao Daren Meng Wei Liu Rumao Tao Jinyong Leng Yanxing Ma Rongtao Su Pu Zhou Zejin Liu | 2018 | High Power Laser Science and Engineering2018，6，4： | 9 |
| 10 | All-fiberized and narrow-linewidth 5 kW power-level fiber amplifier based on a bidirectional pumping configuration显示文摘In this paper,an all-fiberized and narrow-linewidth 5 kW power-level fiber amplifier is presented.The laser is achieved based on the master oscillator power amplification configuration,in which the phase-modulated single-frequency laser is applied as the seed laser and a bidirectional pumping configuration is applied in the power amplifier.The stimulated Brillouin scattering,stimulated Raman scattering,and transverse mode instability effects are all effectively suppressed in the experiment.Consequently,the output power is scaled up to 4.92 kW with a slope efficiency of as high as approximately 80%.The 3-dB spectral width is about 0.59 nm,and the beam quality is measured to be M^(2)~1.22 at maximum output power.Furthermore,we have also conducted a detailed spectral analysis on the spectral width of the signal laser,which reveals that the spectral wing broadening phenomenon could lead to the obvious decrease of the spectral purity at certain output power.Overall,this work could provide a reference for obtaining and optimizing high-power narrow-linewidth fiber lasers. | Pengfei Ma Hu Xiao Wei Liu Hanwei Zhang Xiaolin Wang Jinyong Leng Pu Zhou | 2021 | High Power Laser Science and Engineering2021，9，3： | 9 |
| 11 | cDNA microarray reveals the alterations of cytoskeleton-related genes in osteoblast under high magneto-gravitational environment显示文摘为模仿减少的严肃环境的一个新奇基于地面的模型广泛地在许多地里被使用了的抗磁的悬浮。在这研究,一个专辑设计了超导的磁铁,它能生产三个明显的严肃层次(0, 1,和 2 g ) ,也就是高的磁电机重力的环境(HMGE ) ,被用来模仿空间严肃环境。造骨细胞基因表示侧面上的 HMGE 的效果被 microarray 调查。对抗磁的悬浮环境(0 g ) 敏感的基因,严肃变化,和高磁场变化根据典型房间功能被排序。作为细胞内部的忍受负担的结构,细胞骨架在严肃感觉起一个重要作用。因此, 13 细胞骨架相关的基因根据 microarray 分析的结果被选择,并且这些基因的表情被发现被即时 PCR 在 HMGE 下面改变。基于 PCR 结果, WASF2 的表情(是蛋白质家庭,成员 2 ) , WIPF1 (WAS/WASL 交往蛋白质家庭,成员 1 ) , paxillin,和 talin 1 被西方的污点试金进一步识别。结果显示了那 WASF2, WIPF1 对改变的严肃层次,和 talin 更敏感 1 并且 paxillin 对磁场和严肃变化敏感。我们的调查结果证明 HMGE 能影响造骨细胞基因表示侧面和细胞骨架相关的基因表示。mechanosensitive 基因的鉴定可以提高我们的理解到 microgravity 导致的骨头损失的机制并且可以为阻止并且对待骨头损失或骨质疏松症提供一些潜在的目标。 | Airong Qian Shengmeng Di Xiang Gao Wei Zhang Zongcheng Tian Jingbao Li Lifang Hu Pengfei Yang Dachuan Yin Peng Shang | 2009 | Acta Biochimica et Biophysica Sinica2009，41，7： | 8 |
| 12 | A Simple Approach to Bioconjugation at Diverse Levels: Metal-Free Click Reactions of Activated Alkynes with Native Groups of Biotargets without Prefunctionalization显示文摘Te efcient bioconjugation of functional groups/molecules to targeted matrix and bio-related species drives the great development of material science and biomedicine,while the dilemma of metal catalysis,uneasy premodifcation,and limited reaction efciency in traditional bioconjugation has restricted the booming development to some extent.Here,we provide a strategy for metal-free click bioconjugation at diverse levels based on activated alkynes.As a proof-of-concept,the abundant native groups including amine,thiol,and hydroxyl groups can directly react with activated alkynes without any modifcation in the absence of metal catalysis.Trough this strategy,high-efcient modifcation and potential functionalization can be achieved for natural polysaccharide,biocompatible polyethylene glycol(PEG),synthetic polymers,cell penetrating peptide,protein,fast whole-cell mapping,and even quick diferentiation and staining of Gram-positive bacteria,etc.Terefore,current metal-free click bioconjugation strategy based on activated alkynes is promising for the development of quick fuorescence labeling and functional modifcation of many targets and can be widely applied towards the fabrication of complex biomaterials and future in vivo labeling and detection. | Xianglong Hu Xueqian Zhao Benzhao He Zheng Zhao Zheng Zheng Pengfei Zhang Xiujuan Shi Ryan T.K.Kwok Jacky W.Y.Lam Anjun Qin Ben Zhong Tang | 2018 | Research2018，，1： | 7 |
| 13 | New innovations in pavement materials and engineering:A review on pavement engineering research 2021显示文摘Sustainable and resilient pavement infrastructure is critical for current economic and environmental challenges.In the past 10 years,the pavement infrastructure strongly supports the rapid development of the global social economy.New theories,new methods,new technologies and new materials related to pavement engineering are emerging.Deterioration of pavement infrastructure is a typical multi-physics problem.Because of actual coupled behaviors of traffic and environmental conditions,predictions of pavement service life become more and more complicated and require a deep knowledge of pavement material analysis.In order to summarize the current and determine the future research of pavement engineering,Journal of Traffic and Transportation Engineering(English Edition)has launched a review paper on the topic of'New innovations in pavement materials and engineering:A review on pavement engineering research 2021'.Based on the joint-effort of 43 scholars from 24 well-known universities in highway engineering,this review paper systematically analyzes the research status and future development direction of 5 major fields of pavement engineering in the world.The content includes asphalt binder performance and modeling,mixture performance and modeling of pavement materials,multi-scale mechanics,green and sustainable pavement,and intelligent pavement.Overall,this review paper is able to provide references and insights for researchers and engineers in the field of pavement engineering. | JTTE Editorial Office Jiaqi Chen Hancheng Dan Yongjie Ding Yangming Gao Meng Guo Shuaicheng Guo Bingye Han Bin Hong Yue Hou Chichun Hu Jing Hu Ju Huyan Jiwang Jiang Wei Jiang Cheng Li Pengfei Liu Yu Liu Zhuangzhuang Liu Guoyang Lu Jian Ouyang Xin Qu Dongya Ren Chao Wang Chaohui Wang Dawei Wang Di Wang Hainian Wang Haopeng Wang Yue Xiao Chao Xing Huining Xu Yu Yan Xu Yang Lingyun You Zhanping You Bin Yu Huayang Yu Huanan Yu Henglong Zhang Jizhe Zhang Changhong Zhou Changjun Zhou Xingyi Zhu | 2021 | Journal of Traffic and Transportation Engineering(English Edition)2021，8，6： | 7 |
| 14 | The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation显示文摘Interleukin(IL)17-producing T helper(Th17)cells play critical roles in the clearance of extracellular bacteria and fungi as well as the pathogenesis of various autoimmune diseases,such as multiple sclerosis,psoriasis,and ulcerative colitis.Although a global transcriptional regulatory network of Th17 cell differentiation has been mapped recently,the participation of epigenetic modifications in the differentiation process has yet to be elucidated.We demonstrated here that histone H3 lysine-27(H3K27)demethylation,predominantly mediated by the H3K27 demethylase Jmjd3,crucially regulated Th17 cell differentiation.Activation of naı¨ve CD41 T cells immediately induced high expression of Jmjd3.Genetic depletion of Jmjd3 in CD41 T cells specifically impaired Th17 cell differentiation both in vitro and in vivo.Ectopic expression of Jmjd3 largely rescued the impaired differentiation of Th17 cells in vitro in Jmjd3-deficientCD41 T cells.Importantly,Jmjd3-deficient mice were resistant to the induction of experimental autoimmune encephalomyelitis(EAE).Furthermore,inhibition of the H3K27 demethylase activity with the specific inhibitor GSK-J4 dramatically suppressed Th17 cell differentiation in vitro.At the molecular level,Jmjd3 directly bound to and reduced the level of H3K27 trimethylation(me3)at the genomic sites ofRorc,which encodes the masterTh17 transcription factorRorgt,and Th17 cytokine genes such as Il17,Il17f,and Il22.Therefore,our studies established acritical role of Jmjd3-mediatedH3K27demethylation inTh17 cell differentiation andsuggest that Jmjd3 can be a novel therapeutic target for suppressing autoimmune responses. | Zhi Liu Wei Cao Longxia Xu Xi Chen Yu Zhan Qian Yang Sanhong Liu Pengfei Chen Yuhang Jiang Xiaohua Sun Yu Tao Yiming Hu Cuifeng Li Qi Wang Ying Wang Charlie Degui Chen Yufang Shi Xiaoren Zhang | 2015 | Journal of Molecular Cell Biology2015，7，6： | 6 |
| 15 | Drone-based entanglement distribution towards mobile quantum networks显示文摘Satellites have shown free-space quantum-communication ability;however,they are orbit-limited from full-time all-location coverage.Meanwhile,practical quantum networks require satellite constellations,which are complicated and expensive,whereas the airborne mobile quantum communication may be a practical alternative to offering full-time all-location multi-weather coverage in a cost-effective way.Here,we demonstrate the first mobile entanglement distribution based on drones,realizing multi-weather operation including daytime and rainy nights,with a Clauser-Horne-Shimony-Holt S-parameter measured to be 2.41±0.14 and 2.49±0.06,respectively.Such a system shows unparalleled mobility,flexibility and reconfigurability compared to the existing satellite and fiber-based quantum communication,and reveals its potential to establish a multinode quantum network,with a scalable design using symmetrical lens diameter and single-mode-fiber coupling.All key technologies have been developed to pack quantum nodes into lightweight mobile platforms for local-area coverage,and arouse further technical improvements to establish wide-area quantum networks with high-altitude mobile communication. | Hua-Ying Liu Xiao-Hui Tian Changsheng Gu Pengfei Fan Xin Ni Ran Yang Ji-Ning Zhang Mingzhe Hu Jian Guo Xun Cao Xiaopeng Hu Gang Zhao Yan-Qing Lu Yan-Xiao Gong Zhenda Xie Shi-Ning Zhu | 2020 | National Science Review2020，7，5： | 6 |
| 16 | Recent advancements in metal-organic frameworks for green applications显示文摘A series of environmental and energy issues,such as global warming,water pollution,acid rain,and energy shortage,have to be settled urgently.Metal-organic frameworks(MOFs)are compounds consisting of metal ions or clusters coordinated to organic ligands,which show great promise for alleviating or mitigating these challenges owing to their outstanding physical and chemical properties.In this review,we summarize the recent advances of MOFs in the fields of green applications,including carbon capture,harmful gas removal,sewage treatment,and green energy storage.In addition,the challenges and prospects of the large-scale commercialized use of MOFs in handling environmental issues are also discussed. | Chongxiong Duan Yi Yu Jing Xiao Yuanyuan Li Pengfei Yang Fei Hu Hongxia Xi | 2021 | Green Energy & Environment2021，6，1： | 6 |
| 17 | Two regimes of Atlantic multidecadal oscillation: cross-basin dependent or Atlantic-intrinsic显示文摘The Atlantic Multidedal Oscillation(AMO) is a prominent mode of sea surface temperature variability in the Atlantic and incurs significant global influence. Most coupled models failed to reproduce the observed 50–80-year AMO, but were overwhelmed by a 10–30-year AMO. Here we show that the 50–80-year AMO and 10–30-year AMO represent two different AMO regimes. The key differences are:(1) the 50–80-year AMO involves transport of warm and saline Atlantic water into the Greenland-Iceland-Norwegian(GIN)Seas prior to reaching its maximum positive phase, while such a transport is weak for the 10–30-year AMO;(2) the zonality of atmospheric variability associated with the 50–80 year AMO favors the transport of warm and saline water into the GIN Seas;(3) the disappearance of Pacific variability weakens the zonality of atmospheric variability and the transport of warm and saline water into the GIN Seas, leading to the weakening of the 50–80-year AMO. In contrast, the 10–30-year AMO does not show dependence on the variability in Pacific and in the GIN Seas and may be an Atlantic-intrinsic mode. Our results suggest that differentiating these AMO regimes and a better understanding of the cross-basin connections are essential to reconcile the current debate on the nature of AMO and hence to its reliable prediction, which is still lacking in most of coupled models. | Pengfei Lin Zipeng Yu Jianhua Lü Mengrong Ding Aixue Hu Hailong Liu | 2019 | Science Bulletin2019，64，3： | 6 |
| 18 | Atorvastatin attenuates surgery-induced BBB disruption and cognitive impairment partly by suppressing NF-κB pathway and NLRP3 inflammasome activation in aged mice显示文摘In clinic,perioperative neurocognitive disorder is becoming a common complication of surgery in old patients.Neuroinflammation and blood-brain barrier(BBB)disruption are important contributors for cognitive impairment.Atorvastatin,as a strong HMG-CoA reductase inhibitor,has been widely used in clinic.However,it remains unclear whether atorvastatin could prevent anesthesia and surgery-induced BBB disruption and cognitive injury by its anti-inflammatory property.In this study,aged C57BL/6J mice were used to address this question.Initially,the mice were subject to atorvastatin treatment for 7 days(10 mg/kg).After a simple laparotomy under 1.5%isoflurane anesthesia,Morris water maze was performed to assess spatial learning and memory.Western blot analysis,immunohistochemistry,and enzyme-linked immunosorbent assay were used to examine the inflammatory response,BBB integrity,and cell apoptosis.Terminal-deoxynucleotidyl transferase mediated nick end labeling assay was used to assess cell apoptosis.The fluorescein sodium and transmission electron microscopy were used to detect the permeability and structure of BBB.The results showed that anesthesia and surgery significantly injured hippocampal-dependent learning and memory,which was ameliorated by atorvastatin.Atorvastatin could also reverse the surgery-induced increase of systemic and hippocampal cytokines,including IL-1β,TNF-α,and IL-6,accompanied by inhibiting the nuclear factor kappa-B(NF-κB)pathway and Nucleotide-Binding Oligomerization Domain,or Leucine Rich Repeat and Pyrin Domain Containing 3(NLRP3)inflammasome activation,as well as hippocampal neuronal apoptosis.In addition,surgery triggered an increase of BBB permeability,paralleled by a decrease of the ZO-1,occludin,and Claudin 5 proteins in the hippocampus.However,atorvastatin treatment could protect the BBB integrity from the impact of surgery,by up-regulating the expressions of ZO-1,occludin,and Claudin 5.These findings suggest that atorvastatin exhibits neuroprotective effects on cognition in aged mice undergoing surgery. | Pengfei Liu Quansheng Gao Lei Guan Yanting Hu Jingwen Jiang Teng Gao Weixuan Sheng Xinying Xue Hui Qiao Tianzuo Li | 2021 | Acta Biochimica et Biophysica Sinica2021，53，5： | 6 |
| 19 | Molecular phylogeny and divergence time of Trachypithecus: with implications for the taxonomy of T. phayrei显示文摘 | Kai HE Naiqing HU Joseph D.ORKIN Daw Thida NYEIN Chi MA Wen XIAO Pengfei FAN Xuelong JIANG | 2012 | Zoological Research2012，33，6： | 5 |
| 20 | A Double-Index Method to Classify Kuroshio Intrusion Paths in the Luzon Strait显示文摘A double index(DI), which is made up of two sub-indices, is proposed to describe the spatial patterns of the Kuroshio intrusion and mesoscale eddies west to the Luzon Strait, based on satellite altimeter data. The area-integrated negative and positive geostrophic vorticities are defined as the Kuroshio warm eddy index(KWI) and the Kuroshio cold eddy index(KCI),respectively. Three typical spatial patterns are identified by the DI: the Kuroshio warm eddy path(KWEP), the Kuroshio cold eddy path(KCEP), and the leaking path. The primary features of the DI and three patterns are further investigated and compared with previous indices. The effects of the integrated area and the algorithm of the integration are investigated in detail. In general, the DI can overcome the problem of previously used indices in which the positive and negative geostrophic vorticities cancel each other out. Thus, the proportions of missing and misjudged events are greatly reduced using the DI.The DI, as compared with previously used indices, can better distinguish the paths of the Kuroshio intrusion and can be used for further research. | Zhida HUANG Hailong LIU Jianyu HU Pengfei LIN | 2016 | Advances in Atmospheric Sciences2016，33，6： | 5 |
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