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| 1 | Angiopoietin-1 protects mesenchymal stem cells against serum depriva-tion and hypoxia-induced apoptosis through the PI3K/Akt pathway显示文摘瞄准:表明系统的 angiopoietin-1 (Angl )/Tie-2 不仅在容器生长起一个枢轴的作用,改变,并且 endothelial,神经原,和 cardiomyocytes 的成熟,而且还原剂 apoptosis。然而,相对,很少至于 Angl 是否在间充质的干细胞(MSC ) 上有保护的效果被知道。现在的学习的目的是调查对浆液剥夺和导致组织缺氧的 apoptosis 在 MSC 上发信号的 Angl/Tie-2 的保护的效果,并且决定可能的机制。方法:Hoechst 33342 和终端 deoxynucleotidyl 标记染色的调停 transferase 的 digoxigenin-dUTP 刻痕结束被用来估计 MSC 的 apoptosis。Tie-2, Akt, Bcl-2, Bax,和劈开的 caspase-9 和 -3 的表示被西方的污点分析检测。结果:这研究证明 MSC 表示了 Tie-2 受体,并且 Angl 导致了 Tie-2 受体磷酸化。MSC 上的 Angl 的保护的效果是剂量依赖者并且在 50 ug/L 达到顶点;然而,可溶的 Tie-2/Fc 熔化蛋白质,它由扣押充当一个禁止者 Angl,废除了 anti-apoptotic 效果。Angl 导致了 Akt 磷酸化,增加了 Bcl-2/Bax 比率,并且减少 caspase-9 和 -3 的激活。所有这些效果被 Tie-2/Fc 和 phosphatidylinositol 稀释 3 激酶(PI3K ) 禁止者, wortmannin。结论:这些结果证明 Angl 能保护 MSC 免于浆液剥夺和导致组织缺氧的 apoptosis;Angl/Tie-2 发信号和它的下游的 PI3K/Akt 送信人小径在导致 MSC 幸存的过程是关键的。 | Xian-bao LIU Jun JIANG Chun GUI Xin-yang HU Mei-xiang XIANG Jian-an WANG | 2008 | Acta Pharmacologica Sinica2008，29，7： | 18 |
| 2 | Effect of notoginsenoside R1 on hepatic microcirculation disturbance induced by gut ischemia and reperfusion显示文摘AIM: To assess the effect of notoginsenoside R1 on hepatic microcirculatory disturbance induced by gut ischemia/reperfusion (I/R) in mice.METHODS: The superior mesenteric artery (SMA) of C57/BL mice was ligated for 15 min to induce gut ischemia followed by 30-min reperfusion. In another set of experiments, R1 was continuously infused (10 mg/kg per hour) from 10 min before I/R until the end of the investigation to study the influence of R1 on hepatic microcirculatory disturbance induced by gut I/R. Hepatic microcirculation was observed by inverted microscopy, and the vascular diameter, red blood cell (RBC) velocity and sinusoid perfusion were estimated. Leukocyte rolling and adhesion were observed under a laser confocal microscope. Thirty and 60 min after reperfusion, lactate dehydrogenase (LDH), alanine aminotransferase (ALT) and aspartate transaminase (AST) in peripheral blood were determined. The expression of adhesion molecules CD11b/CD18 in neutrophils and tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and monocyte chemotactic protein-1 (MCP-1) in plasma were evaluated by flow cytometry. E-selectin and intercellular adhesion molecule-1 (ICAM-1) in hepatic tissue were examined by immunofluorescence. RESULTS: After gut I/R, the diameters of terminal portal venules and central veins, RBC velocity and the number of perfused sinusoids were decreased, while the leukocyte rolling and adhesion, the expression of E-selectin in hepatic vessels and CD18 in neutrophils, IL-6, MCP-1, LDH, ALT and AST were increased. R1 treatment attenuated these alterations except for IL-6 and MCP-1.CONCLUSION: R1 prevents I/R-induced hepatic microcirculation disturbance and hepatocyte injury. The effect of R1 is related to its inhibition of leukocyte rolling and adhesion by inhibiting the expression of E-selectin in endothelium and CD18 in neutrophils. | Wei-Xing Chen Fang Wang, Yu-Ying Liu, Qing-Jiang Zeng, Kai Sun, Xin Xue, Xiang Li, Ji-Ying Yang, Li-Hua An,Bai-He Hu, Jin-Hui Yang, Chuan-She Wang, Zhi-Xin Li, Lian-Yi Liu, Yan Li, Jun Zheng, Fu-Long Liao, Dong Han,Jing-Yu Fan, Jing-Yan Han Fang Wang Yu-Ying Liu Qing-Jiang Zeng Kai Sun Xin Xue Xiang Li Ji-Ying Yang Li-Hua An Bai-He Hu Jin-Hui Yang Chuan-She Wang Zhi-Xin Li Lian-Yi Liu Yan Li Jun Zheng Fu-Long Liao Dong Han Jing-Yu Fan Jing-Yan Han | 2008 | World Journal of Gastroenterology2008，14，1： | 17 |
| 3 | Discovery of biclonal origin and a novel oncogene SLC12A5 in colon cancer by single-cell sequencing显示文摘单个房间的定序是为描出的一个强大的工具为个性化的癌症管理的同种细胞的关系和识别关键司机基因。这里,我们执行了结肠癌的一个盒子的单个房间的定序的分析。人口遗传分析在肿瘤房间人口识别了二独立克隆。主要肿瘤克隆作为早 oncogenic 事件怀有 APC 和 TP53 变化,而次要的克隆包含了优势的 CDC27 和 PABPC1 变化。在这二克隆的次要的克隆支持的 APC 和 TP53 变化的缺席从二细胞的起源被导出。体的变化等位基因频率系列的检查另外 21 个整个织物的定序 exome 的盒子在结肠癌揭示了同种细胞的起源的异质。下次,我们识别了在单个房间的水平显示出变化的高频率,但是在人口水平展出了低流行的变异的基因 SLC12A5。变异的 SLC12A5 的功能的描述在结肠癌揭示了它的潜在的 oncogenic 效果。我们的学习在单个房间的水平支持提供第一条 exome 宽的证据那结肠癌能具有 biclonal 起源,并且建议在一个队的低流行的变化可以也在单个水平起重要 protumorigenic 作用。 | Chang Yu Jun Yu Xlaotlan Yao Wllham KK Wu Youyong Lu Senwel Tang Xiangchun Li Li Bao Xiaoxing Li Yong Hou Renhua Wu Min Jian Ruoyan Chen Fan Zhang Lixia Xu Fan Fan Jun He Qiaoyi Liang Hongyi Wang Xueda Hu Minghui He Xiang Zhang Hancheng Zheng Qibin Li Hanjie Wu Yan Chen Xu Yang Shida Zhu Xun Xu Huanming Yang Jian Wang Xiuqing Zhang Joseph JY Sung Yingrui Li Jun Wang | 2014 | Cell Research2014，，6： | 16 |
| 4 | Prognosis-related classifi cation and dynamic monitoring of immune status in patients with sepsis:A prospective observational study显示文摘BACKGROUND:The dynamic monitoring of immune status is crucial to the precise and individualized treatment of sepsis.In this study,we aim to introduce a model to describe and monitor the immune status of sepsis and to explore its prognostic value.METHODS:A prospective observational study was carried out in Zhongshan Hospital,Fudan University,enrolling septic patients admitted between July 2016 and December 2018.Blood samples were collected at days 1 and 3.Serum cytokine levels(e.g.,tumor necrosis factor-α[TNF-α],interleukin-10[IL-10])and CD14+monocyte human leukocyte antigen-D-related(HLA-DR)expression were measured to serve as immune markers.Classifi cation of each immune status,namely systemic inflammatory response syndrome(SIRS),compensatory anti-inflammatory response syndrome(CARS),and mixed antagonistic response syndrome(MARS),was defined based on levels of immune markers.Changes of immune status were classifi ed into four groups which were stabilization(SB),deterioration(DT),remission(RM),and non-remission(NR).RESULTS:A total of 174 septic patients were enrolled including 50 non-survivors.Multivariate analysis discovered that IL-10 and HLA-DR expression levels at day 3 were independent prognostic factors.Patients with MARS had the highest mortality rate.Immune status of 46.1%patients changed from day 1 to day 3.Among four groups of immune status changes,DT had the highest mortality rate,followed by NR,RM,and SB with mortality rates of 64.7%,42.9%,and 11.2%,respectively.CONCLUSIONS:Severe immune disorder defi ned as MARS or deterioration of immune status defi ned as DT lead to the worst outcomes.The preliminary model of the classifi cation and dynamic monitoring of immune status based on immune markers has prognostic values and is worthy of further investigation. | Jun Yin Yao Chen Jun-ling Huang Lei Yan Zhong-shu Kuang Ming-ming Xue Si Sun Hao Xiang Yan-yan Hu Zhi-min Dong Chao-yang Tong Chun-xue Bai Zhen-ju Song | 2021 | World Journal of Emergency Medicine2021，12，3： | 16 |
| 5 | A simple taurocholate-induced model of severe acute pancreatitis in rats显示文摘AIM: To investigate gut barrier damage and intestinal bacteria translocation in severe acute pancreatitis (SAP), a simple rat model of SAP was induced and studied.METHODS: Pancreatitis was induced by uniformly distributed injection of 3.8% Na taurocholate (1 mL/kg) beneath the pancreatic capsule. Rats in the control group were injected with normal saline in the identical location. RESULTS: Serum amylase, plasma endotoxin, intestinal permeability, and pancreatitis pathology scores were all markedly higher in the pancreatitis group than in the control group (P < 0.01). The bacterial infection rate was signif icantly higher in the SAP group than in the control group (P < 0.01), observed in parallel by both bacterial culture and real-time polymerase chain reaction. Acute damage of the pancreas was observed histologically in SAP rats, showing interstitial edema, leukocyte infiltration, acinar cell necrosis and hemorrhage. The microstructure of the intestinal mucosa of SAP ratsappeared to be destroyed with loose, shortened microvilli and rupture of the intercellular junction, as shown by electron microscopy. CONCLUSION: Significant gut barrier damage and intestinal bacterial translocation were def initely observed with few potential study confounders in this SAP rat model, suggesting that it may be an appropriate animal model for study of gut barrier damage and bacterial translocation in SAP. | Zhong-Hui Liu Jun-Sheng Peng Chu-Jun Li Zu-Li Yang Jun Xiang Hu Song Xiao-Bing Wu Jun-Rong Chen De-Chang Diao | 2009 | World Journal of Gastroenterology2009，15，45： | 15 |
| 6 | Human umbilical cord blood stem cell transplantation for the treatment of chronic spinal cord injury Electrophysiological changes and long-term efficacy显示文摘Stem cell transplantation can promote functional restoration following acute spinal cord injury (injury time < 3 months), but the safety and long-term efficacy of this treatment need further exploration. In this study, 25 patients with traumatic spinal cord injury (injury time > 6 months) were treated with human umbilical cord blood stem cells via intravenous and intrathecal injection. The follow-up period was 12 months after transplantation. Results found that autonomic nerve functions were restored and the latent period of somatosensory evoked potentials was reduced. There were no severe adverse reactions in patients following stem cell transplantation. These experimental findings suggest that the transplantation of human umbilical cord blood stem cells is a safe and effective treatment for patients with traumatic spinal cord injury. | Liqing Yao Chuan He Ying Zhao Jirong Wang Mei Tang Jun Li Ying Wu Lijuan Ao Xiang Hu | 2013 | Neural Regeneration Research2013，8，5： | 14 |
| 7 | Genetic Analysis and Primary Mapping of pms4, a Photoperiod-Sensitive Genic Male Sterility Gene in Rice (Oryza sativa)显示文摘To understand the genetic characteristics of a new photoperiod-sensitive genic male sterile line Mian 9S, some reciprocal crosses were made between Mian 9S and six indica rice materials, Yangdao 6, Luhui 602, Shuihui 527, Mianhui 725, Fuhui 838 and Yixiang 1B. Genetic analysis results suggested that the photoperiod-sensitive genic male sterility (PGMS) of Mian 9S was controlled by a single recessive nuclear gene. Thus, the F2 population derived from the cross of Yangdao 6/Mian 9S was used to map the PGMS gene in Mian 9S. By using SSR markers, the PGMS gene of Mian 9S was mapped on one side of the markers, RM6659 and RM1305, on rice chromosome 4, with the genetic distances of 3.0 cM and 3.5 cM, respectively. The gene was a novel PGMS gene and designated tentatively as pms4. In addition, the application of the pms4 gene was discussed. | HUANG Ting-you WANG Zhi HU Yun-gao SHI Shou-pei PENG Tao CHU Xu-dong SHI Jun XIANG Zu-fen LIU Ding-you | 2008 | Rice science2008，15，2： | 13 |
| 8 | Complex coronary lesions and rotational atherectomy:one hospital's experience显示文摘Objective:To evaluate the safety and effectiveness of rotational atherectomy followed by drug eluting stent (DES) implantation in patients with complex coronary lesions. Methods:From August 2006 to August 2012, 253 consecutive patients with 289 lesions and who underwent rotational atherectomy in our center were enrolled in this study. Results:The overall procedure success rate was 98% with the cost of two (0.8%) coronary perforations, three (1.2%) dissections, five (2.0%) slow flows or no flows, three (1.2%) peri-procedure myocardial infarctions, and two (0.8%) in hospital deaths. During follow-up (mean three years), one (0.4%) patient died, two (0.8%) patients had acute myocardial infarction, 14 (5.5%) had restenosis, and target lesion revascularization occurred in eight patients (3.2%). Conclusions:Rotational atherectomy followed by DES implantation is a safe and effective technique for patients with complex coronary lesions, especially calcified and non-dilatable lesions. | Jun JIANG Yong SUN Mei-xiang XIANG Liang DONG Xian-bao LIU Xin-yang HU Yan FENG Jian-an WANG | 2012 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2012，13，8： | 13 |
| 9 | Hesperetin derivative-12 (HDND-12) regulates macrophage polarization by modulating JAK2/STAT3 signaling pathway显示文摘Macrophages show significant heterogeneity in function and phenotype, which could shift into different populations of cells in response to exposure to various micro-environmental signals. These changes, also termed as macrophage polarization, of which play an important role in the pathogenesis of many diseases. Numerous studies have proved that Hesperidin(HDN), a traditional Chinese medicine, extracted from fruit peels of the genus citrus, play key roles in anti-inflammation, anti-tumor, anti-oxidant and so on. However, the role of HDN in macrophage polarization has never been reported. Additional, because of its poor water solubility and bioavailability. Our laboratory had synthesized many hesperidin derivatives. Among them, hesperidin derivatives-12(HDND-12) has better water solubility and bioavailability. So, we evaluated the role of HDND-12 in macrophage polarization in the present study. The results showed that the expression of Arginase-1(Arg-1), interleukin-10(IL-10), transforming growth factor β(TGF-β) were up-regulated by HDND-12, whereas the expression of inducible Nitric Oxide Synthase(iNOS) was down-regulated in LPS-and IFN-γ-treated(M1) RAW264.7 cells. Moreover, the expression of p-JAK2 and p-STAT3 were significantly decreased after stimulation with HDND-12 in M1-like macrophages. More importantly, when we taken AG490(inhibitor of JAK2/STAT3 signaling), the protein levels of iNOS were significantly reduced in AG490 stimulation group compare with control in LPS, IFN-γ and HDND-12 stimulation cells. Taken together, these findings indicated that HDND-12 could prevent polarization toward M1-like macrophages, at least in part, through modulating JAK2/STAT3 pathway. | KONG Ling-Na LIN Xiang HUANG Cheng MA Tao-Tao MENG Xiao-Ming HU Chao-Jie WANG Qian-Qian LIU Yan-Hui SHI Qing-Ping LI Jun | 2019 | Chinese Journal of Natural Medicines2019，17，2： | 12 |
| 10 | Toxic Effects of Atrazine on Reproductive System of Male Rats显示文摘Objective This study was designed to evaluate the toxic effects of Atrazine(ATZ) on the reproductive system of male rats. Methods Male Sprague-Dawley rats were exposed to ATZ by gavage at dosages of 0, 38.5, 77, and 154 mg/kg bw/day for 30 d. The toxic effects of ATZ to rats were assessed through histopathologcal observation, spermatozoa quality evaluation, testicular marker enzyme indicators, antioxidant capacity and reproductive hormone levels. Results Significant adverse effects on reproductive system were observed in rats exposed to ATZ at different dosages compared with 0 mg/kg group, including an irregular and disordered arrangement of the seminiferous epithelium in 154 mg/kg group; a decreased spermatozoa number and an increased spermatozoa abnormality rate in 77 and 154 mg/kg groups; decreased levels of acid phosphatase(ACP), alkaline phosphatase(AKP), lactic dehydrogenase(LDH), and succinate dehydrogenase(SDH) with the increasing of ATZ concentration; a decreased level of total antioxidant capacity(TAC) in a dose-dependent manner, and a decreased reduced glutathione(GSH) level and an increased malondialdehyde(MDA) content in 154 mg/kg group; and decreased serum levels of testosterone(T) and inhibin-B(INH-B) and an increased serum level of follicle stimulating hormone(FSH) in 77 and 154 mg/kg groups, and an increased serum level of luteinizing hormone(LH) in 154 mg/kg group. Conclusion These results suggested that relatively high doses of ATZ could exert reproductive toxicity of male rats. | SONG Yang JIA Zhen Chao CHEN Jin Yao HU Jun Xiang ZHANG Li Shi | 2014 | Biomedical and Environmental Sciences2014，27，4： | 10 |
| 11 | Malnutrition and Quality of Life in Chinese Cancer Patients: a Clinical Study of 23,994 Subjects显示文摘Background Malnutrition is common in patients with cancer,and can negatively impact their quality of life(QoL)and even survival.However,there is currently no large data available on the prevalence of malnutrition in Chinese cancer patients.This study evaluated the prevalence of malnutrition and the QoL of Chinese patients with locoregional,recurrent or metastatic cancer.Methods We conducted a nationwide observational,multi-center,hospital-based cross-sectional study within the Chinese Society of Nutritional Oncology(CSNO)Network.All of the patients were diagnosed with one of the following 18 different types of malignant tumors:lung cancer,gastric cancer,liver cancer,colorectal cancer,breast cancer,esophageal cancer,cervical cancer,endometrial cancer,nasopharyngeal carcinoma,malignant lymphoma,leukemia,pancreatic cancer,ovarian cancer,prostate cancer,bladder cancer,brain cancer,biliary tract malignant tumors or gastrointestinal stromal tumors.These patients were enrolled from 72 hospitals located in different regions of China.The patients’nutritional status was evaluated based on the body mass index(BMI),loss of bodyweight,laboratory measurements and patient generated-subjective global assessment(PG-SGA)scores.The cancer patients’physical status and QoL were assessed by the Karnofsky Performance Status(KPS)questionnaire and the European Organization for Research and Treatment of Cancer(EORTC)QLQ-C30 questionnaire,respectively.Results From December 2013 to April 2016,23,994 patients hospitalized for cancer treatment(such as surgery,chemotherapy or radiotherapy)were enrolled in the study.The patients included 12,494(52.9%)males and 11,124(47.1%)females.The mean age was 55.8±13.7 years.The proportions of patients in cancer stagesⅠ,Ⅱ,Ⅲ,Ⅳand uncertain were 11.5%,20.3%,27.5%,30.2%and 10.5%,respectively.Among the 23,994 inpatients,the proportions of patients who were underweight(BMI<18.5 kg/m2),normal(18.5 kg/m2 | Hong Xia Xu Chun Hua Song Zhen Ming Fu Chang Wang Zeng Qing Guo Yuan Lin Ying Ying Shi Wen Hu Yi Ba Su Yi Li Zeng Ning Li Kun Hua Wang Jing Wu Ying He Jia Jun Yang Cong Hua Xie Fu Xiang Zhou Xin Xia Song Gong Yan Chen Wen Jun Ma Su Xia Luo Zi Hua Chen Ming Hua Cong Hu Ma Chun Ling Zhou Wei Wang Qi Luo Yong Mei Shi Yu Mei Qi Hai Ping Jiang Wen Xian Guan Jun Qiang Chen Jia Xin Chen Yu Fang Lan Zhou Yong Dong Feng Rong Shao Tan Tao Li Jun Wen Ou Qing Chuan Zhao Jian Xiong Wu Min Weng Qing Hua Yao Jiu Wei Cui Wei Li Han Ping Shi the Investigation on Nutrition Status and Clinical Outcome of Common Cancers(INSCOC)Group | 2021 | Journal of Nutritional Oncology2021，6，1： | 8 |
| 12 | Specifically Binding of L-ficolin to N-glycans of HCV Envelope Glycoproteins E1 and E2 Leads to Complement Activation显示文摘 | Jun Liu Mohammed A.M. Ali Yinghua Shi Yinglan Zhao Fenglin Luo Jin Yu Tian Xiang Jie Tang Dongqing Li Quan Hu Wenzhe Ho Xiaolian Zhang | 2009 | Cellular & Molecular Immunology2009，6，4： | 8 |
| 13 | Reversible Histone H2B Monoubiquitination Fine-Tunes Abscisic Acid Signaling and Drought Response in Rice显示文摘Histone H2B monoubiquitination (H2Bub1) plays important roles in several physiological and developmental processes, but its roles in the regulation of plant stress responses remain elusive. Here, we report that H2Bub1 is crucially involved in abscisic acid (ABA) signaling and drought response in rice. We found that rice HISTONE MONOUBIQUITINATION2 (OsHUB2), an E3 ligase for H2Bub1, in teracted with OsbZIP46, a key transcription factor regulating ABA signaling and drought response in rice. Genetic analyses suggest that OsHUB2, upregulated by drought and ABA, positively modulates ABA sensitivity and drought resistance. The H2Bub1 levels were in creased in the target genes of OsbZIP46 under the drought stress and ABA treat- merits, which were positively correlated with their increased expression levels. Interestingly, MODD, a reported suppressor of ABA signaling and drought resistance by mediating OsbZIP46 deactivation and degradation, could reduce the H2Bub1 levels in the target genes of OsbZIP46 by recruiting a putative deubiquitinase OsOTLD1 . Suppression of OsOTLD1in vivo resulted in increased H2Bub1 levels and expression of OsbZIP46 target genes. Collectively, these fin dings established an elaborate mecha nism of histone monoubiquitination in the fine-turning of ABA signaling and drought response by balancing H2Bub1 deposition and removal. | Siqi Ma Ning Tang Xu Li Yongjun Xie Denghao Xiang Jie Fu Jianqiang Shen Jun Yang Haifu Tu Xianghua Li Honghong Hu Lizhong Xiong | 2019 | Molecular Plant2019，12，2： | 7 |
| 14 | A fast decoupled ISAR high-resolution imaging method using structural sparse information under low SNR显示文摘Inverse synthetic aperture radar (ISAR) image can be represented and reconstructed by sparse recovery (SR) approaches. However, the existing SR algorithms, which are used for ISAR imaging, have suffered from high computational cost and poor imaging quality under a low signal to noise ratio (SNR) condition. This paper proposes a fast decoupled ISAR imaging method by exploiting the inherent structural sparse information of the targets. Firstly, the ISAR imaging problem is decoupled into two sub-problems. One is range direction imaging and the other is azimuth direction focusing. Secondly, an efficient two-stage SR method is proposed to obtain higher resolution range profiles by using jointly sparse information. Finally, the residual linear Bregman iteration via fast Fourier transforms (RLBI-FFT) is proposed to perform the azimuth focusing on low SNR efficiently. Theoretical analysis and simulation results show that the proposed method has better performence to efficiently implement higher-resolution ISAR imaging under the low SNR condition. | XIANG Long LI Shaodong YANG Jun CHEN Wenfeng XIANG Hu | 2019 | Journal of Systems Engineering and Electronics2019，30，3： | 6 |
| 15 | Tissue-engineered rhesus monkey nerve grafts for the repair of long ulnar nerve defects:similar outcomes to autologous nerve grafts显示文摘Acellular nerve allografts can help preserve normal nerve structure and extracellular matrix composition.These allografts have low immunogenicity and are more readily available than autologous nerves for the repair of long-segment peripheral nerve defects.In this study,we repaired a 40-mm ulnar nerve defect in rhesus monkeys with tissue-engineered peripheral nerve,and compared the outcome with that of autograft.The graft was prepared using a chemical extract from adult rhesus monkeys and seeded with allogeneic Schwann cells.Pathomorphology,electromyogram and immunohistochemistry findings revealed the absence of palmar erosion or ulcers,and that the morphology and elasticity of the hypothenar eminence were normal 5 months postoperatively.There were no significant differences in the mean peak compound muscle action potential,the mean nerve conduction velocity,or the number of neurofilaments between the experimental and control groups.However,outcome was significantly better in the experimental group than in the blank group.These findings suggest that chemically extracted allogeneic nerve seeded with autologous Schwann cells can repair 40-mm ulnar nerve defects in the rhesus monkey.The outcomes are similar to those obtained with autologous nerve graft. | Chang-qing Jiang Jun Hu Jian-ping Xiang Jia-kai Zhu Xiao-lin Liu Peng Luo | 2016 | Neural Regeneration Research2016，11，11： | 5 |
| 16 | Black phosphorus inverter devices enabled by in-situ aluminum surface modification显示文摘Two-dimensional black phosphorus (BP) generally exhibits a hole-dominated transport characteristic when configured as field-effect transistor devices. The effective control of charge carrier type and concentration is very crucial for the application of BP in complementary electronics. Herein, we report a facile and effective electron doping methodology on BP, through in situ surface modification with aluminum (Al). The electron mobility of few-layer BP is found to be largely enhanced to ~ 10.6 cm^2·V^–1·s^–1 by over 6 times after aluminum modification. In situ photoelectron spectroscopy characterization reveals the formation of Al–P covalent bond at the interface, which can also serve as local gate to tune the transport properties in BP layers. Finally, a spatially-controlled aluminum doping technique is employed to establish a p–n homojunction on a single BP flake, and hence to realize the complementary inverter devices, where the highest gain value of ~ 33 is obtained. | Yue Zheng Zehua Hu Cheng Han Rui Guo Du Xiang Bo Lei Yanan Wang Jun He Min Lai Wei Chen | 2019 | Nano Research2019，12，3： | 5 |
| 17 | Clinical practice guidelines for endoscopic breast surgery in patients with early-stage breast cancer:Chinese Society of Breast Surgery(CSBrS)practice guidelines 2021显示文摘Minimally invasive surgical techniques,represented by endoscopic surgery,are one of the major advances in surgery during the 20th century.Based on the experience in other disciplines. | Peng Tang Ying Hu Zi-Han Wang Guo-Xuan Gao Xiang Qu Jun Jiang Chinese Society of Breast Surgery | 2021 | Chinese Medical Journal2021，，21： | 5 |
| 18 | Postoperative chemotherapy with S-1 plus oxaliplatin versus S-1alone in locally advanced gastric cancer(RESCUE-GC study): a protocol for a phase Ⅲ randomized controlled trial显示文摘Background:The ACTS-GC study had shown postoperative adjuvant therapy with S-1 improved survival of patients with locally advanced gastric cancer.Addition of oxaliplatin to S-1 is considered to be acceptable as one of the treatment options for gastric cancer patients after radical gastrectomy with D2 lymph node excision.Methods:We have commenced a randomized phase III trial in December 2016 to evaluate S-1 plus oxaliplatin compared with S-1 alone in the adjuvant setting for locally advanced gastric cancer.A total of 564 patients will be accrued from 13 Chinese institutions in two years.The primary endpoint is 3-year relapse-free survival.The secondary endpoints are 5-year overall survival,proportion of patients who complete the postoperative chemotherapy and incidence of adverse events.Ethic and dissemination:The trial has been approved by the institutional review board of each participating institution and it was activated on December,2016.The enrollment will be finished in December,2018.Patient’s follow-up will be ended until December,2023.Trial registration:Clinical Trials.gov,identifier:NCT02867839.Registered on August 4,2016. | Xiang Hu Lin Chen Yian Du Biao Fan Zhaode Bu Xin Wang Yingjiang Ye Zhongtao Zhang Gang Xiao Fei Li Qingsi He Guoli Li Xian Shen Bin Xiong Liming Zhu Jiwei Liui Lian Liu Tao Wu Jing Zhou Jun Zhang Gang Zhao Xulin Wang Pin Liang Xinxin Wang Yan Zhang Xiaojiang Wu Ji Zhang Xin Ji Xianglong Zong Tao Fu Ziyu Jia Jiafu Ji | 2017 | Chinese Journal of Cancer Research2017，29，2： | 5 |
| 19 | Polymorphisms of the KCNQ1 gene are associated with the therapeutic responses of sulfonylureas in Chinese patients with type 2 diabetes显示文摘KCNQ1 隧道是电压门钾隧道象 KQT 一样亚科的一个成员。KCNQ1 基因最近为类型 2 糖尿病 mellitus (T2DM ) 作为一个危险性地点被识别了。在现在的学习,我们在对在中国病人的治疗最新与 T2DM 诊断了的修改版本的 gliclazide (gliclazide 先生) 的治疗学的反应上检验了 KCNQ1 变体的效果。没有任何反糖尿病的药的历史的 100 个最新诊断的 T2DM 病人的一个总数与 gliclazide 先生一起被对待 16 个星期,但是 91 个病人完成了全部学习。当临床的实验室测试在基线并且在星期被执行时,人体测量的参数在基线并且在最后的访问被决定 2, 4, 6, 12, 16。二 SNP, rs2237892 和 rs2237895,在 KCNQ1 的区域,基因是在所有参加者的 genotyped。所有计算和统计分析用社会科学统计套装软体被进行。rs2237892 TT 同质接合体在基线展出了显著地更高的 2-h 葡萄糖层次(P < 0.05 ) 并且目标 2-h 葡萄糖水平的更低的累积成就率(P 木头等级 =0.020) 比 C 等位基因搬运人。有 rs2237892 T 等位基因的更大的数字的病人展出了更大的扩大() 在 2-h 葡萄糖层次(P=0.027 ) ;并且有 rs2237892 TT 遗传型的病人比 CC 和 CT 遗传型搬运人展出了对房间功能(HOMA-) 的一个更高的动态平衡模型评价(P=0.021 和 P=0.043,分别地) 。而且, rs2237895 C 等位基因在 glycated 血红素(HbA1c )(P=0.024 ) 与更大的减少被联系;并且有 CC 遗传型的病人与 AA 和交流遗传型比那些展出了更大的变化(P=0.005 并且 0.021,分别地) 。与 C 等位基因相比,为在 rs2237892 T 等位基因的搬运人之中的治疗成功的机会比率是 2.533 (P=0.007 ) ;并且 rs2237895 C 等位基因与 A 相比在 HbA1c 与 2.360 褶层减少被联系等位基因(P=0.009 ) 。KCNQ1 多型性与类型 2 糖尿病在中国病人与 gliclazide 先生功效被联系。 | Qing LI Ting-ting TANG Feng JIANG Rong ZHANG Miao CHEN Jun YIN Yu-qian BAO Xiang CHENG Cheng HU Wei-ping JIA | 2017 | Acta Pharmacologica Sinica2017，38，1： | 4 |
| 20 | Dual functional transparent film for proximity and pressure sensing显示文摘在过去几年,触觉的察觉到的技术的快速的开发显著地作出贡献到直觉的触摸控制和聪明的人机器的相互作用的实现。除了察觉到的物理触觉或压力,最近作为互补功能察觉到能扩大普通单个功能的触觉的传感器的察觉模式。在这个工作,我们在场一透明,矩阵结构集成在一台设备察觉到的最近和压力的能力的双功能的电容的传感器,并且电容的象素的孤立的反应提供的优秀空间分辨率使我们能认识到与快反应,高稳定性和高可逆性接近对象和装载压力的精确地点鉴定。 | Bo Zhang Zemin Xiang Siwei Zhu Qiyi Hu Yuanzhi Cao Junwen Zhong Qize Zhong Bo Wang Yunsheng Fang Bin Hu Jun Zhou Zhonglin wang | 2014 | Nano Research2014，7，10： | 4 |
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