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| 1 | Pediatric reference intervals in China(PRINCE):design and rationale for a large,multicenter collaborative cross-sectional study显示文摘There is a lack of accurate pediatric reference intervals(RIs) in China, with most commonly used RIs established without consideration of the effect of age and gender. The Pediatric Reference Intervals in China(PRINCE) project aims to establish and verify pediatric RIs for 31 common laboratory measurands.The project will be a large, multicenter cross-sectional study:14,490 healthy children and adolescents aged up to 19 years will be surveyed by 10 children's hospitals and one pediatric department of a university hospital. To evaluate the feasibility and efficiency of the study methods, 602 children were surveyed in the pilot phase of the PRINCE study in April 2017: it found that some measurands were distinctly age dependent and that there were differences between values for males and females. The results of the pilot study affirmed the necessity of the PRINCE project for Chinese pediatrics. The pilot also indicated potential difficulties in the full survey, e.g., difficulties in recruiting children aged under 3 years and insufficient collection of blood samples from infants. The operation of the PRINCE project has been modified based on the findings in the pilot study toward improving the validity of the PRINCE project and promoting its openness and transparency. | Xin Ni Wenqi Song Xiaoxia Peng Ying Shen Yaguang Peng Qiliang Li Yan Wang Lixin Hu Yanying Cai Hong Shang Min Zhao Hong Jiang Yaoguo Huang Runqing Mu Wenxiang Chen Mingting Peng Chuanbao Zhang Jie Zeng Chenbin Li Hongling Yang Yongmei Jiang Jin Xu Guixia Li Hongbing Chen Yun Xiang Sancheng Cao Zhenxin Guo Dapeng Chen | 2018 | Science Bulletin2018，63，24： | 12 |
| 2 | Immunity-and-matrix-regulatory cells derived from human embryonic stem cells safely and effectively treat mouse lung injury and fibrosis显示文摘Lung injury and fibrosis represent the most significant outcomes of severe and acute lung disorders,including COVID-19.However,there are still no effective drugs to treat lung injury and fibrosis.In this study,we report the generation of clinical-grade human embryonic stem cells(hESCs)-derived immunity-and matrix-regulatory cells(IMRCs)produced under good manufacturing practice requirements,that can treat lung injury and fibrosis in vivo.We generate IMRCs by sequentially differentiating hESCs with serum-free reagents.IMRCs possess a unique gene expression profile distinct from that of umbilical cord mesenchymal stem cells(UCMSCs),such as higher expression levels of proliferative,immunomodulatory and anti-fibrotic genes.Moreover,intravenous delivery of IMRCs inhibits both pulmonary inflammation and fibrosis in mouse models of lung injury,and significantly improves the survival rate of the recipient mice in a dose-dependent manner,likely through paracrine regulatory mechanisms.IMRCs are superior to both primary UCMSCs and the FDA-approved drug pirfenidone,with an excellent efficacy and safety profile in mice and monkeys.In light of public health crises involving pneumonia,acute lung injury and acute respiratory distress syndrome,our findings suggest that IMRCs are ready for clinical trials on lung disorders. | Jun Wu Dingyun Song Zhongwen Li Baojie Guo Yani Xiao Wenjing Liu Lingmin Liang Chunjing Feng Tingting Gao Yanxia Chen Ying Li Zai Wang Jianyan Wen Shengnan Yang Peipei Liu Lei Wang Yukai Wang Liang Peng Glyn Nigel Stacey Zheng Hu Guihai Feng Wei Li Yan Huo Ronghua Jin Ng Shyh-Chang Qi Zhou Liu Wang Baoyang Hu Huaping Dai Jie Hao | 2020 | Cell Research2020，30，9： | 7 |
| 3 | Achievements in cancer research supported by National Natural Science Foundation of China显示文摘For the past two decades,great achievements have been made in cancer research of China and the majority of them were supported by the National Natural Science Foundation of China(NSFC).In this article,we reviewed the funding history of NSFC including the number of proposals,the amount of grants,distribution of supported program categories during the period of 1987 to 2012 and the representative achievements made by continuous support of NSFC.Also,the impacts of NSFC support on discipline development and talent fostering were analyzed.From 1987 to 2012,a total of 8738 proposals related to cancer research were funded by NSFC.The percentages of the Research Program,Talent-Training Program,and the Research Environment Program were 61.19%,36.32%,and 2.49%,respectively.Under the support of NSFC,cancer research in China has achieved a significantly rapid and balanced development in both disciplines and scientist resources. | HONG Wei LI Cui ZHANG LiPing XU YanYing ZHANG Jun HU Hai DONG ErDan | 2013 | Chinese Science Bulletin2013，58，1： | 5 |
| 4 | The Salt Reduction and Yield Increase Effects of Smashing Ridging Transforming Saline-alkali Land and Its Development Prospects显示文摘Using smashing ridging tillage machine and smashing ridging technology invented by the authors,transformation test of saline-alkali land by smashing ridging was conducted respectively in Xinjiang and Shaanxi during 2015-2016. The results showed,in severe saline-alkali soil of Xinjiang,after growing cotton by smashing ridging,total salt in soil decreased by 31. 31%,cotton production increased by 48. 80%,and salinity level declined from severe to moderate; in mild saline-alkali soil of Shaanxi,after growing summer corn by smashing ridging,total salt in soil decreased by 42. 37%,corn yield increased by 34. 83%,salinity degree changed from mild desalination to normal farmland; in Ningxia,Inner Mongolia,Gansu,Jilin,Henan,Hebei,and so on,smashing ridging tillage practice in different types of saline-alkali land was conducted; according to the salt reduction and yield increase effects of saline-alkali land after smashing ridging,the development prospect of smashing ridging technique in improvement and application of saline-alkali land was proposed. | Wei Benhui Shen Zhangyou Zhou Jia Zhou Lingzhi Gan Xiuqin Lao Chengying Li Yanying Hu Po | 2018 | Meteorological and Environmental Research2018，9，4： | 3 |
| 5 | Contribution of ultrasonic to microstructure and mechanical properties of tilt probe penetrating friction stir welded joint显示文摘Tilt probe penetrating friction stir welding(PFSW)was an innovative technology proposed in recent years to avoid the formation of kissing bond in the root of joint.However,with the heat input decreasing,'S'line or zigzag line was easily introduced in the PFSW joint.In this study,ultrasonic enhanced tilt probe penetrating friction stir welding(U-PFSW)was developed to solve this problem and achieve improved joint mechanical properties.The experimental results confirmed that U-PFSW was a potent technology to completely clear the original butt surface,providing a crucial prerequisite for the achievement of highstrength joint.The application of ultrasonic improves the joint tensile strength and fracture elongation from 336 MPa and 4.3%to 359 MPa and 6.8%,respectively.Furthermore,the strength of stir zone was also increased from 391 MPa in PFSW to 420 MPa in U-PFSW.Analyses of texture and precipitate indicated that the dynamic recrystallization(DRX)and precipitation strengthening were both enhanced by the ultrasonic.Ultrasonic-enhanced DRX enabled a complete elimination of the'S'line;the enhanced precipitation strengthening by vacancy-induced mechanism in U-PFSW was the intrinsic reason for the significantly improved mechanical properties. | Yanying Hu Huijie Liu Dongrui Li | 2021 | Journal of Materials Science & Technology2021，，26： | 2 |
| 6 | In Situ Synthesis of Core-Shell Li4Ti5O(12) @ Polyaniline Composites with Enhanced Rate Performance for Lithium-ion Battery Anodes显示文摘The core-shell Li_4Ti_5O_(12) @ polyaniline composites(LP) have been synthesized via an in situ synthesis with different mole ratios(25:1, 50:1 and 100:1, aniline:LTO). As an anode material of lithium-ion batteries,the LP-2 electrodes(50:1) exhibit a high initial reversible capacity of 205 mAh g^(-1)with an initial coulombic efficiency of 97.6% at 0.1 C. Even at a high current density of 10 C, the reversible capacity of the LP-2 electrodes still remains at 102 mAh g^(-1). Moreover, the LP-2 electrodes retain an impressive high capacity of 161 mAh g^(-1)after 100 cycles at 1 C, with 0.11% capacity fading per cycle. The promising electrochemical performance may be attributed to the significantly decreasing charge-transfer impedance of the LP composite and reductive polarity difference between the cathode and the electrolyte. | Yani Hui Liyun Cao Zhanwei Xu Jianfeng Huang Haibo Ouyang Jiayin Li Hailing Hu | 2017 | Journal of Materials Science & Technology2017，33，3： | 2 |
| 7 | Dopamine D2 Receptor-Mediated Modulation of Rat Retinal Ganglion Cell Excitability显示文摘Ganglion cells(RGCs) are the sole output neurons of the retinal circuity. Here, we investigated whether and how dopamine D2 receptors modulate the excitability of dissociated rat RGCs. Application of the selective D2 receptor agonist quinpirole inhibited outward K^+ currents, which were mainly mediated by glybenclamide-and 4-aminopyridine-sensitive channels, but not the tetraethylammonium-sensitive channel. In addition,quinpirole selectively enhanced Nav1.6 voltage-gated Na^+ currents. The intracellular c AMP/protein kinase A,Ca^2+/calmodulin-dependent protein kinase Ⅱ, and mitogen-activated protein kinase/extracellular signal-regulated kinase signaling pathways were responsible for the effects of quinpirole on K^+ and Na^+ currents, while phospholipase C/protein kinase C signaling was not involved. Under current-clamp conditions, the number of action potentials evoked by positive current injection was increased by quinpirole. Our results suggest that D2 receptor activation increases RGC excitability by suppressing outward K+currents and enhancing Nav1.6 currents, which may affect retinal visual information processing. | Ning Yin Yu-Long Yang Shuo Cheng Hong-Ning Wang Xin Hu Yanying Miao Fang Li Zhongfeng Wang | 2020 | Neuroscience Bulletin2020，36，3： | 2 |
| 8 | A fiber Fabry–Perot interferometer based on a PVA coating for humidity measurement显示文摘 | Dan Su Xueguang Qiao Qiangzhou Rong Hao Sun Jing Zhang Zhengyuan Bai Yanying Du Dingyi Feng Yupeng Wang Manli Hu Zhongyao Feng | 2013 | Optics Communications2013，，： | 1 |
| 9 | Temperature and refractive index sensing characteristics of an MZI-based multimode fiber–dispersion compensation fiber–multimode fiber structure显示文摘 | Hao Sun Shen Yang Jing Zhang Qiangzhou Rong Lei Liang Qinfang Xu Guanghua Xiang Dingyi Feng Yanying Du Zhongyao Feng Xueguang Qiao Manli Hu | 2012 | Optical Fiber Technology2012，，6： | 1 |
| 10 | Authentication is fundamental for standardization of Chinese medicines 显示文摘 | Zhao Zhongzhen Hu Yani Liang Zhitao | 2006 | Planta Med2006，72，： | 1 |
| 11 | Simultaneous determination of naphthoquinone derivatives in Boraginaceous herbs by high-performance liquid chromatography显示文摘 | HU Yani JIANG Zhihong LEUNG K S Y | 2006 | Analytica Chimica Acta2006，577，1： | 1 |
| 12 | Effect of Ti layer thickness on microstructure and magnetic properties of Ti/Co/Ti films显示文摘TiCoTi granular films were prepared by DC facing-target magnetron sputtering system onto glass substrates and subsequently in situ annealing in vacuum. Structural of Ti (t nm)/Co (40 nm)/Ti (t nm) films were investigated in detail, which shows that the majority Co nanograins are formed as the hexagonal-close-packed (HCP) structure. Vibrating sample magnetometer (VSM) and scanning probe microscope (SPM) were applied to study the magnetic properties, morphologies and domain structures of these samples. It has been found that the structure and magnetic properties of the Ti/Co/Ti films depend strongly on the Ti layer thickness. The out-of-plane coercivities (Hc) of the film is maximum about 78.8 kA·m-1 when t=5 nm with annealing at 300 ℃; the distributing of grains of the sample is uniformity; and the average size of particles is about 13 nm. The obtained results suggest that this system is perpendicular anisotropy and might be applicable to perpendicular magnetic recording media. | ZHANG Yujie ZHANG Hanwei FENG Shunzhen SUN Huiyuan HU Yanying PENG Yan | 2006 | Rare Metals2006，25，z1： | 1 |
| 13 | Proteomic profiling of cotton fiber developmental transition from cell elongation to secondary wall deposition显示文摘Cotton fiber developmental transition from elongation to secondary cell wall biosynthesis is a critical growth shifting phase that affects fiber final length,strength,and other properties.Morphological dynamic analysis indicated an asynchronous fiber developmental pattern between two most important commercial cotton species,Gossypium hirsutum(Gh)and G.barbadense(Gb).Using isobaric tags for relative and absolute quantitation techniques,we examined the temporal changes of protein expression at three representative development periods(15-19,19-23,and 23-27 dpa)in both species.Strikingly,a large proportion of differentially expressed proteins(DEPs)were identified at 19-23 dpa in Gh and at 23-27 dpa in Gb,corresponding to their fiber developmental transition timing.To better understand fiber transitional development,we comparatively analyzed those DEPs in 19-23 dpa of Gh vs.in 23-27 dpa of Gb,and noted that these cotton species indeed share fundamentally similar fiber developmental features under the biological processes.We also showed that there are limited overlaps in both specific upregulated and downregulated proteins between the two species,suggesting species-specific protein regulations in the development process.Proteomic profiling results revealed dynamic changes of several key proteins and biological processes that are potentially correlated with fiber developmental transition.During the transition,upregulated proteins are mainly involved in carbohydrate/energy metabolism,oxidation-reduction,cytoskeleton,protein turnover,Ca2+signaling,etc.,whereas important downregulated proteins are mostly involved in phenylpropanoid and flavonoid secondary metabolism pathways.The gene expressions of several changed proteins in this key stage were also examined by quantitative reverse transcription polymerase chain reaction.Overall,the present study provides accurate pictures of the regulatory networks of functional proteins during the fiber developmental transition,therefore highlighting candidate genes/proteins and related pathways for the cotton fiber improvement. | Xiaoyun Zhou Wenran Hu Bo Li Yang Yang Yong Zhang Kieran Thow Ling Fan Yanying Qu | 2019 | Acta Biochimica et Biophysica Sinica2019，51，11： | 1 |
| 14 | Development and application of an indirect ELISA for detection of antibodies against avian hepatitis E virus显示文摘 | Qin Zhao Yani Sun Jinan Zhao Shoubin Hu Feifei Zhao Fuyong Chen Alfonso Clavijo En-Min Zhou Yihong Xiao | 2013 | Journal of Virological Methods2013，，1： | 1 |
| 15 | The binding epitope of sintilimab on PD-1 revealed by AbMap显示文摘PD-1 plays an important role as an immune checkpoint.Sintilimab is a newly approved PD-1 antibody for cancer immunotherapy with an unknown binding epitope on PD-1.In this study,to elucidate the molecular mechanism by which sintilimab blocks PD-1 activation,we applied Antibody binding epitope Mapping(AbMap)to identify the binding epitope of sintilimab.An epitope was successfully identified,i.e.SLAPKA,aa 127-132.By constructing a series of point mutations,the dominant residues S127,L128,A129,P130,and A132 of PD-1 were further validated by western blot analysis,biolayer interferometry,and flow cytometry.Structural analysis showed that the epitope is partially within the binding interface of PD-1 and PD-L1,and this epitope also partially overlaps with that of nivolumab and pembrolizumab.These results demonstrate that sintilimab can attenuate PD-1 activation by directly competing with the interaction between PD-1 and PD-L1 through binding with the key residues of the FG loop on PD-1.This study also demonstrates the high efficiency and accuracy of AbMap for determining the binding epitope of therapeutic antibodies. | Mingliang Ma Huan Qi Chuansheng Hu Zhaowei Xu Fanlin Wu Nan Wang Danyun Lai Yang Li Hainan Zhang Hewei Jiang Qingfeng Meng Shujuan Guo Yani Kang Xiaodong Zhao Hua Li Sheng-ce Tao | 2021 | Acta Biochimica et Biophysica Sinica2021，53，5： | 1 |
| 16 | Studies of Micoscpie Identification of Animal Drugs'Remnant Hair ( 1 ) Identification of Cordyceps sinensis and Its Counterfeits 显示文摘 | Yani Hu | | Natural Medicines0，57，5： | 1 |
| 17 | Simultaneous determination of naphthoquinone derivatives in Boraginaceous herbs by high-performance liquid chromatography显示文摘 | Yani Hu Zhihong Jiang Kelvin Sze-Yin Leung | 2006 | Analytica Chimica Acta2006，577，： | 1 |
| 18 | Appearance of Human Meridian-like Structure and Acupoints and ItsTime Correlation by Infrared thermal lmaging显示文摘 | YANY Hong-qin XIE Shu-sen HU Xiang-long | 2007 | Amer J Chin Med2007，35，： | 1 |
| 19 | Studies on microscopic identification of animal drugs' remnant hair( 1 ) Identification of Cordyceps sinensis and its counterfeits 显示文摘 | Hu Yani Kang Tingguo Zhao Zhongzhen | 2003 | Nat Med2003，57，5： | 1 |
| 20 | In Vitro Antibacterial Effect of Traditional Chinese Medicine on Main Pathogenic Bacteria of Recessive Mastitis in Dairy Cows显示文摘The inhibition zone diameter,minimal inhibitory concentration( MIC) and minimum bactericidal concentration( MBC) of 20 kinds of traditional Chinese medicine on Staphylococcus aureus and Streptococcus agalactiae isolated from recessive mastitis were studied using plate test and tube test. The results showed that S. aureus and S. agalactiae were sensitive to all these 20 kinds of traditional Chinese medicine,and were more sensitive to seven kinds of traditional Chinese medicine,including Taraxacum mongolicum,Coptis chinensis,Forsythia suspense,Andrographis paniculata,Carthamus tinctorius,Scutellaria baicalensis and Dendranthema indicum. | Gao Guisheng Hu Tiefeng An Jiwei Gao Guangping Shi Qiumei Shao Xinhua Zhang Yanying | 2017 | Animal Husbandry and Feed Science2017，9，1： | 1 |
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