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| 1 | The Tea Tree Genome Provides Insights into Tea Flavor and Independent Evolution of Caffeine Biosynthesis显示文摘茶是世界有巨大的经济、药用、文化的重要性的最旧、很流行的包含咖啡因的饮料。这里,我们在场第一个高质量的核苷酸序列充满重复(80.9%) ,栽培的茶树山茶 sinensis 的 3.02-Gb 染色体。我们证明茶树的一种非常地大的染色体尺寸从一些 LTR retrotransposon 家庭的慢、稳定、长期的扩大被结果。除了一个最近的整个染色体的复制事件,基因的系特定的扩大把新陈代谢的生合成与 flavonoid 联系了被发现,它提高 catechin 生产,萜烯酶激活,和应力公差,为茶风味和改编的重要特征。我们相对可可子和咖啡表明一个独立人士和茶咖啡因合成小径的快速的进化。在 25 山茶种类之中的比较研究表明那更高的表情大多数 flavonoid- 和咖啡因铺平 -- 然而并非 theanine 相关的基因贡献 catechins 和咖啡因的增加的生产并且因此提高处理茶的适用性和茶质量。这些新奇调查结果为进一步的 metabolomic 和典型生合成小径的功能的 genomic 精炼铺平道路并且将帮助开发将最后满足并且吸引世界范围的更多的茶喝酒者的茶风味的一个更多样化的集合。 | En-Hua Xia Hai-Bin Zhang Jun Sheng Kui Li Qun-Jie Zhang Changhoon Kim Yun Zhang Yuan Liu Ting Zhu Wei Li Hui Huang Yan Tong Hong Nan Cong Shi Chao Shi Jian-Jun Jiang Shu-Yan Mao Jun-Ying Jiao Dan Zhang Yuan Zhao You-Jie Zhao Li-Ping Zhang Yun-Long Liu Ben-Ying Liu Yue Yu Sheng-Fu Shao De-Jiang Ni Evan E. Eichler Li-Zhi Gao | 2017 | Molecular Plant2017，10，6： | 113 |
| 2 | Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes显示文摘 | Xiao-Lei Shi Yimeng Gao YupengYan HuchengMa Lulu Sun Pengyu Huang Xuan Ni Ludi Zhang Xin Zhao Haozhen Ren Dan Hu Yan Zhou Feng Tian Yuan Ji Xin Cheng Guoyu Pan Yi-Tao Ding LijianHui | 2016 | Cell Research2016，26，2： | 31 |
| 3 | Treatment of abdominal compartment syndrome in severe acute pancreatitis patients with traditional Chinese medicine显示文摘AIM: To investigate the therapeutic effect of traditional Chinese traditional medicines Da Cheng Qi Decoction (Timely-Purging and Yin-Preserving Decoction) and Glauber's salt combined with conservative measures on abdominal compartment syndrome (ACS) in severe acute pancreatitis (SAP) patients. METHODS: Eighty consecutive SAP patients, admitted for routine non-operative conservative treatment, were randomly divided into study group and control group (40 patients in each group). Patients in the study group received Da Cheng Qi Decoction enema for 2 h and external use of Glauber's salt, once a day for 7 d. Patients in the control group received normal saline (NS) enema. Routine non-operative conservative treatments included non-per os nutrition (NPON), gastrointestinal decompression, life support, total parenteral nutrition (TPN), continuous peripancreatic vascular pharmaceutical infusion and drug therapy. Intra-cystic pressure (ICP) of the two groups was measured during treatment. The effectiveness and outcomes of treatment were observed and APACHE Ⅱ scores were applied in analysis. RESULTS: On days 4 and 5 of treatment, the ICP was lower in the study group than in the control group(P < 0.05). On days 3-5 of treatment, acute physiology and chronic health evaluation Ⅱ (APACHE Ⅱ) scores for the study and control groups were significantly different (P < 0.05). Both the effectiveness and outcome of the treatment with Da Cheng Qi Decoction on abdominalgia, burbulence relief time, ascites quantity, cyst formation rate and hospitalization time were quite different between the two groups (P < 0.05). The mortality rate for the two groups had no significant difference. CONCLUSION: Da Cheng Qi Decoction enema and external use of Glauber's salt combined with routine non-operative conservative treatment can decrease the intra-abdominal pressure (IAP) of SAP patients and have preventive and therapeutic effects on abdominal compartment syndrome of SAP. | Min-Jie Zhang Guo-Lei Zhang Wen-Bin Yuan Jun Ni Li-Feng Huang | 2008 | World Journal of Gastroenterology2008，14，22： | 30 |
| 4 | Application and study in aluminum melt degassing technologies显示文摘The classification, characteristics and current situation of aluminum melt hydrogen-removal methods and technologies have been summarized. The latest studies and research results of aluminum melt degassing technology have been summed up. The tendency and prospect of aluminum degassing technology was discussed. | ~*H. J. Ni~(1,2), M. Y. Huang~1, Y. Zhu~1, P. Liao~1, R. Z. WU~2, B. D. Sun~2(1. Department of Mechanical Engineering, Nantong Institute of Technology, Nantong 226007, Jingsu, P. R. China 2. School of Material Science and Engineering, Shanghai Jiaotong University, Shanghai 200030, P. R. China) | 2004 | China Foundry2004，1，S1： | 27 |
| 5 | Prevalence of Thyroid Nodules and Its Relationship with Iodine Status in Shanghai:a Population-based Study显示文摘Objective This study was designed to evaluate the prevalence of thyroid nodules(TNs) and its relationship with urine iodine concentrations(UICs) after the regional rapid economic growth and lifestyle changes. Methods A cross-sectional survey was conducted in the general population aged 15-69 years. A questionnaire regarding general and personal characteristics and relevant information was administered. Ultrasonography of the thyroid was performed, and serum triiodothyronine(T3), tetraiodothyronine(T4), serum thyroid stimulating hormone(TSH), free triiodothyronine(FT3), free tetraiodothyronine(FT4), thyroglobulin antibody(Tg Ab), thyroid peroxidase antibody(TPOAb), and TSH receptor antibody(TRAb) levels were measured for each individual subject. Results The prevalence rates of TNs in the whole population, females and males were 27.76%, 34.04%, and 21.60%, respectively. The prevalence of multiple nodules increased with age, whereas the prevalence peaks differed between males and females. The median UICs in the whole population and females with non-TNs were higher than those of subjects with TNs(P=0.0035, P=0.0068). The median UICs in subjects with a single TN were higher than those in subjects with multiple TNs(P=0.0164, P=0.0127). The result showed a U-shaped curve relationship between UIC and prevalence of TNs. The prevalence of TNs was the lowest when the UIC was 140-400 μg/L. Conclusion The prevalence of TNs was nearly 30% and increased with age. The relationship between UIC and prevalence of TNs is U-shaped, with an increase in risk when the UIC was <140 μg/L and >400 μg/L. Very low or high UIC levels need attention and correction. | SONG Jun ZOU Shu Rong GUO Chang Yi ZANG Jia Jie ZHU Zhen Ni MI Ming HUANG Cui Hua YU Hui Ting LU Xi RUAN Ye WU Fan | 2016 | Biomedical and Environmental Sciences2016，29，6： | 25 |
| 6 | Expenditure and financial burden for the diagnosis and treatment of colorectal cancer in China:a hospital.based,multicenter,cross-sectional survey显示文摘Background: The increasing prevalence of colorectal cancer(CRC) in China and the paucity of information about relevant expenditure highlight the necessity of better understanding the financial burden and effect of CRC diagnosis and treatment. We performed a survey to quantify the direct medical and non-medical expenditure as well as the resulting financial burden of CRC patients in China.Methods: We conducted a multicenter, cross-sectional survey in 37 tertiary hospitals in 13 provinces across China between 2012 and 2014. Each enrolled patient was interviewed using a structured questionnaire. All expenditure data were inflated to the 2014 Chinese Yuan(CNY; 1 CNY = 0.163 USD). We quantified the overall expenditure and financial burden and by subgroup(hospital type, age at diagnosis, sex, education, occupation, insurance type, household income, clinical stage, pathologic type, and therapeutic regimen). We then performed generalized linear modeling to determine the factors associated with overall expenditure.Results: A total of 2356 patients with a mean age of 57.4 years were included, 57.1 % of whom were men; 13.9% of patients had stage I cancer; and the average previous-year household income was 54,525 CNY.The overall average direct expenditure per patient was estimated to be 67,408 CNY, and the expenditures for stage Ⅰ, Ⅱ, Ⅲ, and Ⅳ disease were 56,099 CNY, 59,952 CNY, 67,292 CNY, and 82,729 CNY, respectively. Non-medical expenditure accounted for 8.3%of the overall expenditure. The 1-year out-of-pocket expenditure of a newly diagnosed patient was 32,649 CNY, which accounted for 59.9% of their previous-year household income and caused 75.0% of families to suffer an unmanageable financial burden. Univariate analysis showed that financial burden and overall expenditure differed in almost all subgroups(P < 0.05), except for sex. Multivariate analysis showed that patients who were treated in specialized hospitals and those who were diagnosed with adenocarcinoma or diagnosed at a later stage were likely to spend more,whereas those with a lower household income and those who underwent surgery spent less(all P < 0.05).Conclusions: For patients in China, direct expenditure for the diagnosis and treatment of CRC seemed catastrophic,and non-medical expenditure was non-ignorable. The financial burden varied among subgroups, especially among patients with different clinical stages of disease, which suggests that, in China, CRC screening might be cost-effective. | Hui-Yao Huang Ju-Fang Shi Lan-Wei Guo Ya-Na Bai Xian-Zhen Liao Guo-iangLiu A-Yan Mao Jian-Song Ren Xiao-Jie Sun Xin-Yu Zhu Le Wang Bing-Bing Song Ling-Bin Du Lin Zhu Ji-Yong Gong Qi Zhou Yu-Qin Liu Rong Cao Ling Mai Li Lan Xiao-Hua Sun Ying Ren Jin-Yi Zhou Yuan-Zheng Wang Xiao Qi Pei-An Lou Dian Shi Ni Li Kai Zhang Jie He Min Dai | 2017 | Chinese Journal of Cancer2017，36，8： | 25 |
| 7 | 2016 Chinese expert consensus and guidelines for the diagnosis and treatment of papillary thyroid microcarcinoma显示文摘The incidence of papillary thyroid carcinoma(PTC)has exponentially increased in recent years.Papillary thyroid microcarcinoma(PTMC)accounts for the majority of the reported cases of PTC.The debates and crucial issues in PTMC management have received researchers'attention.To further improve the clinical management of PTMC in China, | Ming Gao Minghua Ge Qinghai Ji Ruochuan Cheng Hankui Lu Haixia Guan Li Gao Zhuming Guo Tao Huang Xiaoming Huang Xiaoming Li Yansong Lin Qinjiang Liu Xin Ni Yi Pan Jianwu Qin Zhongyan Shan Hui Sun Xudong Wang Zhengang Xu Yang Yu Daiwei Zhao Naisong Zhang ShengZhang Ying Zheng Jingqiang Zhu Dapeng Li Xiangqian Zheng 无 | 2017 | Cancer Biology & Medicine2017，14，3： | 23 |
| 8 | Genome-Wide Association Studies of Image Traits Reveal Genetic Architecture of Drought Resistance in Rice显示文摘理解植物怎么对干旱作出回应能有益于繁殖的干旱抵抗(医生) 。用一台非破坏性的 phenotyping 设备,为 507 米饭就职的 51 个基于图象的特点(i 特点) 被提取。这些 i 特点能被用来监视干旱回答 ? 并且高评估医生可遗传性和这些特点的大变化在自然人口在干旱应力下面被观察。染色体宽的协会研究(GWAS )?i 特点和传统的医生特点识别了 470 协会 loci,某包含知道医生相关的基因。这 470 loci, 443 loci (94%) 用 i 特点被识别, 437 loci (93%) 与以前报导的医生相关的量的特点 loci,和 313 loci (66.6%)co 局部性被 GWAS reproducibly 在不同的年里识别。协会网络,基于 GWAS 建立了结果,揭示中心 i 特点和中心 loci。这表明把的可行性和必要性复杂医生特点进可继承、简单的 i 特点。作为原则的证明,我们说明了这条综合途径的力量以前识别 unreported 医生相关的基因。OsPP15 与中心 i 特点被联系,并且它在医生的角色被基因转变实验证实。而且, i 特点能被用于医生连接分析,并且 69 个 i 特点地点协会被 recombinant 的 GWAS 和连接分析识别生来的线人口。最后,我们证实了 i 特点的关联在这个领域里搀。我们的学习为医生为原因的基因的基因解剖和发现提供一条有希望的新奇途径。 | Zilong Guo Wanneng Yang Yu Chang Xiaosong Ma Haifu Tu Fang Xiong Ni Jiang Hui Feng Chenglong Huang Peng Yang Hu Zhao Guoxing Chen Hongyan Liu Lijun Luo Honghong Hu Qian Liu Lizhong Xiong | 2018 | Molecular Plant2018，11，6： | 21 |
| 9 | Heat and power load dispatching considering energy storage of district heating system and electric boilers显示文摘As one of promising clean and low-emission energy, wind power is being rapidly developed in China.However, it faces serious problem of wind curtailment,particularly in northeast China, where combined heat and power(CHP) units cover a large proportion of the district heat supply. Due to the inherent strong coupling between the power and the heat load, the operational flexibility of CHP units is severely restricted in winter to meet the heat supply demand, which imparts considerable stress on the wind power connection to the grid. To promote the integration of wind power and enhance the flexibility of CHP units, this paper presented a method of heat and power load dispatching by exploring the energy storage ability of electric heating boilers and district heating systems. The optimization results indicate that the proposed method can integrate additional wind power into the grid and reduce the coal consumption of CHP units over the optimized period. Furthermore, the thermal inertia of a district heating system is found to contribute more to the reduction of coal consumption, whereas the electric heating boilers contribute to lower wind curtailment. | Xianzheng HUANG Zhaofeng XU Yong SUN Yali XUE Zhe WANG Zhijun LIU Zhenyuan LI Weidou NI | 2018 | Journal of Modern Power Systems and Clean Energy2018，6，5： | 20 |
| 10 | Totally percutaneous thoracic endovascular aortic repair with the preclosing technique: a case-control study显示文摘背景常规胸的 endovascular 大动脉的修理(TEVAR ) 在一般或硬膜上的麻醉下面包含腹股沟切口。作为向更少的侵略过程的技术行动,一条全部的经皮的途径是 desirable.In 这研究,我们描述一种 Preclosing 技术并且为大腿骨的存取地点管理调查它的安全和功效,并且当与那些相比传统的外科的缩小的 approaches.Methods Preclosing 技术包含二,评估它的优点或多重在 upsizing 前在大腿骨的动脉部署到 20-25 F 鞘的 6 台 F Perclose Proglide 设备。缝术被固定在过程的结束关上动脉切开术。经历了用在 2009 年 12 月和 2010 年 11 月(组 A ) 之间的 Preclosing 技术的大动脉的修理与那些用相比的胸的 endovascular 的病人的医药记录外科大腿骨从 2008 年 1 月缩小到 2009 年 11 月(组 B ) 。结果措施包括了技术成功的率,早复杂并发症,麻醉方法,过程时间,心脏的照顾单位( CCU )停留,分泌物的从过程的时间,医院停留,过程开销,在二个组之间的医院 cost.Results ,在基线特征没有重要差别,在 endograft 模型或侧面。技术成功率是 100.0%(85/85 ) 在组 A 对(147/151 )97.4% 不在组 B (P 0.05 ).There 是在两个组的存取相关的死亡。与组 B 相比,早复杂并发症的发生是在组 A 的少数, 9.4%(8/85 ) 对 22.5%(34/151 )(P 0.01 ) 。有有意识的镇静的本地麻醉在组 A 更经常被使用, 68.2%(58/85 ) 对 51.7%(78/151 ) 在组 B (P0.01 ) 。过程持续时间更短,(96 琠浩 ? 慷 ? ㄨ ? 2 ? 鰘? 鰘吗?? | NI Zhong-han LUO Jian-fang HUANG Wen-hui LIU Yuan XUE Ling FAN Rui-xin CHEN Ji-yan | 2011 | Chinese Medical Journal2011，，6： | 19 |
| 11 | Anti-hepatoma effect of arsenic trioxide on experimental liver cancer induced by 2-acetamidofluorene in rats显示文摘瞄准:学习三氧化二砷的 anti-hepatoma 效率(作为(2 ) O (3 )) 在试验性的老鼠肝细胞的治疗,癌(HCC ) 由 2-acetamidofluorene (2-FAA ) 导致了并且阐明可能的机制。方法:SD 老鼠(2 瞬间旧) 用 2-FAA 被喂了让 8 wk 导致 HCC,然后他们被对待与作为(2 ) O (3 ) 或妈三倍。在 d 上 29,老鼠被打死,肝被称,肝肿瘤被数。肝织物的组织学的变化在显微镜下面被观察,并且细胞的动态参数被流动血细胞计数学习。Immunohistochemistry (二拍子的圆舞方法) 被用来在连续的节上观察脉管的内皮生长因素(VEGF ) 和微容器的密度(MVD ) 的表示。病理学的参数也被分析,浆液 aspartate aminotransferase (著名计算机生产厂商) 的层次,丙氨酸 aminotransferase (中高音) ,全部的胆红素(TBi ) ,和直接胆红素(DBi ) 。结果:肝肿瘤的数字在对待与的组显著地减少了作为(2 ) O (3 ) ,在特别中等剂量(1 mg/kg ) 组织(t = 2.80, P<0.01 ) 。当(2 ) O (3 ) 经由 apoptosis 引起了 HCC 细胞死亡;坏死被看见,当剂量是 1 mg/kg 时, apoptosis 是普通的。增长索引严厉地减少了在中等剂量(1 mg/kg ) 组织(7.87+/-4.11 对 24.46+/-6.49, t = 2087, P<0.01 ) ,然而并非在 0.2 mg/kg 组。然而,S阶段部分在两个组戏剧性地减少了,仅仅当剂量与控制相比是 1 mg/kg 时,它到达了底部水平( 0.40+/-0.13 对 3.01+/-0.51 , t = 2.97 , P<0.01 ),并且它显然在 G ( 0 ) /G ( 1 )( G ( 0 ) /G ( 1 )限制)伴有房间的累积。VEGF 和 MVD 在的表情中等剂量(1 mg/kg ) 组比生理盐水组显著地低(0.63+/-0.74 对 2.44+/-0.88, P<0.05;15.75+/-3.99 对 47.44+/-13.41, t = 2.80, P<0.01 ) 。与生理盐水组相比,是的中等剂量、低剂量的组( 2 ) O ( 3 )和妈三倍在浆液降低了中高音的层次( 61.46+/-9.46 , 63.75+/-20.40 , 61.18+/-13.00 对 108.98+/-29.86 , t = 2.14 , P<0.05 ),但是没有浆液著名计算机生产厂商诚实的效果, TBi ,和 DBi 。结论:当(2 ) O (3 ) 穿上禁止的效果,在老鼠的试验性的 HCC 的生长由 2-FAA 导致了,但是没在正常肝细胞上有明显的效果。机制可以通过堵住 VEGF 在血管生成上包含两极分裂,在 /G (1 ) 分阶段执行的 G (0 ) 的房间的累积,肿瘤房间的 apoptosis,和禁止的效果的减少。 | Bing Tan Jie-Fei Huang Qun Wei Hong Zhang Run-Zhou Ni | 2005 | World Journal of Gastroenterology2005，11，38： | 18 |
| 12 | Sources of multidrug-resistant Acinetobacter baumannii and its role in respiratory tract colonization and nosocomial pneumonia in intensive care unit patients显示文摘 | HUANG Jie CHEN Er-zhen QU Hong-ping MAO En-qiang ZHUZheng-gang NI Yu-xing HANLi-zhong TANG Yao-qing | 2013 | Chinese Medical Journal2013，，10： | 17 |
| 13 | Stable carbon and hydrogen isotopes of gases from the large tight gas fields in China显示文摘By the end of the year 2010,a total of 15 large tight gas fields have been found in China,located in the Ordos,Sichuan,and Tarim basins.The annual production and total reserves of these fields in 2010 were 222.5×108and 28657×108m3,respectively,accounting for 23.5%and 37.3%,respectively,of the total annual production and reserves of natural gases in China.They took a major part of all natural gas production and reserves in China.According to the analyses of 81 gas samples,the stable carbon and hydrogen isotopic compositions of tight gases in China have following characteristics:(1)Plots of 13C1-13C2-13C3,13C1-C1/C2+3and 13C1-13C2demonstrate the coal-derived origin of tight gases in China;(2)For the primary alkane gases,both carbon and hydrogen isotopic values increase with increasing molecular mass,i.e.,13C1<13C2<13C3<13C4and2H1<2H2<2H3;(3)The isotopic differences of 13C2-13C1,13C3-13C1,2H2-2H1and 2H3-2H1decrease with increasing Ro(%)and C1/C1–4;(4)There are seven causes for the carbon and hydrogen isotopic reversal,however,the carbon and hydrogen isotopic reversal of tight gases in China is caused mainly by multiple stages of gas charge and accumulation. | DAI JinXing NI YunYan HU GuoYi HUANG ShiPeng LIAO FengRong YU Cong GONG DeYu WU Wei | 2014 | Science China Earth Sciences2014，57，1： | 17 |
| 14 | Asymptomatic patients of chronic obstructive pulmonary disease in China显示文摘背景长期的妨碍的肺的疾病(COPD ) 让可变自然历史和并非所有个人跟随一样的功课。这研究试图在 China.Methods 从基于人口的调查识别无征状的 COPD 病人的流行和特征多级式的簇采样策略从七不同省 / 城市在一张人口被使用。所有居民(超过 40 岁) 与一张标准化问询表被会见, spirometry.Post-bronchodilator 在 1 秒(FEV1 ) 强迫了吐气的体积 /forced 不到 70% 的重要能力(FVC ) 被定义为 COPD 的诊断标准。屏蔽的所有 COPD 病人根据长期的呼吸症状的存在或缺席被划分成征兆的组和无征状的组。Socio 人口统计,个人和暴露变量被收集,在从 25 627 采样与 COPD 被诊断的 1668 个病人之中的 analyzed.Results 使遭到,(35.3%) 589 是无征状的。年龄,性别,身体团索引(BMI ) ,农村、城市的分布,吸烟习惯和教育层次在二个组是类似的。64.7% 无征状的病人的一个总数没有 comorbidities。心血管的疾病和肺癌症比无征状的 group.Asymptomatic COPD 组多半是更少在厨房,呼吸疾病的家庭历史和周期性的童年咳嗽里与差的通风介绍的在征兆的 COPD 病人之中是更普通的。无征状的 COPD 病人有的显著地更高的 FEV1 (73.1% 对 61.0%) , FVC (91.9% 对 82.0%) ,和 FEV1/FVC (62.9%vs.58.7%) 的更高的比率(所有 P < 0.001 ) 比征兆的组。更无征状的病人是 underdiagnosed (91.9%vs.54.3% , P < 0.001 ) 比征兆的 patients.Conclusions,这大基于人口的调查在中国证实了无征状的 COPD 病人的高流行。屏蔽测试的呼吸量测定法的更多的使用可能对 COPD 的早察觉重要。 | LU Ming YAO Wan-zhen ZHONG Nan-shan ZHOU Yu-min WANG Chen CHEN Ping KANG Jian HUANG Shao-guang CHEN Bao-yuan WANG Chang-zheng NI Dian-tao WANG Xiao-ping WANG Da-li LIU Sheng-ming Lv Jia-chun SHEN Ning DING Yan-ling RAN Pi-xin | 2010 | Chinese Medical Journal2010，，12： | 17 |
| 15 | Effect of Combining Acupuncture and Functional Training on Post-stroke Functional Impairment of Hand显示文摘Objective:To observe the clinical effect of combining acupuncture and functional training on post-stroke functional impairment of hand.Methods:A total of 165 cases who met the inclusion criteria were randomized into a treatment group(85 cases)and a control group(80cases).Cases in the treatment group were treated with routine acupuncture points plus Shixuan(EX-UE 11)and Xiaohai(SI 8),whereas cases in the control group were treated with routine acupuncture points alone.After acupuncture,cases in both groups conducted functional training in upper limbs.The finger grip strength and hand function were assessed before and after 3-course treatment.Results:Cases in the treatment group obtained better finger grip strength and hand function than those in the control group(both P<0.05).Conclusion:In addition to functional training,adding Shixuan(EX-UE 11)and Xiaohai(SI 8)to traditional acupuncture formulae works better for post-stroke functional impairment of hand. | Ni Huan-huan Cui Xiao Hu Yong-shan Wu Yi Huang De-quan Qu Pei-yu Wang Jun Wu Ji Shi Jun-chao Han Chou-ping | 2013 | Journal of Acupuncture and Tuina Science2013，11，6： | 16 |
| 16 | Development of cell-based pseudovirus entry assay to identify potential viral entry inhibitors and neutralizing antibodies against SARS-CoV-2显示文摘Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the causative virus of the coronavirus disease 2019(COVID-19)pandemic.To establish a safe and convenient assay system for studying entry inhibitors and neutralizing antibodies against SARS-CoV-2,we constructed a codon-optimized,full-length C-terminal mutant spike(S)gene of SARS-CoV-2.We generated a luciferase(Luc)-expressing pseudovirus containing the wild-type or mutant S protein of SARS-CoV-2 in the envelope-defective HIV-1 backbone.The key parameters for this pseudovirus-based assay,including the S mutants and virus incubation time,were optimized.This pseudovirus contains a Luc reporter gene that enabled us to easily quantify virus entry into angiotensin-converting enzyme 2(ACE2)-expressing 293T cells.Cathepsin(Cat)B/L inhibitor E64d could significantly block SARS-CoV-2 pseudovirus infection in 293T-ACE2 cells.Furthermore,the SARS-CoV-2 spike pseudotyped virus could be neutralized by sera from convalescent COVID-19 patients or recombinant ACE2 with the fused Fc region of human IgG1.Thus,we developed a pseudovirus-based assay for SARS-CoV-2,which will be valuable for evaluating viral entry inhibitors and neutralizing antibodies against this highly pathogenic virus. | Jie Hu Qingzhu Gao Changlong He Ailong Huang Ni Tang Kai Wang | 2020 | Genes & Diseases2020，7，4： | 15 |
| 17 | Preliminary analysis on the relationships between Tibetan Plateau NDVI change and its surface heat source and precipitation of China显示文摘Using the automatic weather station data obtained from the Tibetan Plateau (TP), the normalized dif- ference vegetation index and the monthly precipitation data of China and by the methods of correlation and composite analysis, preliminary analytical results are achieved concerning the relationships be- tween TP NDVI change and its surface heat source and precipitation of China. The results of our re- search may lead to the following conclusions: (1) A positive correlation relationship exists between TP NDVI change and its surface heat source, including the sensible heat and the latent heat. As to the correlation of the former, it is more remarkable in western TP than in eastern TP, and as to the correla- tion of the latter, however it turns out contrary. (2) With the improvement of TP vegetation, its surface heat source of every season is also mainly reinforced, especially in summer. As to the contribution of the sensible heat and the latent heat to the increment of the TP surface heat source intensity, the for- mer is comparatively more significant than the latter in winter and spring, while in summer and autumn, the two have almost the same importance. (3) The correlation coefficient between summer NDVI over TP and the corresponding period precipitation of China displays a belt distribution of '+?+' from south to north China. (4) Anomalous surface heating field over TP derived from vegetation change is probably an important factor to affect summer precipitation of China. | HUA Wei FAN GuangZhou ZHOU DingWen NI ChangJian LI XueMin WANG YongLi LIU YaQin HUANG XianLun | 2008 | Science China Earth Sciences2008，51，5： | 14 |
| 18 | MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1显示文摘MicroRNAs (miRNAs ) 由抑制最近在 carcinogenesis 和转移在我们 non-protein-coding RNA 的角色的理解带给卓见的 posttranscriptional 施加功能。在这研究,我们在 CRC 在 colorectal 癌症(CRC ) 和它的潜在的临床的应用程序描述了函数和 miR-139-5p 的分子的机制。我们发现 miR-139-5p 是显著地, CRC 与邻近的 noncancerous 纸巾(NCT ) 相比取样的在 73.8% 的 downregulated,和减少的 miR-139-5p 与穷人被联系预后。功能的分析证明 miR-139-5p 的那个宫外的表达式在 vivo 在 vitro 和转移压制了 CRC 房间移植和侵略。机械学的调查表明 miR-139-5p 由指向 AMFR 和 NOTCH1 压制 CRC 房间侵略和转移。二基因 phenocopied 击倒 CRC 上的 miR-139-5p 的禁止的效果转移。而且,二基因的蛋白质层次与 NCT 相比是在 CRC 样品的 upregulated,并且相反地与 miR-139-5p 表示相关。增加的 NOTCH1 蛋白质表示与 CRC 病人的差的预后被相关。一起,我们的数据显示 miR-139-5p 为 CRC 是潜在的肿瘤 suppressor 和预示的因素,并且指向 miR-139-5p 可以镇压 CRC 的转移并且改善幸存。 | Mingxu Song Yuan Yin Jiwei Zhang Binbin Zhang Zehua Bian Chao Quan Leyuan Zhou Yaling Hu Qifeng Wang Shujuan Ni Bojian Fei Weili Wang Xiang Du Dong Hua Zhaohui Huang | 2014 | Protein & Cell2014，5，11： | 14 |
| 19 | Timosaponin A3 induces hepatotoxicity in rats through inducing oxidative stress and down-regulating bile acid transporters显示文摘 | Zhi-tao WU Xin-ming QI Jing-jing SHENG Lei-lei MA Xuan NI Jin REN Cheng-gang HUANG Guo-yu PAN | 2014 | Acta Pharmacologica Sinica2014，35，9： | 13 |
| 20 | DIFFERENTIAL QUADRATURE METHOD TO STABILITY ANALYSIS OF PIPES CONVEYING FLUID WITH SPRING SUPPORT显示文摘It is a new attempt to extend the differential quadrature method(DQM)to stability analysis ofthe straight and curved centerline pipes conveying fluid.Emphasis is placed on the study of the influences ofseveral parameters on the critical flow velocity’.Compared to other methods,this method can more easily dealwith the pipe with spring support at its boundaries and asks for much less computing effort while giving ac-ceptable precision in the numerical results. | Ni Qiao Huang Yuying | 2000 | Acta Mechanica Solida Sinica2000，13，4： | 13 |
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