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| 1 | Carbon-containing electrospun nanofibers for lithium-sulfur battery:Current status and future directions显示文摘Lithium-sulfur batteries(LSBs)have become promising next-generation energy storage technologies for electric vehicles and portable electronics,due to its excellent theoretical specific energy.However,the low conductivity of sulfur species,notorious lithium dendrites,the severe'shuttle effect'of polysulfides(LiPSs)and the inferior kinetic reaction for LiPSs/Li_(2)S conversion during discharge-charge have seriously hindered their practical application,and also pose potential safety hazards.Owing to their superior porous architectures,high specific surface areas,excellent structural designability,functional modifiability,abundant active sites and flexibility of carbon-containing electrospun nanofibers(CENFs),they exhibited the superior characteristics that can simultaneously solve the above issues.In this review,we summarize the recent progress and application of CENFs in LSBs.First,we provide a brief introduction to the structure and composition controlled of carbon nanofibers by electrospinning.We then review progress in recent developments of CENFs for LSBs including cathodes,anodes,separators,and interlayers.We focus on how to solve practical issues that arise when the CENFs are applied to various parts of LSBs,and the relevant working mechanisms are described,from high sulfur loading and Li dendrites suppression to LiPSs’confinement and conversion.Finally,we summarize and propose the existing challenges and future prospects of CENFs,for the design and architecture of electrochemical components in Li-S energy storage systems. | Zhaoming Tong Liang Huang Wen Lei Haijun Zhang Shaowei Zhang | 2021 | Journal of Energy Chemistry2021，30，3： | 4 |
| 2 | Timely renal replacement therapy linked to better outcome in patients with sepsis-associated acute kidney injury显示文摘Background:Recent studies suggest that acute kidney injury(AKI)can be treated with renal replacement therapy(RRT).However,its benefits to patients with sepsis-associated AKI(SA-AKI),which is linked to high mortality and morbidity rates,remain under debate.The aim of this study was to compare the outcomes of different RRT strategies for patients with SA-AKI.Methods:This retrospective study evaluated patients who were admitted to the hospital with sepsis and devel-oped SA-AKI during hospitalization from 1st January 2014 to 31st January 2019.Mortality,renal recovery,and systemic organ function at 90 days following admission were compared between the RRT group(RG)and non-RRT group(NRG),as well as the early-RRT group(EG)and delayed-RRT group(DG).The groups were defined according to the time from admission to RRT initiation(criterion 1,EG1 and DG1)and Kidney Disease Improving Global Outcomes(KDIGO)classification(criterion 2,EG2 and DG2).Categorical and continuous variables were compared using the chi-squared test or Fisher’s exact test and Student’s t-test or Wilcoxon test.Kaplan-Meier curves were constructed to determine the unadjusted survival rates for the different subgroups.Results:A total of 116 patients were included in this study;of those,38 received RRT and 46 expired within 90 days.Among different strategies of RRT,there were no significant differences found in 90-day mortality(RG vs.NRG:��2=0.610,P=0.435;EG1 vs.DG1:��2=0.835,P=0.360;EG2 vs.DG2:��2=0.022,P=0.899)and renal recovery.However,the values of change in sequential organ failure assessment(ΔSOFA)max-min of patients in the EG and RG were significantly higher than those recorded in the NRG(ΔSOFA RG=7.0,ΔSOFA NRG=3.60,ΔSOFA EG1=9.00,ΔSOFA EG2=6.30;P<0.050).Also,the 90-day renal recovery in the EG was better than that noted in the DG with criterion 1(87.5%vs.38.5%,respectively,��2=10.425,P=0.032),suggesting that RRT(especially timely RRT)may be beneficial to the restoration of systemic organ function in patients with SA-AKI.Conclusion:RRT did not reduce the 90-day mortality among patients with SA-AKI.However,timely RRT may benefit the restoration of systemic organ function,thereby improving the quality of life of patients. | Yiwen Fan Liang Chen Shaowei Jiang Yingying Huang Yuxin Leng Chengjin Gao | 2022 | Journal of Intensive Medicine2022，2，3： | 2 |
| 3 | Association of Heart Rate Variability in Taxi Drivers with Marked Changes in Particulate Air Pollution in Beijing in 2008显示文摘 | Wu Shaowei Deng Furong Niu Jie Huang Qinsheng Liu Youcheng Guo Xinbiao | 2010 | Environmental Health Perspectives2010，，1： | 1 |
| 4 | Cardiorespiratory Effects of Indoor Ozone Exposure Associated with Changes in Metabolic Profiles among Children:A Repeated-Measure Panel Study显示文摘Ozone is one of the major gaseous pollutants associated with short-term adverse cardiopulmonary effects,even at concentrations below the current indoor air quality limits.However,the underlying biological mechanisms of cardiorespiratory changes with exposure to ozone remain unclear.To further explore molecular linkages between indoor ozone exposure and relevant cardiorespiratory effects,a repeated-measure panel study including 46 schoolchildren was conducted and real-time exposure measurements including ozone were performed inside classrooms every weekday during the study period.Repeated health measurements and urine sample collection were conducted in each participant.Ultra-high-performance liquid chromatography/tandem mass spectrometry and meet-in-metabolite approach were used in metabolomics analysis.Methods including mixed-effect models were adopted to identify metabolites associated with ozone exposure or health indices.Nine metabolites were found to be associated with ozone after mixed-effect model analysis,which are mainly involved in amino acid and bile acid metabolism.Boys may have a greater decrease in bile acid and RNA related metabolites.Four of the nine ozone-related metabolites were also associated with cardiorespiratory function indices.Furthermore,26.67%of the positive association between ozone and heart rate was mediated by cholestane-3,7,12,25-tetrol-3-glucuronide.Exposure to ozone below the current indoor standards was associated with the deteriorated cardiovascular function by disturbing bile acid and endogenous nitric oxide-related oxidation and inflammation,and associated with the exacerbated airway inflammation by reducing GPx-related anti-oxidation.The results provide metabolic evidence of the cardiorespiratory effects of indoor ozone exposure.Indoor ozone pollution should be controlled further,and more attention should be paid to preventing its adverse health effects,especially in children. | Shan Liu Qingyu Huang Xi Zhang Wei Dong Wenlou Zhang Shaowei Wu Di Yang Bingru Nan Jie Zhang Heqing Shen Xinbiao Guo Furong Deng | 2021 | The Innovation2021，2，1： | 1 |
| 5 | Capsid destabilization and epitope alterations of human papillomavirus 18 in the presence of thimerosal显示文摘Thimerosal has been widely used as a preservative in drug and vaccine products for decades.Due to the strong propensity to modify thiols in proteins,conformational changes could occur due to covalent bond formation between ethylmercury(a degradant of thimerosal)and thiols.Such a conformational change could lead to partial or even complete loss of desirable protein function.This study aims to investigate the effects of thimerosal on the capsid stability and antigenicity of recombinant human papillomavirus(HPV)18 virus-like particles(VLPs).Dramatic destabilization of the recombinant viral capsid upon thimerosal treatment was observed.Such a negative effect on the thermal stability of VLPs preserved with thimerosal was shown to be dependent on the thimerosal concentration.Two highly neutralizing antibodies,13H12 and 3C3,were found to be the most sensitive to thimerosal treatment.The kinetics of antigenicity loss,when monitored with 13H12 or 3C3 as probes,yielded two distinctly different sets of kinetic parameters,while the data from both monoclonal antibodies(mAbs)followed a biphasic exponential decay model.The potential effect of thimerosal on protein function,particularly for thiolcontaining proteinaceous active components,needs to be comprehensively characterized during formulation development when a preservative is necessary. | Xiaofen Huang Yike Li Meifeng Nie Mingxi Yue Yufang Li Zhijie Lin Huirong Pan Mujin Fang Ting Wu Shaowei Li Jun Zhang Ningshao Xia Qinjian Zhao | 2021 | Journal of Pharmaceutical Analysis2021，11，5： | 1 |
| 6 | Varia- ble-bandwidth Optical Paths: Comparision Between Optical Code-labeled Path and OCDM Path 显示文摘 | Huang Shaowei Ken-Ichi B Ken-Ichi K | 2006 | IEEE J Lightwave Technol2006，24，10： | 1 |
| 7 | A homologous and molecular dual-targeted biomimetic nanocarrier for EGFR-related non-small cell lung cancer therapy显示文摘The abnormal activation of epidermal growth factor receptor(EGFR)drives the development of non-small cell lung cancer(NSCLC).The EGFR-targeting tyrosine kinase inhibitor osimertinib is frequently used to clinically treat NSCLC and exhibits marked efficacy in patients with NSCLC who have an EGFR mutation.However,free osimertinib administration exhibits an inadequate response in vivo,with only~3%patients demonstrating a complete clinical response.Consequently,we designed a biomimetic nanoparticle(CMNP^(@Osi))comprising a polymeric nanoparticle core and tumor cell-derived membrane-coated shell that combines membrane-mediated homologous and molecular targeting for targeted drug delivery,thereby supporting a dual-target strategy for enhancing osimertinib efficacy.After intravenous injection,CMNP^(@Osi)accumulates at tumor sites and displays enhanced uptake into cancer cells based on homologous targeting.Osimertinib is subsequently released into the cytoplasm,where it suppresses the phosphorylation of upstream EGFR and the downstream AKT signaling pathway and inhibits the proliferation of NSCLC cells.Thus,this dual-targeting strategy using a biomimetic nanocarrier can enhance molecular-targeted drug delivery and improve clinical efficacy. | Bin Xu Fanjun Zeng Jialong Deng Lintong Yao Shengbo Liu Hengliang Hou Yucheng Huang Hongyuan Zhu Shaowei Wu Qiaxuan Li Weijie Zhan Hongrui Qiu Huili Wang Yundong Li Xianzhu Yang Ziyang Cao Yu Zhang Haiyu Zhou | 2023 | Bioactive Materials2023，，9： | 1 |
| 8 | Provenance of Cored Sediments from Active Margin off Southwestern Taiwan Deduced from Geochemical Constraints显示文摘The cored sediments sampled by R/V Marion Dufrense in the active margin off southwestern Taiwan on the east side of the Manila Trench are mostly muds consisting mainly of quartz, feldspar, illite, chlorite + kaolinite with a trace amount of montmorillonite. The cored sediments have higher Fe, Ti, Cr, Cs, Li, Ni, and V but lower Ca, Na, Mn, Hf, Nb, Sr, Ta, U and Zr contents when compared with the upper continental crust(UCC, Taylor and McLennan, 1985). The Eu/Eu* ratios of the sediments averaging 0.69 indicate that the recycling effect on the Eu anomaly may be minor and the contribution of mafic source rock was unimportant, which can also be depicted in the La-Th-Sc plot(Cullers, 1994) showing a 'mixed origin' close to the felsic end member. The chemistry of the cored sediment can be explained by a mixing model designed by Ho and Chen(1996) with four end members i.e., greywacke, shale, quartzite and limestone, which are widely distributed in the Cenozoic formations of southern Taiwan with greywacke as the dominant contributor followed by shale. | HUANG Shaowei CHEN Juchin LO Chienying LEE Yungtan JIANG Weiteh WANG Yunshuen CHUNG Sanhsiung | 2014 | Acta Geologica Sinica(English Edition)2014，88，1： | 1 |
| 9 | Exposures to PM 2.5 components and heart rate variability in taxi drivers around the Beijing 2008 Olympic Games显示文摘 | Shaowei Wu Furong Deng Jie Niu Qinsheng Huang Youcheng Liu Xinbiao Guo | 2011 | Science of the Total Environment2011，，13： | 1 |
| 10 | Exploration of Artificial-intelligence Oriented Power System Dynamic Simulators显示文摘With the rapid development of artificial intelligence(AI),it is foreseeable that the accuracy and efficiency of dynamic analysis for future power system will be greatly improved by the integration of dynamic simulators and AI.To explore the interaction mechanism of power system dynamic simulations and AI,a general design for AI-oriented power system dynamic simulators is proposed,which consists of a high-performance simulator with neural network supportability and flexible external and internal application programming interfaces(APIs).With the support of APIs,simulation-assisted AI and AIassisted simulation form a comprehensive interaction mechanism between power system dynamic simulations and AI.A prototype of this design is implemented and made public based on a highly efficient electromechanical simulator.Tests of this prototype are carried out in four scenarios including sample generation,AI-based stability prediction,data-driven dynamic component modeling,and AI-aided stability control,which prove the validity,flexibility,and efficiency of the design and implementation for AI-oriented power system dynamic simulators. | Tannan Xiao Ying Chen Jianquan Wang Shaowei Huang Weilin Tong Tirui He | 2023 | Journal of Modern Power Systems and Clean Energy2023，11，2： | 1 |
| 11 | Variable-Bandwidth Optical Paths: Comparison between Optical Code-Labeled Path and OCDM Path 显示文摘 | HUANG Shaowei BABA Ken-ichi MURATA Masayuki | 2006 | Journal of Lightwave Technology2006，24，10： | 1 |
| 12 | Determination of fracture toughness and K-R Curve for 2524-I3 aluminum alloy 显示文摘 | Xie Wei Tu Shaowei Huang Qiqing | 2011 | Advanced Material Research2011，，： | 1 |
| 13 | Dynamic simulation based on Jacobian-free Newton-GMRES methods with adaptive preconditioner for power systems显示文摘Dynamic simulation is one of the most complex and important computations for power systems researches.Traditional solutions based on normal Newton iterations almost all depend on evaluations of Jacobian matrixes,which increases the programming complexity of and limits the parallelizability of the whole simulation.In this paper,a new adaptive preconditioned Jacobian-free Newton-GMRES(m)method is proposed to be applied to dynamic simulations of power systems.This new method has totally Jacobian-free characteristics,which saves calculations and storages of Jacobian matrixes and features strong parallelizability.Moreover,several speedup strategies are introduced to enhance efficiency and parallelizability of overall computations.Numerical tests are carried out on IEEE standard test systems and results show that in series computing environment,simulations based on the proposed method have comparable speed to those based on classical Newton-Raphson methods. | HUANG ShaoWei CHEN Ying SHEN Chen MEI ShengWei | 2013 | Science China(Technological Sciences)2013，56，8： | 1 |
| 14 | MiR-516a-3p is a Novel Mediator of Hepatocellular Carcinoma Oncogenic Activity and Cellular Metabolism显示文摘Hepatocellular carcinoma(HCC)remains one of the most lethal malignancies.We previously demonstrated that the chromosome 19 microRNA cluster(C19MC)was associated with tumor burden and prognosis in patients with HCC.In the current study,we aim to explore the role of miR-516a-3p-an identical mature microRNA(miRNA)co-spliced by four oncogenic pre-miRNAs of C19MC(i.e.,mir-516a-1,mir-516a-2,mir-516b-1,and mir-516b-2)-in HCC.In our cohort of HCC patients,miR-516a-3p was highly expressed in HCC tissues in comparison with adjacent non-tumor tissues.High expression of tumor miR-516a-3p significantly correlated with advanced tumor stages,distinguished high HCC recurrence and mortality,and independently predicted poor prognosis.We further found that miR-516a-3p enhanced the proliferation,migration,and invasiveness of HCC cells in vitro and promoted tumor growth and metastasis in vivo.Among cancer cells,miR-516a-3p could be delivered via exosomes or extracellular vesicles and increased the oncogenic activity of recipient cells.Moreover,we performed comprehensive transcriptomics,proteomics,and metabolomics analysis on the potential mechanism underlying miR-516a-3p-promoted oncogenicity.MixOmic DIABLO analysis showed a close correlation and strong cluster consistency between the proteomics and metabolomics datasets.We further confirmed six proteins(i.e.,LMBR1,CHST9,RBM3,SLC7A6,PTGFRN,and NOL12)as the direct targets of miR-516a-3p and as central players in miR-516a-3p-mediated metabolism regulation.The integrated multi-omics and co-enriched pathway analysis showed that miR-516a-3p regulates the metabolic pathways of HCC cells,particularly purine and pyrimidine metabolism.In conclusion,our findings suggest that miR-516a-3p promotes malignant behaviors in HCC cells by regulating cellular metabolism and affecting neighboring cells via the exosome delivery system.Thus,we suggest miR-516a-3p as a novel molecular target for HCC therapy. | Tao Rui Xueyou Zhang Shi Feng Haitao Huang Shaowei Zhan Haiyang Xie Lin Zhou Shusen Zheng Qi Ling | 2022 | Engineering2022，，9： | 0 |
| 15 | High-yield production of carbon nanotubes from waste polyethylene and fabrication of graphene-carbon nanotube aerogels with excellent adsorption capacity显示文摘Waste plastics recycling and oil/organics remediation are environmental issues of global concern.In this work,a protectant was introduced,for the first time,to make highly efficient catalysts for pyrolysis of waste plastics into carbon nanotubes(CNTs)with high yield.By using waste polyethylene,Co(NO_(3))_(2) and oleylamine respectively as carbon source,catalyst precursor and protectant,a yield as high as 59.0%was achieved.The CNTs exhibited a high adsorption capacity for methylene blue(up to 107.1 mg/g).Furthermore,by combining the CNTs with graphene oxide,a graphene-CNT aerogel with a low density of8.2 mg/cm^(3)and high porosity of 96.0%was successfully prepared.It showed excellent hydrophobicity and mechanical stability,as well as high adsorption capacity of 289-410 g/g oil/organic solvent,which was much higher than most of these achieved by carbon-based three-dimensional materials reported previously,making the as-prepared aerogel a very promising adsorbent for oil/water separation. | Zhong Huang Yangfan Zheng Haijun Zhang Faliang Li Yuan Zeng Quanli Jia Jun Zhang Junyi Li Shaowei Zhang | 2021 | Journal of Materials Science & Technology2021，，35： | 0 |
| 16 | A Modelling Study on PM_(2.5)-Related Health Impacts from Climate Change and Air Pollution Emission Control--China,2010s and 2040s显示文摘What is already known about this topic?Climate change and air pollution are two important environmental issues in China.It is important to investigate particulate matter with aerodynamic diameter less than 2.5μm(PM2.5)-related health impacts from climate change and air pollution emission control.What is added by this report?Deaths and years of life lost related to PM2.5 would increase in climate change scenario,although emission control would outweigh the influence of climate change.What are the implications for public health practice?More targeted actions should be taken to meet challenges of exacerbated PM2.5 pollutions and its health impacts related to climate change in the future. | Jing Huang Heng Tian Jiawei Wang Teng Yang Yiran Peng Shaowei Wu Tzung-May Fu Guoxing Li | 2021 | China CDC weekly2021，3，23： | 0 |
| 17 | Two antibodies show broad,synergistic neutralization against SARS-CoV-2 variants by inducing conformational change within the RBD显示文摘Continual evolution of the severe acute respiratory syndrome coronavirus(SARS-CoV-2)virus has allowed for its gradual evasion of neutralizing antibodies(nAbs)produced in response to natural infection or vaccination.The rapid nature of these changes has incited a need for the development of superior broad nAbs(bnAbs)and/or the rational design of an antibody cocktail that can protect against the mutated virus strain.Here,we report two angiotensin-converting enzyme 2 competing nAbs—8H12 and 3E2—with synergistic neutralization but evaded by some Omicron subvariants.Cryo-electron microscopy reveals the two nAbs synergistic neutralizing virus through a rigorous pairing permitted by rearrangement of the 472-489 loop in the receptor-binding domain to avoid steric clashing.Bispecific antibodies based on these two nAbs tremendously extend the neutralizing breadth and restore neutralization against recent variants including currently dominant XBB.1.5.Together,these findings expand our understanding of the potential strategies for the neutralization of SARS-CoV-2 variants toward the design of broad-acting antibody therapeutics and vaccines. | Hui Sun Tingting Deng Yali Zhang Yanling Lin Yanan Jiang Yichao Jiang Yang Huang Shuo Song Lingyan Cui Tingting Li Hualong Xiong Miaolin Lan Liqin Liu Yu Li Qianjiao Fang Kunyu Yu Wenling Jiang Lizhi Zhou Yuqiong Que Tianying Zhang Quan Yuan Tong Cheng Zheng Zhang Hai Yu Jun Zhang Wenxin Luo Shaowei Li Qingbing Zheng Ying Gu Ningshao Xia | 2024 | Protein & Cell2024，15，2： | 0 |
| 18 | 血压变化和空气污染微粒的化学成分显示文摘[背景]血压升高与颗粒物(PM)空气污染相关,但是与PM化学成分的关联尚不明确。[目的]通过对一组39名大学生进行460次反复访查,探讨血压与不同化学成分的细颗粒物(PM2.5)之间的关联。 | Shaowei Wu Furong Deng Jing Huang Hongyi Wang Masayuki Shima Xin Wang Yu Qin Chanjuan Zheng Hongying Wei Yu Hao Haibo Lv Xiuling Lu Xinbiao Guo | 2013 | 环境与职业医学2013，30，4： | 0 |
| 19 | NiCoP/NiOOH nanoflowers loaded on ultrahigh porosity Co foam for hydrogen evolution reaction under large current density显示文摘Developing user-friendly electrodes for efficiently producing hydrogen from water to substitute non-renewable fossil fuels is one of the challenges in the hydrogen energy field.For the first time,we have prepared self-supporting ultrahigh porosity cobalt foam loaded with NiCoP/NiOOH nanoflowers(NiCoP/CF)via freeze-drying and phosphorization.The as-prepared hierarchical NiCoP/CF electrodes showed superior catalytic activity for hydrogen evolution reaction(HER)in alkaline media.The one resulted from phosphorization at 350℃(NiCoP/CF-350)only required overpotential of-47,and-126 mV to deliver geometrical current density of-10 mA cm^(-2) and-100 mA cm^(-2),respectively,demonstrating improved catalytic activity than the electrodes prepared using a commercial nickel foam as a support.Moreover,it could retain its superior stability at a current density higher than-500 mA cm^(-2) for 16 h.Such an outstanding performance can be attributed to the ultrahigh porosity of Co foam support,optimal adsorption energies of HER intermediates(H^(*)),facile water dissociation on the NiCoP/NiOOH heterointerfaces,and the assistance of NiOOH facilitating the electrons transfer from the Co foam inside to the NiCoP outside.The work would provide a new strategy for future design of advanced HER electrocatalysts. | Yuantao Pei Liang Huang Lei Han Haijun Zhang Longhao Dong Quanli Jia Shaowei Zhang | 2022 | Green Energy & Environment2022，7，3： | 0 |
| 20 | Advances in extracellular vesicle-based combination therapies for spinal cord injury显示文摘Spinal cord injury is a severe insult to the central nervous system that causes persisting neurological deficits.The currently available treatments involve surgical,medical,and rehabilitative strategies.However,none of these techniques can markedly reverse neurological deficits.Recently,extracellular vesicles from various cell sources have been applied to different models of spinal cord injury,thereby generating new cell-free therapies for the treatment of spinal cord injury.However,the use of extracellular vesicles alone is still associated with some notable shortcomings,such as their uncertainty in targeting damaged spinal cord tissues and inability to provide structural support to damaged axons.Therefore,this paper reviews the latest combined strategies for the use of extracellular vesicle-based technology for spinal cord injury,including the combination of extracellular vesicles with nanoparticles,exogenous drugs and/or biological scaffold materials,which facilitate the targeting ability of extracellular vesicles and the combinatorial effects with extracellular vesicles.We also highlight issues relating to the clinical transformation of these extracellular vesicle-based combination strategies for the treatment of spinal cord injury. | Tingting Wang Guohao Huang Zhiheng Yi Sihan Dai Weiduan Zhuang Shaowei Guo | 2024 | Neural Regeneration Research2024，19，2： | 0 |
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