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| 1 | The rational design of multiple molecular module-based assemblies for simultaneously improving rice yield and grain quality显示文摘Rice is one of the most important staple food for over half of the world's population,and a substantial increase in productivity and quality of rice grain will be required to feed a growing human population.Grain size and shape are the two important components contributing to grain yield and quality,because they impact both yield potential and end-use quality.Over the past 50 years。 | Kun Wu Xiaopeng Xu Nan Zhong Haixiang Huang Jianping Yu Yafeng Ye Yuejin Wu Xiangdong Fu | 2018 | Journal of Genetics and Genomics2018，45，6： | 4 |
| 2 | Apoptotic extracellular vesicles are metabolized regulators nurturing the skin and hair显示文摘Over 300 billion of cells die every day in the human body,producing a large number of endogenous apoptotic extracellular vesicles(apoEVs).Also,allogenic stem cell transplantation,a commonly used therapeutic approach in current clinical practice,generates exogenous apoEVs.It is well known that phagocytic cells engulf and digest apoEVs to maintain the body’s homeostasis.In this study,we show that a fraction of exogenous apoEVs is metabolized in the integumentary skin and hair follicles.Mechanistically,apoEVs activate the Wnt/β-catenin pathway to facilitate their metabolism in a wave-like pattern.The migration of apoEVs is enhanced by treadmill exercise and inhibited by tail suspension,which is associated with the mechanical force-regulated expression of DKK1 in circulation.Furthermore,we show that exogenous apoEVs promote wound healing and hair growth via activation of Wnt/β-catenin pathway in skin and hair follicle mesenchymal stem cells.This study reveals a previously unrecognized metabolic pathway of apoEVs and opens a new avenue for exploring apoEV-based therapy for skin and hair disorders. | Lan Ma Chider Chen Dawei Liu Zhiqing Huang Jiaqi Li Haixiang Liu Ryan Tsz Kin Kwok Benzhong Tang Bingdong Sui Xiao Zhang Jianxia Tang Xueli Mao Weiying Huang Songtao Shi Xiaoxing Kou | 2023 | Bioactive Materials2023，，1： | 3 |
| 3 | Enhanced electrocatalytic oxidation of dyes in aqueous solution using cobalt phthalocyanine modified activated carbon fiber anode显示文摘Cobalt tetra(2,4-dichloro-1,3,5-triazine)aminophthalocyanine(CoPc)was immobilized covalently on activated carbon fiber(ACF)felt to obtain CoPc-modified ACF(CoPc-ACF)catalyst,and an electrocatalytic oxidation system using CoPc-ACF as the anode was constructed.The electrocatalytic oxidation of Acid Red 1(AR1)was investigated in aqueous solution by an UV-vis spectrophotometer and UPLC.The results indicated that AR1 could be eliminated efficiently in this electrocatalytic oxidation system.In addition,the results of FTIR,TOC and GC-MS suggested that the electrocatalytic oxidation experienced the decoloration achieved by destroying the azo linkage and the further mineralization due to the cleavages of benzene ring and naphthalene ring.The intermediates were mainly small molecular compounds such as maleic acid and succinic acid,etc.Repetitive tests showed that CoPc-ACF can maintain high electrocatalytic activity over several cycles.The further EPR spin-trap experiments indicated that the hydroxyl radicals did not dominate the reaction in this electrocatalytic system,which was completely different from the traditional electro-Fenton system.Based on the non-radical reaction mechanism,the CoPc-modified ACF electrocatalyst has potential application in treating actual dyestuffs wastewaters,which are accompanied with high concentration of hydroxyl radical scavengers such as chlorine ions and additives in the textile printing and dyeing industry. | LI Nan DONG SuSu LV WangYang HUANG SanQing CHEN HaiXiang YAO YuYuan CHEN WenXing | 2013 | Science China Chemistry2013，56，12： | 2 |
| 4 | Optimization of phenazine-1-carboxylic acid production by a gacA/qscR-inactivated Pseudomonas sp. M18GQ harboring pME6032Phz using response surface methodology显示文摘 | Quan Zhou Jinjiang Su Haixiang Jiang Xianqing Huang Yuquan Xu | 2010 | Applied Microbiology and Biotechnology2010，，6： | 1 |
| 5 | Enhanced hydrogen storage properties of NaBH_(4)–Mg(BH_(4))_(2) composites by NdF_(3) addition显示文摘As two important members of complex hydrides,Mg(BH_(4))2 and Na BH_(4) have a high gravimetric capacity(14.9 and10.8 wt%,respectively).In this study,the Mg(BH_(4))2 was synthesized by the ion exchange method.Afterwards,the Mg(BH_(4))_(2) and Na BH_(4) composites with different amounts(30,40 and 50 wt%)of NdF3 were prepared by mechanical milling.Effects of the Nd F3 on the microstructural evolution and hydrogen storage properties were investigated.The results show that Nd F3catalyst can significantly improve the dehydrogenation kinetics of the eutectic composites of Na BH_(4)–Mg(BH_(4))_(2).The onset hydrogen desorption temperature of the composites is about88.6C,which is about 110C lower than that of Mg(BH_(4))_(2)and Na BH_(4)composites.Mg(BH_(4))_(2)–Na BH_(4)-0.5NdF3composites can released 5.2 wt%H_(2)at 250C within 30 min,and the dehydrogenation capacity is significantly higher than that of Mg(BH_(4))_(2)–Na BH_(4)composites.The analysis of the dehydrogenation mechanism reveals that NdF3takes participate in the reaction to generate Na MgF3 to promote the dehydrogenation reaction process of the composites. | Jianguang Yuan Jinting Chen Haixiang Huang Yujie Lv Bogu Liu Zhongyu Li Bao Zhang Wei Lv Ying Wu | 2021 | Progress in Natural Science:Materials International2021，31，4： | 1 |
| 6 | An invasive zone in human liver cancer identified by Stereo-seq promotes hepatocyte–tumor cell crosstalk,local immunosuppression and tumor progression显示文摘Dissecting and understanding the cancer ecosystem,especially that around the tumor margins,which have strong implications for tumor cell infiltration and invasion,are essential for exploring the mechanisms of tumor metastasis and developing effective new treatments.Using a novel tumor border scanning and digitization model enabled by nanoscale resolution-SpaTial Enhanced REsolution Omics-sequencing(Stereo-seq),we identified a 500µm-wide zone centered around the tumor border in patients with liver cancer,referred to as“the invasive zone”.We detected strong immunosuppression,metabolic reprogramming,and severely damaged hepatocytes in this zone.We also identified a subpopulation of damaged hepatocytes with increased expression of serum amyloid A1 and A2(referred to collectively as SAAs)located close to the border on the paratumor side.Overexpression of CXCL6 in adjacent malignant cells could induce activation of the JAK-STAT3 pathway in nearby hepatocytes,which subsequently caused SAAs’overexpression in these hepatocytes.Furthermore,overexpression and secretion of SAAs by hepatocytes in the invasive zone could lead to the recruitment of macrophages and M2 polarization,further promoting local immunosuppression,potentially resulting in tumor progression.Clinical association analysis in additional five independent cohorts of patients with primary and secondary liver cancer(n=423)showed that patients with overexpression of SAAs in the invasive zone had a worse prognosis.Further in vivo experiments using mouse liver tumor models in situ confirmed that the knockdown of genes encoding SAAs in hepatocytes decreased macrophage accumulation around the tumor border and delayed tumor growth.The identification and characterization of a novel invasive zone in human cancer patients not only add an important layer of understanding regarding the mechanisms of tumor invasion and metastasis,but may also pave the way for developing novel therapeutic strategies for advanced liver cancer and other solid tumors. | Liang Wu Jiayan Yan Yinqi Bai Feiyu Chen Xuanxuan Zou Jiangshan Xu Ao Huang Liangzhen Hou Yu Zhong Zehua Jing Qichao Yu Xiaorui Zhou Zhifeng Jiang Chunqing Wang Mengnan Cheng Yuan Ji Yingyong Hou Rongkui Luo Qinqin Li Liang Wu Jianwen Cheng Pengxiang Wang Dezhen Guo Waidong Huang Junjie Lei Shang Liu Yizhen Yan Yiling Chen Sha Liao Yuxiang Li Haixiang Sun Na Yao Xiangyu Zhang Shiyu Zhang Xi Chen Yang Yu Yao Li Fengming Liu Zheng Wang Shaolai Zhou Huanming Yang Shuang Yang Xun Xu Longqi Liu Qiang Gao Zhaoyou Tang Xiangdong Wang Jian Wang Jia Fan Shiping Liu Xinrong Yang Ao Chen Jian Zhou | 2023 | Cell Research2023，33，8： | 1 |
| 7 | Optimization of phenazine-1-carboxylic acid production by a gacA/qscR-inactivated Pseudomonas sp. M18GQ harboring pME6032Phz using response surface methodology显示文摘 | Quan Zhou Jinjiang Su Haixiang Jiang Xianqing Huang Yuquan Xu | 2010 | Applied Microbiology and Biotechnology2010，，6： | 1 |
| 8 | Genetic relatedness and association mapping of horticulturally valuable traits for the Ceiba plants using ddRAD sequencing显示文摘Ceiba species have high ornamental value and are widely cultivated in tropical regions.However,genetic background of cultivated Ceiba plants remains unclear.To understand the genetic relatedness of cultivated Ceiba plants and genetic basis of key horticultural traits,here we explored the genetic relatedness of 153 accessions of Ceiba plants cultivated in Southern China and identified SNPs associated with five horticultural traits,based on 11704 SNPs derived from double-digest restriction-site associated DNA sequencing(ddRAD-seq).Clustering analysis revealed that these accessions were composed of three groups:C.speciosa group,C.insignis group,and hybrid group.The GWAS identified two,four,two,three,and four SNPs related to petal color,petal striation number,flowering time,trunk shape,and prickles on the trunk and branches,respectively.One to two candidate genes were found near the SNPs strongly associated with these traits.This study revealed the genetic relatedness in the Ceiba plants cultivated in Southern China and presented the first GWAS analysis for five horticultural traits for them,laying a foundation for phenotype-related marker selection and molecular breeding. | Bingqian Han Songyi Huang Guilian Huang Xin Wu Haixiang Jin Ying Liu Yiqiang Xiao Renchao Zhou | 2023 | Horticultural Plant Journal2023，9，4： | 1 |
| 9 | Modulating the C-terminus of DEP1 synergistically enhances grain quality and yield in rice显示文摘Grain shape is a key breeding target that influences both grain yield and appearance quality in rice. Breeding for long-slender grains is an effective strategy to improve grain quality (Jain et al., 2004;Wang et al., 2012, 2015a). In the past two decades, several quantitative trait loci (QTLs) responsible for grain size and shape have been identified, including GS3 (Fan et al., 2006), GS5 (Li et al., 2011). | Haixiang Huang Yafeng Ye Wenzhen Song Qi Li Ruixi Han Chenchen Wu Shuoxun Wang Jianping Yu Xueying Liu Xiangdong Fu Qian Liu Kun Wu | 2022 | Journal of Genetics and Genomics2022，49，5： | 1 |
| 10 | Rotor End Factors for 2-D FEA of Induction Motors with Smooth or Slitted Solid Rotor显示文摘Modifying the equivalent rotor resistivity with rotor end factor in 2-dimension(2-D)finite element analysis(FEA)is an effective way to analyze the 3-dimension(3-D)solid rotor problems.For the smooth solid rotor,five different rotor end factors are discussed and compared with each other.It is theoretically clarified that the resistivity of rotor in 2-D FEA should be multiplied by the square of rotor end factors to take the 3-D end effect of solid rotor into account.For the slitted solid rotor,an improved rotor end factor is proposed based on the equivalent area algorithm of eddy currents in rotor,since the end factors of smooth solid rotor are not applicable.Finally,the time-harmonic finite element method(FEM)combined with the rotor end factor is applied to analyze the performance of solid rotor induction motor.The tested and computed results are in good agreement,which proves the effectiveness of rotor end factor for the simplication of 3-D solid rotor problems. | Shanming Wang Ziguo Huang Yuguang Sun Haixiang Cao | 2017 | CES Transactions on Electrical Machines and Systems2017，1，2： | 1 |
| 11 | Catalytic mechanism of in-situ Ni/C co-incorporation for hydrogen absorption of Mg显示文摘Ni and carbon materials exhibit remarkable catalysis for the hydriding reaction of Mg.But the underlying mechanism of Ni/C hybrid catalysis is still unclear.In this work,density functional theory(DFT)calculation is applied to investigate the effect of Ni/C co-incorporation on the hydriding reaction of Mg crystal.The morphology and crystal structure of the Ni/C co-incorporated Mg sample show that the coincorporated structure is credible.The transition state searching calculation suggests that both the incorporations of Ni and C are beneficial for the H_(2) dissociation.But Ni atom has a dramatic improvement for H_(2) dissociation and makes the H diffusion become limiting step of the hyriding reaction.The Ni dz_(2)orbit and H s orbit accept the electrons and combine together compactly,while the Ni d_(xy) orbit is half-occupied.The catalytic effect of Ni on H_(2) dissociation can be ascribed to the bridging effect of Ni d_(xy) orbit.The incorporation of C can weaken the over-strong interaction between Ni and H which hindered the H diffusion on Mg(0001).The Ni/C co-incorporated Mg(0001)shows the best performance during hyriding reaction compared with the clean and single incorporated Mg(0001). | Bogu Liu Bao Zhang Haixiang Huang Xiaohong Chen Yujie Lv Zhongyu Li Jianguang Yuan Ying Wu | 2023 | Journal of Magnesium and Alloys2023，11，5： | 0 |
| 12 | A highly efficient hydrolysis of MgH_(2)catalyzed by NiCo@C bimetallic synergistic effect显示文摘MgH_(2)has a high theoretical hydrogen production capacity and mild conditions for hydrogen production by hydrolysis,so it is suitable as an ideal hydrogen source for fuel cells.However,with the progress of the hydrolysis reaction,MgH_(2)is impeded from reacting further by the continuous deposition of magnesium hydroxide on its surface,resulting in low hydrogen yield and slow reaction kinetics.In the present work,a highly efficient NiCo bimetallic synergistic catalysis is developed to improve the hydrolysis performance of MgH_(2).The MgH_(2)-8 wt%NiCo@C composite ball-milled for 5 h achieves nearly 100%hydrogen desorp-tion efficiency within 15 min in 0.05 mol L^(-1)MgCl_(2)solution.Because the interaction between Ni and Co on the surface of MgH_(2)can form a channel for rapid hydrogen evolution,which hinders the continuous formation of the Mg(OH)_(2)passivation layer and promotes the hydrolysis reaction of MgH_(2).This is very important for the implementation of MgH_(2)hydrolysis to produce hydrogen in the future. | Yang Zhao Tong Li Haixiang Huang Tingting Xu Bogu Liu Bao Zhang Jianguang Yuan Ying Wu | 2023 | Journal of Materials Science & Technology2023，，6： | 0 |
| 13 | Discovery and Preliminary Analysis of a Natural Lateflowering Rice Mutant显示文摘In previous experiments,a natural late-flowering mutant was obtained from a late-season japonica rice line. The mutant exhibits no significant differences in various traits except growth period at the basic vegetative growth stage compared with other wild-type varieties. In Jiaxing City,the heading stage of the late-flowering mutant was averagely delayed by about 20 days compared with other wild-type varieties. According to the results of progeny investigation and statistical analysis,the late-flowering mutant is controlled by a single recessive gene,which can be utilized with breeding technology to obtain sterile lines and multiple lines,thus expanding the germplasm resources for production application,which laid the foundation for subsequent studies. | Shilei WANG Haixiang HUANG | 2015 | Agricultural Biotechnology2015，4，5： | 0 |
| 14 | Niobium fluoride-modified hydrogen evolution reaction of magnesium borohydride diammoniate显示文摘Metal borohydride ammoniates have become one of the most promising hydrogen storage materials due to their ultrahigh capacities.However,their application is still restricted by the high temperature of hydrogen desorption and the release of ammonia.Here,to promote the dehydrogenation evolution and suppress the ammonia release,different amounts of NbF 5 were introduced into Mg(BH4)2·2NH3.Compared to the pure Mg(BH_(4))_(2)·2NH_(3),the Mg(BH_(4))_(2)·2NH_(3)-NbF_(5) composites exhibit lower onset dehydriding temperatures(53–57℃)and higher dehydriding capacities(5.6 wt.%–8.2 wt.%)at below 200℃,with the complete suppression of ammonia.In addition,7.4 wt.%H_(2) could be released from Mg(BH_(4))_(2)·2NH_(3)–5 mol%NbF5 composite at 200℃ within 20 min and the apparent activation energy is calculated to be 60.28 kJ mol^(-1),which is much lower than that of pure Mg(BH_(4))_(2)·2NH_(3)(92.04 kJ mol^(-1)).Mg(BH_(4))_(2)·2NH_(3) should mechanochemically react with NbF5,forming dual-metal(Mg,Nb)borohydride ammoniate and spherical MgF2.The introduction of electronegative Nb cation results in-situ formation of(Mg,Nb)borohydride ammoniate towards a lower dehydrogenation temperature and a higher hydrogen release purity.The increased phase boundaries among the Mg(BH_(4))_(2)·2NH_(3),dual-metal(Mg,Nb)borohydride ammoniate,and MgF2 phases further facilitate the hydrogen diffusion during the dehydrogenation of the composites. | Yujie Lv Bao Zhang Haixiang Huang Bogu Liu Wei Lv Jianguang Yuan Guanglin Xia Xuebin Yu Dalin Sun Ying Wu | 2023 | Journal of Materials Science & Technology2023，，25： | 0 |
| 15 | Transcriptome sequencing of black and white hair follicles in the giant panda显示文摘With the completion of the draft assembly of the giant panda genome sequence,RNA sequencing technology has been widely used in genetic research on giant pandas.We used RNA-seq to examine black and white hair follicle samples from adult pandas.By comparison with the giant panda genome,75963 SNP loci were labeled,2426 differentially expressed genes(DEGs)were identified,and 2029 new genes were discovered,among which 631 were functionally annotated.A cluster analysis of the DEGs showed that they were mainly related to the Wnt signaling pathway,ECM–receptor interaction,the p53 signaling pathway,and ribosome processing.The enrichment results showed that there were significant differences in the regulatory networks of hair follicles with different colors during the transitional stage of hair follicle resting growth,which may play a regulatory role in melanin synthesis during growth.In conclusion,our results provide new insights and more data support for research on the color formation in giant pandas. | Yi ZHENG Yingmin ZHOU Yijie HUANG Haoqi WANG Haixiang GUO Bao YUAN Jiabao ZHANG | 2023 | Integrative Zoology2023，18，3： | 0 |
| 16 | Regulation of Axon Initial Segment Diameter by COUP-TFI Fine-tunes Action Potential Generation显示文摘The axon initial segment(AIS)is a specialized structure that controls neuronal excitability via action potential(AP)generation.Currently,AIS plasticity with regard to changes in length and location in response to neural activity has been extensively investigated,but how AIS diameter is regulated remains elusive.Here we report that COUP-TFI(chicken ovalbumin upstream promotor-transcription factor 1)is an essential regulator of AIS diameter in both developing and adult mouse neocortex.Either embryonic or adult ablation of COUP-TFI results in reduced AIS diameter and impaired AP generation.Although COUP-TFI ablations in sparse single neurons and in populations of neurons have similar impacts on AIS diameter and AP generation,they strengthen and weaken,respectively,the receiving spontaneous network in mutant neurons.In contrast,overexpression of COUP-TFI in sparse single neurons increases the AIS diameter and facilitates AP generation,but decreases the receiving spontaneous network.Our findings demonstrate that COUP-TFI is indispensable for both the expansion and maintenance of AIS diameter and that AIS diameter fine-tunes action potential generation and synaptic inputs in mammalian cortical neurons. | Xuanyuan Wu Haixiang Li Jiechang Huang Mengqi Xu Cheng Xiao Shuijin He | 2022 | Neuroscience Bulletin2022，38，5： | 0 |
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