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| 1 | Clinical Features of Adult/Adolescent Atopic Dermatitis and Chinese Criteria for Atopic Dermatitis显示文摘 | Ping Liu Yan Zhao Zhang-Lei Mu Qian-Jin Lu Qian-Jin L U Li Zhang Xu Yao Min Zheng Yi-Wen Tang Xin-Xiano Lu Xiu-Juan xia You-Kun Lin Yu-Zhen Li Cai-Xia Tu Zhi-Rong Yao Jin-Hua Xu Wei Li Wei Lai Hui-Min Yang Hong-Fu Xie Xiu-Ping Han Zhi-Qiang Xie Xiang Nong Zai-Pei Guo Dan-Qi Deng Tong-Xin Shi Jian-Zhong Zhang | 2016 | Chinese Medical Journal2016，，7： | 64 |
| 2 | Therapeutic imaging window of cerebral infarction revealed by multisequence magnetic resonance imaging An animal and clinical study显示文摘In this study, we established a Wistar rat model of right middle cerebral artery occlusion and observed pathological imaging changes (T2-weighted imaging [T2WI], T2FLAIR, and diffusion-weighted imaging [DWI]) following cerebral infarction. The pathological changes were divided into three phases: early cerebral infarction, middle cerebral infarction, and late cerebral infarction. In the early cerebral infarction phase (less than 2 hours post-infarction), there was evidence of intracellular edema, which improved after reperfusion. This improvement was defined as the ischemic penumbra. In this phase, a high DWI signal and a low apparent diffusion coefficient were observed in the right basal ganglia region. By contrast, there were no abnormal T2WI and T2FLAIR signals. For the middle cerebral infarction phase (2-4 hours post-infarction), a mixed edema was observed. After reperfusion, there was a mild improvement in cell edema, while the angioedema became more serious. A high DWI signal and a low apparent diffusion coefficient signal were observed, and some rats showed high T2WI and T2FLAIR signals. For the late cerebral infarction phase (4-6 hours post-infarction), significant angioedema was visible in the infarction site. After reperfusion, there was a significant increase in angioedema, while there was evidence of hemorrhage and necrosis. A mixed signal was observed on DWI, while a high apparent diffusion coefficient signal, a high T2WI signal, and a high T2FLAIR signal were also observed. All 86 cerebral infarction patients were subjected to T2WI, T2FLAIR, and DWI. MRI results of clinic data similar to the early infarction phase of animal experiments were found in 51 patients, for which 10 patients (10/51) had an onset time greater than 6 hours. A total of 35 patients had MRI results similar to the middle and late infarction phase of animal experiments, of which eight patients (8/35) had an onset time less than 6 hours. These data suggest that defining the 'therapeutic time window' as the time 6 hours after infarction may not be suitable for all patients. Integrated application of MRI sequences including T2WI, T2FLAIR, DW-MRI, and apparent diffusion coefficient mapping should be used to examine the ischemic penumbra, which may provide valuable information for identifying the 'therapeutic time window'. | Hong Lu Hui Hu Zhanping He Xiangjun Han Jing Chen Rong Tu | 2012 | Neural Regeneration Research2012，7，31： | 16 |
| 3 | Overexpression of microRNA-124 promotes the neuronal differentiation of bone marrow-derived mesenchymal stem cells显示文摘microRNAs(miRNAs) play an important regulatory role in the self-renewal and differentiation of stem cells. In this study, we examined the effects of miRNA-124(miR-124) overexpression in bone marrow-derived mesenchymal stem cells. In particular, we focused on the effect of overexpression on the differentiation of bone marrow-derived mesenchymal stem cells into neurons. First, we used GeneChip technology to analyze the expression of miRNAs in bone marrow-derived mesenchymal stem cells, neural stem cells and neurons. miR-124 expression was substantially reduced in bone marrow-derived mesenchymal stem cells compared with the other cell types. We constructed a lentiviral vector overexpressing miR-124 and transfected it into bone marrow-derived mesenchymal stem cells. Intracellular expression levels of the neuronal early markers β-III tubulin and microtubule-associated protein-2 were significantly increased, and apoptosis induced by oxygen and glucose deprivation was reduced in transfected cells. After miR-124-transfected bone marrow-derived mesenchymal stem cells were transplanted into the injured rat spinal cord, a large number of cells positive for the neuronal marker neurofilament-200 were observed in the transplanted region. The Basso-Beattie-Bresnahan locomotion scores showed that the motor function of the hind limb of rats with spinal cord injury was substantially improved. These results suggest that miR-124 plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells into neurons. Our findings should facilitate the development of novel strategies for enhancing the therapeutic efficacy of bone marrow-derived mesenchymal stem cell transplantation for spinal cord injury. | Defeng Zou Yi Chen Yaxin Han Chen Lv Guanjun Tu | 2014 | Neural Regeneration Research2014，9，12： | 15 |
| 4 | Gene interference regulates aquaporin-4 expression in swollen tissue of rats with cerebral ischemic edema Correlation with variation in apparent diffusion coefficient显示文摘To investigate the effects of mRNA interference on aquaporin-4 expression in swollen tissue of rats with ischemic cerebral edema, and diagnose the significance of diffusion-weighted MRI, we injected 5 μL shRNA- aquaporin-4 (control group) or siRNA- aquaporin-4 solution (1:800) (RNA interference group) into the rat right basal ganglia immediately before occlusion of the middle cerebral artery. At 0.25 hours after occlusion of the middle cerebral artery, diffusion-weighted MRI displayed a high signal; within 2 hours, the relative apparent diffusion coefficient decreased markedly, aquaporin-4 expression increased rapidly, and intracellular edema was obviously aggravated; at 4 and 6 hours, the relative apparent diffusion coefficient slowly returned to control levels, aquaporin-4 expression slightly increased, and angioedema was observed. In the RNA interference group, during 0.25- 6 hours after injection of siRNA- aquaporin-4 solution, the relative apparent diffusion coefficient slightly fluctuated and aquaporin-4 expression was upregulated; during 0.5-4 hours, the relative apparent diffusion coefficient was significantly higher, while aquaporin-4 expression was significantly lower when compared with the control group, and intracellular edema was markedly reduced; at 0.25 and 6 hours, the relative apparent diffusion coefficient and aquaporin-4 expression were similar when compared with the control group; obvious angioedema remained at 6 hours. Pearson's correlation test results showed that aquaporin-4 expression was negatively correlated with the apparent diffusion coefficient (r = -0.806, P < 0.01). These findings suggest that upregulated aquaporin-4 expression is likely to be the main molecular mechanism of intracellular edema and may be the molecular basis for decreased relative apparent diffusion coefficient. Aquaporin-4 gene interference can effectively inhibit the upregulation of aquaporin-4 expression during the stage of intracellular edema with time-effectiveness. Moreover, diffusion-weighted MRI can accurately detect intracellular edema. | Hui Hu Hong Lu Zhanping He Xiangjun Han Jing Chen Rong Tu | 2012 | Neural Regeneration Research2012，7，21： | 14 |
| 5 | One-pot synthesis of thermally stable gold@mesoporous silica core-shell nanospheres with catalytic activity显示文摘一个灵巧的一个壶方法被开发了综合一致 gold@mesoporous 硅石 nanospheres (Au@MSNs ) ,它作为壳与订的 mesoporous 硅石有明确的核心壳结构。产生 Au@MSNs 为 mesoporous 硅石壳有一个高表面区域(521 m2/g ) 和一致毛孔尺寸(2.5 nm ) 。金核心的直径能被调整 HAuCl4 的数量调整。Au@MSNs 的催化表演作为模型反应用 4-nitrophenol 的减小被调查。硅石壳的 mesopores 提供直接存取让反应物分子与金核心扩散并且随后交往。另外, Au@MSNs 显示到 950 | Junchen Chen Renyuan Zhang Lu Han Bo Tu Dongyuan Zhao | 2013 | Nano Research2013，6，12： | 13 |
| 6 | Interface issues of lithium metal anode for high-energy batteries: Challenges, strategies, and perspectives显示文摘Lithium(Li)metal is considered as one of the most promising anode materials for next-generation high-energy-density storage systems.However,the practical application of Li metal anode is hindered by interfacial instability and air instability due to the highly reactivity of Li metal.Unstable interface in Li metal batteries(LMBs)directly dictates Li dendrite growth,“dead Li”and low Coulombic efficiency,resulting in inferior electrochemical performance of LMBs and even safety issues.In addition,its sensitivity to ambient air leads to the severe corrosion of Li metal anode,high requirements of production and storage,and increased manufacturing cost.Plenty of efforts in recent years have overcome many bottlenecks in these fields and hastened the practical applications of high-energy-density LMBs.In this review,we focus on emerging methods of these two aspects to fulfill a stable and low cost electrode.In this perspective,design artificial solid electrolyte interphase(SEI)layers,construct three-dimensional conductive current collectors,optimize electrolytes,employ solid-state electrolytes,and modify separators are summarized to be propitious to ameliorate interfacial stability.Meanwhile,ex situ/in situ formed protective layers are highlighted in favor of heightening air stability.Finally,several possible directions for the future research on advanced Li metal anode are addressed. | Yiyao Han Bo Liu Zhen Xiao Wenkui Zhang Xiuli Wang Guoxiang Pan Yang Xia Xinhui Xia Jiangping Tu | 2021 | InfoMat2021，3，2： | 11 |
| 7 | Continuous Positive Airway Pressure Effectively Alleviates Arrhythmias in Patients with Obstructive Sleep Apnea:Possible Relationship with Counteracting Oxidative Stress显示文摘This work is aimed at exploring the clinical efficacy of continuous positive airway pressuie(CPAP)in treatment of patients with arrhythmias combined with obstructive sleep apnea(OSA).Through evaluating serum native thiol,malonaldehyde(MDA)and nicotinamide adenine dinucleotide phosphate oxidase(NADPH oxidase)in these patients and describing the effects on oxidative parameters of CPAP therapy for 3 months,we confirmed the impact of oxidative stress on arrhythmias.A total of 64 patients with OSA combined with arrhythmias were collected from April 2014 to April 2017 with full clinical information.Patients were divided into two groups(paired experiment design):32 patients in group A(control group),who received unchanged anti-arrhythmia treatment and 32 patients in group B,who were subjected to unchanged pharmacological anti-arrhythmia therapy combined with CPAP.OSA related parameters were compared between the two groups after 3-month therapy.And the levels of parameters of oxidative stress in patients were measured before and after CPAP therapy.After 3 months of CPAP therapy,compared with the control group,the percentage of sage N3(NREM 3)and stage R(REM)in total sleep time was significantly increased,while apnea-hypopnea index(AHI)and the Epworth Sleepiness Scale(ESS)score were evidently decreased.Meanwhile,the lowest oxygen saturation(LSpCh)was also elevated after CPAP treatment for 3 months.The CPAP therapy significantly prevented the occurrence of arrhythmias(P<0.05).Both the MDA level and NADPH oxidase levels were significantly lower in the group B than in the group A(P<0.05).But serum native thiol was improved by CPAP treatment(P<0.05).In conclusion,proper use of CPAP therapy provides significant benefits for the treatment of arrhythmia in patients with OSA. | Xiao-ting WANG Gang ZHAO Ling TU Zhi-yong YUE Zhen-hua LIU Jie HAN Kun GAO Xuan-chen ZHOU Shuai XU Jian-feng LI | 2019 | Current Medical Science2019，39，1： | 10 |
| 8 | Pico-satellite Autonomous Navigation with Magnetometer and Sun Sensor Data显示文摘This article presents a near-Earth satellite orbit estimation method for pico-satellite applications with light-weight and low-power requirements. The method provides orbit information autonomously from magnetometer and sun sensor, with an extended Kalman filter (EKF). Real-time position/velocity parameters are estimated with attitude independently from two quantities: the measured magnitude of the Earth’s magnetic field, and the measured dot product of the magnetic field vector and the sun vector. To guarantee the filter’s effectiveness, it is recommended that the sun sensor should at least have the same level of accuracy as magnetometer. Furthermore, to reduce filter’s computation expense, simplification methods in EKF’s Jacobian calculations are introduced and testified, and a polynomial model for fast magnetic field calculation is developed. With these methods, 50% of the computation expense in dynamic model propagation and 80% of the computation burden in measurement model calculation can be reduced. Tested with simulation data and compared with original magnetometer-only methods, filter achieves faster convergence and higher accuracy by 75% and 30% respectively, and the suggested simplification methods are proved to be harmless to filter’s estimation performance. | HAN Ke WANG Hao TU Binjie JIN Zhonghe | 2011 | Chinese Journal of Aeronautics2011，24，1： | 8 |
| 9 | Removal of cyanide adsorbed on pyrite by H_2O_2 oxidation under alkaline conditions显示文摘Large amounts of cyanide tailings are produced during the cyanidation process in gold extraction,which are hazardous solid wastes due to the toxic cyanide.Pyrite is one of the main minerals in cyanide tailings.The removal of cyanide adsorbed on pyrite by H_2O_2 oxidation under alkaline conditions was investigated in this study.It was found that the removal efficiency was positively correlated with pH from 5 to 12,but remained almost constant when pH was higher than 12.The highest cyanide removal efficiency of 91.10% was achieved by adding no less than 0.6 wt.% of H_2O_2.Cyanide removal was positively correlated with the CN^-adsorption amount between 1.06 and 8.5 mg/g,and temperature between 25 and 85°C.The removal of cyanide adsorbed on pyrite by H_2O_2 oxidation under alkaline conditions was due to the oxidation of pyrite.Hexacyanoferrate,thiocyanate and sulfate were generated with mole ratios of about 2.03:1.12:3.17 during the cyanide removal.?2018 The Research Center for Eco-Environmental Sciences,Chinese Academy of Sciences. | Yubo Tu Peiwei Han Lianqi Wei Xiaomeng Zhang Bo Yu Peng Qian Shufeng Ye | 2019 | Journal of Environmental Sciences2019，31，4： | 8 |
| 10 | Allogeneic Vγ9Vδ2 T-cell immunotherapy exhibits promising clinical safety and prolongs the survival of patients with late-stage lung or liver cancer显示文摘Vγ9Vδ2 T cells are promising candidates for cellular tumor immunotherapy.Due to their HLA-independent mode of action,allogeneic Vγ9Vδ2 T cells can be considered for clinical application.To apply allogeneic Vγ9Vδ2 T cells in adoptive immunotherapy,the methodology used to obtain adequate cell numbers with optimal effector function in vitro needs to be optimized,and clinical safety and efficacy also need to be proven.Therefore,we developed a novel formula to improve the expansion of peripheralγδT cells from healthy donors.Then,we used a humanized mouse model to validate the therapeutic efficacy of expandedγδT cells in vivo;furthermore,the expandedγδT cells were adoptively transferred into late-stage liver and lung cancer patients.We found that the expanded cells possessed significantly improved immune effector functions,including proliferation,differentiation,and cancer cell killing,both in vitro and in the humanized mouse model.Furthermore,a phase I clinical trial in 132 late-stage cancer patients with a total of 414 cell infusions unequivocally validated the clinical safety of allogeneic Vγ9Vδ2 T cells.Among these 132 patients,8 liver cancer patients and 10 lung cancer patients who received≥5 cell infusions showed greatly prolonged survival,which preliminarily verified the efficacy of allogeneic Vγ9Vδ2 T-cell therapy.Our clinical studies underscore the safety and efficacy of allogeneic Vγ9Vδ2 T-cell immunotherapy,which will inspire further clinical investigations and eventually benefit cancer patients. | Yan Xu Zheng Xiang Mohammed Alnaggar Léonce Kouakanou Jiawei Li Junyi He Jiashuang Yang Yi Hu Yan Chen Li Lin Jianlei Hao Jingxia Li Jibing Chen Man Li Qingling Wu Christian Peters Qinghua Zhou Jianshuang Li Yingqing Liang Xiaohua Wang Baohui Han Meili Ma Dieter Kabelitz Kecheng Xu Wenwei Tu Yangzhe Wu Zhinan Yin | 2021 | Cellular & Molecular Immunology2021，18，2： | 8 |
| 11 | Transarterial chemoembolization with PD-(L)1 inhibitors plus molecular targeted therapies for hepatocellular carcinoma(CHANCE001)显示文摘There is considerable potential for integrating transarterial chemoembolization(TACE),programmed death-(ligand)1(PD-[L]1)inhibitors,and molecular targeted treatments(MTT)in hepatocellular carcinoma(HCC).It is necessary to investigate the therapeutic efficacy and safety of TACE combined with PD-(L)1 inhibitors and MTT in real-world situations.In this nationwide,retrospective,cohort study,826 HCC patients receiving either TACE plus PD-(L)1 blockades and MTT(combination group,n=376)or TACE monotherapy(monotherapy group,n=450)were included from January 2018 to May 2021.The primary endpoint was progression-free survival(PFS)according to modified RECIST.The secondary outcomes included overall survival(OS),objective response rate(ORR),and safety.We performed propensity score matching approaches to reduce bias between two groups.After matching,228 pairs were included with a predominantly advanced disease population.Median PFS in combination group was 9.5 months(95%confidence interval[CI],8.4-11.0)versus 8.0 months(95%CI,6.6-9.5)(adjusted hazard ratio[HR],0.70,P=0.002).OS and ORR were also significantly higher in combination group(median OS,19.2[16.1-27.3]vs.15.7 months[13.0-20.2];adjusted HR,0.63,P=0.001;ORR,60.1%vs.32.0%;P<0.001).Grade 3/4 adverse events were observed at a rate of 15.8%and 7.5%in combination and monotherapy groups,respectively.Our results suggest that TACE plus PD-(L)1 blockades and MTT could significantly improve PFS,OS,and ORR versus TACE monotherapy for Chinese patients with predominantly advanced HCC in real-world practice,with an acceptable safety profile. | Hai-Dong Zhu Hai-Liang Li Ming-Sheng Huang Wei-Zhu Yang Guo-Wen Yin Bin-Yan Zhong Jun-Hui Sun Zhi-Cheng Jin Jian-Jian Chen Nai-Jian Ge Wen-Bin Ding Wen-Hui Li Jin-Hua Huang Wei Mu Shan-Zhi Gu Jia-Ping Li Hui Zhao Shu-Wei Wen Yan-Ming Lei Yu-Sheng Song Chun-Wang Yuan Wei-Dong Wang Ming Huang Wei Zhao Jian-Bing Wu Song Wang Xu Zhu Jian-Jun Han Wei-Xin Ren Zai-Ming Lu Wen-Ge Xing Yong Fan Hai-Lan Lin Zi-Shu Zhang Guo-Hui Xu Wen-Hao Hu Qiang Tu Hong-Ying Su Chuan-Sheng Zheng Yong Chen Xu-Ya Zhao Zhu-Ting Fang Qi Wang Jin-Wei Zhao Ai-Bing Xu Jian Xu Qing-Hua Wu Huan-Zhang Niu Jian Wang Feng Dai Dui-Ping Feng Qing-Dong Li Rong-Shu Shi Jia-Rui Li Guang Yang Hai-Bin Shi Jian-Song Ji Yu-E Liu Zheng Cai Po Yang Yang Zhao Xiao-Li Zhu Li-Gong Lu Gao-Jun Teng | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 7 |
| 12 | Suppressive Effects of Plumbagin on Invasion and Migration of Breast Cancer Cells via the Inhibition of STAT3 Signaling and Down-regulation of Inflammatory Cytokine Expressions显示文摘Objective:The aim of this study was to investigate the effects of plumbagin(PL),a naphthoquinone derived from the medicinal plant plumbago zeylanica,on the invasion and migration of human breast cancer cells.Methods:Human breast cancer MDA-MB-231SArfp cells were treated with different concentrations of plumbagin for 24 h.The effects of plumbagin on the migration and invasion were observed by a transwell method.The expressions of IL-1α,IL-1β,IL-6,IL-8,TGF-β,TNFα,MMP-2 and MMP-9 mRNA in MDA-MB-231SArfp cells were detected using Real-Time PCR.MDA-MB-231SArfp cells were treated with plumbagin at different concentrations for 45 minutes.The activation of STAT3 was detected by western blot.Following this analysis,STAT3 in MDA-MB-231SArfp cells was knocked out using specific siRNA.mRNA levels of IL-1α,TGF-β,MMP-2 and MMP-9 were then detected.Consequently,MDA-MB-231SArfp cells were injected intracardially into BALB/c nude mice to construct a breast cancer bone metastatic model.The mice were injected intraperitoneally with plumbagin.Non-invasive in vivo monitoring,X-ray imaging and histological staining were performed to investigate the effects of plumbagin on the invasion and migration of breast cancer cells in vivo.Results:The in vitro results showed that plumbagin could suppress the migration and invasion of breast cancer cells and down-regulate mRNA expressions of IL-1α,TGF-β,MMP-2 and MMP-9.Western blotting demonstrated that plumbagin inhibited the activation of STAT3 signaling in MDA-MB-231SArfp cells.The inactivation of STAT3 was found to have an inhibitory effect on the expressions of IL-1α,TGF-β,MMP-2 and MMP-9.In vivo studies showed that plumbagin inhibited the metastasis of breast cancer cells and decreased osteolytic bone metastases,as well as the secretion of MMP-2 and MMP-9 by tumor cells at metastatic lesions.Conclusions:Plumbagin can suppress the invasion and migration of breast cancer cells via the inhibition of STAT3 signaling and by downregulation of IL-1α,TGF-β,MMP-2 and MMP-9. | Wei Yan Bing Tu Yun-yun Liu Ting-yu Wang Han Qiao Zan-jing Zhai Hao-wei Li Ting-ting Tang | 2013 | Bone Research2013，1，4： | 5 |
| 13 | Effect of six years of nitrogen additions on soil chemistry in a subtropical Pleioblastus amarus forest, Southwest China显示文摘Soil chemistry influences plant health and carbon storage in forest ecosystems. Increasing nitrogen(N) deposition has potential effect on soil chemistry. We studied N deposition effects on soil chemistry in subtropical Pleioblastus amarus bamboo forest ecosystems. An experiment with four N treatment levels(0, 50, 150,and300 kg N ha^(-1)a^(-1),applied monthly, expressed as CK,LN,MN, HN,respectively) in three replicates. After6 years of N additions, soil base cations, acid-forming cations, exchangeable acidity(EA), organic carbon fractions and nitrogen components were measured in all four seasons. The mean soil pH values in CK,LN,MN and HN were 4.71, 4.62, 4.71, and 4.40, respectively, with a significant difference between CK and HN. Nitrogen additions significantly increased soil exchangeable Al3+,EA, and Al/Ca,and exchangeable Al3+ in HN increased by 70%compared to CK. Soil base cations(Ca^(2+), Mg^(2+), K+, and Na+) did not respond to N additions. Nitrogen treatments significantly increased soil NO3--N but had little effect on soil total nitrogen, particulate organic nitrogen, or NH4^+-N. Nitrogen additions did not affect soil total organic carbon, extractable dissolved organic carbon,incorporated organic carbon, or particulate organic carbon.This study suggests that increasing N deposition could increase soil NO3--N, reduce soil pH, and increase mobilization of Al^(3+). These changes induced by N deposition can impede root grow and function, further may influence soil carbon storage and nutrient cycles in the future. | Guan-tao Chen Li-hua Tu Guang-sheng Chen Jin-yao Hu Zhou-lin Han | 2018 | Journal of Forestry Research2018，29，6： | 4 |
| 14 | SIMULATION OF THE MICROSTRUCTURE DISTRIBUTION OF HYDROGEN STORAGE ALLOY AND OPTIMAL DESIGN OF CASTING MOULDS显示文摘In this paper,a simulation model for the temperature field in the solidification process and microstructure distribution is presented. Then, the result of simulation for the final microstructure distribution is compared with experiment using 10-Kg ingot of MlNi3.55Al0.3Mn0.4CO0.75 (Ml: Lanthanum-rich Mischmetal) hydrogen stor- age alloy cast in a mould, which agrees with the experiment well. Finally, in order to obtain the expected as-cast microstructure distribution of 15-Kg ingot of MlNi3.55Al0.3Mn0.4Co0.75 alloy, the size of Cu mould is optimized using the model described. The optimized mould is then made and the alloy is cast in it, the expected as-cast microstructure distribution is obtained. | Q.A. Li, H.Q. Mo, Y.Z. Huo, G. Sang, Y.F. Chen, M.G. Han, Y.G. Chen and M.J. Tu Department of Metal Materials, Sichuan University, Chengdu 610065, China | 2000 | Acta Metallurgica Sinica(English Letters)2000，13，2： | 4 |
| 15 | The long non-coding RNA expression profile of Coxsackievirus A16 infected RD cells identified by RNA-seq显示文摘Coxsackievirus A16(CVA16) is one of major pathogens of hand, foot and mouth disease(HFMD) in children. Long non-coding RNAs(Inc RNAs) have been implicated in various biological processes,but they have not been associated with CVA16 infection. In this study, we comprehensively characterized the landscape of Inc RNAs of normal and CVA16 infected rhabdomyosarcoma(RD)cells using RNA-Seq to investigate the functional relevance of Inc RNAs. We showed that a total of 760 Inc RNAs were upregulated and 1210 Inc RNAs were downregulated. Out of these dysregulated Inc RNAs, 43.64% were intergenic, 22.31% were sense, 15.89% were intronic, 8.67% were bidirectional, 5.59% were antisense, 3.85% were s RNA host Inc RNAs and 0.05% were enhancer. Six dysregulated Inc RNAs were validated by quantitative PCR assays and the secondary structures of these Inc RNAs were projected. Moreover, we conducted a bioinformatics analysis of an Inc RNAs(ENST00000602478) to elucidate the diversity of modification and functions of Inc RNAs. In summary, the current study compared the dysregulated Inc RNAs profile upon CVA16 challenge and illustrated the intricate relationship between coding and Inc RNAs transcripts. These results may not only provide a complete picture of transcription in CVA16 infected cells but also provide novel molecular targets for treatments of HFMD. | Yingying Shi Huilin Tu Xiong Chen Yingying Zhang Liujun Chen Zhongchun Liu Jiqun Sheng Song Han Jun Yin Biwen Peng Xiaohua He Wanhong Liu | 2016 | Virologica Sinica2016，31，2： | 4 |
| 16 | Estimating purple-soil moisture content using Vis-NIR spectroscopy显示文摘Soil moisture is essential for plant growth in terrestrial ecosystems.This study investigated the visible-near infrared(Vis-NIR)spectra of three subgroups of purple soils(calcareous,neutral,and acidic)from western Chongqing,China,containing different water contents.The relationship between soil moisture and spectral reflectivity(R)was analyzed using four spectral transformations,and estimation models were established for estimating the soil moisture content(SMC)of purple soil based on stepwise multiple linear regression(SMLR)and partial least squares regression(PLSR).We found that soil spectra were similar for different moisture contents,with reflectivity decreasing with increasing moisture content and following the order neutral>calcareous>acidic purple soil(at constant moisture content).Three of the four spectral transformations can highlight spectral sensitivity to SMC and significantly improve the correlation between the reflectance spectra and SMC.SMLR and PLSRmethods provide similar prediction accuracy.The PLSR-based model using a first-order reflectivity differential(R?)is more effective for estimating the SMC,and gave coefficient of determination(v2),root mean square errors of validation(RMSEV),and ratio of performance to inter-quartile distance(RPIQ)values of 0.946,1.347,and 6.328,respectively,for the calcareous purple soil,and 0.944,1.818,and 6.569,respectively,for the acidic purple soil.For neutral purple soil,the best prediction was obtained using the SMLR method with R?transformation,yieldingv2,RMSEV and RPIQ values of 0.973,0.888 and 8.791,respectively.In general,PLSR is more suitable than SMLR for estimating the SMC of purple soil. | GOU Yu WEI Jie LI Jin-lin HAN Chen TU Qing-yan LIU Chun-hong | 2020 | Journal of Mountain Science2020，17，9： | 4 |
| 17 | Anti-cyclic citrullinated peptide antibody predicts the development of rheumatoid arthritis in patients with undifferentiated arthritis显示文摘Background:Clinical outcomes of undifferentiated arthritis(UA)are diverse,and only 40%of patients with UA develop rheumatoid arthritis(RA)after 3 years.Discovering predictive markers at disease onset for further intervention is critical.Therefore,our objective was to analyze the clinical outcomes of UA and ascertain the predictors for RA development.Methods:We performed a prospective,multi-center study from January 2013 to October 2016 among Chinese patients diagnosed with UA in 22 tertiary-care hospitals.Clinical and serological parameters were obtained at recruitment.Follow-up was undertaken in all patients every 12 weeks for 2 years.Predictive factors of disease progression were identified using multivariate Cox proportional hazards regression.Results:A total of 234 patients were recruited in this study,and 17(7.3%)patients failed to follow up during the study.Among the 217 patients who completed the study,83(38.2%)patients went into remission.UA patients who developed RA had a higher rheumatoid factor(RF)-positivity(42.9%vs.16.8%,χ^2=8.228,P=0.008),anti-cyclic citrullinated peptide(CCP)antibodypositivity(66.7%vs.10.7%,χ^2=43.897,P<0.001),and double-positivity rate of RF and anti-CCP antibody(38.1%vs.4.1%,χ^2=32.131,P<0.001)than those who did not.Anti-CCP antibody but not RF was an independent predictor for RA development(hazard ratio 18.017,95%confidence interval:5.803–55.938;P<0.001).Conclusion:As an independent predictor of RA,anti-CCP antibody should be tested at disease onset in all patients with UA. | Chun Li Yan Zhang Hui Song Jie Gao Dong-Bao Zhao Qi Zhu Dong-Yi He Li Wang Xiang-Pei Li Xu-Dong Liu Wei-Guo Xiao Xin-Yu Wu Hua-Xiang Wu Wei Tu Shao-Xian Hu Xin Wang Zhi-Jun Li Zhi-Min Lu Zhan-Yun Da Bo Liang Xiao-Min Liu Jin-Wei Zhao Ling Li Feng Han Wu-Fang Qi Wei Wei Xu Ma Zhen-Bin Li Gui-Min Zheng Feng-Xiao Zhang Yi Li You-Lian Wang Guang-Hui Ling Jin-Wei Chen Xiao-Qiang Hou Jing Zhang Qing-Ping Chen Chang-Lian Liu Yan Zhang Jia-Shun Zeng Qing-Hua Zou Yong-Fei Fang Yin Su Zhan-Guo Li | 2019 | Chinese Medical Journal2019，，24： | 4 |
| 18 | Should temporary extracorporeal continuous portal diversion replace meso/porta-caval shunts in “small-for-size” syndrome in porcine hepatectomy?显示文摘AIM:To investigate the feasibility of temporary extracorporeal continuous porta-caval diversion(ECPD) to relieve portal hyperperfusion in 'small-for-size' syndrome following massive hepatectomy in pigs.METHODS:Fourteen pigs underwent 85%-90% liver resection and were then randomly divided into thecontrol group(n = 7) and diversion group(n = 7).In the diversion group,portal venous blood was aspirated through the portal catheter and into a tube connected to a centrifugal pump.After filtration,the blood was returned to the pig through a double-lumen catheter inserted into the internal jugular or subclavian vein.With the conversion pump,portal venous inflow was partially diverted to the inferior vena cava through a catheter inserted via the gastroduodenal vein at 100-130 m L/min.Portal hemodynamics,injury,and regeneration in the liver remnant were compared between the two groups.RESULTS:Compared to the control group,porta-caval diversion via ECPD significantly mitigated excessive portal venous flow and portal vein pressure(PVP); the portal vein flow(PVF),hepatic artery flow(HAF),and PVP in the two groups were not significantly different at baseline; however,the PVF(431.8 ± 36.6 vs 238.8 ± 29.3,P < 0.01; 210.3 ± 23.4 vs 122.3 ± 20.6,P < 0.01) and PVP(13.8 ± 2.6 vs 8.7 ± 1.4,P < 0.01; 15.6 ± 2.1 vs 10.1 ± 1.3,P < 0.05) in the control group were significantly higher than those in the diversion group,respectively.The HAF in the control group was significantly lower than that in the diversion group at 2 h and 48 h post hepatectomy,and ECPD significantly attenuated injury to the sinusoidal lining and hepatocytes,increased the regeneration index of the liver remnant,and relieved damage that the liver remnant suffered due to endotoxin and bacterial translocation.CONCLUSION:ECPD,which can dynamically modulate portal inflow,can reduce injury to the liver remnant and facilitate liver regeneration,and therefore should replace permanent meso/porta-caval shunts in 'smallfor-size' syndrome. | Da-Dong Wang Yong Xu Zi-Man Zhu Xiang-Long Tan Yu-Liang Tu Ming-Ming Han Jing-Wang Tan | 2015 | World Journal of Gastroenterology2015，21，3： | 3 |
| 19 | 2022 Chinese expert consensus and guidelines on clinical management of toxicity in anti-CD19 chimeric antigen receptor T-cell therapy for B-cell non-Hodgkin lymphoma显示文摘Adoptive cellular immunotherapy with chimeric antigen receptor(CAR)T cells has emerged as a novel modality for treating relapsed and/or refractory B-cell non-Hodgkin lymphoma(B-NHL).With increasing approval of CAR T-cell products and advances in CAR T cell therapy,CAR T cells are expected to be used in a growing number of cases.However,CAR T-cell-associated toxicities can be severe or even fatal,thus compromising the survival benefit from this therapy.Standardizing and studying the clinical management of these toxicities are imperative.In contrast to other hematological malignancies,such as acute lymphoblastic leukemia and multiple myeloma,anti-CD19 CAR T-cell-associated toxicities in B-NHL have several distinctive features,most notably local cytokine-release syndrome(CRS).However,previously published guidelines have provided few specific recommendations for the grading and management of toxicities associated with CAR T-cell treatment for B-NHL.Consequently,we developed this consensus for the prevention,recognition,and management of these toxicities,on the basis of published literature regarding the management of anti-CD19 CAR T-cell-associated toxicities and the clinical experience of multiple Chinese institutions.This consensus refines a grading system and classification of CRS in B-NHL and corresponding measures for CRS management,and delineates comprehensive principles and exploratory recommendations for managing anti-CD19 CAR T-cell-associated toxicities in addition to CRS. | Ping Li Yang Liu Yun Liang Jian Bo Sujun Gao Yongxian Hu Yu Hu He Huang Xiaojun Huang Hongmei Jing Xiaoyan Ke Jianyong Li Yuhua Li Qifa Liu Peihua Lu Heng Mei Ting Niu Yongping Song Yuqin Song Liping Su Sanfang Tu Jianxiang Wang Depei Wu Zhao Wang Kailin Xu Zhitao Ying Qingming Yang Yajing Zhang Fengxia Shi Bin Zhang Huilai Zhang Xi Zhang Mingfeng Zhao Weili Zhao Xiangyu Zhao Liang Huang Jun Zhu Wenbin Qian Weidong Han Aibin Liang | 2023 | Cancer Biology & Medicine2023，20，2： | 3 |
| 20 | Forecasting Scenario Generation for Multiple Wind Farms Considering Time-series Characteristics and Spatial-temporal Correlation显示文摘Scenario forecasting methods have been widely studied in recent years to cope with the wind power uncertainty problem. The main difficulty of this problem is to accurately and comprehensively reflect the time-series characteristics and spatial-temporal correlation of wind power generation. In this paper, the marginal distribution model and the dependence structure are combined to describe these complex characteristics. On this basis, a scenario generation method for multiple wind farms is proposed. For the marginal distribution model, the autoregressive integrated moving average-generalized autoregressive conditional heteroskedasticity-t (ARIMA-GARCH-t) model is proposed to capture the time-series characteristics of wind power generation. For the dependence structure, a time-varying regular vine mixed Copula (TRVMC) model is established to capture the spatial-temporal correlation of multiple wind farms. Based on the data from 8 wind farms in Northwest China, sufficient scenarios are generated. The effectiveness of the scenarios is evaluated in 3 aspects. The results show that the generated scenarios have similar fluctuation characteristics, autocorrelation, and crosscorrelation with the actual wind power sequences. | Qingyu Tu Shihong Miao Fuxing Yao Yaowang Li Haoran Yin Ji Han Di Zhang Weichen Yang | 2021 | Journal of Modern Power Systems and Clean Energy2021，9，4： | 3 |
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