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| 1 | Transformative hyaluronic acid-based active targeting supramolecular nanoplatform improves long circulation and enhances cellular uptake in cancer therapy显示文摘Hyaluronic acid(HA) is a natural ligand of tumor-targeted drug delivery systems(DDS) due to the relevant CD44 receptor overexpressed on tumor cell membranes. However, other HA receptors(HARE and LYVE-1) are also overexpressing in the reticuloendothelial system(RES). Therefore,polyethylene glycol(PEG) modification of HA-based DDS is necessary to reduce RES capture.Unfortunately, pegylation remarkably inhibits tumor cellular uptake and endosomal escapement,significantly compromising the in vivo antitumor efficacy. Herein, we developed a Dox-loaded HA-based transformable supramolecular nanoplatform(Dox/HCVBP) to overcome this dilemma. Dox/HCVBP contains a tumor extracellular acidity-sensitive detachable PEG shell achieved by a benzoic imine linkage.The in vitro and in vivo investigations further demonstrated that Dox/HCVBP could be in a 'stealth' state at blood stream for a long circulation time due to the buried HA ligands and the minimized nonspecific interaction by PEG shell. However, it could transform into a 'recognition' state under the tumor acidic microenvironment for efficient tumor cellular uptake due to the direct exposure of active targeting ligand HA following PEG shell detachment. Such a transformative concept provides a promising strategy to resolve the dilemma of natural ligand-based DDS with conflicting two processes of tumor cellular uptake and in vivo nonspecific biodistribution. | Lu Zhong Lu Xu Yanying Liu Qingsong Li Dongyang Zhao Zhenbao Li Huicong Zhang Haotian Zhang Qiming Kan Yongjun Wang Jin Sun Zhonggui He | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 7 |
| 2 | Erythrocyte membrane-camouflaged carrier-free nanoassembly of FRET photosensitizer pairs with high therapeutic efficiency and high security for programmed cancer synergistic phototherapy显示文摘Phototherapy has been intensively investigated as a non-invasive cancer treatment option.However,its clinical translation is still impeded by unsatisfactory therapeutic efficacy and severe phototoxicity.To achieve high therapeutic efficiency and high security,a nanoassembly of Forster Resonance Energy Transfer(FRET)photosensitizer pairs is developed on basis of dual-mode photosensitizer co-loading and photocaging strategy.For proof-of-concept,an erythrocyte-camouflaged FRET pair co-assembly of chlorine e6(Ce6,FRET donor)and 1,1′-dioctadecyl-3,3,3′,3′-tetramethylindotricarbocyanine iodide(DiR,FRET acceptor)is investigated for breast cancer treatment.Notably,Ce6 in the nanoassemby is quenched by DiR and could be unlocked for photodynamic therapy(PDT)only when DiR is photobleached by 808-nm laser.As a result,Ce6-caused phototoxicity could be well controlled.Under cascaded laser irradiation(808-660 nm),tumor-localizing temperature rise following laser irradiation on DiR not only induces tumor cell apoptosis but also facilitates the tumor penetration of NPs,relieves tumor hypoxia,and promotes the PDT efficacy of Ce6.Such FRET pair-based nanoassembly provides a new strategy for developing multimodal phototherapy nanomedicines with high efficiency and good security. | Xuanbo Zhang Jianchen Xiong Kaiyuan Wang Han Yu Bingjun Sun Hao Ye Zhiqiang Zhao Ning Wang Yuequan Wang Shenwu Zhang Wutong Zhao Haotian Zhang Zhonggui He Cong Luo Jin Sun | 2021 | Bioactive Materials2021，6，8： | 4 |
| 3 | M3SC:A Generic Dataset for Mixed Multi-Modal(MMM)Sensing and Communication Integration显示文摘The sixth generation(6G)of mobile communication system is witnessing a new paradigm shift,i.e.,integrated sensing-communication system.A comprehensive dataset is a prerequisite for 6G integrated sensing-communication research.This paper develops a novel simulation dataset,named M3SC,for mixed multi-modal(MMM)sensing-communication integration,and the generation framework of the M3SC dataset is further given.To obtain multimodal sensory data in physical space and communication data in electromagnetic space,we utilize Air-Sim and WaveFarer to collect multi-modal sensory data and exploit Wireless InSite to collect communication data.Furthermore,the in-depth integration and precise alignment of AirSim,WaveFarer,andWireless InSite are achieved.The M3SC dataset covers various weather conditions,multiplex frequency bands,and different times of the day.Currently,the M3SC dataset contains 1500 snapshots,including 80 RGB images,160 depth maps,80 LiDAR point clouds,256 sets of mmWave waveforms with 8 radar point clouds,and 72 channel impulse response(CIR)matrices per snapshot,thus totaling 120,000 RGB images,240,000 depth maps,120,000 LiDAR point clouds,384,000 sets of mmWave waveforms with 12,000 radar point clouds,and 108,000 CIR matrices.The data processing result presents the multi-modal sensory information and communication channel statistical properties.Finally,the MMM sensing-communication application,which can be supported by the M3SC dataset,is discussed. | Xiang Cheng Ziwei Huang Lu Bai Haotian Zhang Mingran Sun Boxun Liu Sijiang Li Jianan Zhang Minson Lee | 2023 | China Communications2023，20，11： | 3 |
| 4 | Oxidation-strengthened disulfide-bridged prodrug nanoplatforms with cascade facilitated drug release for synergetic photochemotherapy显示文摘One of the major barriers in utilizing prodrug nanocarriers for cancer therapy is the slow release of parent drug in tumors.Tumor cells generally display the higher oxidative level than normal cells,and also displayed the heterogeneity in terms of redox homeostasis level.We previously found that the disulfide bond-linkage demonstrates surprising oxidationsensitivity to form the hydrophilic sulfoxide and sulphone groups.Herein,we develop oxidation-strengthened prodrug nanosystem loaded with pyropheophorbide a(PPa)to achieve light-activatable cascade drug release and enhance therapeutic efficacy.The disulfide bond-driven prodrug nanosystems not only respond to the redox-heterogeneity in tumor,but also respond to the exogenous oxidant(singlet oxygen)elicited by photosensitizers.Once the prodrug nanoparticles(NPs)are activated under irradiation,they would undergo an oxidative self-strengthened process,resulting in a facilitated drug cascade release.The IC50 value of the PPa@PTX-S-S NPs without irradiation was 2-fold higher than those of NPs plus irradiation.In vivo,the PPa@PTX prodrug NPs display prolonged systemic circulation and increased accumulation in tumor site.The PPa@PTXS-S NPs showed much higher efficiency than free PTX or the PPa@PTX-C-C NPs to suppress the growth of 4 T1 tumors.Therefore,this novel oxidation-strengthened disulfide-bridged prodrug-nanosystem has a great potential in the enhanced efficacy of cancer synergetic photochemotherapy. | Bin Yang Lin Wei Yuequan Wang Na Li Bin Ji Kaiyuan Wang Xuanbo Zhang Shenwu Zhang Shuang Zhou Xiaohui Yao Hang Song Yusheng Wu Haotian Zhang Qiming Kan Tao Jin Jin Sun | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，5： | 2 |
| 5 | Morphology and property investigation of primary particulate matter particles from different sources显示文摘 | Rufan Zhang Chong Liu Guangmin Zhou Jie Sun Nian Liu Po-Chun Hsu Haotian Wang Yongcai Qiu Jie Zhao Tong Wu Wenting Zhao Yi Cui | 2018 | Nano Research2018，11，6： | 2 |
| 6 | Low-dose IL-2 mitigates glucocorticoid-induced Treg impairment and promotes improvement of SLE显示文摘Dear Editor,Previous studies have proved that regulatory T cell(Treg)insufficiency contributed to the development of autoimmune conditions including systemic lupus erythematosus(SLE).Conventional immunosuppressive treatment was reported to downregulate beneficial Tregs together with pathogenic effector immune cells,which may impede a rapid achievement of optimal therapeutic effects. | Haotian Zhou Xiaozhen Zhao Ruijun Zhang Miao Miao Wenwen Pei Zijun Li Yimin Li Jing He Zhanguo Li Xiaolin Sun | 2023 | Signal Transduction and Targeted Therapy2023，8，5： | 1 |
| 7 | Amino functionalized chiral mesoporous silica nanoparticles for improved loading and release of poorly water-soluble drug显示文摘In the present paper, chiral mesoporous silica nano-cocoon(A-CMSN) functionalized with amino group was synthesized, and its loading and release of indomethacin(IMC), a poorly soluble drug, was studied. Due to the use of chiral anionic surfactants as a template, ACMSN possessed 2D hexagonal nano-cocoon morphology with curled channels on its surface, which was quite different from another 2D hexagonal mesoporous silica nanoparticles(MCM-41) with straightway channels. After being loaded into the two silica carriers by hydrogen bond, crystalline IMC converted to amorphous form, leading to the improved drug dissolution. And IMC loading capacity of A-CMSN was higher than MCM-41 because curled loading process originating from curvature chiral channels can hold more drug molecules. Compared with IMC, IMC loaded A-CMSN presented obviously fast release throughout the in vitro release experiment, while IMC loaded MCM-41 released faster than IMC at the initial 5 h then showed controlled slow release afterwards, which was closely related to the mesoporous silica nanoparticles and different channel mesostructures of these two carriers. A-CMSN possessed nano-cocoon morphology with curled 2D hexagonal channel and its channel length was shorter than MCM-41, therefore IMC molecules can easily get rid of the constraint of A-CMSN then to be surrounded by dissolution medium. | Xin Wang Chang Li Na Fan Jing Li Haotian Zhang Lei Shang Zhonggui He Jin Sun | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，4： | 1 |
| 8 | Exploring the relationship of hyaluronic acid molecular weight and active targeting efficiency for designing hyaluronic acid-modified nanoparticles显示文摘Although it is reported that the targeting ability of hyaluronic acid(HA)-based nanoparticles(NPs) is molecular weight(MW) dependent,the influence of HA MW on targeting efficiency of HA-functionalized NPs and the underlying mechanism remain elusive. In this study,we constituted three HA-functionalized Dox-loaded NPs(Dox/HCVs) different HA MWs(7,63,and 102 k Da) and attempted to illustrate the effects of HA MW on the targeting efficiency.The three Dox/HCVs had similar physiochemical and pharmaceutical characteristics,but showed different affinity to CD44 receptor. Furthermore,Dox/HCV-63 exerted the best targeting effect and the highest cytotoxicity compared with Dox/HCV-7 and Dox/HCV-102. It was interesting to found that both the HA-CD44 binding affinity and induced CD44 clustering by HA-based NPs were HA MW-dependent,the two of which determine the apparent targeting efficacy of Dox/HCV NPs in the conflicting directions. Those results laid a good foundation for rationally designing HA-based NPs in cancer therapy. | Lu Zhong Yanying Liu Lu Xu Qingsong Li Dongyang Zhao Zhenbao Li Huicong Zhang Haotian Zhang Qiming Kan Jin Sun Zhonggui He | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，5： | 1 |
| 9 | Integration of phospholipid-drug complex into self-nanoemulsifying drug delivery system to facilitate oral delivery of paclitaxel显示文摘Self-nanoemulsifying drug delivery system(SNEDDS) has emerged as a promising platform to improve oral absorption of drugs with poor solubility and low permeability. However,large polarity molecules with insufficient lipid solubility,such as paclitaxel(PTX),would suffer from inferior formulation of SNEDDS due to poor compatibility. Herein,phospholipid-drug complex(PLDC) and SNEDDS were integrated into one system to facilitate oral delivery of PTX. First,PTX was formulated into PLDC in response to its inferior physicochemical properties. Then,the prepared PLDC was further formulated into SNEDDS by integrating these two drug delivery technologies into one system(PLDC-SNEDDS). After PLDC-SNEDDS dispersed in aqueous medium,nanoemulsion was formed immediately with an average particle size of ~30 nm. Furthermore,the nanomulsion of PLDC-SNEDDS showed good colloidal stability in both HCl solution(0.1 mol/l,p H 1.0) and phosphate buffer solution(PBS,p H 6.8). In vivo,PTX-PLDC-SNEDDS showed distinct advantages in terms of oral absorption efficiency,with a3.42-fold and 2.13-fold higher bioavailability than PTX-PLDC and PTX solution,respectively.Our results suggest that the integration of PLDC into SNEDDS could be utilized to facilitate the oral delivery of hydrophobic drugs with large polarity. | Dawei Ding Bingjun Sun Weiping Cui Qin Chen Xuanbo Zhang Haotian Zhang Zhonggui He Jin Sun Cong Luo | 2019 | Asian Journal of Pharmaceutical Sciences2019，14，5： | 1 |
| 10 | Precisely engineering a dual-drug cooperative nanoassembly for proteasome inhibition-potentiated photodynamic therapy显示文摘Photodynamic therapy(PDT) has been widely investigated for cancer therapy. The intracellular accumulation of reactive oxygen species(ROS)-damaged protein facilitates tumor cell apoptosis. However, there is growing evidence that the ubiquitin-proteasome pathway(UPP) significantly impedes PDT by preventing the enrichment of ROS-damaged proteins in tumor cells. To tackle this challenge, we report a facile dual-drug nanoassembly based on the discovery of an interesting co-assembly of bortezomib(BTZ, a proteasome inhibitor) and pyropheophorbide a(PPa) for proteasome inhibition-mediated PDT sensitization.The precisely engineered nanoassembly with the optimal dose ratio of BTZ and PPa demonstrates multiple advantages, including simple fabrication, high drug co-loading efficiency, flexible dose adjustment,good colloidal stability, long systemic circulation, favorable tumor-specific accumulation, as well as significant enrichment of ROS-damaged proteins in tumor cells. As a result, the cooperative nanoassembly exhibits potent synergistic antitumor activity in vivo. This study provides a novel dual-drug engineering modality for multimodal cancer treatment. | Fujun Yang Qingyu Ji Rui Liao Shumeng Li Yuequan Wang Xuanbo Zhang Shenwu Zhang Haotian Zhang Qiming Kan Jin Sun Zhonggui He Bingjun Sun Cong Luo | 2022 | Chinese Chemical Letters2022，33，4： | 1 |
| 11 | Unbiased transcriptomic analyses reveal distinet effects of immune deficiency in CNS function with and without injury显示文摘The mammalian central nervous system (CNS) is considered an immune privileged system as it is separated from the periphery by the blood brain barrier (BBB). Yet, immune functions have been postulated to heavily influence the functional state of the CNS, especially after injury or during neurodegeneration. There is controversy regarding whether adaptive immune responses are beneficial or detrimental to CNS injury repair. In this study, we utilized immunocompromised SCID mice and subjected them to spinal cord injury (SCI). We analyzed motor function, electrophysiology, histochemistry, and performed unbiased RNA-sequencing. SCID mice displayed improved CNS functional recovery compared to WT mice after SCI. Weighted gene-coexpression network analysis (WGCNA) of spinal cord transcriptomes revealed that SCID mice had reduced expression of immune function-related genes and heightened expression of neural transmission-related genes after SCI, which was confirmed by immunohistochemical analysis and was consistent with better functional recovery. Transcriptomic analyses also indicated heightened expression of neurotransmission-related genes before injury in SCID mice, suggesting that a steady state of immune-deficiency potentially led to CNS hyper-connectivity. Consequently, SCID mice without injury demonstrated worse performance in Morris water maze test. Taken together, not only reduced inflammation after injury but also dampened steady-state immune function without injury heightened the neurotransmission program, resulting in better or worse behavioral outcomes respectively. This study revealed the intricate relationship between immune and nervous systems, raising the possibility for therapeutic manipulation of neural function via immune modulation. | Dandan Luo Weihong Ge Xiao Hu Chen Li Chia-Ming Lee Liqiang Zhou Zhourui Wu Juehua Yu Sheng Lin Jing Yu Wei Xu Lei Chen Chong Zhang Kun Jiang Xingfei Zhu Haotian Li Xinpei Gao Yanan Geng Bo Jing Zhen Wang Changhong Zheng Rongrong Zhu Qiao Yan Quan Lin Keqiang Ye Yi E. Sun Liming Cheng | 2019 | Protein & Cell2019，10，8： | 1 |
| 12 | Modularly engineered prodrug-nanoassemblies for cancer therapy:Nonpharmacological moiety dominating delivery fates显示文摘Self-engineered small-molecule prodrug-nanoassemblies have emerged as promising nanomedicines for cancer treatment.Modular design of prodrug molecules is crucial to guarantee the favorable assembly stability,tumor-specific prodrug activation,and satisfactory antitumor effect.However,too much attention has been paid to the pharmacophores and chemical linkages in prodrug molecules while neglects the vital roles of nonpharmacological moieties.Herein,we found that iso-carbon fatty acids with different number,position,and cis-trans configuration of double bonds dramatically affect the nanoassembly feature and drug delivery fates of thioether-linked paclitaxel prodrug-nanoassemblies.Particularly,the number and cis-trans configuration of double bonds in fatty acid moieties not only dominate the self-assembly ability and colloidal stability of prodrugs,but also exert significant influences on the pharmacokinetics,prodrug activation,and antitumor activity of prodrug-nanoassemblies.Finally,oleic acid with one cis double bond stands out as the optimal nonpharmacological moiety for thioether-linked paclitaxel prodrugnanoassemblies.This study elucidates the crucial roles of nonpharmacological moieties in prodrugs,and provides new insights into the modular design of prodrug-based nanomedicines for cancer therapy. | Yuequan Wang Qian Qiu Rui Liao Xinhui Wang Ziran Zhou Xuanbo Zhang Haotian Zhang Zhonggui He Shenwu Zhang Cong Luo Jin Sun | 2023 | Nano Research2023，16，1： | 0 |
| 13 | Hierarchical Engineering for High-Energy-Oriented Sodium-Ion Batteries显示文摘CONSPECTUS:Sodium-ion batteries(SIBs)have obtained extensive attention as desirable candidates for smart grids and large-scale energy storage systems(ESSs)because they have the conspicuous advantages of resource abundance and competitive price.However,the biggish radius and heavier molar mass of Na^(+) and the lower negative redox potential of Na^(+)/Na give rise to low volumetric/gravimetric energy densities,sluggish reaction dynamics,and an inferior life-span.It is therefore crucial to concentrate on the development of tailored electrode materials with robust architectures and expedited Na+diffusion kinetics so as to take SIB energy systems one step closer to practical applications. | Pei Liu Haotian Yi Xuchun Chen Kunjie Zhu Zhaopeng Li Zhiqin Sun Lifang Jiao | 2022 | Accounts of Materials Research2022，3，7： | 0 |
| 14 | Micro-seismic Event Detection of Hot Dry Rock based on the Gated Recurrent Unit Model and a Support Vector Machine显示文摘Micro-seismic monitoring is one of the most critical technologies that guide hydraulic fracturing in hot dry rock resource development. Micro-seismic monitoring requires high precision detection of micro-seismic events with a low signal-to-noise ratio. Because of this requirement, we propose a recurrent neural network model named gated recurrent unit and support vector machine(GRU;VM). The proposed model ensures high accuracy while reducing the parameter number and hardware requirement in the training process. Since micro-seismic events in hot dry rock produce large wave amplitudes and strong vibrations, it is difficult to reverse the onset of each individual event. In this study, we utilize a support vector machine(SVM) as a classifier to improve the micro-seismic event detection accuracy. To validate the methodology, we compare the simulation results of the short-term-average to the long-term-average(STA/LTA) method with GRU;VM method by using hot dry rock micro-seismic event data in Qinghai Province, China. Our proposed method has an accuracy of about 95% for identifying micro-seismic events with low signal-to-noise ratios. By ignoring smaller micro-seismic events, the detection procedure can be processed more efficiently, which is able to provide a real-time observation on the types of hydraulic fracturing in the reservoirs. | SUN Feng HU Haotian ZHAO Fa YANG Xinran CHEN Zubin WU Haidong ZHANG Linyou | 2021 | Acta Geologica Sinica(English Edition)2021，95，6： | 0 |
| 15 | Boosting SN38-based oral chemotherapy to combine reductionbioactivated structured lipid-mimetic prodrug with ascorbic acid显示文摘The reduction-responsive disulfide bonds have been widely used as bioactive linkages to facilitate a rapid release of anticancer drugs into tumor cells.However,the activation can be hindered by the kinetics of the thiol-disulfide exchange reactions.Supplementing with an additional reductant is a promising strategy to further boost drug release.Herein,inspired by the specific absorption mechanism of triglyceride fat,structured lipid-mimetic oral prodrugs of 7-ethyl-10-hydroxycamptothecin(SN38)were designed to improve intestinal permeability and bypass the first-pass effect.SN38 prodrugs were prepared into lipid formulations that could self-emulsify into nano-sized particles after entering the gastrointestinal tract.Surprisingly,we found that the oral bioavailability of the prodrug lipid formulation could be up to 2.69-fold higher than that of the parent SN38,indicating an effective oral delivery.In addition,the reduction-responsive disulfide bond was used as a linker,and ascorbic acid(ASC)was coadministrated to further promote the efficient release of SN38 from the prodrug.ASC enhanced the oral antitumor effect of the reduction-responsive oral prodrug and exhibited good safety.In summary,the combination of a structured lipid-mimetic prodrug and ASC was firstly demonstrated to boost the oral chemotherapy effect of the difficult-for-oral chemotherapeutics. | Helin Wang Qi Lu Yifan Miao Jiaxuan Song Mingyang Zhang Zixuan Wang Haotian Zhang Zhonggui He Chutong Tian Jin Sun | 2022 | Nano Research2022，15，10： | 0 |
| 16 | Hierarchical Frequency-dependent Chance Constrained Unit Commitment for Bulk AC/DC Hybrid Power Systems with Wind Power Generation显示文摘As the steady-state frequency of an actual power system decreases from its nominal value,the composite load of the system generally responds positively to lower power consumption,and vice versa.It is believed that this load frequency damping(LFD)effect will be artificially enhanced,i.e.,sensitivities of loads with respect to operational frequency will increase,in future power systems.Thus,for wind-integrated power systems,this paper proposes a frequency-dependent chance constrained unit commitment(FDCCUC)model that employs the operational frequency as a dispatching variable so that the LFD effect-based load power can act as a supplemental reserve.Because the frequency deviation is safely restricted,this low-cost reserve can be sufficiently exerted to upgrade the wind power accommodation capability of a power system that is normally confined by an inadequate reserve to cope with uncertain wind power forecasting error.Moreover,when the FDCCUC model is applied to a bulk AC/DC hybrid power system consisting of several independently operated regional AC grids interconnected by DC tie-lines,a hierarchically implemented searching algorithm is proposed to protect private scheduling information of the regional AC grids.Simulations on a 2-area 6-bus system and a 3-area 354-bus system verify the effectiveness of the FDCCUC model and hierarchical searching algorithm. | Rui Chen Deping Ke Yuanzhang Sun C.Y.Chung Haotian Wu Siyang Liao Jian Xu Congying Wei | 2023 | Journal of Modern Power Systems and Clean Energy2023，11，4： | 0 |
| 17 | gem-Difluorovinylation of alkynyl bromoarenes via dual nickel-/palladium-catalyzed crosselectrophile coupling显示文摘A dual nickel-/palladium-catalyzed gem-difluorovinylation of alkynyl bromoarenes is presented.This method proceeds smoothly to afford various dihydrobenzofuran compounds containing gem-difluorovinyl fragments with excellent stere-oselectivities in moderate to excellent yields.This strategy also features good functional group tolerance.Mechanistic studies reveal that the C-OTs bond and C-Br bond are selectively oxidative-added by nickel and palladium complexes respec-tively,and palladium is the center metal in the reductive elimination step. | Haotian Sun Baojian Xiong Yuan Yang Jiangjun Liu Xuemei Zhang Zhong Lian | 2022 | Organic Chemistry Frontiers2022，9，2： | 0 |
| 18 | Erratum to:Boosting SN38-based oral chemotherapy to combine reduction-bioactivated structured lipid-mimetic prodrug with ascorbic acid显示文摘Erratum to Nano Research 2022,15(10):9092-9104 http://gffzzd3cc09b8251d45dfsov5xcp6fouov6kk9.ffgz.tsg.suse.edu.cn/10.1007/s12274-022-4544-7 Figure 9 was unfortunately mistakenly typeset.This error did not affect any of the conclusions from the published paper. | Helin Wang Qi Lu Yifan Miao Jiaxuan Song Mingyang Zhang Haotian Zhang Zhonggui He Zixuan Wang Chutong Tian Jin Sun | 2023 | Nano Research2023，16，4： | 0 |
| 19 | Influence of thermodynamic disfigurement on the convective heat transfer of solar greenhouse显示文摘Solar greenhouse is a typical greenhouse without any additional heating system,which has developed rapidly in Northern China.However,due to the construction quality,management methods,especially the long-term use and other factors,there are usually different degrees of thermodynamic disfigurements in the envelop enclosure of solar greenhouse.The purpose of this study was to investigate the influences of thermodynamic disfigurement on the temperature distribution and convective heat transfer of solar greenhouse.In this study,the east and west compartments of a typical solar greenhouse which is located in Yangling,China(108°4′E,34°16′N)were tested.The air temperature of each compartment was collected using temperature recorders,and the thermal infrared images of different compartment envelopes were obtained by a thermal infrared imager on a typical cloudy day.Convective heat transfer coefficients and heat flux densities of different compartment envelopes in the solar greenhouse were calculated.The results showed that the temperature difference can be displayed in the thermal infrared images of compartment envelopes,the surface temperature of the front roof was the lowest,followed by the back roof,the wall surface temperature was the highest.The minimum average surface temperature of the front roof in the eastern compartment was only 3.8℃,which was 6.8℃ and 9.2℃ lower than the average surface temperature of the back roof and back wall,respectively.The surface average temperature of thermodynamic disfigurements located at the bottom of the south side in the front roof of the eastern compartment,whose area accounted for 16.5%of the total front roof in the eastern compartment,was only 5.4℃.Compared with non-thermodynamic disfigurement,the average convective heat transfer coefficient and heat flux density of thermodynamic disfigurements in the front roof of the eastern compartment were increased by 20.3%and 110.3%,respectively.The average air temperature in the eastern compartment was 3.5℃ lower than the average air temperature in the western compartment of the solar greenhouse.Construction of brick wall at the bottom of the south side of the front roof in the solar greenhouse helped to increase the inner surface temperature of the front roof,with an average temperature rise of 6.2℃,and reduce the area of thermodynamic disfigurement,which only accounted for 2.6%of the total front roof in the western compartment.The average surface temperature of thermodynamic disfigurements mainly caused by the entry and exit door in the wall of the eastern compartment was only 9.8℃,which was lower 3.2℃ than the average temperature of non-thermodynamic disfigurement of the wall.Thermodynamic disfigurement helped to increase heat loss.The weighted average proportion of thermodynamic disfigurement in the western compartment was 2.1%,while that of thermodynamic disfigurement in the eastern compartment was 10.7%.The thermal insulation performance of the western compartment envelope in the solar greenhouse was better than that of the eastern compartment envelope. | Yachen Sun Yanfei Cao Haotian Wang Changji Zhou Jinxin Xiao Chengyao Jiang Jianming Li Encai Bao Zhirong Zou | 2020 | International Journal of Agricultural and Biological Engineering2020，13，4： | 0 |
| 20 | Additive manufactured osseointegrated screws with hierarchical design显示文摘Bone screws are devices used to fix implants or bones to bones.However,conventional screws are mechanically fixed with thread and often face long-term failure due to poor osseointegration.To improve osseointegration,screws are evolving from solid and smooth to porous and rough.Additive manufacturing(AM)offers a high degree of manufacturing freedom,enabling the preparation of predesigned screws that are porous and rough.This paper provides an overview of the problems currently faced by bone screws:long-term loosening and screw breakage.Next,advances in osseointegrated screws are summarized hierarchically(sub-micro,micro,and macro).At the sub-microscale level,we describe surface-modification techniques for enhancing osseointegration.At the micro level,we summarize the micro-design parameters that affect the mechanical and biological properties of porous osseointegrated screws,including porosity,pore size,and pore shape.In addition,we highlight three promising pore shapes:triply periodic minimal surface,auxetic structure with negative Poisson ratio,and the Voronoi structure.At the macro level,we outline the strategies of graded design,gradient design,and topology optimization design to improve the mechanical strength of porous osseointegrated screws.Simultaneously,this paper outlines advances in AM technology for enhancing the mechanical properties of porous osseointegrated screws.AM osseointegrated screws with hierarchical design are expected to provide excellent long-term fixation and the required mechanical strength. | Wenbo Yang Hao Chen Haotian Bai Yifu Sun Aobo Zhang Yang Liu Yuchao Song Qing Han Jincheng Wang | 2024 | Bio-Design and Manufacturing2024，7，2： | 0 |
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