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| 1 | The second natural gas hydrate production test in the South China Sea显示文摘Clayey silt reservoirs bearing natural gas hydrates(NGH)are considered to be the hydrate-bearing reservoirs that boast the highest reserves but tend to be the most difficult to exploit.They are proved to be exploitable by the first NGH production test conducted in the South China Sea in 2017.Based on the understanding of the first production test,the China Geological Survey determined the optimal target NGH reservoirs for production test and conducted a detailed assessment,numerical and experimental simulation,and onshore testing of the reservoirs.After that,it conducted the second offshore NGH production test in 1225 m deep Shenhu Area,South China Sea(also referred to as the second production test)from October 2019 to April 2020.During the second production test,a series of technical challenges of drilling horizontal wells in shallow soft strata in deep sea were met,including wellhead stability,directional drilling of a horizontal well,reservoir stimulation and sand control,and accurate depressurization.As a result,30 days of continuous gas production was achieved,with a cumulative gas production of 86.14×104 m3.Thus,the average daily gas production is 2.87×10^4 m^3,which is 5.57 times as much as that obtained in the first production test.Therefore,both the cumulative gas production and the daily gas production were highly improved compared to the first production test.As indicated by the monitoring results of the second production test,there was no anomaly in methane content in the seafloor,seawater,and atmosphere throughout the whole production test.This successful production test further indicates that safe and effective NGH exploitation is feasible in clayey silt NGH reservoirs.The industrialization of hydrates consists of five stages in general,namely theoretical research and simulation experiments,exploratory production test,experimental production test,productive production test,and commercial production.The second production test serves as an important step from the exploratory production test to experimental production test. | Jian-liang Ye Xu-wen Qin Wen-wei Xie Hai-long Lu Bao-jin Ma Hai-jun Qiu Jin-qiang Liang Jing-an Lu Zeng-gui Kuang Cheng Lu Qian-yong Liang Shi-peng Wei Yan-jiang Yu Chunsheng Liu Bin Li Kai-xiang Shen Hao-xian Shi Qiu-ping Lu Jing Li Bei-bei Kou Gang Song Bo Li He-en Zhang Hong-feng Lu Chao Ma Yi-fei Dong Hang Bian | 2020 | China Geology2020，3，2： | 22 |
| 2 | The HuangZaoSi Maize Genome Provides Insights into Genomic Variation and Improvement History of Maize显示文摘Maize is a globally important crop that was a classic model plant for genetic studies. Here, we report a 2.2 Gb draft genome sequence of an elite maize line, HuangZaoSi (HZS). Hybrids bred from HZS-improved lines (HILs) are planted in more than 60% of maize fields in China. Proteome clustering of six completed sequeneed maize genomes show that 638 proteins fall into 264 HZS-specific gene families with the majority of contributions from tandem duplication events. Resequencing and comparative analysis of 40 HZSrelated lines reveals the breeding history of HILs. More than 60% of identified selective sweeps were clustered in identity.by.descent conserved regions, and yield-related genes/QTLs were enriched in HZS characteristic selected regions. Furthermore, we dem on strated that HZS-specific family genes were not uniformly distributed in the genome but enriched in improvement/function.related genomic regions. This study provides an important and novel resource for maize genome research and expands our knowledge on the breadth of genomic variation and improvement history of maize. | Chunhui Li Wei Song Yingfeng Luo Shenghan Gao Ruyang Zhang Zi Shi Xiaqing Wang Ronghuan Wang Fengge Wang Jidong Wang Yanxin Zhao Aiguo Su Shuai Wang Xin Li Meijie Luo Shuaishuai Wang Yunxia Zhang Jianrong Ge Xinyu Tan Ye Yuan Xiaochun Bi Hang He Jianbing Yan Yuandong Wang Songnian Hu Jiuran Zhao | 2019 | Molecular Plant2019，12，3： | 15 |
| 3 | Acupuncture at Baihui and Dazhui reduces brain cell apoptosis in heroin readdicts显示文摘Acupuncture at Baihui(GV20) and Dazhui(GV14) reduces neuronal loss and attenuates ultrastructural damage in cerebral ischemic rats. However, whether acupuncture can treat addiction and prevent readdiction through changes to brain cell ultrastructure remains unknown. In this study, cell apoptosis was observed in the hippocampus and frontal lobe of heroin readdicted rats by electron microscopy. Immunohistochemical staining displayed a reduction in Bcl-2 expression and an increase in Bax expression in the hippocampus and frontal lobe. After rats were given acupuncture at Baihui and Dazhui, the pathological damage in the hippocampus and frontal lobe was significantly reduced, Bcl-2 expression was upregulated and Bax expression was downregulated. Acupuncture exerted a similar effect with methadone, a commonly used drug for clinical treatment of drug addiction. Experimental findings suggest that acupuncture at Dazhui and Baihui can prevent brain cell apoptosis in heroin readdicted rats. | Xiaorong Hou Rongjun Zhang Hang Lv Xinghui Cai Guangchuan Xie Xiaoge Song | 2014 | Neural Regeneration Research2014，9，2： | 12 |
| 4 | Morinda officinalis oligosaccharides increase serotonin in the brain and ameliorate depression via promoting 5-hydroxytryptophan production in the gut microbiota显示文摘Morinda officinalis oligosaccharides(MOO) are an oral drug approved in China for the treatment of depression in China. However, MOO is hardly absorbed so that their anti-depressant mechanism has not been elucidated. Here, we show that oral MOO acted on tryptophan → 5-hydroxytryptophan(5-HTP) → serotonin(5-HT) metabolic pathway in the gut microbiota. MOO could increase tryptophan hydroxylase levels in the gut microbiota which accelerated 5-HTP production from tryptophan;meanwhile, MOO inhibited 5-hydroxytryptophan decarboxylase activity, thus reduced 5-HT generation,and accumulated 5-HTP. The raised 5-HTP from the gut microbiota was absorbed to the blood, and then passed across the blood-brain barrier to improve 5-HT levels in the brain. Additionally, pentasaccharide,as one of the main components in MOO, exerted the significant anti-depressant effect through a mechanism identical to that of MOO. This study reveals for the first time that MOO can alleviate depression via increasing 5-HTP in the gut microbiota. | Zheng-Wei Zhang Chun-Sheng Gao Heng Zhang Jian Yang Ya-Ping Wang Li-Bin Pan Hang Yu Chi-Yu He Hai-Bin Luo Zhen-Xiong Zhao Xin-Bo Zhou Yu-Li Wang Jie Fu Pei Han Yu-Hui Dong Gang Wang Song Li Yan Wang Jian-Dong Jiang Wu Zhong | 2022 | Acta Pharmaceutica Sinica B2022，12，8： | 12 |
| 5 | A comprehensive analysis of the response of the fungal community structure to long-term continuous cropping in three typical upland crops显示文摘Certain agricultural management practices are known to affect the soil microbial community structure;however,knowledge of the response of the fungal community structure to the long-term continuous cropping and rotation of soybean,maize and wheat in the same agroecosystem is limited.We assessed the fungal abundance,composition and diversity among soybean rotation,maize rotation and wheat rotation systems and among long-term continuous cropping systems of soybean,maize and wheat as the effect of crop types on fungal community structure.We compared these fungal parameters of same crop between long-term crop rotation and continuous cropping systems as the effect of cropping systems on fungal community structure.The fungal abundance and composition were measured by quantitative real-time PCR and Illumina MiSeq sequencing.The results revealed that long-term continuous soybean cropping increased the soil fungal abundance compared with soybean rotation,and the fungal abundance was decreased in long-term continuous maize cropping compared with maize rotation.The long-term continuous soybean cropping also exhibited increased soil fungal diversity.The variation in the fungal community structure among the three crops was greater than that between long-term continuous cropping and rotation cropping.Mortierella,Guehomyces and Alternaria were the most important contributors to the dissimilarity of the fungal communities between the continuous cropping and rotation cropping of soybean,maize and wheat.There were 11 potential pathogen and 11 potential biocontrol fungi identified,and the relative abundance of most of the potential pathogenic fungi increased during the long-term continuous cropping of all three crops.The relative abundance of most biocontrol fungi increased in long-term continuous soybean cropping but decreased in long-term continuous maize and wheat cropping.Our results indicate that the response of the soil fungal community structure to long-term continuous cropping varies based upon crop types. | LIU Hang PAN Feng-juan HAN Xiao-zeng SONG Feng-bin ZHANG Zhi-ming YAN Jun XU Yan-li | 2020 | Journal of Integrative Agriculture2020，19，3： | 8 |
| 6 | Endovascular therapy for Acute ischemic Stroke Trial (EAST): study protocol for a prospective, multicentre control trial in China显示文摘Background and purpose:5 recent trials have shown the benefit of endovascular treatment for acute ischaemic stroke(AIS)due to large vessel occlusion of the anterior circulation.This study aims to evaluate the safety and efficacy of Solitaire thrombectomy in patients with moderate-to-severe stroke in the Chinese population,which has a high prevalence of intracranial atherosclerosis.Methods and analysis:This multicentre prospective control study will involve 17 stroke centres in China,and plans to recruit 150 patients in the intervention group,and 150 patients in the medical group,in which patients meet enrolment criteria but refuse intervention.Patients with AIS due to large vessel occlusion indicated for treatment with Solitaire stent retriever within 12 hours of symptom onset,and who meet the inclusion and exclusion criteria,will be enrolled in this study.The primary efficacy endpoint is functional independence as defined by a modified Rankin Scale(mRS)score≤2 at 90 days or by functional improvement as defined by mRS,using shift analysis.The procedural efficacy endpoint is arterial recanalisation of the occluded target vessel measured by a modified Thrombolysis in Cerebral Infarction(mTICI)score equal or superior to 2b right following the use of the study device.The primary safety endpoint is symptomatic intracranial haemorrhage(sICH)within 24±3 hours postprocedure.Ethics and dissemination:The protocol was approved by the Ethics Committee at the coordinating centre and by the local Institutional Review Board of each participating centre.Trial registration number:NCT02350283. | Zhongrong Miao Xiaochuan Huo Feng Gao Xiaoling Liao Chunjuan Wang Ya Peng Yibin Cao Shengli Chen Meng Zhang Changchun Jiang Xiaoxiang Peng Cunfeng Song Liping Wei Qiyi Zhu Zaiyu Guo Li Liu Hang Lin Hua Yang Wei Wu Hui Liang Anding Xu Kangning Chen Xingquan Zhao Yuesong Pan Hao Li Liping Liu Yilong Wang Yongjun Wang EAST investigators | 2016 | Stroke & Vascular Neurology2016，1，2： | 8 |
| 7 | Daytime HONO formation in the suburban area of the megacity Beijing, China显示文摘Nitrous acid(HONO),as a primary precursor of OH radicals,has been considered one of the most important nitrogencontaining species in the atmosphere.Up to 30%of primary OH radical production is attributed to the photolysis of HONO.However,the major HONO formation mechanisms are still under discussion.During the Campaigns of Air Quality Research in Beijing and Surrounding Region(CAREBeijing2006)campaign,comprehensive measurements were carried out in the megacity Beijing,where the chemical budget of HONO was fully constrained.The average diurnal HONO concentration varied from 0.33 to 1.2 ppbv.The net OH production rate from HONO,POH(HONO)net,was on average(from 05:00 to 19:00)7.1×106 molecule/(cm3 s),2.7 times higher than from O3 photolysis.This production rate demonstrates the important role of HONO in the atmospheric chemistry of megacity Beijing.An unknown HONO source(Punknown)with an average of 7.3×106molecule/(cm3 s)was derived from the budget analysis during daytime.Punknown provided four times more HONO than the reaction of NO with OH did.The diurnal variation of Punknown showed an apparent photo-enhanced feature with a maximum around 12:00,which was consistent with previous studies at forest and rural sites.Laboratory studies proposed new mechanisms to recruit NO2 and J(NO2)in order to explain a photo-enhancement of of Punknown.In this study,these mechanisms were validated against the observation-constraint Punknown.The reaction of exited NO2 accounted for only 6%of Punknown,and Punknown poorly correlated with[NO2](R=0.26)and J(NO2)[NO2](R=0.35).These results challenged the role of NO2 as a major precursor of the missing HONO source. | YANG Qiang SU Hang LI Xin CHENG YaFang LU KeDing CHENG Peng GU JianWei GUO Song HU Min ZENG LiMin ZHU Tong ZHANG YuanHang | 2014 | Science China Chemistry2014，57，7： | 8 |
| 8 | Evaluation of the safety and efficacy of therapeutic bandage contact lenses on post-cataract surgery patients显示文摘AIM: To evaluate the safety of therapeutic bandage contact lens for post-cataract surgery patients and to illustrate its efficacy on post-operative comfort and tear-film stability. METHODS: A total of 40 participants were recruited and randomly divided into two groups. Group one was instructed to wear bandage contact lenses for a week and use antibiotic eye drops for a month since the first day after surgery. Group two received sub-conjunctival injection of tobramycin and was asked to wear eye pads on the first day after surgery and then were instructed to use antibiotic eye drops as the first group did. Ocular surface disease index(OSDI) questionnaire, slit-lamp microscope examination of tear break-up time(TBUT), corneal fluorescein score(CFS), tear meniscus height(TMH) together with anterior segment optical coherence tomography(AS-OCT) and corneal topography were evaluated preoperatively and postoperatively. RESULTS: The subjective feeling(P=0.004), TBUT(P<0.001) and TMH(P=0.02) post-surgery had improved in patients who used bandage contact lenses compared with those who did not at 1wk post-surgery. Until three month postoperatively, the comfort degree(P=0.004) and TMH(P=0.01) of group two were still worse than group one. Moreover, TBUT(P<0.001) and CFS(P=0.004) of the group with eye pads got worse than the results before, whereas the group with bandage contact lenses recovered to normal. None of these patients had infections or other complications. CONCLUSION: Wearing therapeutic bandage contact lens after cataract surgery, compared with traditional eye-pads, is a safe method to improve tear-film stability and reduce post-operative discomfort without hindering corneal incision recovery. | Dan-Na Shi Hang Song Tong Ding Wei-Qiang Qiu Wei Wang | 2018 | International Journal of Ophthalmology(English edition)2018，11，2： | 6 |
| 9 | A Comparison Study of Working Memory Deficits between Patients with Methamphetamine-Associated Psychosis and Patients with Schizophrenia显示文摘 | Hong GAN Zhenhua SONG Peiwei XU Hang SU Yingying PAN Min ZHAO Dengtang LIU | 2018 | 上海精神医学2018，30，3： | 6 |
| 10 | Long-term surface water changes and driving cause in Xiong'an,China:from dense Landsat time series images and synthetic analysis显示文摘China's government statement recently reported the plan of constructing Xiong'an New Area, which aims to phase out some extra capital functions from Beijing and to explore an innovative urban development mode with the priority in eco-environmental protection. The New Area is located in the semi-arid North China Plain(NCP) and is home to NCP's largest natural freshwater wetland, Baiyangdian Lake. A comprehensive realization of surface water dynamics would be crucial for policy-makers to outline a sustainable environment development strategy for New Area. In this study, we used a total of 245 time slices of cloud-free Landsat images to document the continuous changes of water bodies within Xiong'an City during 1984-2016 and to provide detailed evidence of water presence and persistency states and changes under the influences of climate change and human actions. Our results reveal that the New Area water body areas varied dramatically during the past 33 years, ranging from 0.44 km^2 in April 1988 to317.85 km^2 in February 1989. The change of surface water area was not characterized by a monotonically decreasing tendency. The evolution processes can be divided into four sub-stages: the first extreme desiccation in mid-1980 s, the wet stage with the most extensive inundation areas and strong inter-annual fluctuations from late-1988 to late 1999, another desiccation stage in early 2000 s, and the overall recovering stage between 2007 and 2016. We also mapped the maximum water inundation extents and frequencies of all-season, pre-wet season(February-May) and post-wet season(September-December) for the 33 years and different sub-periods. Although there is good agreement between time series of surface water area evolution in the New Area and station-based precipitation and evaporation variations, multiple lines of evidences reviewed in previous research indicate that the degraded Baiyangdian Lake was also tightly associated with human activities from various aspects, including dam construction, groundwater extraction, agricultural irrigation, etc. We highlighted the current status of exploring the driving mechanism of surface water changes and existing problems, and then offer recommendations. | Chunqiao Song Linghong Ke Hang Pan Shengan Zhan Kai Liu Ronghua Ma | 2018 | Science Bulletin2018，63，11： | 6 |
| 11 | Activation of mitogen-activated protein kinases in satellite glial cells of the trigeminal ganglion contributes to substance P-mediated inflammatory pain显示文摘Inflammatory orofacial pain,in which substance P (SP) plays an important role,is closely related to the cross-talk between trigeminal ganglion (TG) neurons and satellite glial cells (SGCs).SGC activation is emerging as the key mechanism underlying inflammatory pain through different signalling mechanisms,including glial fibrillary acidic protein (GFAP) activation,phosphorylation of mitogen-activated protein kinase (MAPK) signalling pathways,and cytokine upregulation.However,in the TG,the mechanism underlying SP-mediated orofacial pain generated by SGCs is largely unknown.In this study,we investigated whether SP is involved in inflammatory orofacial pain by upregulating interleukin (IL)-1β and tumour necrosis factor (TNF)-α from SGCs,and we explored whether MAPK signalling pathways mediate the pain process.In the present study,complete Freund’s adjuvant (CFA) was injected into the whisker pad of rats to induce an inflammatory model in vivo.SP was administered to SGC cultures in vitro to confirm the effect of SP.Facial expression analysis showed that pre-injection of L703,606 (an NK-1 receptor antagonist),U0126 (an inhibitor of MAPK/extracellular signal-regulated kinase [ERK] kinase [MEK] 1/2),and SB203580 (an inhibitor of P38) into the TG to induce targeted prevention of the activation of the NK-1 receptor and the phosphorylation of MAPKs significantly suppressed CFA-induced inflammatory allodynia.In addition,SP promoted SGC activation,which was proven by increased GFAP,p-MAPKs,IL-1β and TNF-α in SGCs under inflammatory conditions.Moreover,the increase in IL-1β and TNF-α was suppressed by L703,606,U0126 and SB203580 in vivo and in vitro.These present findings suggested that SP,released from TG neurons,activated SGCs through the ERK1/2 and P38 pathways and promoted the production of IL-1β and TNF-α from SGCs,contributing to inflammatory orofacial pain associated with peripheral sensitization. | Yanyan Zhang Ning Song Fei Liu Jiu Lin Mengke Liu Chaolan Huang Daqing Liao Cheng Zhou Hang Wang Jiefei Shen | 2019 | International Journal of Oral Science2019，11，3： | 6 |
| 12 | A HIGH RESOLUTION FINITE VOLUME METHOD FOR SOLVING SHALLOW WATER EQUATIONS显示文摘A high resolution finite volume numerical method for solving the shallow water equations is developed in this paper. In order to extend finite difference TVD scheme to finite volume method, a new geometry and topology of control bodies is defined by considering the corresponding relationships between nodes and elements. This solver is implemented on arbitrary quadrilateral meshes and their satellite elements, and based on a second order hybrid type of TVD scheme in space discretization and a two step Runge Kutta method in time discretization. Then it is used to deal with two typical dam break problems and very satisfactory results are obtained comparied with other numerical solutions. It can be considered as an efficient implement for the computation of shallow water problems, especially concerning those having discontinuities, subcritical and supercritical flows and complex geometries. | Wang Jia song School of Civil Engineering and Mechanics, Shanghai Jiaotong University, Shanghai 200030, P.R.ChinaNi Hang gen Department of Civil and Structure Engineering, Dalian University of Technology, Dalian 116024, P.R.China | 2000 | Journal of Hydrodynamics2000，12，1： | 5 |
| 13 | 2,3,5,4'-Tetra hyd roxystil bene-2-O-β-D-gl ucoside protects murine hearts against ischemia/reperfusion injury by activating Notchl/Hesl signaling and attenuating endoplasmic reticulum stress显示文摘2,3,5,4-Tetrahydroxystilbene-2-O--D-glucoside (TSG ) 是从蓼 multiflorum Thunb 提取的一个水溶性的活跃部件。很多研究证明 TSG 施加 cardioprotective 效果。自从 endoplasmic 蜂窝胃(嗯) 应力在导致的心肌的 ischemia/reperfusion (MI/R ) 起一个关键作用房间 apoptosis,我们寻求了决定 ER 压力的调整是否在 MI/R 损害期间涉及 TSG 的 cardioprotective 行动。雄的老鼠与 TSG 被对待(60 mg ??? ?????????????? ??? 猯'T? 删 ?? 乃 ?????? 瀠瑡潨桰獹潩潬祧吗?? | Meng ZHANG Li-ming YU Hang ZHAO Xuan-xuan ZHOU Qian YANG Fan SONG Li YAN Meng-en ZHAI Bu-ying LI Bin ZHANG Zhen-xiao JIN Wei-xun DUAN Si-wang WANG | 2017 | Acta Pharmacologica Sinica2017，38，3： | 5 |
| 14 | Simultaneous determination of indapamide,perindopril and perindoprilat in human plasma or whole blood by UPLC-MS/MS and its pharmacokinetic application显示文摘Simple and sensitive methods were developed for the determination of indapamide, perindopril and its active metabolite perindoprilat in human plasma or whole blood by hyphenated ultra-performance liquid chromatography-mass spectrometry(UPLC-MS/MS). Indapamide-d3, perindopril-d4 and perindoprilat-d4 were used as the internal standards. The separation was performed on a Thermo BDS Hypersil C_(18) column(4.6 mm×100 mm, 2.4 mm) for indapamide and perindopril simultaneously following a protein precipitation pretreatment of the biosamples. The separation of perindoprilat was achieved independently on a phenomenex PFP column(4.6 mm×150 mm, 5 mm). All the analytes were quantitated with positive electrospray ionization and multiple reactions monitoring mode. The assay exhibited a linear range of 1–250 ng/mL for indapamide, 0.4–100 ng/mL for perindopril and 0.2–20 ng/mL for perindoprilat. The methods were fully validated to meet the requirements for bioassay in accuracy, precision,recovery, reproducibility, stabilities and matrix effects, and successfully applied to the pharmacokinetic study of perindopril tert-butylamine/indapamide compound tablets in Chinese healthy volunteers and the comparative pharmacokinetic study between plasma and whole blood. | Yi Tao Sheng Wang Lei Wang Min Song Taijun Hang | 2018 | Journal of Pharmaceutical Analysis2018，8，5： | 5 |
| 15 | Photocatalytic Dye Methyl Orange Decomposition on Ternary Sulfide (CdIn2S4) under Visible-light显示文摘A novel and efficient photocatalyst, CdIn2S4, was simply prepared by a programmed temperature hydrothermal method. The product had a nanometer size (10-15 nm) and strong absorption in the range of 200 to 580 nm, and it exhibited visible-light photocatalytic activity to decompose dye methyl orange in aqueous system. | Xiao Dan YU Xue Song QU Yi Hang GUO Chang Wen HU | 2005 | Chinese Chemical Letters2005，16，9： | 5 |
| 16 | Seed dormancy and germination characteristics of two Rheum species in the Himalaya-Hengduan Mountains显示文摘Seed dormancy and germination characteristics are important factors determining plant reproductive success, and may be expected to have a major influence on plant distribution. In this study, we aimed to explore the characteristics of seed dormancy and germination in two endemic Rheum species(Rheum nobile and Rheum alexandrae) in the Himalaya-Hengduan Mountains. To determine the type of dormancy,fresh seeds of the two species(one population each) were incubated in light at 25/15 and 15/5℃, and then dry after-ripening(DAR) seeds were incubated on water agar substrate with or without GA_3. To determine the effect of temperature and light on germination, DAR seeds of the two species(two populations each) were incubated both in the light and in the dark at several temperatures, including constant and alternating temperatures. Base temperature(T_b) and thermal times for 50% germination(θ_(50)) were calculated. DAR released physiological dormancy(PD), increasing final germination at 15/5℃ and widening the range of germination temperatures from higher to lower, indicative of type 2 non-deep PD for the two Rheum species. Light had no significant effect on germination of seeds from the two species(two populations each). Seeds of the two species germinated significantly better(>80%) at medium temperatures(10-25℃) than at extreme low(5℃) or high(35℃) temperatures. Alternating temperatures(25/15 and 15/5℃) did not significantly increase the final germination of the two species either in the light and in the dark, but it promoted seed germination more quickly than corresponding constant temperatures in the light in both Rh. alexandrae populations, especially at 15/5℃. Germination in response to temperature was well described by the thermal-time model at suboptimal temperatures. The estimated Tbvalues were 1 and 0.9℃, respectively, in two Rh. nobile populations; 4 and 4.1℃,respectively, in two Rh. alexandrae populations; θ_(50)(thermal time) were 100 and 125℃d, respectively in two Rh. nobile populations; 76.92 and 83.33℃d, respectively in two Rh. alexandrae populations. The dormancy type, and germination responses to temperature and light condition does not explain why the two Rheum species are distributed in contrasting habitats. However, these findings reflect an advantageous germination strategy of these two Rheum species to adapt to the same alpine environments. | Deli Peng Zhe Chen Xiaojian Hu Zhimin Li Bo Song Hang Sun | 2017 | Plant Diversity2017，39，4： | 4 |
| 17 | 2010–2014年广州市结直肠癌发病率的时空分析显示文摘背景与目的结直肠癌(colorectal cancer,CRC)是一种常见的恶性肿瘤。本研究分析了2010–2014年广州地区结直肠癌发病率的时空分布。方法结直肠癌发病数据来自广州癌症登记系统。采用空间自相关分析和回顾性时空扫描评估CRC病例的时空聚集分布。结果 2010–2014年期间,在广州共登记了14,618例CRC病例,粗发病率为35.56/100,000,世界人口标化发病率(age?standardized rate of incidence by the world standard population,ASRIW)为23.58/100,000。粗发病率从2010年(32.88/100,000)到2014年(39.36/100,000)增长了19.70%,平均年变化率(average annual percentage change,AAPC)为4.33%。ASRIW的AAPC无统计学意义。空间自相关分析显示了广州市中心城区为一个CRC的发病热点,该区域包括了位于白云区西南部、海珠区西北部以及荔湾和越秀区的交界部的共25条街道。CRC发病聚集区的时空扫描分析确定了3个高发和5个低发病聚集区。高发聚集区位于中心城区,包括白云、海珠、荔湾和越秀区之间的交界地区。结论本研究展示出了广州地区CRC发病率的时空聚集模式。该数据可为CRC筛查中合理分配健康资源提供参考信息。 | Ke Li Guo-Zhen Lin Yan Li Hang Dong Huan Xu Shao-Fang Song Ying-Ru Liang Hua-Zhang Liu | 2018 | 癌症2018，37，5： | 4 |
| 18 | Woolly and overlapping leaves dampen temperature fluctuations in reproductive organ of an alpine Himalayan forb显示文摘Aims studying the ecological significance of highly specialized morpho-logical traits evolved by alpine plants could help us to understand the adaptation and evolution of these plants under severe alpine environ-ment.We explored the adaptive significance of woolly and overlap-ping leaves for reproduction in Eriophyton wallichii,a perennial herb native to the subnival belt of the Himalaya-Hengduan mountains.Methods We examined whether the trichomes could influence the leaf wet-tability,temperature and leaf reflectance spectra in the lab.and we investigated the thermal benefits of the woolly and overlapping leaves for flowers and fruits in the field.Pollen viability and seed germination were also examined in the lab to assess whether these leaves enhance reproductive fitness.Important Findingsour results showed that dense trichomes impart good water repel-lency,absorption of solar radiation and accumulation of leaf heat.The woolly and overlapping leaves increased the interior tempera-ture of flowers and fruits to an optimal level on sunny hours,but prevented them from overheating when transient intense solar radi-ation occurs.This kept optimal temperatures in plants’reproduc-tive organs,thus promoting the development of pollen and seed in alpine environment. | De-Li Peng Yang Niu Bo Song Jian-Guo Chen Zhi-Min Li Yang Yang Hang Sun | 2015 | Journal of Plant Ecology2015，8，2： | 4 |
| 19 | The combination of chidamide with the CHOEP regimen in previously untreated patients with peripheral T-cell lymphoma: a prospective, multicenter, single arm, phase 1b/2 study显示文摘Objective:To assess the efficacy and safety of the novel histone deacetylase inhibitor,chidamide,in combination with cyclophosphamide,doxorubicin,vincristine,etoposide,and prednisone(Chi-CHOEP)for untreated peripheral T-cell lymphoma(PTCL).Methods:A prospective,multicenter,single arm,phase 1 b/2 study was conducted.A total of 128 patients with untreated PTCL(18–70 years of age)were enrolled between March 2016 and November 2019,and treated with up to 6 cycles with the Chi-CHOEP regimen.In the phase 1 b study,3 dose levels of chidamide were evaluated and the primary endpoint was determination of the maximumtolerated dose and recommended phase 2 dose(RP2 D).The primary endpoint of the phase 2 study was 2-year progression-free survival(PFS).Results:Fifteen patients were enrolled in the phase 1 b study and the RP2 D for chidamide was determined to be 20 mg,twice a week.A total of 113 patients were treated at the RP2 D in the phase 2 study,and the overall response rate was 60.2%,with a complete response rate of 40.7%.At a median follow-up of 36 months,the median PFS was 10.7 months,with 1-,2-,and 3-year PFS rates of 49.9%,38.0%,and 32.8%,respectively.The Chi-CHOEP regimen was well-tolerated,with grade 3/4 neutropenia occurring in approximately two-thirds of the patients.No unexpected adverse events(AEs)were reported and the observed AEs were manageable.Conclusions:This large cohort phase 1 b/2 study showed that Chi-CHOEP was well-tolerated with modest efficacy in previously untreated PTCL patients. | Wei Zhang Liping Su Lihong Liu Yuhuan Gao Quanshun Wang Hang Su Yuhuan Song Huilai Zhang Jing Shen Hongmei Jing Shuye Wang Xinan Cen Hui Liu Aichun Liu Zengjun Li Jianmin Luo Jianxia He Jingwen Wang O.A.O’Connor Daobin Zhou | 2021 | Cancer Biology & Medicine2021，18，3： | 4 |
| 20 | The effects of diltiazem in renal transplantation patients treated with cyclosporine A显示文摘Objective:To investigate the effects of diltiazem and cyclosporine A(CsA)combination therapy on protecting the kidney,promoting graft functioning and improving post-transplanted kidney recovery.Methods:The blood concentrations of CsA,the condition of the post-transplant kidney,the rate of acute rejection(AR),as well as hepatic and renal toxicity in 636 cases of renal transplant recipients were determined after being treated by CsA,with or without diltiazem.Results:Compared with the control group which received CsA,mycophenolate mofetil(MMF) and prednisolone(Pred)but lacked diltiazem,the group receiving these agents together with diltiazem required reduced dosage of CsA(P<0.01),while blood concentrations of CsA were significantly increased(P<0.01);the recovery time of graft function was reduced from(6.2±1.5)d to(3.9±1.4)d(P<0.01),and the rate of AR was decreased from 13.2%to 7.9%(P<0.01).Conclusion:In renal transplantation patients treated with CsA and diltiazem,blood concentrations of CsA were increased while the dosage was decreased.This efficient combination therapy reduced patients'economic burden,at the same time retained kidney function,promoted graft function recovery and decreased hepatic and renal toxicity and the rate of AR. | Wujun Xue Yong Song Puxun Tian Xiaoming Ding Xiaoming Pan Hang Yan Jun Hou Xinshun Feng Heli Xiang Xiaohui Tian | 2010 | The Journal of Biomedical Research2010，24，4： | 4 |
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