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| 1 | Stability improvement under high efficiency—next stage development of perovskite solar cells显示文摘With efficiency of perovskite solar cells(PSCs) overpassing 23%, to realize their commercialization, the biggest challenge now is to boost the stability to the same level as conventional solar cells. Thus, tremendous effort has been directed over the past few years toward improving the stability of these cells. Various methods were used to improve the stability of bulk perovskites,including compositional engineering, interface adjustment, dimensional manipulation, crystal engineering, and grain boundary decoration. Diverse device configurations, carrier transporting layers, and counter electrodes are investigated. To compare the stability of PSCs and clarify the degradation mechanism, diverse characterization methods were developed. Overall stability of PSCs has become one central topic for the development of PSCs. In this review, we summarize the state-of-the-art progress on the improvement of device stability and discuss the directions for future research, hoping it provides an overview of the current status of the research on the stability of PSCs and guidelines for future research. | Danni Yu Yue Hu Jiangjian Shi Haoying Tang Wenhao Zhang Qingbo Meng Hongwei Han Zhijun Ning He Tian | 2019 | Science China Chemistry2019，62，6： | 7 |
| 2 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 3 | A BODIPY-based Fluorescent Probe for Thiophenol显示文摘 | Dongxiang Zhang Ning Xu Liman Xian Haoying Ge Jiangli Fan Jianjun Du Xiaojun Peng | 2018 | Chinese Journal of Chemistry2018，36，2： | 3 |
| 4 | Isolation of Trehalose-6-Hosphate Phosphatase Gene from Tobacco and Its Functional Analysis in Yeast Cells显示文摘 | WANG Y J HAOY J ZHANG Z G | 2005 | J Plant Physiol2005，162，2： | 1 |
| 5 | Advances in understanding epigenetic regulation of plant trichome development: a comprehensive review显示文摘Plant growth and development are controlled by a complex gene regulatory network,which is currently a focal point of research.It has been established that epigenetic factors play a crucial role in plant growth.Trichomes,specialized appendages that arise from epidermal cells,are of great significance in plant growth and development.As a model system for studying plant development,trichomes possess both commercial and research value.Epigenetic regulation has only recently been implicated in the development of trichomes in a limited number of studies,and microRNA-mediated post-transcriptional regulation appears to dominate in this context.In light of this,we have conducted a review that explores the interplay between epigenetic regulations and the formation of plant trichomes,building upon existing knowledge of hormones and transcription factors in trichome development.Through this review,we aim to deepen our understanding of the regulatory mechanisms underlying trichome formation and shed light on future avenues of research in the field of epigenetics as it pertains to epidermal hair growth. | Yuming Dong Sen Li Haoying Wu Yiming Gao Zhongxuan Feng Xi Zhao Li Shan Zhongren Zhang Huazhong Ren Xingwang Liu | 2023 | Horticulture Research2023，10，9： | 0 |
| 6 | A Cascade Targeted and Activatable NIR-ⅡNanoprobe for Highly Sensitive Detection of Acute Myeloid Leukemia in an Orthotopic Model显示文摘Acute myeloid leukemia(AML)remains a significant concern in modern medicine.Early diagnosis is the key to improving the therapeutic effects of AML.In the present work,a cascade-targeted and activatable NIR-Ⅱ nanoprobe(Ald&A1094@Ag_(2)S)was developed for early detection of AML in an orthotopic model.Upon intravenous injection,Ald&A1094@Ag_(2)S effectively accumulated in bone tissue due to its high affinity for alendronate(Ald)to the bone.Thereafter,the AML microenvironment allowed for the membrane-penetrating peptide TAT(cell‐penetrating peptide(CGRRRQRRKKRG))to be exposed via pH-sensitive hydrazone bond-mediated detaching of bone-targeted ligands,resulting in efficient internalization of nanoprobes in HL60 cells.Endogenous peroxynitrite(ONOO–)in HL60 cells further activated NIR-Ⅱ fluorescence of Ag_(2)S QDs via A1094 oxidation,thereby inhibiting fluorescence resonance energy transfer(FRET).Such a unique cascade-targeted and activatable strategy enables the nanoprobes to only light up the AML lesion region in the bone marrow with negligible background effects,which holds great potential for clinical applications in the future. | Xiaohu Yang Xinyi An Sisi Ling Haoying Huang Yejun Zhang Guangcun Chen Chunyan Li &Qiangbin Wang | 2021 | CCS Chemistry2021，3，3： | 0 |
| 7 | PET imaging on neurofunctional changes after optogenetic stimulation in a rat model of panic disorder显示文摘Panic disorder (PD) is an acute paroxysmal anxiety disorder with poorly understood pathophysiology. The dorsal periaqueductal gray (dPAG) is involved in the genesis of PD. However, the downstream neurofunctional changes of the dPAG during panic attacks have yet to be evaluated in vivo. In this study, optogenetic stimulation to the dPAG was performed to induce panic-like behaviors, and in vivo positron emission tomography (PET) imaging with ,8F-flurodeoxyglucose (18F-FDG) was conducted to evaluate neurofunctional changes before and after the optogenetic stimulation. Compared with the baseline, post-optogenetic stimulation PET imaging demonstrated that the glucose metabolism significantly increased (P < 0.001) in dPAG, the cuneiform nucleus, the cerebellar lobule, the cingulate cortex, the alveus of the hippocampus, the primary visual cortex, the septohypothalamic nucleus, and the retrosplenial granular cortex but significantly decreased (P < 0.001) in the basal ganglia, the frontal cortex, the forceps minor corpus callosum, the primary somatosensory cortex, the primary motor cortex, the secondary visual cortex, and the dorsal lateral geniculate nucleus. Taken together, these data indicated that in vivo PET imaging can successfully detect downstream neurofunctional changes involved in the panic attacks after optogenetic stimulation to the dPAG. | Xiao He Chentao Jin Mindi Ma Rui Zhou Shuang Wu Haoying Huang Yuting Li Qiaozhen Chen Mingrong Zhang Hong Zhang Mei Tian | 2019 | Frontiers of Medicine2019，13，5： | 0 |
| 8 | Switching Phenomena of CuTCNQ Induced Mainly by the Interaction among Microcrystaline Grains显示文摘CuTCNQ organic films were prepared separately by spontaneous charge transfer(CT) reaction of Cu with TCNQ in an acetonitrile or thermally activated solid phase diffusion and CT reaction of an alternative vapor deposition of Cu and TCNQ thin films. The m | Gu Ning a1 Sheng Haoying b Lu Wu a1 Pang Shuming a2 Zhang Lan b Wei Yu a1 ( a1 Department of Biology Science and Medical Engineering,Southeast University,Nanjing 210018) ( a2 Department of Electronics Engineering, South | 1996 | Journal of Southeast University(English Edition)1996，12，1： | 0 |
| 9 | Se-sensitized NIR hot band absorption photosensitizer for anti-Stokes excitation deep photodynamic therapy显示文摘Conventional anti-Stokes materials-involved deep photodynamic therapy(dPDT)requires much high-intensity irradiance due to low photosensitization efficiency.Herein,we proposed a'booster effector'approach to construct highly efficient hot band absorption phototherapeutics for low/biosafety power anti-Stokes light-triggered d PDT.Se,as'booster effector',was introduced into hot band absorption luminophores(HBAs),which not only significantly facilitated intersystem crossing,but also simultaneously enhanced hot band excitation efficiency atν808,as a result successfully enabling excellent photogenerated singlet oxygen capability of HBAs under ultra-low power anti-Stokes excitation(10 mW cm^(-2)in vitro).As far as we know,such low laser power-initiated photosensitization activity has never been reported in the existing anti-Stokes material systems.Importantly,FUC-Se ME can self-assemble into uniform nanospheres in water,greatly boosting cellular uptake(>25-fold larger than FUC-Se),and achieve superior cancer-killing effect(808 nm,10 mW cm^(-2),5 min,the half-maximal inhibitory concentration IC50=1.36μM).After further PEGylation with folate-attached polymer,the resultant FUC-Se ME@FA can effectively enrich at the tumor(signal-to-background ratio,10).Under safety irradiation(330 mW cm^(-2)),FUC-Se ME@FA effectively inhibits deep-seated tumor progression(the tumor growth inhibition rate,84%).This work provides a successful paradigm,possibly being more clinically beneficial than conventional anti-Stokes materials. | Dandan Ma Hui Bian Saran Long Panwang Zhou Ruisong Tian Yingnan Wu Haoying Ge Mingle Li Jianjun Du Jiangli Fan Yukui Zhang Xiaojun Peng | 2022 | Science China Chemistry2022，65，3： | 0 |
| 10 | Flow control of double bypass variable cycle engine in modal transition显示文摘To study the change mechanism and the control of the variable cycle engine in the process of modal transition,a variable cycle engine model based on component level characteristics is established.The two-dimensional CFD technology is used to simulate the influence of mode selection valve rotation on the engine flow field,which improves the accuracy of the model.Furthermore,the constant flow control plan is proposed in the modal transition process to reduce the engine installed drag.The constant flow control plan adopts the augmentation linear quadratic regulator control method.Simulation results indicate that the control method is able to effectively control the bypass ratio and demand flow of the variable cycle engine,and make the engine transform smoothly,which ensures the stable operation of the engine in modal transition and the constant demand flow of the engine. | Haoying CHEN Changpeng CAI Jiayi LUO Haibo ZHANG | 2022 | Chinese Journal of Aeronautics2022，35，10： | 0 |
| 11 | Research on the detection of early caries based on hyperspectral imaging显示文摘Objective:We applied hyperspectral imaging(HSI)system to distinguish early caries from soundand pigmented areas.It will provide a theoretical basis and technical support,for research anddevelopment of an instrument that could be used for screening and detection of early dentalcaries.Methods:Eighteen extracted human teeth(molars and premolars),with varying degrees ofnatural pathology and no degree of decay involving dentin were obtained.HSI system with awavelength range from 400 to 1000nm was used to obtain images of all 18 teeth containingsound,carious and pigmented areas.We compared the spectra of the wavebands at both 500 nmand 780 nm from the different tooth states,and the reflectance diference bet ween sound versuscarious lesions and sound versus pigmented areas,respectively.Results:There was a slight diference in refectance bet ween carious areas and pigmented areas at500 nm.A substantial difference was additionally noted in refectance bet ween carious areas andpigmented areas at 780 nm.Conclusion:The results have shown that the interference of tooth surface pigment can be elim-inated in the near-infrared(NIR)waveband,and the caries can be effectively identifed from the pigmented areas.Thus,it could be used to detect carious areas of teeth in place of the traditionalvisual inspection method or white light endoscopy.Clinical significance:The NIR difused light signal enables the identification of early caries frompigment and other interference,providing a reasonable detection tool for early detection andearly treatment of teeth diseases. | Cheng Wang Haoying Zhang Guangyun Lai Songzhu Hu Jun Wang Dawei Zhang | 2023 | Journal of Innovative Optical Health Sciences2023，16，3： | 0 |
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