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| 1 | ICG@ZIF-8:One-step encapsulation of indocyanine green in ZIF-8 and use as a therapeutic nanoplatform显示文摘How to fabricate zeolitic imidazole framework-8(ZIF-8) based therapeutic nanoplatform will be of significance in biomedicine considering its good biocompatibility. Herein, we report a one-step encapsulation of indocyanine green(ICG) in ZIF-8 nanoparticles(NPs). The as-prepared ICG@ZIF-8 NPs possess an absorption band in the near infrared region and have the good photothermal conversion efficiency. The in vivo and in vitro studies show that, after loading chemotherapy agent hydrophobic doxorubicin(DOX), ICG@ZIF-8-DOX NPs exhibit the chem-and photothermal synergistic therapy for tumor. In addition, it is found that the embedded ICG molecules in ICG@ZIF-8 NPs can be disassociated and released into the solution upon the 808 nm laser irradiation, demonstrating that as-prepared ICG@ZIF-8 NPs can also be used as the optical imaging probe to trace the degradability behavior of resulting NPs in | Chao Yang Jing Xu Dandan Yang Xiaoxiao Wang Bin Liu Nongyue He Zhifei Wang | 2018 | Chinese Chemical Letters2018，29，9： | 5 |
| 2 | s-HBEGF/SIRT1 circuit-dictated crosstalk between vascular endothelial cells and keratinocytes mediates sorafenib-induced hand-foot skin reaction that can be reversed by nicotinamide显示文摘Hand-foot skin reaction(HFSR),among the most significant adverse effects of sorafenib,has been limiting the clinical benefits of this frontline drug in treating various malignant tumors.The mechanism underlying such toxicity remains poorly understood,hence the absence of effective intervention strategies.In the present study,we show that vascular endothelial cells are the primary cellular target of sorafenib-induced HFSR wherein soluble heparin-binding epidermal growth factor(s-HBEGF)mediates the crosstalk between vascular endothelial cells and keratinocytes.Mechanistically,s-HBEGF released from vascular endothelial cells activates the epidermal growth factor receptor(EGFR)on keratinocytes and promotes the phosphorylation of c-Jun N-terminal kinase 2(JNK2),which stabilizes sirtuin 1(SIRT1),an essential keratinization inducer,and ultimately gives rise to HFSR.The administration of s-HBEGF in vivo could sufficiently induce hyper-keratinization without sorafenib treatment.Furthermore,we report that HBEGF neutralization antibody,Sirtl knockdown,and a classic SIRTI inhibitor nicotinamide could all significantly reduce the sorafenib-induced HFSR in the mouse model.It is noteworthy that nicotinic acid,a prodrug of nicotinamide,could substantially reverse the sorafenib-induced HFSR in ten patients in a preliminary clinical study.Collectively,our findings reveal the mechanism of vascular endothelial cell-promoted keratinization in keratinocytes and provide a potentially promising therapeutic strategy for the treatment of sorafenib-induced HFSR. | Peihua Luo Hao Yan Xueqin Chen Ying Zhang Ziying Zhao Ji Cao Yi Zhu Jiangxia Du Zhifei Xu Xiaochen Zhang Su Zeng Bo Yang Shenglin Ma Qiaojun He | 2020 | Cell Research2020，30，9： | 5 |
| 3 | Direct sound field separation method on holography surface显示文摘In order to simplify the process which aims at separating the coherent sources located at different sides of holography surface,a direct sound field separation method which only depends on the data of holography surface is proposed.Assume that the reconstruction surface is holography surface,according to the equivalent sources located at the spherical surface,there exists a relationship between the measured sound pressure and the calculated value based on equivalent source method.Then,the coherent sources are separated.Numerical simulation analyzes the separation results when the interference sources are pulsating ball source and simply supported steel sheet with forced oscillation,respectively.The separation method is validated by experiment with two loudspeakers.The results show that the proposed method has high accuracy to the two kinds of interference sources and high tolerate deviation. | MAO Jin XU Zhongming LI Shu HE Yansong ZHANG Zhifei | 2017 | Chinese Journal of Acoustics2017，36，1： | 2 |
| 4 | Abundant heterointerfaces in MOF-derived hollow CoS_(2)-MoS_(2) nanosheet array electrocatalysts for overall water splitting显示文摘Rational coupling of hydrogen evolution reaction(HER) and oxygen evolution reaction(OER) catalysts is extremely important for practical overall water splitting,but it is still challenging to construct such bifunctional heterostructures.Herein,we present a metal-organic framework(MOF)-etching strategy to design free-standing and hierarchical hollow CoS_(2)-MoS_(2) heteronanosheet arrays for both HER and OER.Resulting from the controllable etching of MOF by MoO_(4)^(2-) and in-situ sulfuration,the obtained CoS_(2)-MoS_(2) possesses abundant heterointerfaces with modulated local charge distribution,which promote water dissociation and rapid electrocatalytic kinetics.Moreover,the two-dimensional hollow array architecture can not only afford rich surface-active sites,but also facilitate the penetration of electrolytes and the release of evolved H_(2)/O_(2) bubbles.Consequently,the engineered CoS_(2)-MoS_(2) heterostructure exhibits small overpotentials of 82 mV for HER and 266 mV for OER at 10 mA cm^(-2).The corresponding alkaline electrolyzer affords a cell voltage of 1.56 V at 10 mA cm^(-2) to boost overall water splitting,along with robust durability over 24 h, even surpassing the benchmark electrode couple composed of IrO_(2) and Pt/C The present work may provide valuable insights for developing MOF-derived heterogeneous electrocatalysts with tailored interface/surface structure for widespread application in catalysis and other energyrelated areas. | Yuanjian Li Wenyu Wang Baojun Huang Zhifei Mao Rui Wang Beibei He Yansheng Gong Huanwen Wang | 2021 | Journal of Energy Chemistry2021，30，6： | 2 |
| 5 | Synthesis of aptamer-functionalized Ag nanoclusters for MCF-7 breast cancer cells imaging显示文摘Aptamer-functionalized silver nanoclusters(Ag NCs) have been attracting a lot of interest as label-free probes which have been successfully applied to both cell imaging and molecular detection.MUCl aptamer is an ssDNA aptamer that specifically binds to MUCl mucin which is a large transmembrane glycoprotein whose expression level increases at least 10-fold in primary and metastatic breast cancers.Using C4A4C3-linker-MUCl as template,the Ag NCs were synthesized through one-pot process.The fluorescence intensity of Ag NCs was found to be closely related to the length and type(poly adenine or thymine) of the linker,the optimum linker being-AAAAA-.Using the C4A4C3-A5-MUC1 as the scaffold,the synthesized Ag NCs emitted fluorescence with high quantum yield(QY) of 66.5%.Based on the specific interaction between the MUCl aptamer and MUCl mucin,the C4A4C3-A5-MUC1-stabilized Ag NCs could recognize and differentiate the MCF-7 breast cancer cells from MDA-MB-231 breast cancer and A549 human lung cancer cells. | Taotao Li Jingjing Yang Zeeshan Ali Zunliang Wang Xianbo Mou Nongyue He Zhifei Wang | 2017 | Science China Chemistry2017，60，3： | 2 |
| 6 | Going below and beyond the surface: Microneedle structure, materials, drugs, fabrication, and applications for wound healing and tissue regeneration显示文摘Microneedle, as a novel drug delivery system, has attracted widespread attention due to its non-invasiveness, painless and simple administration, controllable drug delivery, and diverse cargo loading capacity. Although microneedles are initially designed to penetrate stratum corneum of skin for transdermal drug delivery, they, recently, have been used to promote wound healing and regeneration of diverse tissues and organs and the results are promising. Despite there are reviews about microneedles, few of them focus on wound healing and tissue regeneration. Here, we review the recent advances of microneedles in this field. We first give an overview of microneedle system in terms of its potential cargos (e.g., small molecules, macromolecules, nucleic acids, nanoparticles, extracellular vesicle, cells), structural designs (e.g., multidrug structures, adhesive structures), material selection, and drug release mechanisms. Then we briefly summarize different microneedle fabrication methods, including their advantages and limitations. We finally summarize the recent progress of microneedle-assisted wound healing and tissue regeneration (e.g., skin, cardiac, bone, tendon, ocular, vascular, oral, hair, spinal cord, and uterine tissues). We expect that our article would serve as a guideline for readers to design their microneedle systems according to different applications, including material selection, drug selection, and structure design, for achieving better healing and regeneration efficacy. | Shang Lyu Zhifei Dong Xiaoxiao Xu Ho-Pan Bei Ho-Yin Yuen Chung-Wai James Cheung Man-Sang Wong Yong He Xin Zhao | 2023 | Bioactive Materials2023，，9： | 2 |
| 7 | Effect of high-pressure treatment on the fatty acid composition of intramuscular lipid in pork显示文摘 | Zhifei He Yechuan Huang Hongjun Li Gang Qin Ting Wang Jiayi Yang | 2011 | Meat Science2011，，1： | 1 |
| 8 | Effect of antioxidant on the fatty acid composition and lipid oxidation of intramuscular lipid in pressurized pork 显示文摘 | Yechuan Huang Zhifei He Hongjun Li | 2012 | Meat Science2012，91，： | 1 |
| 9 | Effect of antioxidant on the fatty acid composition and lipid oxidation of intramuscular lipid in pressurized pork显示文摘 | HUANG Yechuan HE Zhifei LI Hongjun | 2012 | Meat Science2012，91，2： | 1 |
| 10 | Optimization of nobiletin extraction assisted by microwave from orange byproduct using response surface methodology显示文摘 | Yu Zhang Hongjun Li Huating Dou Zhifei He Houjiu Wu Zhigao Sun Hua Wang Xuegen Huang Yaqin Ma | 2013 | Food Science and Biotechnology2013，，1： | 1 |
| 11 | Development and application of a method for the analysis of two trichothecenes:deoxynivalenol and T 2 toxin in meat in China by HPLC MS/MS显示文摘 | Zou Zhongyi He Zhifei Li Hongjun | 2012 | Meat Science2012，90，3： | 1 |
| 12 | Development and application of a method for the analysis of two trichothecenes: Deoxynivalenol and T-2 toxin in meat in China by HPLC–MS/MS显示文摘 | Zhongyi Zou Zhifei He Hongjun Li Pengfei Han Jun Tang Cunxian Xi Yingguo Li Lei Zhang Xianliang Li | 2011 | Meat Science2011，，3： | 1 |
| 13 | Effect ofantioxidant on the fatty acid composition and lipid oxidation ofintramuscular lipid in pressurized pork显示文摘 | Yechuan Huangr Zhifei He Hongjun Li | 2012 | Meat Science2012，91，： | 1 |
| 14 | Development and application of a method for the analysis of two trichothecenes : de- oxynivalenol and T-2 toxin in meat in China by HPLC-MS/MS显示文摘 | Zou Zhongyi He Zhifei Li Hongjun | 2012 | Meat Science2012，90，3： | 1 |
| 15 | Development andapplication of a method for the analysis of two trichothecenes:deoxynivalenol and T-2 toxin in meat in China by HPLC-MS/MS显示文摘 | ZOU Zhongyi HE Zhifei LI Hongjun | 2012 | Meat Science2012，90，3： | 1 |
| 16 | Synthesis and characteristics of carbon encapsulated magnetic nanoparticles produced by a hydrothermal reaction 显示文摘 | WANG Zhifei XIAO Pengfen HE Nongyue | 2006 | Carbon2006，44，15： | 1 |
| 17 | Study on dual-site inhibitors of acetylcholinestemse: Highly potent derivatives ofbis-and bifunctional huperzine B显示文摘 | He Xuchang Feng Song Wang Zhifei | 2007 | Bioorganic & Medicinal Chemistry2007，15，3： | 1 |
| 18 | Development and application of a method for the analysis of two trichothecenes: Deoxynivalenol and T-2 toxin in meat in China by HPLC-MS/MS显示文摘 | ZOU Zhongyi HE Zhifei LI Hongjun | 2012 | Meat Science2012，90，3： | 1 |
| 19 | Development of an Open - Air and Robust Method for Large - Scale Palladium - Catalyzed Cyanation of Aryl Halides: The Use of i - PrOH to Prevent Catalyst Poisoning by Oxygen 显示文摘 | Yunlai Ren Zhifei Liu Shebin He | 2009 | Organic Process Research & Development2009，13，： | 1 |
| 20 | Study on the flavor contribution of phospholipids and triglyccrides to pork显示文摘 | HUANG Yechuan LI Hongjun HE Zhifei | 2010 | Food Science and Biotcchnology2010，19，5： | 1 |
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