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| 1 | Arsenic Disulfide Induced Apoptosis and Concurrently Promoted Erythroid Differentiation in Cytokine-Dependent Myelodysplastic Syndrome-progressed Leukemia Cell Line F-36p with Complex Karyotype Including Monosomy 7显示文摘Objective:Acute myeloid leukemia progressed from myelodysplastic syndrome(MDS/AML)is generally incurable with poor prognosis for complex karyotype including monosomy 7(-7).Qinghuang Powder(青黄散,QHP),which includes Qing Dai(Indigo naturalis)and Xiong Huang(realgar)in the formula,is effective in treating MDS or MDS/AML even with the unfavorable karyotype,and its therapeutic efficacy could be enhanced by increasing the Xiong huang content in the formula,while Xiong huang contains>90%arsenic disulfide(As_2S_2).F-36p cell line was established from a MDS/AML patient with complex karyotype including-7,and was in cytokine-dependent.The present study was to investigate the effects of AS_2S_2 on F-36p cells.Methods:Cell proliferation was measured by an3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)assay.Cell apoptosis was identified by Annexin V-staining.Cell viability was determined by a propidium iodide(PI)exclusion.Erythroid differentiation was evaluated by the expression of cell surface antigen CD235a(GpA).Results:After treatment with AS_2S_2,at concentrations of 0.5to 16μmol/L for 72 h,As_2S_2 inhibited the proliferation of F-36p cells.The 50%inhibitory concentrations(IC_(50))of As_2S_2against the proliferation of F-36p cells was 6μmol/L.The apoptotic cells significantly increased in a dose-dependent mannar(P<0.05).The cell viabilities were significantly inhibited by As_2S_2 dose-dependent in a dose-dependent manner(P<0.05).Significant increases of CD235a-positive cells were concurrently observed(P<0.05)also in a dosedependent manner.Conclusions:As_2S_2 could inhibit proliferation and viability,induce apoptosis,and concurrently promote erythroid differentiation dose-dependently in F-36p cells.AS_2S_2 can inhibit proliferation and viability,induce apoptosis,and concurrently promote erythroid differentiation in cytokine-dependent MDS-progressed human leukemia cell line F-36p with complex karyotype including-7.The data suggest that QHP and/or As_2S_2 could be a potential candidate in the treatment of MDS or MDS/AML even with unfavorable cytogenetics. | 胡晓梅 Sachiko Tanaka Kenji Onda 袁博 Hiroo Toyoda 麻柔 刘峰 Toshihiko Hirano | 2014 | Chinese Journal of Integrative Medicine2014，20，5： | 20 |
| 2 | Novel zinc alloys for biodegradable surgical staples显示文摘BACKGROUND The development of biodegradable surgical staples is desirable as non-biodegradable Ti alloy staples reside in the human body long after wound healing, which can cause allergic/foreign-body reactions, adhesion, or other adverse effects. In order to develop a biodegradable alloy suitable for the fabrication of surgical staples, we hypothesized that Zn, a known biodegradable metal, could be alloyed with various elements to improve the mechanical properties while retaining biodegradability and biocompatibility. Considering their biocompatibility, Mg, Ca, Mn, and Cu were selected as candidate alloying elements, alongside Ti, the main material of clinically available surgical staples.AIM To investigate the in vitro mechanical properties and degradation behavior and in vivo safety and feasibility of biodegradable Zn alloy staples.METHODS Tensile and bending tests were conducted to evaluate the mechanical properties of binary Zn alloys with 0.1–6 wt.% Mg, Ca, Mn, Cu, or Ti. Based on the results,three promising Zn alloy compositions were devised for staple applications(wt.%): Zn-1.0Cu-0.2Mn-0.1Ti(Zn alloy 1), Zn-1.0Mn-0.1Ti(Zn alloy 2), and Zn-1.0Cu-0.1Ti(Zn alloy 3). Immersion tests were performed at 37℃ for 4 wk using fed-state simulated intestinal fluid(Fe SSIF) and Hank’s balanced salt solution(HBSS). The corrosion rate was estimated from the weight loss of staples during immersion. Nine rabbits were subjected to gastric resection using each Zn alloy staple, and a clinically available Ti staple was used for another group of nine rabbits. Three in each group were sacrificed at 1, 4, and 12 wk post-operation.RESULTS Additions of ≤1 wt.% Mn or Cu and 0.1 wt.% Ti improved the yield strength without excessive deterioration of elongation or bendability. Immersion tests revealed no gas evolution or staple fracture in any of the Zn alloy staples. The corrosion rates of Zn alloy staples 1, 2, and 3 were 0.02 mm/year in HBSS and 0.12, 0.11, and 0.13 mm/year, respectively, in Fe SSIF. These degradation times are sufficient for wound healing. The degradation rate is notably increased under low pH conditions. Scanning electron microscopy and energy dispersive spectrometry surface analyses of the staples after immersion indicated that the component elements eluted as ions in Fe SSIF, whereas corrosion products were produced in HBSS, inhibiting Zn dissolution. In the animal study, none of the Zn alloy staples caused technical failure, and all rabbits survived without complications. Histopathological analysis revealed no severe inflammatory reaction around the Zn alloy staples.CONCLUSION Staples made of Zn-1.0Cu-0.2Mn-0.1Ti, Zn-1.0Mn-0.1Ti, and Zn-1.0Cu-0.1Ti exhibit acceptable in vitro mechanical properties, proper degradation behavior,and in vivo safety and feasibility. They are promising candidates for biodegradable staples. | Hizuru Amano Koichi Miyake Akinari Hinoki Kazuki Yokota Fumie Kinoshita Atsuko Nakazawa Yujiro Tanaka Yasuhiro Seto Hiroo Uchida | 2020 | World Journal of Clinical Cases2020，8，3： | 2 |
| 3 | JGES guidelines for colorectal endoscopic submucosal dissection/endoscopic mucosal resection显示文摘 | Shinji Tanaka Hiroshi Kashida Yutaka Saito Naohisa Yahagi Hiroo Yamano Shoichi Saito Takashi Hisabe Takashi Yao Masahiko Watanabe Masahiro Yoshida Shin‐ei Kudo Osamu Tsuruta Ken‐ichi Sugihara Toshiaki Watanabe Yusuke Saitoh Masahiro Igarashi Takashi Toyon | 2015 | Digestive Endoscopy2015，，4： | 2 |
| 4 | Effect of Sevelamer and Calcium-Based Phosphate Binders on Coronary Artery Calcification and Accumulation of Circulating Advanced Glycation End Products in Hemodialysis Patients显示文摘 | Takatoshi Kakuta Reika Tanaka Toru Hyodo Hajime Suzuki Genta Kanai Mikako Nagaoka Hiroo Takahashi Nobuhito Hirawa Yoichi Oogushi Toshio Miyata Hiroyuki Kobayashi Masafumi Fukagawa Akira Saito | 2011 | American Journal of Kidney Diseases2011，，3： | 2 |
| 5 | Hofmann reaction of polyacrylamide reahionship between reaction condition and degree of polymerization of polyvinylamine 显示文摘 | Hiroo Tanaka | 1979 | Journal of Polymer Science : Polymer Chemistry Edition1979，17，4： | 1 |
| 6 | Preparation of polyvinlamine by the Hofmann degradation of polyacrylamide 显示文摘 | TANAKA Hiroo SENJU Ryoichi | 1976 | Bulletin of The Chemical Society of Japan1976，49，10： | 1 |
| 7 | Copolymerization of cationic monomers with acrylamide in an aqueous solution显示文摘 | Hiroo Tanaka | 1986 | Journal of Polymer Science: Part A: Polymer Chemistry Edition1986，24，： | 1 |
| 8 | Surface analysis of paper con- taining polymer additives by X-ray pholoelectron spectroscopy 1:Application to paper containing dry strength additives显示文摘 | Shaoping Chen Hiroo Tanaka | 1988 | J Wood Sci1988，44，： | 1 |
| 9 | Evaluation of risk for incident hypertension using glomerular filtration rate in the normotensive general population显示文摘 | Hiroyuki Takase Yasuaki Dohi Takayuki Toriyama Tateo Okado Satoru Tanaka Hiroo Sonoda Genjiro Kimura | 2012 | Journal of Hypertension2012，，3： | 1 |
| 10 | Transfer of cationic retention aid from fibers to fine particles and cleavage of polymer chains under wet - end papermaking conditions显示文摘 | Hiroo Tanaka Agne Swefin | 1993 | TAPPI1993，76，5： | 1 |
| 11 | Technical Survey on Polymer Additives for Papermaking 显示文摘 | Hiroo Tanaka | 1996 | Mokuzai Gakkaishi1996，42，11： | 1 |
| 12 | Effects of polyamine structure on rosin sizing under neutral papermaking conditions 显示文摘 | WU Zong-hua CHEN Shao-ping TANAKA Hiroo | 1997 | J Appl Polym Sci1997，65，： | 1 |
| 13 | Hofmann reaction of polyacrylamide: Relationship between reaction condition and degree of polymerization of polyvinylamine显示文摘 | TANAKA Hiroo | 1979 | J Polym Sci: Polym Chem1979，17，： | 1 |
| 14 | Aminated poly-N-vinylformamide as a modem retention aid of alkaline paper sizing with acid rosin sizes 显示文摘 | Wang Fei Tanaka Hiroo | 2000 | Journal of Applied Polymer Science2000，78，： | 1 |
| 15 | Loss of autophagy promotes murine acetaminophen hepatotoxicity显示文摘 | Yuki Igusa Shunhei Yamashina Kousuke Izumi Yoshihiro Inami Hiroo Fukada Masaaki Komatsu Keiji Tanaka Kenichi Ikejima Sumio Watanabe | 2012 | Journal of Gastroenterology2012，，4： | 1 |
| 16 | Distinct pharmacodynamics of insulin glargine and insulin detemir: Crossover comparison in Type 1 and Type 2 diabetic patients on basal-bolus regimen显示文摘 | Tomoko Kato Ichiro Tokubuchi Kazuhisa Muraishi Shuichi Sato Tamotsu Kato Kento Hara Kayo Tanaka Hiroo Kaku Yuji Tajiri Kentaro Yamada | 2010 | Diabetes Research and Clinical Practice2010，，3： | 1 |
| 17 | Technical Survey on Polymer Additives for Papermaking显示文摘 | Hiroo Tanaka | 1996 | Mokuzai Gakkaishi1996，42，11： | 1 |
| 18 | Effects of Polyamine Structure On Rosin Sizing Under Neutral Papermaking Conditions显示文摘 | WU ZONG-HUA CHEN SHAO-PING HIROO TANAKA | 1997 | Journal of Applied Polymer Science1997，65，1： | 1 |
| 19 | The long-term outcome of patients with bleeding gastric varices after balloon-occluded retrograde transvenous obliteration显示文摘 | Nobuhiko Hiraga Hiroshi Aikata Shintaro Takaki Hideaki Kodama Hiroo Shirakawa Michio Imamura Yoshiiku Kawakami Shoichi Takahashi Naoyuki Toyota Katsuhide Ito Shinji Tanaka Mikiya Kitamoto Kazuaki Chayama | 2007 | Journal of Gastroenterology2007，，8： | 1 |
| 20 | Funcion Mechanisms of Polyamines in Rosin Sizing Under Neutral Papermaking Conditions显示文摘 | WU ZONG-HUA CHEN SHAO-PING HIROO TANAKA | 2001 | Journal of Applied Polymer Science2001，80，7： | 1 |
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