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| 1 | 胆道肿瘤临床实践指南(英文第三版)显示文摘日本肝胆胰外科学会(JSHBPS)于2007年出版第一版胆道肿瘤(胆管癌、胆囊癌及壶腹癌)临床实践指南,于2014年更新第二版,2021年英文第三版胆道肿瘤临床实践指南围绕6个主题提出若干临床问题,基于相关循证医学证据并组织专家讨论后,最终确定推荐意见、推荐强度以及推荐说明。根据证据推荐分级的评估、制订与评价(GRADE)系统,推荐强度被分为1级(强)或者2级(弱)。英文第三版胆道肿瘤临床实践指南中提出的31个临床问题涵盖:(1)预防性治疗;(2)诊断;(3)胆道引流;(4)外科治疗;(5)化疗;(6)放疗。31个临床问题中,14个问题给予推荐强度为强的推荐意见,14个问题给予推荐强度为弱的推荐意见,剩余的3个问题未给予推荐意见。每条推荐意见都进行推荐强度说明。最新版指南基于循证医学证据,为临床提供了重要建议。未来与癌症登记数据库协作将是评估指南和建立新证据的关键。 | Masato Nagino Satoshi Hirano Hideyuki Yoshitomi Taku Aoki Katsuhiko Uesaka Michiaki Unno Tomoki Ebata Masaru Konishi Keiji Sano Kazuaki Shimada Hiroaki Shimizu Ryota Higuchi Toshifumi Wakai Hiroyuki Isayama Takuji Okusaka Toshio Tsuyuguchi Yoshiki Hirooka Junji Furuse Hiroyuki Maguchi Kojiro Suzuki Hideya Yamazaki Hiroshi Kijima Akio Yanagisawa Masahiro Yoshida Yukihiro Yokoyama Takashi Mizuno Itaru Endo 杨翼飞(译) 仇毓东(译) 赵梦珂(译) 伏旭(译) 蔡正华(译) 毛凉(审校) | 2021 | 中华消化外科杂志2021，20，4： | 7 |
| 2 | Expression of 5-Lipoxygenase in human colorectal cancer显示文摘AIM: To evaluate the 5-lipoxygenases (Loxs) expression level in human colorectal cancer specimens in order to determine its clinicopathologic significance in human tumorigenesis. METHODS: The relative quantity of 5-Lox mRNA in paired 91 colorectal tumor and adjacent normal mucosa samples was determined by real time quantitative PCR. Additionally, the expression of 5-Lox and cyclooxygenase (Cox)-2 proteins was also examined using immunohistochemical staining methods. RESULTS: There was a marked increase in 5-Lox mRNA levels in the tumor compared with paired normal mucosa samples (P < 0.0001). Sixty six (72.5%) tumors showed high 5-Lox mRNA levels. The positivity rate of 5-Lox and Cox-2 protein expression was 68.7% and 79.1% respectively. There was a significant association between tumoral 5-Lox mRNA level and tumor size (Rho = 0.392, P = 0.0002), depth or vessel invasion. CONCLUSION: These results suggest that 5-Lox is up-regulated in colorectal cancer and that inhibition of its expression might be valuable in the prevention and treatment of colorectal cancer. | Labile Togba Soumaoro Satoru Iida Hiroyuki Uetake Megumi Ishiguro Yoko Takagi Tetsuro Higuchi Masamichi Yasuno Masayuki Enomoto Kenichi Sugihara | 2006 | World Journal of Gastroenterology2006，12，39： | 3 |
| 3 | Microsatellite polymorphism in the human heme oxygenase-1 gene promoter and its application in association studies with Alzheimer and Parkinson disease显示文摘 | Teiko Kimpara A. Takeda Koichi Watanabe Yasuto Itoyama Shuntaro Ikawa Minro Watanabe Hiroyuki Arai Hidetada Sasaki Susumu Higuchi Naoshi Okita Sadao Takase Hiroshi Saito Kazuhiro Takahashi Shigeki Shibahara | 1997 | Human Genetics1997，，1： | 1 |
| 4 | Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction显示文摘 | Kazuo Takayama Mitsuru Inamura Kenji Kawabata Michiko Sugawara Kiyomi Kikuchi Maiko Higuchi Yasuhito Nagamoto Hitoshi Watanabe Katsuhisa Tashiro Fuminori Sakurai Takao Hayakawa Miho Kusuda Furue Hiroyuki Mizuguchi | 2012 | Journal of Hepatology2012，，3： | 1 |
| 5 | Short-term and long-term outcome of endoluminal gastroplication for the treatment of GERD: the first multicenter trial in Japan显示文摘 | Soji Ozawa Koichiro Kumai Kazuhide Higuchi Tetsuo Arakawa Mototsugu Kato Masahiro Asaka Natsuya Katada Hiroyuki Kuwano Masaki Kitajima | 2009 | Journal of Gastroenterology2009，，7： | 1 |
| 6 | A patient with undifferentiated carcinoma of gallbladder presenting with hemobilia显示文摘 | Hiroyuki Kubota Masanobu Kageoka Hirohiko Iwasaki Ken Sugimoto Ryota Higuchi Satoshi Honda Fumitoshi Watanabe Kenji Koda Hiroyuki Hanai Eizo Kaneko | 2000 | Journal of Gastroenterology2000，，1： | 1 |
| 7 | Prognostic Impact of Hypoxia-Inducible miRNA-210 in Patients with Lung Adenocarcinoma显示文摘 | Jun Osugi Yuka Kimura Yuki Owada Takuya Inoue Yuzuru Watanabe Takumi Yamaura Mitsuro Fukuhara Satoshi Muto Naoyuki Okabe Yuki Matsumura Takeo Hasegawa Athushi Yonechi Mika Hoshino Mitsunori Higuchi Yutaka Shio Hiroyuki Suzuki Mitsukazu Gotoh James L. Muls | 2015 | Journal of Oncology2015，，： | 1 |
| 8 | Evaluation and analysis of exposure levels of di(2-ethylhexyl) phthalate from blood bags显示文摘 | Koichi Inoue Migaku Kawaguchi Retsuji Yamanaka Tae Higuchi Rie Ito Koichi Saito Hiroyuki Nakazawa | 2005 | Clinica Chimica Acta2005，，1： | 1 |
| 9 | Characteristics of patients with non‐variceal upper gastrointestinal bleeding taking antithrombotic agents显示文摘 | Daisuke Yamaguchi Yasuhisa Sakata Nanae Tsuruoka Ryo Shimoda Toru Higuchi Hiroyuki Sakata Kazuma Fujimoto Ryuichi Iwakiri | 2015 | Digestive Endoscopy2015，，1： | 1 |
| 10 | Effect of classification based on combination of mutation and methylationin colorectal cancer prognosis显示文摘 | Haruhiko Aoyagi Satoru Iida Hiroyuki Uetake Toshiaki Ishikawa Yoko Takagi Hirotoshi Kobayashi Tetsuro Higuchi Masamichi Yasuno Masayuki Enomoto Kenichi Sugihara | 2011 | Oncology Reports2011，，3： | 1 |
| 11 | Pressure stimulates proliferation and DNA synthesis in rat intestinal epithelial cells显示文摘 | Masahiko Hirokawa Soichiro Miura Takeharu Shigematsu Hideo Yoshida Ryota Hokari Hajime Higuchi Iwao Kurose Hiroyuki Kimura Hidetsugu Saito Toshio Nakaki Hiromasa Ishii | 1997 | Life Sciences1997，，7： | 1 |
| 12 | The First Isolation of Lignan Tri- and TetraGlycosides 显示文摘 | Katsura Fukui Hiroyuki Higuchi | 1991 | Chem Pharm Bull1991，39，6： | 1 |
| 13 | The first isolation tri - and tetra - glycosides 显示文摘 | Junei Kinjo Katsura Fukui Hiroyuki Higuchi et at | 1991 | chem Pharm Bull1991，39，6： | 1 |
| 14 | The first isolation tri- and tetra- glycosides 显示文摘 | Junei Kinjo Katsura Fukui Hiroyuki Higuchi | 1991 | Chem Pharm Bull1991，39，6： | 1 |
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