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| 1 | Successful laparoscopic splenectomy after living-donor liver transplantation for thrombocytopenia caused by antiviral therapy显示文摘Although interferon (IFN) based therapy for recurrent hepatitis C virus (HCV) infection after liver transplantation has been widely accepted, it induces various adverse effects such as thrombocytopenia, resulting in its interruption. Recently, concomitant splenectomy at the time of living donor liver transplantation (LDLT) has been tried to overcome this problem, but this procedure leads to several complications such as excessive intraoperative bleeding and serious infection. A 60-year-old female received LDLT using a left lobe graft from her second son for liver failure caused by hepatitis C-related cirrhosis. Six months after LDLT, she was diagnosed as recurrent HCV infection by liver biopsy. IFN monotherapy was started from 7 mo after LDLT and her platelet count decreased to less than 50 000/μL, which thus made it necessary to discontinue the treatment. We decided to attempt laparoscopic splenectomy (LS) under general anesthesia. Since intra-abdominal findings did not show any adhesion formations around the spleen, LS could be successfully performed. After LS, since her platelet count immediately increased to 225 000/μL 14 d after operation, IFN therapy was restarted and we could convert the combination therapy of IFN and ribavirin, resulting in no detectable viral marker. Inconclusion, LS can be performed safely even after LDLT, and LS after LDLT is a feasible and less invasive modality for thrombocytopenia caused by antiviral therapy. | Hiroyuki Kato Masanobu Usui Yoshinori Azumi Ichiro Ohsawa Masashi Kishiwada Hiroyuki Sakurai Masami Tabata Shuji Isaji | 2008 | World Journal of Gastroenterology2008，14，26： | 7 |
| 2 | Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer显示文摘AIM: To investigate the clinical significance of BMP and activin membrane-bound inhibitor (BAMBI) which is a pseudoreceptor of transforming growth factor-beta (TGF-β) type Ⅰreceptors and acts as a negative regulator of TGF-β signaling and expression aberrantly elevated in colorectal cancers (CRCs). We studied BAMBI expression in CRCs. METHODS: We studied BAMBI expression in 183 surgically resected CRCs by immunochemical and immunoblotting analyses using a generated monoclonal anti-BAMBI antibody. Commercially available anti-β-catenin and anti-p53 antibodies were also applied for immunochemical analyses as a comparison control.RESULTS: Immunohistochemical analysis revealed that BAMBI expression was observed in 148 (80.8%), and strong BAMBI expression was observed in 46% of the CRCs. Strong BAMBI expression was positively correlated with histological type, depth of invasion, lymph node metastases, and tumor node metastasis (TNM) stage (P < 0.05). Clear associations were found between BAMBI and β-catenin (P = 0.035) and p53 (P = 0.049) expression. In curatively resected CRC, 5-year recurrence-free survival was 51.9% (P = 0.037) for strong BAMBI expression compared to 79.8% for weak BAMBI expression. In the Cox’s multivariate analysis, lymph node metastases (RR 6.685; P < 0.001) and depth of invasion (RR 14.0; P = 0.013) were signifi cant indicators for recurrence, and strong BAMBI expression (RR 2.26; P = 0.057) tended to be signifi cant. CONCLUSION: BAMBI was linked to a potentially aggressive tumor phenotype and predicted tumor recurrence and cancer-related death in CRC. BAMBI expression might be applicable in the routine clinical setting of CRC. | Nozomi Togo Susumu Ohwada Shinji Sakurai Hiroyuki Toya Ichiro Sakamoto Tatsuya Yamada Tetsuhiro Nakano Ken Muroya Izumi Takeyoshi Takashi Nakajima Takashi Sekiya Yusuke Yamazumi Tsutomu Nakamura Tetsu Akiyama | 2008 | World Journal of Gastroenterology2008，14，31： | 3 |
| 3 | A standardized technique for safe pancreaticojejunostomy:Pair-Watch suturing technique显示文摘AIM:To prevent pancreatic leakage after pancreaticoje-junostomy,we designed a new standardized technique that we term the 'Pair-Watch suturing technique'.METHODS:Before anastomosis,we imagine the faces of a pair of watches on the jejunal hole and pancreatic duct.The first stitch was put between 9 o'clock of the pancreatic side and 3 o'clock of the jejunal side,and a total of 7 stitches were put on the posterior wall,followed by the 5 stitches on the anterior wall.Using this technique,twelve stitches can be sutured on the first layer anastomosis regardless of the caliber of the pancreatic duct.In all cases the amylase activity of the drain were measured.A postoperative pancreatic fistula was diagnosed using postoperative pancreatic fistula grading.RESULTS:From March 2007 to July 2008,29 consecutive cases underwent pancreaticojejunostomy using this technique.Pathologic examination results showed pancreatic carcinoma(n=14),intraductal papillary-mucinous neoplasm(n=10),intraductal papillary-mucinous carcinoma(n=1),carcinoma of ampulla of Vater(n=1),carcinoma of extrahepatic bile duct(n=1),metastasis of renal cell carcinoma(n=1),and duodenal carcinoma(n=1).Pancreaticojejunal anastomoses using this technique were all watertight during the surgical procedure.The mean diameter of main pancreatic duct was 3.4 mm(range 2-7 mm).Three patients were recognized as having an amylase level greater than 3 times the serum amylase level,but all of them were diagnosed as grade A postoperative pancreatic fistula grading and required no treatment.None of the cases developed complications such as hemorrhage,abdominal abscess,and pulmonary infection.There was no postoperative mortality.CONCLUSION:Our technique is less complicated than other methods and very secure,providing reliable anastomosis for any size of pancreatic duct. | Yoshinori Azumi Shuji Isaji Hiroyuki Kato Yuu Nobuoka Naohisa Kuriyama Masashi Kishiwada Takashi Hamada Shugo Mizuno Masanobu Usui Hiroyuki Sakurai Masami Tabata | 2010 | World Journal of Gastrointestinal Surgery2010，2，8： | 2 |
| 4 | EFFICACY OF PROCALCITONIN IN THE EARLY DIAGNOSIS OF BACTERIAL INFECTIONS IN A CRITICAL CARE UNIT显示文摘 | Akiko Nakamura Hideo Wada Makoto Ikejiri Tsuyoshi Hatada Hiroyuki Sakurai Yoshiko Matsushima Junji Nishioka Kazuo Maruyama Shuji Isaji Taichi Takeda Tsutomu Nobori | 2009 | Shock2009，，6： | 2 |
| 5 | Nuclear survivin expression predicts poorer prognosis in glioblastoma显示文摘 | Katsuyuki Shirai Yoshiyuki Suzuki Kuniyuki Oka Shin-ei Noda Hiroyuki Katoh Yoshihiko Suzuki Jun Itoh Hideaki Itoh Shogo Ishiuchi Hideyuki Sakurai Masatoshi Hasegawa Takashi Nakano | 2009 | Journal of Neuro - Oncology2009，，3： | 1 |
| 6 | Generation of metabolically functioning hepatocytes from human pluripotent stem cells by FOXA2 and HNF1α transduction显示文摘 | Kazuo Takayama Mitsuru Inamura Kenji Kawabata Michiko Sugawara Kiyomi Kikuchi Maiko Higuchi Yasuhito Nagamoto Hitoshi Watanabe Katsuhisa Tashiro Fuminori Sakurai Takao Hayakawa Miho Kusuda Furue Hiroyuki Mizuguchi | 2012 | Journal of Hepatology2012，，3： | 1 |
| 7 | Remediation of cadmium contamination in paddy soils by washing with chemicals: Selection of washing chemicals显示文摘 | Tomoyuki Makino Kazuo Sugahara Yasuhiro Sakurai Hiroyuki Takano Takashi Kamiya Kouta Sasaki Tadashi Itou Naoki Sekiya | 2006 | Environmental Pollution2006，，1： | 1 |
| 8 | Internal mammary artery perforator flap for reconstruction of the chest wall显示文摘 | Masaki Takeuchi Hiroyuki Sakurai | 2013 | Journal of Plastic Surgery and Hand Surgery2013，，4： | 1 |
| 9 | Cold-inducible RNA-binding protein (Cirp) interacts with Dyrk1b/Mirk and promotes proliferation of immature male germ cells in mice显示文摘 | Tomoko Masuda Katsuhiko Itoh Hiroaki Higashitsuji Hisako Higashitsuji Noa Nakazawa Toshiharu Sakurai Yu Liu Hiromu Tokuchi Takanori Fujita Yan Zhao Hiroyuki Nishiyama Takashi Tanaka Manabu Fukumoto Masahito Ikawa Masaru Okabe Jun Fujita | 2012 | Proceedings of the National Academy of Sciences2012，，27： | 1 |
| 10 | HER2-positive adenocarcinoma arising from heterotopic pancreas tissue in the duodenum:A case report显示文摘BACKGROUND Adenocarcinoma originating from heterotopic pancreas tissue is a rare disease.Furthermore,to our knowledge,no HER2-positive cases in the duodenum have been reported in the scientific literature nor has the efficacy of trastuzumab treatment for the disease been reported.CASE SUMMARY A 65-year-old woman whose clinical diagnosis was unresectable advanced duodenal cancer with HER2 overexpression responded well to trastuzumab chemotherapy.The main tumor in the duodenum reduced drastically.The patient underwent pancreaticoduodenectomy and lymph node dissection.A small number of cancer cells remained in the submucosal layer of the duodenum and pancreas head.After histological and immunohistochemical examination,the patient was diagnosed with duodenal adenocarcinoma originating from heterotopic pancreas tissue.CONCLUSION Trastuzumab treatment is effective in HER2-positive adenocarcinoma originating from heterotopic pancreas tissue in the duodenum. | Yoshifumi S Hirokawa Takashi Iwata Yoshinaga Okugawa Koji Tanaka Hiroyuki Sakurai Masatoshi Watanabe | 2021 | World Journal of Gastroenterology2021，27，28： | 1 |
| 11 | Development of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) after pancreaticoduodenectomy: proposal of a postoperative NAFLD scoring system显示文摘 | Hiroyuki Kato Shuji Isaji Yoshinori Azumi Masashi Kishiwada Takashi Hamada Shugo Mizuno Masanobu Usui Hiroyuki Sakurai Masami Tabata | 2010 | Journal of Hepato - Biliary - Pancreatic Sciences2010，，3： | 1 |
| 12 | Changes in the gene expression profile of Acetobacter aceti during growth on ethanol显示文摘 | Kenta Sakurai Hiroyuki Arai Masaharu Ishii | 2012 | Journal of Bioscienee and Bioengineering2012，113，3： | 1 |
| 13 | Administration of poly(ADP-ribose) polymerase inhibitor into bronchial artery attenuates pulmonary pathophysiology after smoke inhalation and burn in an ovine model显示文摘 | Atsumori Hamahata Perenlei Enkhbaatar Matthias Lange Takashi Yamaki Hiroyuki Sakurai Katsumi Shimoda Hiroaki Nakazawa Lillian D. Traber Daniel L. Traber | 2012 | Burns2012，，8： | 1 |
| 14 | Administration of a Peroxynitrite Decomposition Catalyst Into the Bronchial Artery Attenuates Pulmonary Dysfunction After Smoke Inhalation and Burn Injury in Sheep显示文摘 | Atsumori Hamahata Perenlei Enkhbaatar Matthias Lange Takashi Yamaki Hiroaki Nakazawa Motohiro Nozaki Hiroyuki Sakurai Lillian D. Traber Daniel L. Traber | 2012 | Shock2012，，5： | 1 |
| 15 | CD24 Expression Is a Novel Prognostic Factor in Esophageal Squamous Cell Carcinoma显示文摘 | Akihiko Sano MD Hiroyuki Kato MD PhD Shinji Sakurai MD PhD Makoto Sakai MD Naritaka Tanaka MD Takanori Inose MD Kana Saito MD PhD Makoto Sohda MD PhD Masanobu Nakajima MD PhD Takashi Nakajima MD PhD Hiroyuki Kuwano MD PhD | 2009 | Annals of Surgical Oncology2009，，2： | 1 |
| 16 | Direct Delivery of Low-Dose 7-Nitroindazole Into the Bronchial Artery Attenuates Pulmonary Pathophysiology After Smoke Inhalation and Burn Injury in an Ovine Model显示文摘 | Atsumori Hamahata Perenlei Enkhbaatar Matthias Lange Robert A. Cox Hal K. Hawkins Hiroyuki Sakurai Lillian D. Traber Daniel L. Traber | 2011 | Shock2011，，6： | 1 |
| 17 | Emerging new technologies in pharamcoge- nomics : rapid SNP detection, molecular dynamic simulation, and QSAR analysis methods to validate clinically important genetic variants of human ABC transporter ABCB1 (P-gp/ MDR1 ) 显示文摘 | TOSHIHISA ISHIKAWA AKI SAKURAI HIROYUKI HIRANO | 2010 | Pharmacology & Therapeutics2010，126，1： | 1 |
| 18 | Approaches to improving the kinetics of adenovirus-delivered genes and gene products显示文摘 | Zhi-Li Xu Hiroyuki Mizuguchi Fuminori Sakurai | 2004 | Advanced Drug Delivery Reviews2004，57，： | 1 |
| 19 | Regulation of Src homology 2–containing protein tyrosine phosphatase by advanced glycation end products: the role on atherosclerosis in diabetes显示文摘 | Naoto Seki Naotake Hashimoto Masato Taira Sayaka Yagi Yuriko Yoshida Kou Ishikawa Yoshifumi Suzuki Hiroyuki Sano Seikou Horiuchi Shouji Yoshida Kenichi Sakurai Kazuo Yagui Hideichi Makino Yasushi Saito | 2007 | Metabolism2007，，： | 1 |
| 20 | Effect of ablated bronchial blood flow on survival rate and pulmonary function after burn and smoke inhalation in sheep显示文摘 | Atsumori Hamahata Perenlei Enkhbaatar Sakurai Hiroyuki Motohiro Nozaki Daniel L. Traber | 2009 | Burns2009，，6： | 1 |
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