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| 1 | The Arabidopsis bZIP1 Transcription Factor Is Involved in Sugar Signaling, Protein Networking, and DNA Binding显示文摘糖发信号是种使用集成各种各样的内部、外部的暗示完成滋养的动态平衡的机制,调停发展节目,和清晰压力回答。许多 bZIP 抄写因素被知道涉及营养素或应力发信号。Arabidopsis S1 组 bZIP 基因, AtbZIP1,在介绍学习的以前的基因表情作为糖敏感的基因被识别(植物房间。16, 21282150 ) 。在这份报告,我们证明 AtbZIP1 的表示被糖以一个快、敏感、可逆的方法镇压。AtbZIP1 的糖压抑被表明部件的保存的糖影响, hexokinase。除是调整糖的基因以外, AtbZIP1 能调停糖发信号并且影响基因表示,植物生长,和开发。当碳营养素是有限的时, AtbZIP1 原因的功能的获得或损失处于早幼苗建立的率变化。phenotypic 分析的结果显示 AtbZIP1 充当早幼苗生长的一个否定管理者。用在 microarray 分析的 gain-of-function 和 loss-of-function 植物,通常认为的调整 AtbZIP1 的基因的二个集合被识别了。在他们之中,糖应答的基因是高度过去代表的,含有在调停糖的基因表示的 AtbZIP1 的一个角色。用酵母二混血儿(Y-2-H ) 屏蔽,双分子的荧光互补(BiFC ) 分析,我们能概括广泛的 C/S1 AtbZIP 蛋白质交往在生活房间的网络。最后,我们证明 AtbZIP1 能在 vitro 绑基于 ACGT 的主题并且有约束力的特征看起来被在 AtbZIP1 和 C 组 AtbZIPs 之间的 heterodimerization 影响,包括 AtbZIP10 和 AtbZIP63。 | Shin Gene Kang John Price Pei-Chi Lin Jong Chan Hong Jyan-Chyun Jang | 2010 | Molecular Plant2010，3，2： | 13 |
| 2 | 内窥镜胸交感神经链切断术治疗多汗症显示文摘目的 评价内镜下胸交感神经链切断术治疗多汗症的临床效果。 方法 回顾性分析内镜下胸交感神经链切断术治疗 5 8例多汗症的结果。 结果 5 8例均治愈 ;出现气胸 4例、代偿性多汗 2例、肋间神经痛 1例。 结论 内镜下胸交感神经链切断术比较安全。 | 胡泽勇 Churnpon Chan Prem Pillay Alvin Hong | 2001 | 中国微创外科杂志2001，1，6： | 13 |
| 3 | Clinical significance of loss of heterozygosity for M6P/IGF2R in patients with primary hepatocellular carcinoma显示文摘AIM:To investigate the relationship between loss of heterozygosity (LOH) for mannose 6-phosphate/insulin- like growth factor 2 receptor (M6P/IGF2R) and the outcomes for primary HCC patients treated with partial hepatectomy. METHODS: The LOH for M6P/IGF2R in primary HCC patients was assessed using six different gene-specific nucleotide polymorphisms. The patients studied were enrolled to undergo partial hepatectomy. RESULTS: M6P/IGF2R was found to be polymorphic in 73.3% (22/30) of the patients, and of these patients, 50.0% (11/22) had tumors showing LOH in M6P/IGF2R. Loss of heterozygosity in M6P/IGF2R was associated with significant reductions in the two year overall survival rate (24.9% vs 65.5%; P = 0.04) and the disease-free survival rate (17.8% vs 59.3%; P = 0.03). CONCLUSION: These results show M6P/IGF2R LOH predicts poor clinical outcomes in surgically resected primary HCC patients. | Hong Seok Jang Ki Mun Kang Byung Ock Choi Gyu Young Chai Soon Chan Hong Woo Song Ha Randy L Jirtle | 2008 | World Journal of Gastroenterology2008，14，9： | 12 |
| 4 | Dapper1 promotes autophagy by enhancing the Beclinl -Vps34-Atg14L complex formation显示文摘 | Benvu Ma Weipeng Cao Wenxia Li Chan Gao Zhen Qi Yan Zhao Jun Du Hua Xue Junya Peng Jun Wen Hua Chen Yuanheng Ning Lei Huang Hong Zhang Xiang Gao Li Yu Ye-Guang Chen | 2014 | Cell Research2014，24，8： | 12 |
| 5 | Tanshinone IIA attenuates angiotensin II-induced apoptosis via Akt pathway in neonatal rat cardiomyocytes显示文摘 | Hong-jye HONG Ju-chi LIU Tzu-hurng CHENG Paul CHAN | 2010 | Acta Pharmacologica Sinica2010，31，12： | 10 |
| 6 | Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway显示文摘 | Youjun Li Hao Zhou Fengzhi Li Siew Wee Chan Zhijie Lin Zhiyi Wei Zhou Yang Fusheng Guo Chun Jye Lim Wancai Xing Yuequan Shen Wanjin Hong Jiafu Long Mingjie Zhang | 2015 | Cell Research2015，25，7： | 9 |
| 7 | Heteroepitaxial growth of ZnO nanosheet bands on ZnCo204 submicron rods toward high-performance Li ion battery electrodes显示文摘 | Chan Woo Lee Seung-Deok Seo Dong Wook Kim Sangbaek Park Kyoungsuk Jin Dong-Wan Kim Kug Sun Hong | 2013 | Nano Research2013，6，5： | 8 |
| 8 | Two VOZ transcription factors link an E3 ligase and an NLR immune receptor to modulate immunity in rice显示文摘Nucleotide-binding leucine-rich repeat(NLR)proteins play critical roles in plant immunity.However,how NLRs are regulated and activate defense signaling is not fully understood.The rice(Oryza sativa)NLR receptor Piz-t confers broad-spectrum resistance to the fungal pathogen Magnaporthe oryzae and the RING-type E3 ligase AVRPIZ-T INTERACTING PROTEIN 10(APIP10)negatively regulates Piz-t accumulation.In this study,we found that APIP10 interacts with two rice transcription factors,VASCULAR PLANT ONEZINC FINGER 1(OsVOZ1)and OsVOZ2,and promotes their degradation through the 26S proteasome pathway.OsVOZ1 displays transcriptional repression activity while OsVOZ2 confers transcriptional activation activity in planta.The osvoz1 and osvoz2 single mutants display modest but opposite M.oryzae resistance in the non-Piz-t background.However,the osvoz1 osvoz2 double mutant exhibits strong dwarfism and cell death,and silencing of both genes via RNA interference also leads to dwarfism,mild cell death,and enhanced resistance to M.oryzae in the non-Piz-t background.Both OsVOZ1 and OsVOZ2 interact with Piz-t.Double silencing of OsVOZ1 and OsVOZ2 in the Piz-t background decreases Piz-t protein accumulation and transcription,reactive oxygen species-dependent cell death,and resistance to M.oryzae containing AvrPiz-t.Taken together,these results indicate that OsVOZ1 and OsVOZ2 negatively regulate basal defense but contribute positively to Piz-t-mediated immunity. | Jiyang Wang Ruyi Wang Hong Fang Chongyang Zhang Fan Zhang Zeyun Hao Xiaoman You Xuetao Shi Chan Ho Park Kangyu Hua Feng He Maria Bellizzi Kieu Thi Xuan Vo Jong-Seong Jeon Yuese Ning Guo-Liang Wang | 2021 | Molecular Plant2021，14，2： | 8 |
| 9 | Individual having a parent with early-onset gastric cancer may need screening at younger age显示文摘AIM: To evaluate whether individuals with gastric cancer(GC) are diagnosed earlier if they have firstdegree relatives with GC.METHODS: A total of 4282 patients diagnosed with GC at National Cancer Center Hospital from 2002 to 2012 were enrolled in this retrospective study. We classified the patients according to presence or absence of first-degree family history of GC and compared age at diagnosis and clinicopathologic characteristics. In addition, we further classified patients according to specific family member with GC(father, mother, sibling, or offspring) and compared age at GC diagnosis among these patient groups. Baseline characteristics were obtained from a prospectively collected database. Information about the family member's age at GC diagnosis was obtained by questionnaire.RESULTS: A total of 924 patients(21.6%) had a firstdegree family history of GC. The mean age at GC diagnosis in patients having paternal history of GC was 54.4 ± 10.4 years and was significantly younger than in those without a first-degree family history(58.1 ± 12.0 years, P < 0.001). However, this finding was not observed in patients who had an affected mother(57.2 ± 10.0 years) or sibling(62.2 ± 9.8 years). Among patients with family member having early-onset GC(< 50 years old), mean age at diagnosis was 47.7 ± 10.3 years for those with an affected father, 48.6 ± 10.4 years for those with an affected mother, and 57.4 ± 11.5 years for those with an affected sibling. Thus, patients with a parent diagnosed before 50 years of age developed GC 10.4 or 9.5 years earlier than individuals without a family history of GC(both P <0.001).CONCLUSION: Early-onset GC before age of 50 was associated with parental history of early-onset of GC. Individual having such family history need to start screening earlier. | Hee-Won Kwak Il Ju Choi Chan Gyoo Kim Jong Yeul Lee Soo-Jeong Cho Bang Wool Eom Hong Man Yoon Jungnam Joo Keun Won Ryu Young-Woo Kim | 2015 | World Journal of Gastroenterology2015，21，15： | 7 |
| 10 | Modeling hot deformation behavior of low-cost Ti-2Al-9.2Mo-2Fe beta titanium alloy using a deep neural network显示文摘Ti-2 Al-9.2 Mo-2 Fe is a low-cost β titanium alloy with well-balanced strength and ductility, but hot working of this alloy is complex and unfamiliar. Understanding the nonlinear relationships among the strain,strain rate, temperature, and flow stress of this alloy is essential to optimize the hot working process.In this study, a deep neural network(DNN) model was developed to correlate flow stress with a wide range of strains(0.025–0.6), strain rates(0.01–10 s^-1) and temperatures(750–1000℃). The model, which was tested with 96 unseen datasets, showed better performance than existing models, with a correlation coefficient of 0.999. The processing map constructed using the DNN model was effective in predicting the microstructural evolution of the alloy. Moreover, it led to the optimization of hot-working conditions to avoid the formation of brittle precipitates(temperatures of 820–1000℃ and strain rates of 0.01-0.1 s^-1). | Cheng-Lin Li P.L.Narayana N.S.Reddy Seong-Woo Choi Jong-Taek Yeom Jae-Keun Hong Chan Hee Park | 2019 | Journal of Materials Science & Technology2019，35，5： | 7 |
| 11 | Recent updates and current issues of sentinel node navigation surgery for early gastric cancer显示文摘With the increase in the incidence of early gastric cancer(EGC),several endoscopic and laparoscopic approaches,such as endoscopic submucosal dissection and function-preserving gastrectomy,have been accepted as standard treatments.Sentinel node navigation surgery(SNNS)is an ideal surgical option for preservation of most parts of the stomach and consequent maintenance of normal gastric function to improve quality of life in patients with EGC.Although many previous studies and clinical trials have demonstrated the safety and feasibility of the sentinel node concept in gastric cancer,the clinical application of SNNS is debatable.Several issues regarding technical standardization and oncological safety need to be resolved.Recently several studies to resolve these problems are being actively performed,and SNNS might be an important surgical option in the treatment of gastric cancer in the future. | Sung Gon Kim Bang Wool Eom Hong Man Yoon Chan Gyoo Kim Myeong-Cherl Kook Young-Woo Kim Keun Won Ryu | 2021 | Chinese Journal of Cancer Research2021，33，2： | 7 |
| 12 | The clinical association of programmed cell death protein 4(PDCD4) with solid tumors and its prognostic significance:a meta-analysis显示文摘Background: Programmed cell death protein 4(PDCD4) is a novel tumor suppressor protein involved in pro?grammed cell death. Its association with cancer progression has been observed in multiple tumor models, but evidence supporting its association with solid tumors in humans remains controversial. This study aimed to determine the clinical signiicance and prognostic value of PDCD4 in solid tumors.Methods: A systematic literature review was performed to retrieve publications with available clinical informa?tion and survival data. The eligibility of the selected articles was based on the criteria of the Dutch Cochrane Centre proposed by the Meta?analysis Of Observational Studies in Epidemiology group. Pooled odds ratios(ORs), hazard ratios(HRs), and 95% conidence intervals(CIs) for survival analysis were calculated. Publication bias was examined by Begg's and Egger's tests.Results: Clinical data of 2227 cancer patients with solid tumors from 23 studies were evaluated. PDCD4 expression was signiicantly associated with the diferentiation status of head and neck cancer(OR 4.25, 95% CI 1.87–9.66) and digestive system cancer(OR 2.87, 95% CI 1.84–4.48). Down?regulation of PDCD4 was signiicantly associated with short overall survival of patients with head and neck(HR: 3.44, 95% CI 2.38–4.98), breast(HR: 1.86, 95% CI 1.36–2.54), digestive system(HR: 2.12, 95% CI 1.75–2.56), and urinary system cancers(HR: 3.16, 95% CI 1.06–9.41).Conclusions: The current evidence suggests that PDCD4 down?regulation is involved in the progression of several types of solid tumor and is a potential marker for solid tumor prognoses. Its clinical usefulness should be conirmed by large?scale prospective studies. | John Zeng Hong Li Wei Gao Wai-Kuen Ho Wen Bin Lei William Ignace Wei Jimmy Yu-Wai Chan Thian-Sze Wong | 2016 | Chinese Journal of Cancer2016，35，12： | 7 |
| 13 | Tailoring uniform γ-MnO2 nanosheets on highly conductive three-dimensional current collectors for high-performance supercapacitor electrodes显示文摘最近的努力集中了于制造和应用程序三维(3-D ) nanoarchitecture 电极,它能展出优秀电气化学的性能。此处,向设计和合成的新奇策略尺寸悦耳、厚度悦耳二维( 2-D ) MnO <潜水艇class=“ a-plus-plus ”> 2 nanosheets 在上高度传导性一个维( 1-D )脊梁数组被开发了经由一灵巧,一步舞提高了化学洗澡免职( ECBD )在低温度的方法( 50 湡睯物吗?? | Sangbaek Park Hyun-Woo Shim Chan Woo Lee Hee Jo Song Ik Jae Park Jae-Chan Kim Kug Sun Hong Dong-Wan Kim | 2015 | Nano Research2015，8，3： | 7 |
| 14 | Characteristics of vertical ozone distribution in the lower troposphere in the Yangtze River Delta at Lin'an in the spring of 2001显示文摘We analyzed vertical distributions of ozone (O3) in the lower troposphere (< 5 km above ground) at Lin’an (119.75°E, 30.30°N), Zhejiang Province using electrochemical concen- tration cell (ECC) ozonesonde data obtained from February 21 to April 13, 2001. The results showed that the vertical O3 distributions are controlled by metrological conditions and the char- acteristics of O3 profiles are related to those of wet bulb potential temperature and wind field. O3 below 2 km showed that the strongest variability and enhanced O3 mixing ratios were associated with easterly winds that blow pollutants from the upwind source region of the Yangtze River Delta (YRD) region. Vertical O3 profiles below 5 km can be grouped into 5 categories: (1) peak mixing ratio type, (2) well-mixed type, (3) layered-structure type, (4) episodic pollution type and (5) alti- tudinal increasing type. Vertical distributions of O3 affected by regional transport of polluted air masses were investigated. Transport of polluted air from high latitudes of northern China, ac- companying subsiding motion of air and stagnant atmospheric conditions are important factors that lead to high mixing ratios of O3 at Lin’an. The stagnant atmospheric conditions associated with a continental high pressure system and pollution plume transported from the YRD and cen- tral-eastern China also lead to regional accumulation of O3 and high O3 mixing ratio at Lin’an. Long-range transport of O3 and pollutants from the Pearl River Delta in South China and in-situ O3 formation also resulted in elevated O3 mixing ratios at around 1 km altitudes and layered O3 distribution in the lower troposphere. | ZHENG Xiangdong1, CHAN Chuenyu2, CUI Hong2, QIN Yu3, CHAN Loyan2, ZHENG Yongguang3 & LEE Yusiang2 1. Chinese Academy of Meteorological Sciences, Beijing 100081, China 2. Department of Civil and Structural Engineering, Hong Kong Polytechnic University, Hung Hom, Hong Kong, China 3. Department of Atmospheric Sciences, Peking University, Beijing 100871, China | 2005 | Science China Earth Sciences2005，48，9： | 6 |
| 15 | Multifunctional organically modified graphene with super-hydrophobicity显示文摘 | Huawen Hu Chan C. K. Allan Jianhua Li Yeeyee Kong Xiaowen Wang John H. Xin Hong Hu | 2014 | Nano Research2014，7，3： | 5 |
| 16 | Current status and challenges in sentinel node navigation surgery for early gastric cancer显示文摘Although a number of feasibility studies for sentinel node(SN) concepts in gastric cancer have been conducted since 2000, there remains a debate regarding detailed detection techniques and oncological safety. Two important multicenter phase II clinical trials were performed in Japan that used different methods and reached different conclusions; one confirmed acceptable results with a false-negative rate of 7%, and the other showed an unacceptably high false-negative rate of 46.4%. The Sentinel Node Oriented Tailored Approach(SENORITA)trial is a multicenter randomized controlled phase III trial being performed in Korea. Patient enrollment is now complete and the long-term results are currently awaited. Recently, an image-guided SN mapping technique using infrared ray/fluorescence was introduced. This method might be a promising technology because it allows the clear visualization of SNs. With regard to the primary tumor, the non-exposed endoscopic wall-inversion surgery technique and non-exposure endolaparoscopic full-thickness resection with simple suturing technique have been reported. These methods prevent abdominal infection and tumor seeding and can be good alternatives to conventional laparoscopic gastric wedge resection. For indications, SN navigation surgery can be extended to patients who underwent non-curative endoscopic resection. Although a few studies have been performed on these patients, sentinel concepts may be beneficial to patients as they omit the need for additional gastrectomy. SN navigation surgery can lead to actual organ-preserving surgery and plays a key role in improving the quality of life of patients with early gastric cancer in the future. | Bang Wool Eom Young-II Kim Hong Man Yoon Soo-Jeong Cho Jong Yeul Lee Chan GyooKim Soo Jin Kim Ji Yoon Rho Seok Ki Kim Myeong-Cherl Kook Young-Woo Kim Keun Won | 2017 | Chinese Journal of Cancer Research2017，29，2： | 5 |
| 17 | Continuous and comprehensive atmospheric observations in Beijing:a station to understand the complex urban atmospheric environment显示文摘Due to profound impact on climate and human health,air quality has attracted attention from all levels of the civil society.The key step in the provision of required tools for the society to tackle the complex air quality problem is to characterize it in a comprehensive manner with a long-term perspective.Here,we describe a continuous and comprehensive observation station and its accompanying state-ofthe-art instrumentation that was established to investigate the complex urban atmospheric environment in a rapidly developing Chinese Megacity.The station,located in downtown Beijing,aims to study air quality by identifying the major atmospheric pollutants and key processes determining their formation and loss mechanisms.A few hundreds of parameters are continuously measured with the state-of-the-art instruments,including trace gas concentrations,aerosol particle size distributions,and mass concentrations,covering aerosol particle chemical composition from molecules to micrometer-sized aerosol particles.This produced long-term,comprehensive big data with around 1�10^(11)bytes per year.In this paper,we provide an overview on the facilities of the station,the instrumentation used,the workflow of continuous observations and examples of results from 2018 to 2019 and a basis for establishing a modern long-term,comprehensive atmospheric urban observation station in other megacities. | Yongchun Liu Chao Yan Zemin Feng Feixue Zheng Xiaolong Fan Yusheng Zhang Chang Li Ying Zhou Zhuohui Lin Yishou Guo Ying Zhang Li Ma Wenshuo Zhou Zhikun Liu Lubna Dada Kaspar Dallenbach Jenni Kontkanen Runlong Cai Tommy Chan Biwu Chu Wei Du Lei Yao Yonghong Wang Jing Cai Juha Kangasluoma Tom Kokkonen Joni Kujansuu Anton Rusanen Chenjuan Deng Yueyun Fu Rujing Yin Xiaoxiao Li Yiqun Lu Yiliang Liu Chaofan Lian Dongsen Yang Weigang Wang Maofa Ge Yuesi Wang Douglas R.Worsnop Heikki Junninen Hong He Veli-Matti Kerminen Jun Zheng Lin Wang Jingkun Jiang Tuukka Petaja Federico Bianchi Markku Kulmala | 2020 | Big Earth Data2020，4，3： | 3 |
| 18 | On the adjacent vertex-distinguishing acyclic edge coloring of some graphs显示文摘A proper edge coloring of a graph G is called adjacent vertex-distinguishing acyclic edge coloring if there is no 2-colored cycle in G and the coloring set of edges incident with u is not equal to the coloring set of edges incident with v,where uv ∈ E(G).The adjacent vertex distinguishing acyclic edge chromatic number of G,denoted by χAa(G),is the minimal number of colors in an adjacent vertex distinguishing acyclic edge coloring of G.If a graph G has an adjacent vertex distinguishing acyclic edge coloring,then G is called adjacent vertex distinguishing acyclic.In this paper,we obtain adjacent vertex-distinguishing acyclic edge coloring of some graphs and put forward some conjectures. | SHIU Wai Chee CHAN Wai Hong ZHANG Zhong-fu BIAN Liang | 2011 | Applied Mathematics(A Journal of Chinese Universities)2011，26，4： | 3 |
| 19 | Helicobacter Pylori Infection Increases the Risk of Colorectal Adenomas: Cross-Sectional Study and Meta-Analysis显示文摘 | Sung Hong Seung Lee Jeong Kim Tae Lee Jeong Kim Won Choe Sun-Young Lee Young Cheon In Sung Hyung Park Chan Shim | 2012 | Digestive Diseases and Sciences2012，，8： | 3 |
| 20 | Understanding microstructure and mechanical properties of(AlTa(0.76))xCoCrFeNi(2.1) eutectic high entropy alloys via thermo-physical parameters显示文摘(AlTa(0.76))xCoCrFeNi(2.1)(x values in molar ratio,x=0.1,0.3,0.5,0.7,1.0,and 1.5) alloys were designed to investigate the microstructure and mechanical properties of the eutectic high entropy alloys(EHEAs)consisting of FCC,B2,and Laves phases.Depending on the compositional variatio,clear microstructural variation was observed,as follows:(1) Group 1:FCC dendrite+Laves interdendrite(x=0.1),(2) Group 2:FCC dendrite+fine-eutectic structure consisting of FCC and Laves phases(x=0.3,0.5 and 0.7),(3) Group 3:B2 dendrite+bimodal eutectic structure [FCC/B2+Laves](x=1.0),(4) Group 4:Laves dendrite+eutectic structure consisting of B2 and Laves phases(x=1.5).As the fraction of Laves or B2 phases increases,yield stress increases from 293 to 2336 MPa,while the plastic strain decreases from 50 % to 2%.Thermo-physical parameters,such as mixing entropy(△S(mix)),mixing enthalpy(△H(mix)),valence electron concentration(VEC),and atomic size difference(δr),were calculated to understand the microstructural variation.Two criteria(δr-VEC and δr-△H(mix)) were utilized to elucidate the formation of the eutectic structures in the present EHEAs,revealing the usefulness of the thermo-physical parameters in the development of EHEAs. | Min Jung Kim Gyeol Chan Kang Sung Hwan Hong Hae Jin Park Sang Chul Muna Gian Song Ki Buem Kim | 2020 | Journal of Materials Science & Technology2020，54，22： | 3 |
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