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| 1 | Ciliary parathyroid hormone signaling activates transforming growth factor-βto maintain intervertebral disc homeostasis during aging显示文摘Degenerative disc disease(DDD) is associated with intervertebral disc degeneration of spinal instability. Here, we report that the cilia of nucleus pulposus(NP) cells mediate mechanotransduction to maintain anabolic activity in the discs. We found that mechanical stress promotes transport of parathyroid hormone 1 receptor(PTH1 R) to the cilia and enhances parathyroid hormone(PTH) signaling in NP cells. PTH induces transcription of integrin α_vβ_6 to activate the transforming growth factor(TGF)-β-connective tissue growth factor(CCN2)-matrix proteins signaling cascade. Intermittent injection of PTH(iPTH) effectively attenuates disc degeneration of aged mice by direct signaling through NP cells, specifically improving intervertebral disc height and volume by increasing levels of TGF-β activity, CCN2, and aggrecan. PTH1 R is expressed in both mouse and human NP cells. Importantly,knockout PTH1 R or cilia in the NP cells results in significant disc degeneration and blunts the effect of PTH on attenuation of aged discs. Thus, mechanical stress-induced transport of PTH1 R to the cilia enhances PTH signaling, which helps maintain intervertebral disc homeostasis, particularly during aging, indicating therapeutic potential of iPTH for DDD. | Liwei Zheng Yong Cao Shuangfei Ni Huabin Qi Zemin Ling Xin Xu Xuenong Zou Tianding Wu Ruoxian Deng Bo Hu Bo Gao Hao Chen Yusheng Li Jianxi Zhu Francis Tintani Shadpour Demehri Amit Jain Khaled M.Kebaish Shenghui Liao Cheryle A.Séguin Janet L.Crane Mei Wan Hongbin Lu Paul D.Sponseller Lee H.RileyIII Xuedong Zhou Jianzhong Hu Xu Cao | 2018 | Bone Research2018，6，3： | 13 |
| 2 | MicroRNA-4661 inhibits antiviral innate immune response by targeting interferon-alpha显示文摘 | Yingke Li Xiaohua Fan Xingying He Haijing Sun Zui Zou Hongbin Yuan Haitao Xu Chengcai Wang Xueyin Shi | 2012 | Cellular & Molecular Immunology2012，9，6： | 8 |
| 3 | Highly efficient pure white polymer light-emitting devices based on poly(N-vinylcarbazole) doped with blue and red phosphorescent dyes显示文摘Efficient white-polymer-light-emitting devices (WPLEDs) have been fabricated with a single emitting layer containing a hole-transporting host polymer,poly(N-vinylcarbzole),and an electron-transporting auxiliary,1,3-bis[(4-tert-butylphenyl)-1,3,4-oxadiazolyl]-phenylene,codoped with two phosphorescent dyes:Iridium(III)bis (2-(4,6-difluorophenyl)-pyridinato-N,C2') picolinate (FIrpic) and home-made Ir-G2 for blue and red emission,respectively.With the structure of ITO/PEDOT:PSS 4083(40 nm)/emission layer(80 nm)/Ba(4 nm)/Al(120 nm),the device showed a maximal luminous efficiency (LE) of 13.5 cd A-1(corresponding to an external quantum efficiency (EQE) of 6.8%),and a peak power efficiency (PE) of 6.5 lm W-1 at 6.0 V.Meanwhile,the device exhibited pure white emission with Commission Internationale de l'Eclairage (CIE) coordinates of (0.34,0.35) at a current density of 12 mA cm-2,which is very close to the equi-energy white point with CIE coordinates of (0.33,0.33).The device performance can be further optimized when more balanced hole/electron injection is achieved by incorporating a lower conducting type anode buffer layer (PEDOT:PSS) and incorporating poly[(9,9-bis(3'-(N,N-dimethylamino)propyl)-2,7-fluorenene)-alt-2,7-(9,9-dioctyfluorene)] (PFN) as an electron injection layer at the cathode.The optimized device showed an LE of 24.6 cd A-1 (with an EQE of 14.1%),while the peak power efficiency reached 12.66 lm W-1.Moreover,the WPLEDs showed good electroluminescence (EL) stability over a wide range of operating current density and luminance. | HU SuJun ZOU JianHua ZHOU GuiJiang LI DongYun WU HongBin SU ShiJian WONG Wai-Yeung YANG Wei PENG JunBiao CAO Yong | 2011 | Science China Chemistry2011，54，4： | 4 |
| 4 | Expert consensus on the establishment and maintenance of native arteriovenous fistula显示文摘Vascular access is the lifeline of hemodialysis patients.There are great differences in the establishment and use of vascular access in different countries and regions around the world.We believe that on the basis of good evaluation and planning,it is recommended that hemodialysis patients choose native arteriovenous fistula first.In view of the new progress of vascular access views domestic and international at home and abroad in recent years,we organized experts to recommend the establishment and maintenance of arteriovenous fistula(AVF)for the Chinese population,including preoperative evaluation and planning of the establishment of AVF,AVF surgery,perioperative drug intervention measures and postoperative maintenance,and put forward suggestions for future research directions.The recommendations in this consensus are general and clinicians need to make treatment decisions based on the actual situation. | Hongtao Zhang Haitao Lu Wenge Li Gengru Jiang Hongbin Zou Expert Group of Nephrology Branch of China Academy of Chronic Disease Urology Nephrology and Blood Purification Commission of China Medical Education Association | 2021 | Chronic Diseases and Translational Medicine2021，7，4： | 3 |
| 5 | Brain interstitial fluid drainage and extracellular space affected by inhalational isoflurane: in comparison with intravenous sedative dexmedetomidine and pentobarbital sodium显示文摘Brain interstitial fluid drainage and extracellular space are closely related to waste clearance from the brain. Different anesthetics may cause different changes of brain interstitial fluid drainage and extracellular space but these still remain unknown. Herein,effects of the inhalational isoflurane, intravenous sedative dexmedetomidine and pentobarbital sodium on deep brain matters’ interstitial fluid drainage and extracellular space and underlying mechanisms were investigated. When compared to intravenous anesthetic dexmedetomidine or pentobarbital sodium, inhalational isoflurane induced a restricted diffusion of extracellular space, a decreased extracellular space volume fraction, and an increased norepinephrine level in the caudate nucleus or thalamus with the slowdown of brain interstitial fluid drainage. A local administration of norepinephrine receptor antagonists, propranolol,atipamezole and prazosin into extracellular space increased diffusion of extracellular space and interstitial fluid drainage whilst norepinephrine decreased diffusion of extracellular space and interstitial fluid drainage. These findings suggested that restricted diffusion in brain extracellular space can cause slowdown of interstitial fluid drainage, which may contribute to the neurotoxicity following the waste accumulation in extracellular space under inhaled anesthesia per se. | Guomei Zhao Hongbin Han Jun Yang Min Sun Dehua Cui Yuanyuan Li Yajuan Gao Jing Zou | 2020 | Science China(Life Sciences)2020，63，9： | 3 |
| 6 | Validation of AMSU-A measurements from two different calibrations in the lower stratosphere using COSMIC radio occultation data显示文摘GPS radio occultation data from the Constellation Observing System for Meteorology, Ionosphere, and Climate(COSMIC) mission were used to validate the measurements of the advanced microwave sounding unit-A(AMSU-A) in the lower stratosphere from different satellites. AMSU-A observations from two different calibrations—the pre-launch operational and post-launch simultaneous nadir overpass(SNO) calibrations—were compared to microwave brightness temperatures(Tb)simulated from COSMIC data. Observations from three satellites(NOAA-15,-16, and-18) were used in the comparison. The results showed that AMSU-A Tb measurements from both calibrations and from all three NOAA satellites were underestimated in the lower stratosphere,and that the biases were larger in polar winters, especially over the southern high latitudes. In comparison to operational calibration, the SNO-calibrated AMSU-A data produced much smaller biases relative to the COSMIC data.The improvement due to SNO calibration was quantified by a Ratio index, which measured the bias changes from operational to SNO calibrations relative to the biases between the operational-calibrated AMSU-A data and the COSMIC data. The Ratio values were 70 % for NOAA-15and [80 % for NOAA-18 and-16, indicating that the SNO calibration method significantly reduced AMSU-A biases and effectively improved AMSU-A data quality. | Wenying He Chengzhi Zou Hongbin Chen | 2014 | Chinese Science Bulletin2014，59，11： | 2 |
| 7 | Dexamethasone does not affect endolymphatic hydrops(EH)in patients with Meniere's disease within 24 h,and intratympanic administration of gadolinium plus dexamethasone simplifies high-quality imaging of EH using a novel protocol of 7 min显示文摘Background:Intratympanic administration of gadolinium chelate allows for a better visualization of endolymphatic hydrops(EH)using MRI than intravenous injection and was recently further improved to facilitate high-quality imaging of EH in 7 min.The aim of the present study was to simplify the intratympanic administration protocol by mixing gadolinium chelate with therapeutic dexamethasone and to evaluate the effects of this mixture on the visualization of EH in MRI.Materials and methods:In an in vitro study,the potential impact of gadolinium-diethylenetriamine pentaacetic acid(Gd-DTPA)on the stability of dexamethasone was evaluated by analyzing dynamic changes in dexamethasone with high-performance liquid chromatography(HPLC)after mixing with GdDTPA.Ten patients with definite Meniere's disease(MD)were recruited to study the potential interference of dexamethasone on MRI visualization of EH,and 49 patients with MD were recruited to evaluate the effect of intratympanic injection of Gd-DTPA mixed with dexamethasone on MRI of EH using a 3T MR machine and a novel heavily T2-weighted 3-dimensional fluid-attenuated inversion recovery reconstructed using a magnitude plus zero-filled interpolation(hT2FLAIR-MZFI)sequence.Results:The retention times and peak area of dexamethasone in HPLC were not modified by the addition of Gd-DTPA.EH grading in the cochlea and vestibule was not influenced in any ear by intratympanic injection of dexamethasone.Excellent inner ear images were obtained from all patients,and EHs with various grades were displayed.There were significant correlations between diagnosis and cochlear EH(p<0.01,Spearman's Rho),between diagnosis and vestibular EH(p<0.01,Spearman's Rho),and between cochlear and vestibular EH(p<0.01,Spearman's Rho).The distribution of Gd-DTPA plus dexamethasone negatively correlated with the grade of vestibular EH.Injury of the endolymph-perilymph barrier was detected in one cochlea and three vestibules of 59 inner ears with MD.Conclusions:Intratympanic administration of Gd-DTPA plus dexamethasone yielded high-quality MRI images of EH in patients with MD using a novel 7-min protocol and simplified the clinical application.Intratympanic administration of Gd-DTPA plus dexamethasone might be used to test its therapeutic effect in future work. | Jing Zou Zikai Zhao Hongbin Li Guoping Zhang Qing Zhang Jianping Lu Ilmari Pyykko | 2022 | Journal of Otology2022，17，3： | 2 |
| 8 | Evaluation of SARS-CoV-2-Neutralizing Nanobody Using Virus Receptor Binding Domain-Administered Model Mice显示文摘Due to the rapid spread of coronavirus disease 2019(COVID-19),there is an urgent requirement for the development of additional diagnostic tools for further analysis of the disease.The isolated nanobody Nb11-59 binds to the severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)reeptor-binding domain[RBD]with high afinity to neutralize the virus and block the angiotensin-converting enzyme 2-(ACE2-)RBD interaction.Here,we introduce a novel nanobody-based radiotracer named^(68)Ga-Nb1159.The radiotracer retained high affinity for the RBD and showed reliable radiochemical characteristics both in vitro and in vivo.Predinical positron emission tomography(PET)studies of Ga-Nb1159 in mice revealed is rapid dearance from circulation and robust uptake into the renal and urinary systems.Fortunately,^(68)Ga-Nb1159 could speifcally reveal the distribution of the RBD in mice.This sudy also helped to evaluate the pharmacodynamic efects of the neutralizing nanobody.Moreover,^(68)Ga-Nb1159 may be a promising l0ol lo explore the distribution of the RBD and improve the understanding of the virus.In particular,this study identified a novel molecular radioagent and established a reliable evaluation method for speifially investigating the RBD through noninvasive and visual PET technology. | Song Liu Guanghui Li Lei Ding Jin Ding Qian Zhang Dan Li Xingguo Hou Xiangxing Kong Jing Zou Shiming Zhang Hongbin Han Yakun Wan Zhi Yang Hua Zhu | 2022 | Research2022，，2： | 2 |
| 9 | Lowing the energy loss of organic solar cells by molecular packing engineering via multiple molecular conjugation extension显示文摘The central unit(benzo[c][1,2,5]thiadiazole) in Y6 series of molecules plays a determining role in their unique intermolecular packing for a three-dimensionally(3D) network, largely endowing their organic solar cells(OSCs) with so far the best power conversion efficiencies(PCEs) and also largely suppressed energy losses(Eloss). Despite its vital role in molecular packing, very few explorations for central unit have been conducted due to possibly the constructing challenge of central heterocyclic units.Herein, a highly efficient acceptor-donor-acceptor(A-D-A) type electron acceptor, CH17, has been designed and constructed,featured with a prominent π extension in both directions of the central and end units with respect to Y6 series. Such a multiple and much enhanced conjugation extension in CH17 enables a much more effective and compact 3D molecular packing compared with that of Y6 supported by X-ray single crystal and other analysis, mainly caused by a newly observed distinctive dual “end unit to central unit” packing mode. This much favorable molecular packing, also kept in its blends with donor materials, leads a larger electron and hole transfer integrals and hence much improved charge transport, and reduced energetic disorders in CH17blends. More importantly, the observed upshifted charge transfer(CT) state of CH17 blends compared with that of Y6, due to its increased molecular conjugation extension in both directions, further enhances the hybridization between its CT and local exciton(LE) states, resulting in higher luminescence efficiency, much suppressed non-radiative recombination loss and smaller Elosswith respect to that of Y6. Consequently, an excellent PCE of 17.84% is achieved with PM6 as the donor in a binary device compared with a PCE of 16.27% for the controlled Y6 device. Furthermore, a further improved PCE of 18.13% is achieved by CH17-based ternary single-junction OSCs along with a markedly reduced Elossof 0.49 e V and larger open-circuit voltage(Voc) of0.89 V, compared with that(16.27% of PCE, 0.85 V of Voc, and 0.53 e V of Eloss) of the control device using Y6. This significantly improved photovoltaic performance caused by molecular multiple conjugation extension, especially through the largely unexplored central unit, indicates that there is still much room to further enhance OSC performance by addressing the most important issue for OSC, i.e, the smaller Voccaused by larger Eloss, through engineering molecular packing by designing/tuning molecule more dedicatedly. | Hongbin Chen Yalu Zou Huazhe Liang Tengfei He Xiaoyun Xu Yunxin Zhang Zaifei Ma Jing Wang Mingtao Zhang Quanwen Li Chenxi Li Guankui Long Xiangjian Wan Zhaoyang Yao Yongsheng Chen | 2022 | Science China Chemistry2022，65，7： | 1 |
| 10 | Efficient hybrid white polymer light-emitting devices with electro- luminescence covered the entire visible range and reduced efficiency roll-off显示文摘 | Hu Sunjun Zhu Minrong Zou Hongbin | 2012 | Applied Physics Letters2012，100，6： | 1 |
| 11 | Hepatic Differentiation of Rat Mesenchymal Stem Cells by a Small Molecule显示文摘 | Jingfeng Ouyang Jiaan Shao Hongbin Zou Yijia Lou Yongping Yu | 2012 | ChemMedChem2012，，8： | 1 |
| 12 | Two-dimensional SEM image-based analysis of coal porosity and its pore structure显示文摘A quantitative analysis of the porosity,pore size distribution,and fractal dimensions of pores is significant for studying the pore structure characteristics of coal.This study utilized 12 anthracite coal samples from the Sihe mining area to explore the pore structure characteristics of the coal therein.Hundred randomly selected points on each sliced coal sample were imaged via scanning electron microscopy,and a total of 1200 images were used for the analysis.The porosity and fractal dimensions of the coal samples were analyzed via digital image processing and box-counting dimension methods.This method is characterized by extensive graphical analysis,and the results are based on statistical methods.These were also used to analyze the structural and development characteristics of the microscopic pores in the coal.The results reveal that the surface porosity obtained via digital image processing was 16.11%lower than that measured experimentally.The fractal dimension and porosity of the pore surface were fitted to a natural logarithmic curve.The rate of change in the pore fractal dimension depends on the porosity such that,to some degree,a greater porosity is associated with more complex pore structures,a higher degree of micropore development,and improved pore connectivity. | Guangui Zou Jiasheng She Suping Peng Quanchun Yin Hongbin Liu Yuyan Che | 2020 | International Journal of Coal Science & Technology2020，7，2： | 1 |
| 13 | Relationship between brachial-ankle pulse wave velocity and metabolic syndrome components in a Chinese population显示文摘The purpose of this study was to assess the relationship between arterial stiffness,as measured by brachial-ankle pulse wave velocity(baPWV),and the presence of the metabolic syndrome(MS)in a Chinese population.A total of 4,445 subjects were enrolled.The prevalence of MS in our study population was 21.7%,17.2%and 25.6%for the general population,males and females,respectively.With adjustments for age,gender,cigarette smoking,heart rate,total cholesterol,low-density lipoprotein(LDL)cholesterol,and the use of anti-hypertensive drug,the stepwise regression analysis showed that baPWV had a significant relationship with components of MS,including systolic blood pressure(P<0.001),diastolic blood pressure(P<0.001),glucose(P<0.001),highdensity lipoprotein(HDL)cholesterol(P=0.04),and triglycerides(P<0.001),but no relationship with waist circumference(P=0.25).With an increase in the number of the MS components,baPWV increased significantly both in women and men.This study indicated that the MS is indeed a risk factor for arterial stiffness.Monitoring of baPWV in patients with MS may help in identifying persons at high risk for cardiovascular disease. | Fang Zhou Haifeng Zhang Wenming Yao Hongbin Mei Dongjie Xu Yanhui Sheng Rong Yang Xiangqing Kong Liansheng Wang Jiangang Zou Zhijian Yang Xinli Li | 2014 | The Journal of Biomedical Research2014，28，4： | 1 |
| 14 | A novel annealing method to uniformly refine deformed mixed grain microstructure of a solution-treated Ni-based superalloy显示文摘Increasing static recrystallization(SRX)nucleation rate and decreasing grain growth rate are the main ways to obtain uniform and fine grain microstructure by annealing treatment.However,it is contradictory to raise the SRX nucleation rate and reduce grain growth rate during isothermal annealing treatment.This is because the increase of the SRX nucleation rate needs to raise annealing temperature,while the decline of grain growth rate needs to reduce the annealing temperature.To solve the contradiction,a novel method named cooling recrystallization annealing treatment(CRT)is designed and verified.For the CRT,the relatively high annealing temperature in the primary stage can promote SRX nucleation,and the gradually decreased annealing temperature can reduce the growth rate of SRX grains.Besides,an aged treatment is first carried out to precipitate high content of theδphase before the CRT.Enoughδphases not only provide large numbers of sites for SRX nucleation but also limit the grain growth due to the pinning effect,especially in the primary high-temperature stage.The results show that the novel method can refine deformed mixed grain microstructure well when the suitable cooling rate,start and final recrystallization annealing temperatures are employed.The deformed mixed grain can be uniformly refined to an average size of 8.26μm with the route of 900℃×12 h+1020℃→970℃×20 min. | WANG GuanQiang CHEN MingSong LIN YongCheng LI HongBin ZENG WeiDong MA YanYong CAI JinLiang PENG ChengXu ZOU FenYang | 2021 | Science China(Technological Sciences)2021，64，8： | 1 |
| 15 | Counteracting lineage-specific transcription factor network finely tunes lung adeno-to-squamous transdifferentiation through remodeling tumor immune microenvironment显示文摘Human lung adenosquamous cell carcinoma(LUAS),containing both adenomatous and squamous pathologies,harbors strong plasticity and is significantly associated with poor prognosis.We established an up-to-date comprehensive genomic and transcriptomic landscape of LUAS in 109 Chinese specimens and demonstrated LUAS development via adeno-to-squamous transdifferentiation.Unsupervised transcriptomic clustering and dynamic network biomarker analysis identified an inflammatory subtype as the critical transition stage during LUAS development.Dynamic dysregulation of the counteracting lineage-specific transcription factors(TFs),containing adenomatous TFs NKX2-1 and FOXA2,and squamous TFs TP63 and SOX2,finely tuned the lineage transition via promoting CXCL3/5-mediated neutrophil infiltration.Genomic clustering identified the most malignant subtype featured with STK11-inactivation,and targeting LSD1 through genetic deletion or pharmacological inhibition almost eradicated STK11-deficient lung tumors.These data collectively uncover the comprehensive molecular landscape,oncogenic driver spectrum and therapeutic vulnerability of Chinese LUAS. | Shijie Tang Yun Xue Zhen Qin Zhaoyuan Fang Yihua Sun Chongzhe Yuan Yunjian Pan Yue Zhao Xinyuan Tong Jian Zhang Hsinyi Huang Yuting Chen Liang Hu Dasong Huang Ruiqi Wang Weiguo Zou Yuan Li Roman KThomas Andrea Ventura Kwok-Kin Wong Haiquan Chen Luonan Chen Hongbin Ji | 2023 | National Science Review2023，10，4： | 0 |
| 16 | Location of the AICA influences the severity but not occurrence of ISSNHL:A reappraisal using high-resolution 3 T MRI显示文摘Objective:To investigate the potential influence of anatomical variation in the anterior inferior cerebellar artery(AICA)on the occurrence and severity of idiopathic sudden sensorineural hearing loss(ISSNHL).Methods:Ninety ISSNHL patients were enrolled.The anatomical location of the AICA was exhibited using high-resolution magnetic resonance imaging(MRI),and the various AICA types classified by previously reported Chavda and Gorrie methods were analyzed.The severity of hearing loss in the ipsilateral ear among different AICA types was compared.Results:Approximately 85.6%of subjects had unilateral ISSNHL(uISSNHL),and the others had bilateral ISSNHL(bISSNHL).In the uISSNHL group,the ratios of different AICA types were similar between the ipsilateral and contralateral ears.The ratios of the different AICA types in the bISSNHL group were similar to those in the uISSNHL group.In the uISSNHL group,pure tone audiometry(PTA)thresholds at 2 kHz,4 kHz and 8 kHz of patients with Chavda type II AICA were higher than those of patients with Chavda type I and type III,with a significant difference at 4 kHz between type I and type II.There was a tendency of the PTA threshold in patients with Chavda type II or Gorrie type C to gradually increase from low to high frequency zones.Conclusion:When the AICA enters the IAC(Chavda type II)or crosses between the 7th and 8th cranial nerves(Gorrie type C),the severity and frequency of hearing impairment in ISSNHL but not the occurrence of ISSNHL will be affected. | Guoping Zhang Hongbin Li Zikai Zhao Mingxing Zhang Jing Zou | 2023 | Journal of Otology2023，18，4： | 0 |
| 17 | Patterns of presence-absence variants in Upland cotton显示文摘Dear Editor,Sources of genetic variations in genomes include small-scale sources(such as single-nucleotide polymorphisms(SNPs),insertions/deletions(InDels),and simple sequence repeats and larger-scale structural variations(mainly presence-absence variants(PAVs))and copy number variants).PAVs are sequences that are either inserted or missing in genomes in comparison with a reference sequence or genome.PAVs can have a much longer sequence than SNPs and InDels,as illustrated in the human genome(Conrad et al.,2010).PAVs are important genomic structural variations that can directly affect genomic structure and key functional genes in the genome(Kumar et al.,2007).Moreover,the use of PAVs for studying quantitative traits has been valuable(Lam et al.,2010). | Junfang Liu Xianliang Zhang Lingling Dou Wei Li Xiaojian Zhou Yangai Liu Xiaoyu Pei Zhongying Ren Wensheng Zhang Huaizhu Li Wenbo Wang Changsong Zou Kunlun He Fei Zhang Wenyu Ma Haihong Shang Hongbin Li Daigang Yang Guanghui Xiao Xiongfeng Ma | 2020 | Science China(Life Sciences)2020，63，10： | 0 |
| 18 | Data-driven based variable geometry design显示文摘Conventionally,the method to make up for the missing data of middle-shallow layer in the obstacle area is by variable geometry,for example,deviating physical points and adding sources and receivers.And the missing data of middle-shallow layer is evaluated according to the effective coverage of the target layer.Since the traditional method doesn't consider the actual seismic data,it is impossible to actually predict the gap of section and the imaging effect.The paper proposes the evaluation method of data-driven based variable geometry:Firstly,the obstacle avoidance design is realized according to the coordinate range and safe distance of the obstacle area;Secondly,the local similarity of each common image gather(CIG)is calculated,and the contribution of the sources and receivers to the target area is also calculated;Thirdly,according to the variable geometry design,choose the required trace to perform sorting and stacking according to the contribution of the sources and receivers in the CIG,the stack data volume of the whole work area is generated;finally,evaluate the missing data in the obstacle area by the extracted seismic stacked sections in different direction and guide the designer in the infilling plan.Meanwhile,for area with very low signal to noise ratio(SNR),the new method can be used to evaluate the imaging potential and guide the survey design.The new method has achieved very good effect in the production,and the analysis result is very consistent with the processed result of the actual seismic data. | Yinpo Xu Cheng Yin Xuefeng Zou Yingjie Pan Yudong Ni Hongbin Yi | 2021 | Earthquake Research Advances2021，1，S01： | 0 |
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