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61篇 您的检索式:作者名="Hongchuan"
    题名 作者 年代 出处 被引量
1基于波射线路径偏移压制多次波显示文摘波射线路径压制多次波的反射波成像是在偏移过程去除多次波同时仅对反射波成像 .通过在共炮道集和共检波点道集分别计算炮点射线的入射角和检波点射线的出射角计算射线的路径 .从炮点入射的射线与从检波点出射的射线的交点形成的走时 ,若等于观测走时 ,可以判断此条射线是反射波 ;反之 ,若不相等 ,则是多次波 .数值实验表明此方法可以有效地去掉由于多次波能量产生的假成像点和压制多次波 ,因此界面可以正确归位 。刘伊克 Hongchuan Sun 常旭 2004地球物理学报2004,47,4:34
2波路径偏移压制层间多次波的理论与应用显示文摘消除层间多次波是地震勘探资料处理研究领域的难题,尤其对于实际资料的处理,到目前为止还很难找到一种完全有效的方法.本文给出了仅对一次波成像既波路径偏移方法压制层间多次波方法,在共炮道集和共检波点道集分别计算炮点射线的入射角和检波点射线的出射角,由此计算的角度作为射线追踪的初始角度,计算地震波射线的传播路径.结合由程函方程计算的走时表,判断偏移范围是反射波还是多次波.在前期偏移过程压制多次波的理论研究基础上,本文主要研究波路径偏移消除多次波的应用部分.为了进一步说明效果的有效性,计算了在单炮和共成像点道集压制层间多次波,给出了实际资料的压制多次波的偏移结果.刘伊克 常旭 王辉 卢孟夏 Hongchuan Sun 2008地球物理学报2008,51,2:25
3目标函数叠前保幅偏移方法与应用显示文摘将理论反射率与偏移反射率的差作为目标函数,给出一种迭代振幅补偿保幅偏移方法.把偏移看作一个反问题,寻找反问题中的最优解.偏移算子是正演算子的伴随共轭,其伴随矩阵非对角占优.通过预条件优化伴随矩阵,使Hessian矩阵准对角化.依据地震波传播稳定相位理论,计算反射点,以反射点为中心、菲涅耳带为半径偏移.考虑振幅几何扩散补偿、散射角度补偿,在迭代反演过程求出最优解,即保幅偏移解.本文给出了一个保幅数值模拟结果和一个实际地震数据实例.刘伊克 常旭 卢孟夏 Hongchuan Sun 2006地球物理学报2006,49,4:22
4Multi-center investigation of breast reconstruction after mastectomy from Chinese Society of Breast Surgery:A survey based on 31 tertiary hospitals(CSBrS-004)显示文摘Objective:Multi-center data on the current status and trends of breast reconstruction after mastectomy in China are lacking.Herein,we conducted a cross-sectional survey to investigate the current clinical practice pattern of postmastectomy breast reconstruction among Chinese female patients with breast cancer.Methods:A standardized questionnaire used to collect information on breast reconstruction among females diagnosed with breast cancer was distributed by 31 members of the Chinese Society of Breast Surgery between January 1,2018 and December 31,2018.Information was collected on tumor characteristics,treatment,mesh application,nipple-areola complex(NAC)preservation,postoperative complications,bilateral reconstruction,patient satisfaction and local recurrence.The overall rate of breast reconstruction was assessed,and the characteristics were compared across patient groups with different reconstruction approaches.Results:A total of 1,554 patients underwent breast reconstruction after total mastectomy,with a reconstruction rate of 9.6%.Among them,1,190 were implant-based,and 262 underwent autologous reconstructions,while 102 cases underwent a combination of both.Patients who underwent implant-based reconstruction were younger than those who received autologous reconstruction(40.1±4.6 vs.45.0±5.9,P=0.004).Compared to patients with autologous reconstruction,mesh application(25.5%vs.6.5%),NAC preservation(51.8%vs.40.5%)and reconstruction failure(1.8%vs.0)were more frequently reported among those with implant-based reconstruction.There was no significant difference in general satisfaction across three reconstruction approaches,though patients with autologous reconstruction reported the highest aesthetic satisfaction among the three groups(P=0.044).Conclusions:Implant-based breast reconstruction remains the dominant choice among patients,while autologous reconstruction was associated with higher aesthetic satisfaction.Our multi-center investigation based on the findings of the tertiary hospitals of Chinese Society of Breast Surgery may guide a future series of clinical studies on breast reconstruction in China.Feng Xu Chuqi Lei Heng Cao Jun Liu Jie Li Hongchuan Jiang Chinese Society of Breast Surgery 2021Chinese Journal of Cancer Research2021,33,1:7
5The El Ni?o-Southern Oscillation cycle simulated by the climate system model of Chinese Academy of Sciences显示文摘On the basis of more than 200-year control run, the performance of the climate system model of Chinese Academy of Sciences(CAS-ESM-C) in simulating the El Ni?o-Southern Oscillation(ENSO) cycle is evaluated, including the onset, development and decay of the ENSO. It is shown that, the model can reasonably simulate the annual cycle and interannual variability of sea surface temperature(SST) in the tropical Pacific, as well as the seasonal phase-locking of the ENSO. The model also captures two prerequisites for the El Ni?o onset, i.e., a westerly anomaly and a warm SST anomaly in the equatorial western Pacific. Owing to too strong forcing from an extratropical meridional wind, however, the westerly anomaly in this region is largely overestimated. Moreover, the simulated thermocline is much shallower with a weaker slope. As a result, the warm SST anomaly from the western Pacific propagates eastward more quickly, leading to a faster development of an El Ni?o. During the decay stage, owing to a stronger El Ni?o in the model, the secondary Gill-type response of the tropical atmosphere to the eastern Pacific warming is much stronger, thereby resulting in a persistent easterly anomaly in the western Pacific. Meanwhile, a cold anomaly in the warm pool appears as a result of a lifted thermocline via Ekman pumping. Finally, an El Ni?o decays into a La Ni?a through their interactions. In addition, the shorter period and larger amplitude of the ENSO in the model can be attributed to a shallower thermocline in the equatorial Pacific, which speeds up the zonal redistribution of a heat content in the upper ocean.SU Tonghua XUE Feng SUN Hongchuan ZHOU Guangqing 2015Acta Oceanologica Sinica2015,34,1:6
6Multicenter prospective study of magnetic resonance imaging prior to breast-conserving surgery for breast cancer显示文摘Liu Qian Liu Yinhua Xu Ling Duan Xuening Li Ting Qin Naishan Kang Hua Jiang Hongchuan Yang Deqi Qu Xiang Jiang Zefei Yu Chengze 2014Chinese Medical Journal2014,,13:6
7Bisphenol A in combination with TNF-a selectively induces Th2 cell-promoting dendritic cells in vitro with an estrogen-like activity显示文摘Bisphenol A(BPA)is a monomer used in manufacturing a wide range of chemical products,including epoxy resins and polycarbonate.BPA,an important endocrine disrupting chemical that exerts estrogen-like activities,is detectable at nanomolar levels in human serum worldwide.The pregnancy associated doses of 17b-estradiol(E2)plus tumor-necrosis factor-a(TNF-a)induce distorted maturation of human dendritic cells(DCs)that result in an increased capacity to induce T helper(Th)2 responses.The current study demonstrated that the presence of BPA during DC maturation influences the function of human DCs,thereby polarizing the subsequent Th response.In the presence of TNF-a,BPA treatment enhanced the expression of CC chemokine ligand 1(CCL1)in DCs.In addition,DCs exposed to BPA/TNF-a produced higher levels of IL-10 relative to those of IL-12p70 on CD40 ligation,and preferentially induced Th2 deviation.BPA exerts the same effect with E2 at the same dose(0.01–0.1 mM)with regard to DC-mediated Th2 polarization.These findings imply that DCs exposed to BPA will provide one of the initial signals driving the development and perpetuation of Th2-dominated immune response in allergic reactions.Hongchuan Guo Tianyi Liu Yasushi Uemura Shunchang Jiao Deqing Wang Zilin Lin Yayoi Narita Motoharu Suzuki Narumi Hirosawa Yasuko Ichihara Osamu Ishihara Hirosato Kikuchi Yasushi Sakamoto Satoru Senju Qiuhang Zhang Feng Ling 2010Cellular & Molecular Immunology2010,7,3:6
8中国人口生育意愿变迁:1980-2011(英文)显示文摘本文基于1980—2011年间开展的227项关于中国人生育意愿的调查结果,运用横断历史元分析方法,考察了生育意愿的纵向变化趋势。研究发现:1980年以来中国人理想子女数呈减少趋势。2000年之后平均理想子女数基本稳定在1.6—1.8人之间。1980年代中国人生育水平高于生育意愿。随着经济和教育发展水平的提升,二者均呈下降趋势,但是生育水平下降快于生育意愿。1990年之后生育水平低于生育意愿,即人们实际生育子女数少于理想子女数。这为认识生育意愿和生育水平在中国的变化趋势提供了实证依据。侯佳伟 Huang Silin Xin Ziqiang Sun Ling Zhang Hongchuan Dou Donghui Zhao Yuanyuan 2015Social Sciences in China2015,36,1:5
9Influences of Sputtering Angles and Annealing Temperatures on the Magnetic and Magnetostrictive Performances of TbFe Films显示文摘To increase the low-field magnetostriction of TbFe films, the influences of sputtering angles and annealing temperatures on its magnetic and magnetostrictive performances were systematically investigated. With the change in detection of magnetic domains by MFM (magnetic force microscopy) indicates that the easy magnetization direction shifts gradually from perpendicular to parallel to the film plane with decreasing sputtering angles. Annealing can enhance the magnetization and magnetostriction of the TbFe films. However, at too high annealing temperature,both the magnetization and magnetostriction of the TbFe films were suppressed to some extent.Hongchuan JIANG, Wanli ZHANG, Wenxu ZHANG, Shiqing YANG and Huaiwu ZHANG College of Microelectronics and Solid State Electronics, University of Electronic Science and Technology of China, Chengdu 610054, China 2005Journal of Materials Science & Technology2005,21,3:4
10Influence of Annealing Temperature on the Microstructure and Electrical Properties of Indium Tin Oxide Thin Films显示文摘Indium tin oxide(ITO) thin films were prepared on alumina ceramic substrates by radio frequency magnetron sputtering.The samples were subsequently annealed in air at temperatures ranging from 500 to 1,100 °C for 1 h.The influences of the annealing temperature on the microstructure and electrical properties of the ITO thin films were investigated,and the results indicate that the as-deposited ITO thin films are amorphous in nature.All samples were crystallized by annealing at 500 °C.As the annealing temperature increases,the predominant orientation shifts from(222)to(400).The carrier concentration decreases initially and then increases when the annealing temperature rises beyond1,000 °C.The resistivity of the ITO thin films increases smoothly as the annealing temperature increases to just below900 °C.Beyond 900 °C,however,the resistivity of the films increases sharply.The annealing temperature has a significant effect on the stability of the ITO/Pt thin film thermocouples(TFTCs).TFTCs annealed at 1,000 °C show improved hightemperature stability and Seebeck coefficients of up to 77.73 μV/°C.Yinzhi Chen Hongchuan Jiang Shuwen Jiang Xingzhao Liu Wanli Zhang Qinyong Zhang 2014Acta Metallurgica Sinica(English Letters)2014,27,2:4
11Opposite effects of miR-155 in the initial and later stages of lipopolysaccharide(LPS)-induced inflammatory response显示文摘Although microRNA-155(miR-155)is considered a pro-inflammatory mediator,cumulative evidence indicates that it also has anti-inflammatory effects in macrophages and dendritic cells.In this study,we identified the dramatic expression changes of more than half of potential miR-155-targeted genes upon lipopolysaccharide(LPS)stimulation;223 genes were down-regulated and 85 genes were up-regulated,including suppressor of cytokine signaling 1(SOCS1)and transforming growth factor-β-activated kinase 1-binding protein 2(TAB2),two well-known genes involved in miR-155-mediated regulation of the Toll-like receptor 4(TLR4)signaling pathway.We also found that miR-155 acted as an anti-inflammatory mediator in the initial stage of LPS-induced inflammatory response mainly through repressing TAB2 protein translation,and as a proinflammatory mediator by down-regulating SOCS1 in the later stage.Meanwhile,overexpression of TAB23'untranslated region(UTR)in macrophages promoted the development of endotoxin tolerance by competing for binding with miR-155,which resulted in an elevated expression level of SOCS1 protein.These findings provide new insights for understanding the regulatory mechanisms in fine-tuning of LPS-induced innate immune response.Yuhua LIU Xiaopeng WAN Yuan YUAN Jingjing HUANG Yijia JIANG Kaiyue ZHAO Yan WANG Yang LIU Qingqing WANG Hongchuan JIN 2021Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021,22,7:4
12Influences of Film Thickness on the Electrical Properties of TaN_x Thin Films Deposited by Reactive DC Magnetron Sputtering显示文摘TaNx thin films were deposited on commercial polished Al2O3 ceramic substrates by reactive dc magnetron sputtering. The influences of the film thickness on the electrical properties of the samples were examined in detail. It is found that the film thickness does not influence the phase structures of the TaNx thin films. The sheet resistances of the samples shift from 173 Ω/sq. to 7.5 Ω/sq. with the film thickness shifting from 30 nm to 280 nm. With the increase of the film thickness from 30 nm to 280 nm, the temperature coefficient of resistance (TCR) of the samples shifts from negative value to positive value. When the film thickness is about 100 nm, TaNx thin films exhibits a near-zero TCR value (approximately -15×10-6/℃). This fact implies that TaNx thin films with a null TCR can be obtained by adjusting the film thickness. The variation in the electrical properties of the TaNx thin films with the film thickness can be qualitatively explained by the parallel connection of surface layer with high resistivity and negative TCR and TaNx layer with low resistivity and positive TCR.Hongchuan Jiang Chaojie Wang Wanli Zhang Xu Si Yanrong Li 2010Journal of Materials Science & Technology2010,26,7:3
13A phase 3,double-blind,randomized placebo-controlled efficacy and safety study of abiraterone acetate in chemotherapynaı¨ve patients with mCRPC in China,Malaysia,Thailand and Russia显示文摘Objective:This double-blind,placebo-controlled phase 3 study was designed to compare efficacy and safety of abiraterone acetate+prednisone(abiraterone)to prednisone alone in chemotherapy-naı¨ve,asymptomatic or mildly symptomatic metastatic castrationresistant prostate cancer(mCRPC)patients from China,Malaysia,Thailand and Russia.Methods:Adult chemotherapy-naı¨ve patients with confirmed prostate adenocarcinoma,Eastern Cooperative Oncology Group(ECOG)performance status(PS)grade 0e1,ongoing androgen deprivation(serum testosterone<50 ng/dL)with prostate specific antigen(PSA)or radiographic progression were randomized to receive abiraterone acetate(1000 mg,QD)t prednisone(5 mg,BID)or placebo t prednisone(5 mg,BID),until disease progression,unacceptable toxicity or consent withdrawal.Primary endpoint was improvements in time to PSA progression(TTPP).Results:Totally,313 patients were randomized(abiraterone:n Z 157;prednisone:n Z 156);and baseline characteristics were balanced.At clinical cut-off(median follow-up time:3.9 months),80% patients received treatment(abiraterone:n Z 138,prednisone:n Z 112).Median time to PSA progression was not reached with abiraterone versus 3.8 months for prednisone,attaining 58%reduction in PSA progression risk(HR=0.418;p<0.0001).Abirateronetreated patients had higher confirmed PSA response rate(50%vs.21%;relative odds=2.4;p<0.0001)and were 5 times more likely to achieve radiographic response than prednisonetreated patients(22.9%vs.4.8%,p=0.0369).Median survival was not reached.Most common(≥10% abiraterone vs.prednisone-treated)adverse events:bone pain(7%vs.14%),pain in extremity(6%vs.12%),arthralgia(10%vs.8%),back pain(7%vs.11%),and hypertension(15%vs.14%).Conclusion:Interim analysis confirmed favorable benefit-to-risk ratio of abiraterone in chemotherapy-naı¨ve men with mCRPC,consistent with global study,thus supporting use of abiraterone in this patient population.Dingwei Ye Yiran Huang Fangjian Zhou Keji Xie Vsevolod Matveev Changling Li Boris Alexeev Ye Tian Mingxing Qiu Hanzhong Li Tie Zhou Peter De Porre Margaret Yu Vahid Naini Hongchuan Liang Zhuli Wu Yinghao Sun 2017Asian Journal of Urology2017,4,2:3
14Hepatitis B virus hijacks CTHRC1 to evade host immunity and maintain replication显示文摘HepatitisBvirus(HBV)infection causes acuteand chronic liver diseases,but is not directly cytopathic.Liver injury results fromrepeated attempts of the cellular immune response system to control the viral infection.Here,we investigate the roles of cellular factors and signaling pathways involved in the regulation of HBV replication to reveal the mechanism underlying HBV infection and pathogenesis.Weshowthat collagen triple helix repeat containing 1(CTHRC1)expression is elevated in HBV-infected patients andin HBV-transfected cells through epigenetic modification and transcriptional regulation.CTHRC1 facilitates HBV replication in cultured cells and BALB/c mice by activating the PKCa/ERK/JNK/c-Jun cascade to repress the IFN/JAK/STAT pathway.HBV-activated CTHRC1 downregulates the activityof typeI interferon(IFN),theproductionof IFN-stimulatedgenes(ISGs),andthephosphorylationofsignal transducerandactivator of transcription 1/2(STAT1/2),whereas it upregulates the phosphorylation and ubiquitination of type I IFN receptors(IFNARa/b).Thus,our results showthat HBV uses a novelmechanismto hijack cellular factors and signal cascades in order to evade host antiviral immunity and maintain persistent infection.We also demonstrate that CTHRC1 has a novel role in viral infection.Lan Bai Wei Zhang Li Tan Hongchuan Yang Maolin Ge Chengliang Zhu Rui Zhang Yanhua Cao Junbo Chen Zhen Luo Wenzhe Ho Fang Liu Kailang Wu Jianguo Wu 2015Journal of Molecular Cell Biology2015,7,6:2
15Broadband isolated attosecond pulse generation in a two-color laser field combined with an orthogonally polarized laser pulse显示文摘We present a method to generate broadband isolated attosecond pulses. Using a two-color laser field, which is synthesized by a mid-infrared (12.5 fs, 2000 nm) and a weaker (12 fs, 800 nm) pulse in the x direction, a modulated supercontinuum from 290 to 430 eV is obtainable. By properly adding a second-harmonic control field of the driving pulse in the y direction, the short quantum path is well selected and a smooth supercontinuum from 290 to 440 eV is generated. The bandwidth of the supercontinuum can be controlled by adjusting the electric field of the control pulse in the x direction. When the electric field increases to 0.051 a.u., a smooth supercontinuum from 295 to 520 eV is obtained. Using this method we expect that isolated 63-as attosecond pulses with tunable central wavelengths are straightforwardly obtained.DU HongChuan WANG XiaoShan HU BiTao 2012Science China(Physics,Mechanics & Astronomy)2012,55,1:2
16Relationships between hemorrhage, angioarchitectural factors and collagen of arteriovenous malformations显示文摘Objective While associations between the angioarchitecture of arteriovenous malformations (AVMs) in the brain and pathological features have been described, here we investigated the relationship between the angioarchitecture, the pathological features of the vessel wall, and hemorrhagic events. Methods The study was conducted on 43 patients: 16 with ruptured AVM (rAVM), 15 with non-ruptured AVM (nrAVM), 6 with craniocerebral trauma (control) and 6 with epilepsy (control). The diagnosis of AVM was confirmed by preoperative digital subtraction angiography. Tissues were stained with hematoxylin and eosin and Masson's trichrome (for collagen fibers) to evaluate the vessel wall structure and endothelial integrity. The content and distribution of collagen types I and III in the vessel wall were assessed by immunohistochemical staining. Results In the nrAVM group, the nidus had more draining veins than the rAVM group (P <0.05). Severely damaged endothelial cells, significantly fewer smooth muscle cells in the media, and hyperplasic type-I and -III collagen fibers were found in the rAVM group. The content of collagen types I and III in rAVMs was higher than that in the nrAVM (P <0.05) and control groups (P <0.01). Conclusion There is an association between angioarchitectural features such as the number of draining veins and the pathological structure of the AVM wall. These abnormalities may contribute to AVM rupture.Hongchuan Niu Yong Cao Xuejiang Wang Xiaowei Xue Lanbing Yu Ming Yang Rong Wang 2012Neuroscience Bulletin2012,28,5:2
17Stress corrosion cracking of L360NS pipeline steel in sulfur environment显示文摘Slow strain rate test(SSRT)and tensile fracture observation are applied to study the stress corrosion cracking(SCC)of L360NS pipeline steel.5.0 wt.%sodium chloride solution containing elemental sulfur and 0.5 wt.%glacial acetic acid solution containing elemental sulfur are used.The results show that brittle fracture mainly occurs on the samples in high sulfur environment.In the sulfur suspension solution,the SCC sensitivity of L360NS pipeline steel increases along elemental sulfur content.In sulfur melting cladding condition,obvious corrosion can be observed with a large amount of corrosion pits appearing on the gauge section of the sample.The corrosion products are Fe1txS,black easily detached,and H2.In sulfur suspension and sulfur melting cladding conditions,stress oriented hydrogen induced cracking(SOHIC)is the main cracking,which is caused by the joint effect of SCC and hydrogen induced cracking(HIC).Zhou Fan Xiaogang Hu Jianyi Liu Hongchuan Li Jinwen Fu 2017Petroleum2017,3,3:2
18Hierarchically structured Fe/ZSM-5 as catalysts for the oxidation of benzene to phenol显示文摘Arjan J.J. Koekkoek Hongchuan Xin Qihua Yang Can Li Emiel J.M. Hensen 2011Microporous and Mesoporous Materials2011,,1:2
19EGFR TKIs impair lysosome-dependent degradation of SQSTM1 to compromise the effectiveness in lung cancer显示文摘Tyrosine kinase inhibitors for epidermal growth factor receptor(EGFR TKIs)greatly improved clinical outcomes of patients with non-small cell lung cancer(NSCLC).Unfortunately,primary and acquired resistance limits their clinical benefits.To overcome such resistance,new generations of EGFR TKIs have been developed by targeting newly identified mutations in EGFR.However,much less effort has been put into alternative strategies,such as targeting the intrinsic protective responses to EGFR TKIs.In this study,we found that EGFR TKIs,including gefitinib and AZD9291,impaired lysosome-dependent degradation of SQSTM1,thus compromising their anti-cancer efficiency.By accumulating in the lysosome lumen,gefitinib and AZD9291 attenuated lysosomal acidification and impaired autolysosomal degradation of SQSTM1 owing to their intrinsic alkalinity.As a result,SQSTM1 protein was stabilized in response to gefitinib and AZD9291 treatment and conferred EGFR TKI resistance.Depleting SQSTM1 significantly increased the sensitivity of NSCLC cells to gefitinib and AZD9291 both in vitro and in vivo.Furthermore,a chemically modified gefitinib analog lacking alkalinity displayed stronger inhibitory effects on NSCLC cells.Therefore,targeting accumulated SQSTM1 or chemically modified EGFR TKIs may represent new strategies to increase the effectiveness of EGFR targeted therapy.Lixian Yang Shilong Ying Shiman Hu Xiangtong Zhao Muchun Li Miaoqin Chen Yiran Zhu Ping Song Liyuan Zhu Tingting Jiang Huimin An Neelum Aziz Yousafzai Wenxia Xu Zhiguo Zhang Xian Wang Lifeng Feng Hongchuan Jin 2019Signal Transduction and Targeted Therapy2019,4,1:2
20On Unitary Invariant Weakly Complex Berwald Metrics with Vanishing Holomorphic Curvature and Closed Geodesics显示文摘In this paper, the authors construct a class of unitary invariant strongly pseudoconvex complex Finsler metrics which are of the form F =√[ rf(s- t)[, where r = ||v||~ 2, s =| z,v |~2/r, t =|| z||~ 2, f(w) is a real-valued smooth positive function of w ∈ R,and z is in a unitary invariant domain M  C^n. Complex Finsler metrics of this form are unitary invariant. We prove that F is a class of weakly complex Berwald metrics whose holomorphic curvature and Ricci scalar curvature vanish identically and are independent of the choice of the function f. Under initial value conditions on f and its derivative f, we prove that all the real geodesics of F =√[rf(s- t)] on every Euclidean sphere S^(2n-1) M are great circles.Hongchuan XIA Chunping ZHONG 2016Chinese Annals of Mathematics,Series B2016,37,2:2
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