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| 1 | The frequency and skewed T-cell receptor beta-chain variable patterns of peripheral CD4+CD25+ regulatory T-cells are associated with hepatitis B e antigen seroconversion of chronic hepatitis B patients during antiviral treatment显示文摘 | Jiezuan Yang Guoping Sheng Dangsheng Xiao Haiyan Shi Wei Wu Haifeng Lu Ping Yi Hongcui Cao Lanjuan Li | 2016 | Cellular & Molecular Immunology2016，13，5： | 9 |
| 2 | Profiling the repertoire of T-cell receptor beta-chain variable genes in peripheral blood lymphocytes from subjects who have recovered from acute hepatitis B virus infection显示文摘T 房间受体贝它链的侧面变量(TRBV ) 基因通常与病毒感染或癌症在题目扭曲。融化的基因光谱模式(GMSP ) 能被用来决定 TRBV 基因家庭的侧面。从从尖锐肝炎 B 病毒感染(AHI ) 恢复了的题目在外部血淋巴细胞探索 TRBV 家庭的肖像,外部血 mononuclear 房间(PBMC ) 被分开并且进一步排序 + 和 CD8 +T 房间子集进 CD4。TRBV 的分子的特征补足的决定区域 3 (CDR3 ) 主题用 GMSP 分析被决定。当 GMSP 侧面显示出一座单个山峰时, monoclonally 扩展的 TRBV 基因被克隆并且定序。多重 TRBV 基因的扭曲的扩大在 CD4 + 和 CD8 +T 房间子集和 PBMC 之中被观察。在 CD8 +T 房间子集的 monoclonally 扩展的 TRBV 基因的频率比 CD4 +T 房间子集和 PBMC 的显著地高。比作 TRBV 基因家庭, TRBV11, BV15 和 BV20 的另外的成员主要在恢复 AHI 题目在外部血淋巴细胞的全部剧目被表示。TRBV5.1 和 BV20 CDR3 的相对保存的氨基酸主题也在 CD4 + 和 CD8 +T 房间子集被检测。这些结果在恢复 AHI 题目表明多重偏导的 TRBV 家庭的存在。特别从 CD8 +T 房间子集, TRBV11, BV15 和 BV20 可能与有 AHI 的题目的致病相关。有相对保存的 CDR3 主题的优先地选择的 TRBV5.1 和 BV20 可以是为长期的 HBV 感染的个性化的处理的潜在的目标。 | Jiezuan Yang | 2014 | Cellular & Molecular Immunology2014，11，4： | 6 |
| 3 | Genome wide abnormal DNA methylome of human blastocyst in assisted reproductive technology显示文摘Proper reprogramming of parental DNA methylomes is essential for mammalian embryonic development.However,it is unknown whether abnormal methylome reprogramming occurs and is associated with the failure of embryonic development.Here we analyzed the DNA methylomes of 57 blastocysts and 29 trophectoderm samples with different morphological grades during assisted reproductive technology(ART) practices.Our data reveal that the global methylation levels of high-quality blastocysts are similar(0.30 ± 0.02,mean ± SD).while the methylation levels of low-quality blastocysts are divergent and away from those of high-quality blastocysts.The proportion of blastocysts with a methylation level falling within the range of 0.30 ± 0.02 in different grades correlates with the live birth rate for that grade.Moreover,abnormal methylated regions are associated with the failure of embryonic development.Furthermore,we can use the methylation data of cells biopsied from trophectoderm to predict the blastocyst methylation level as well as to detect the aneuploidy of the blastocysts.Our data indicate that global abnormal methylome reprogramming often occurs in human embryos,and suggest that DNA methylome is a potential biomarker in blastocyst selection in ART. | Guoqiang Li Yang Yu Yong Fan Congru Li Xiaocui Xu Jialei Duan Rong Li Xiangjin Kang Xin Ma Xuepeng Chen Yuwen Ke Jie Yan Ying Lian Ping Liu Yue Zhao Hongcui Zhao Yaoyong Chen Xiaofang Sun Jianqiao Liu Jie Qiao Jiang Liu | 2017 | Journal of Genetics and Genomics2017，44，10： | 5 |
| 4 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 5 | Prognostic Nomogram for Patients with Hepatitis E Virus-related Acute Liver Failure:A Multicenter Study in China显示文摘Background and Aims:Timely and effective assessment scoring systems for predicting the mortality of patients with hepatitis E virus-related acute liver failure(HEV-ALF)are urgently needed.The present study aimed to establish an effective nomogram for predicting the mortality of HEV-ALF patients.Methods:The nomogram was based on a cross-sectional set of 404 HEV-ALF patients who were identified and enrolled from a cohort of 650 patients with liver failure.To compare the performance with that of the model for end-stage liver disease(MELD)scoring and CLIF-Consortiumacute-on-chronic liver failure score(CLIF-C-ACLFs)models,we assessed the predictive accuracy of the nomogram using the concordance index(C-index),and its discriminative ability using time-dependent receiver operating characteristics(td-ROC)analysis,respectively.Results:Multivariate logistic regression analysis of the development set carried out to predict mortality revealed that γ-glutamyl transpeptidase,albumin,total bilirubin,urea nitrogen,creatinine,international normalized ratio,and neutrophil-to-lymphocyte ratio were independent factors,all of which were incorporated into the new nomogram to predict the mortality of HEV-ALF patients.The area under the curve of this nomogram for mortality prediction was 0.671(95%confidence interval:0.602-0.740),which was higher than that of the MELD and CLIF-C-ACLFs models.Moreover,the td-ROC and decision curves analysis showed that both discriminative ability and threshold probabilities of the nomogram were superior to those of the MELD and CLIF-C-ACLFs models.A similar trend was observed in the validation set.Conclusions:The novel nomogram is an accurate and efficient mortality prediction method for HEV-ALF patients. | Jian Wu Cuifen Shi Xinyu Sheng Yanping Xu Jinrong Zhang Xinguo Zhao Jiong Yu Xinhui Shi Gongqi Li Hongcui Cao Lanjuan Li | 2021 | Journal of Clinical and Translational Hepatology2021，9，6： | 2 |
| 6 | Human bone marrow mesenchymal stem cell‐derived hepatocytes express tissue inhibitor of metalloproteinases 4 and follistatin显示文摘 | Jiaojiao Xin Wenchao Ding Shaorui Hao Longyan Jiang Qian Zhou Tianzhou Wu Dongyan Shi Hongcui Cao Lanjuan Li Jun Li | 2015 | Liver Int2015，，10： | 1 |
| 7 | Establishment and characterization of immortalized human hepatocyte cell line for applications in bioartificial livers显示文摘 | XiaoPing Pan JianZhou Li WeiBo Du XiaoPeng Yu ChunXia Zhu ChengBo Yu HongCui Cao YiMin Zhang Yu Chen LanJuan Li | 2012 | Biotechnology Letters2012，，12： | 1 |
| 8 | Co‐culture with mesenchymal stem cells enhances metabolic functions of liver cells in bioartificial liver system显示文摘 | Ying Yang Jianzhou Li Xiaoping Pan Pengcheng Zhou Xiaopeng Yu Hongcui Cao Yingjie Wang Lanjuan Li | 2012 | Biotechnol Bioeng2012，，3： | 1 |
| 9 | Subtypes of irritable bowel syndrome on Rome III criteria: A multicenter study显示文摘 | XinYao Yun ShengYang Li HongCui Ka BingZhao Zhen HuaZhang Li HuaPeng XuGuo GangSun JunShang Wei FengWang JiaFeng QiyangHuang | 2012 | Journal of Gastroenterology and Hepatology2012，，4： | 1 |
| 10 | Chromatin accessibility landscapes revealed the subgenome-divergent regulation networks during wheat grain development显示文摘Development of wheat(Triticum aestivum L.)grain mainly depends on the processes of starch synthesis and storage protein accumulation,which are critical for grain yield and quality.However,the regulatory network underlying the transcriptional and physiological changes of grain development is still not clear.Here,we combined ATAC-seq and RNA-seq to discover the chromatin accessibility and gene expression dynamics during these processes.We found that the chromatin accessibility changes are tightly associated with differential transcriptomic expressions,and the proportion of distal ACRs was increased gradually during grain development.Specific transcription factor(TF)binding sites were enriched at different stages and were diversified among the 3 subgenomes.We further predicted the potential interactions between key TFs and genes related with starch and storage protein biosynthesis and found different copies of some key TFs played diversified roles.Overall,our findings have provided numerous resources and illustrated the regulatory network during wheat grain development,which would shed light on the improvement of wheat yields and qualities. | Hongcui Pei Yushan Li Yanhong Liu Pan Liu Jialin Zhang Xueni Ren Zefu Lu | 2023 | aBIOTECH2023，4，1： | 1 |
| 11 | Ginsenoside Rb1 inhibits oxidative stress-induced ovarian granulosa cell injury through Akt-FoxO1 interaction显示文摘Ginsenoside Rb1 shows a strong antioxidant effect and has potential activation effects on Akt.The aim of the present study was to investigate the protective effect of Rb1 on age-related ovarian granulosa cell injury.Ovarian granulosa cells(GCs)were obtained from 50 young women(≤30 years)and 50 aged women(≥38 years)at an IVF center.Young and aged ICR mice were administered with or without Rb1(10 mg kg^(-1),i.p.)for 2 weeks.The protective effects of Rb1 were investigated and the role of Rb1 on the modulation of Akt-FoxO1 interaction was determined with immunofluorescence,Western blotting,immunoprecipitation,si RNA silencing and pharmacological inhibitor.Rb1 effectively decreased LDH and MDA,and reversed the apoptotic-related protein levels in h GL cells from old patients.Similar results were found in mice.In addition,the mitochondrial membrane potential was restored and the overaccumulation of ROS was reversed by Rb1.Rb1 preserved peroxide-impaired Akt activation,to some extent,by increasing phosphorylation at Ser473.Rb1 also facilitated p-Akt binding to FoxO1 and promoted the phosphorylation of FoxO1.Si RNA silencing of Akt,Akt inhibitor LY294002,and FoxO1 inhibitor AS1842856 attenuated the effects of Rb1.Ginsenoside Rb1 inhibits age-related GCs oxidative damage by activating Akt phosphorylation at Ser473 and by further interaction with FoxO1. | Ping Zhou Feng Deng Zi Yang Canhui Cao Hongcui Zhao Fenting Liu Ke Zhong Lin Fu Tianliu Peng Di Sun Hui Liu Rong Li Yang Yu | 2022 | Science China(Life Sciences)2022，65，11： | 1 |
| 12 | Improving the interfacial contact between CH_3NH_3PbI_(3–x)Cl_x and Au by LiTFSI solution treatment for efficient photoelectric devices显示文摘Organic lead halide compounds with perovskite structure become a promising photovoltaic material for lowcost thin film solar cells in recent years. The property of perovskite/metal interface is a fundamental topic for the effective charge transfer at metal electrodes. In this work, we develop an interface modification method of lithium bis(trifluoromethane sulfonimide)(Li TFSI) solution treatment, which can effectively decrease the charge transfer resistance at the CH_3NH_3PbI_(3 –x)Cl_x/Au interface. After the solution treatment, uniform nanodots are formed at the surface of CH_3NH_3PbI_(3–x)Cl_x films, and the barrier height at CH_3NH_3PbI_(3 –x)Cl_x/Au interface reduces from 0.51 V to 0.08 V. As a consequence, the efficiency of hole conductor free solar cells with CH_3NH_3PbI_(3 –x)Cl_x harvester increase from 4.0% to 7.6% under one sun condition. It is also found that the hole conductor free perovskite solar cell can work in a photodetector mode, which has the same output properties with phototransistors. After the Li TFSI solution treatment, the sensitivity of this photodetector can be improved for about one time. | Xiang Xia Hongcui Li Yanhua Li Cailong Liu Xizhe Liu | 2015 | Journal of Energy Chemistry2015，24，6： | 0 |
| 13 | Powdery mildew disease resistance and markerassisted screening at the Pm60 locus in wild diploid wheat Triticum urartu显示文摘Triticum urartu,a diploid wild wheat and progenitor of the A genome of bread wheat,is an important resource for resistance to powdery mildew fungus caused by Blumeria graminis f.sp.tritici(Bgt).In the present study we systematically characterized the interaction between the Bgt fungus and T.urartu at the microscopic level.We also tested 227 T.urartu accessions for reaction to Bgt isolate E09 and discovered previously uncategorized powdery mildew resistance in this collection.Pm60 is a CC-NB-LRR type powdery mildew resistance gene that has at least three functional alleles,Pm60,Pm60a,and Pm60b.A marker-assisted screen targeting the Pm60 locus identified a non-functional allele of Pm60a,designated as Pm60a′.A sequence comparison of Pm60a′and Pm60a revealed that they differed by 58 SNPs and one 3-nucleotide deletion.Based on the sequence variations two molecular markers were developed to differentiate the functional Pm60a allele from the non-functional Pm60a′.Our screen revealed the presence of a previously uncharacterized powdery mildew resistance in T.urartu and provides new insights into the Pm60 locus.We believe that the two molecular markers developed here and new T.urartu resistant accessions will facilitate further identification of novel powdery mildew resistance genes and benefit breeding for powdery mildew resistance. | Fukai Zhao Yinghui Li Baoju Yang Hongbo Yuan Cong Jin Lixun Zhou Hongcui Pei Lifang Zhao Yiwen Li Yilin Zhou Jiankun Xie Qian-Hua Shen | 2020 | The Crop Journal2020，8，2： | 0 |
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