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| 1 | Durability of neutralizing antibodies and T-cell response post SARS-CoV-2 infection显示文摘The ongoing pandemic of coronavirus disease 19(COVID-19)is caused by a newly discoveredβcoronavirus named severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).How long the adaptive immunity triggered by SARS-CoV-2 can last is of critical clinical relevance in assessing the probability of second infection and efficacy of vaccination.Here we examined,using ELISA,the IgG antibodies in serum specimens collected from 17 COVID-19 patients at 6–7 months after diagnosis and the results were compared to those from cases investigated 2 weeks to 2 months post-infection.All samples were positive for IgGs against the S-and N-proteins of SARS-CoV-2.Notably,14 samples available at 6–7 months post-infection all showed significant neutralizing activities in a pseudovirus assay,with no difference in blocking the cell-entry of the 614D and 614G variants of SARS-CoV-2.Furthermore,in 10 blood samples from cases at 6–7 months post-infection used for memory T-cell tests,we found that interferonγ-producing CD4+and CD8+cells were increased upon SARS-CoV-2 antigen stimulation.Together,these results indicate that durable anti-SARS-CoV-2 immunity is common in convalescent population,and vaccines developed from 614D variant may offer protection from the currently predominant 614D variant of SARS-CoV-2. | Yun Tan Feng Liu Xiaoguang Xu Yun Ling Weijin Huang Zhaoqin Zhu Mingquan Guo Yixiao Lin Ziyu Fu Dongguo Liang Tengfei Zhang Jian Fan Miao Xu Hongzhou Lu Saijuan Chen | 2020 | Frontiers of Medicine2020，14，6： | 6 |
| 2 | Distinct immune signatures discriminate between asymptomatic and presymptomatic SARS-CoV-2^(pos)subjects显示文摘Increasing numbers of SARS-CoV-2-positive(SARS-CoV-2^(pos))subjects are detected at silent SARS-CoV-2 infection stage(SSIS).Yet,SSIS represents a poorly examined time-window wherein unknown immunity patterns may contribute to the fate determination towards persistently asymptomatic or overt disease.Here,we retrieved blood samples from 19 asymptomatic and 12 presymptomatic SARS-COV-2^(pos)subjects,47 age/gender-matched patients with mild or moderate COVID-19 and 27 normal subjects,and interrogated them with combined assays of 44-plex CyTOF,RNA-seq and Olink.Notably,both asymptomatic and presymptomatic subjects exhibited numerous readily detectable immunological alterations,while certain parameters including more severely decreased frequencies of CD107a^(low)classical monocytes,intermediate monocytes,non-classical monocytes and CD62L^(hi)CD8^(+)Tnaive cells,reduced plasma STC1 level but an increased frequency of CD4^(+)NKT cells combined to distinguish the latter.Intercorrelation analyses revealed a particular presymptomatic immunotype mainly manifesting as monocytic overactivation and differentiation blockage,a likely lymphocyte exhaustion and immunosuppression,yielding mechanistic insights into SSIS fate determination,which could potentially improve 5ARS-CoV-2 management. | Shanhe Yu Caixia Di Shijun Chen Mingquan Guo Jiayang Yan Zhaoqin Zhu Li Liu Ruixue Feng Yinyin Xie Ruihong Zhang Juan Chen Mengxi Wang Dong Wei Hai Fang Tong Yin Jinyan Huang Saijuan Chen Hongzhou Lu Jiang Zhu Jieming Qu | 2021 | Cell Research2021，31，11： | 4 |
| 3 | Biocontrol of Rhizoctonia solani Kühn Using Fermentative Solution of Streptomyces corchorusii Strain NF0919显示文摘A strain of Streptomyces corchorusii( NF0919) antagonistic to Rhizoctonia solani Kühn was isolated,which produced alkyl glycoside with high antifungal activity. To investigate the antifungal activity of Streptomyces corchorusii strain NF0919,the treatments amended with the non-sterilized supernatant resulted in the highest growth inhibition rate of about 100% at a concentration of 20%. The antifungal compound,which inhibited the growth of Rhizoctonia solani Kühn,was extracted by Et OAC and purified by silica gel,Sephadex LH-20 column,and HPLC,where an active fraction was confirmed by LC-MS and NMR techniques. These results suggested that NF0919 had a high potential in the biocontrol of Rhizoctonia solani Kühn,which was mainly due to surface active agent APG. | Jinghui YANG Wenwen ZHANG Hongzhou CHEN Ting XIAO Qinyan WU | 2015 | Agricultural Biotechnology2015，4，1： | 3 |
| 4 | Evaluation of Epstein-Barr Virus Salivary Shedding in HIV/AIDS Patients and HAART Use: A Retrospective Cohort Study显示文摘Little data is available on the evaluation of the occurrence rates of Epstein-Barr virus(EBV) in saliva and relationship with highly active antiretroviral therapy(HAART) use in HIV/AIDS patients in China. We conducted a retrospective cohort study of EBV serological tests for HIV/AIDS patients who were treated in the hospitals for infectious diseases in Wuxi and Shanghai, China from May 2016 to April 2017. The EBV-seropositive samples were identified by ELISA. EBV-specific primers and probes were used for the quantitative detection of viral DNA from saliva via quantitative real-time polymerase chain reaction. CD4 cell counts of the HIV/AIDS patients were detected by a flow cytometry. A total of 372 HIV/AIDS patients were ultimately selected and categorized for this retrospective cohort study. For EBV IgG and IgM, the HIV/AIDS HAART use(H) and non-HAART use(NH) groups had significantly higher seropositive rates than the HIV-negative control group. The HIV/AIDS(NH) group had the highest seropositive rate(IgG, 94.27%; IgM, 68.98%) and the highest incidence of EBV reactivation or infection. For salivary EBV DNA-positive rates and quantities, the HIV/AIDS(H)(73.69%) and the HIV/AIDS(NH)(100%) groups showed significantly higher values than the HIV-negative control group(35.79%,[ twofold). Further, the salivary EBV DNA-negative population had significantly higher CD4 cell counts than the EBV DNA-positive population in the HIV/AIDS(H) group and the HIV/AIDS(NH) groups. Thus, HAART use is beneficial in decreasing the EBV salivary shedding in HIV/AIDS patients and indirectly decreases EBV transmission risk. | Yan Yan Yong Ren Renfang Chen Jing Hu Yongjia Ji Junyang Yang Jiayin Shen Lvyin Hu Hao Pei Jun Wang Yuanwang Qiu Hongzhou Lu Lihua Huang | 2018 | Virologica Sinica2018，33，3： | 3 |
| 5 | Hymecromone:a clinical prescription hyaluronan inhibitor for efficiently blocking COVID-19 progression显示文摘Currently,there is no effective drugs for treating clinically COVID-19 except dexamethasone.We previously revealed that human identical sequences of SARS-CoV-2 promote the COVID-19 progression by upregulating hyaluronic acid(HA).As the inhibitor of HA synthesis,hymecromone is an approved prescription drug used for treating biliary spasm.Here,we aimed to investigate the relation between HA and COVID-19,and evaluate the therapeutic effects of hymecromone on COVID-19.Firstly,HA was closely relevant to clinical parameters,including lymphocytes(n=158;r=−0.50;P<0.0001),C-reactive protein(n=156;r=0.55;P<0.0001),D-dimer(n=154;r=0.38;P<0.0001),and fibrinogen(n=152;r=0.37;P<0.0001),as well as the mass(n=78;r=0.43;P<0.0001)and volume(n=78;r=0.41;P=0.0002)of ground-glass opacity,the mass(n=78;r=0.48;P<0.0001)and volume(n=78;r=0.47;P<0.0001)of consolidation in patient with low level of hyaluronan(HA<48.43 ng/mL).Furthermore,hyaluronan could directly cause mouse pulmonary lesions.Besides,hymecromone remarkably reduced HA via downregulating HAS2/HAS3 expression.Moreover,89%patients with hymecromone treatment had pulmonary lesion absorption while only 42%patients in control group had pulmonary lesion absorption(P<0.0001).In addition,lymphocytes recovered more quickly in hymecromone-treated patients(n=8)than control group(n=5)(P<0.05).These findings suggest that hymecromone is a promising drug for COVID-19 and deserves our further efforts to determine its effect in a larger cohort. | Shuai Yang Yun Ling Fang Zhao Wei Li Zhigang Song Lu Wang Qiuting Li Mengxing Liu Ying Tong Lu Chen Daoping Ru Tongsheng Zhang Kaicheng Zhou Baolong Zhang Peng Xu Zhicong Yang Wenxuan Li Yuanlin Song Jianqing Xu Tongyu Zhu Fei Shan Wenqiang Yu Hongzhou Lu | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 2 |
| 6 | LOGIC STRUCTURE OF PROGRAMMABLE INSTRUCTIONS FOR JAVA PROCESSORS显示文摘There are varieties of embedded systems in the world. It is a big challenge to optimize the instruction sets of System on Chips (SoCs) according to different systems' working environments. The idea of programmable instruction set is an effective method to gain embedded system's re-configurability. This letter presents a logic module for Java processor to be capable of using programmable instruction set. Cost (area, power, and timing) of the module is trivial. Such module is also reusable for other embedded system solutions besides Java systems. | Chen Zhirui Tan Hongzhou | 2009 | Journal of Electronics(China)2009，26，5： | 2 |
| 7 | N,P-codoped porous carbon derived from chitosan with hierarchical N-enriched structure and ultra-high specific surface Area toward high-performance supercapacitors显示文摘In this work,a facile'carbonization-activation'strategy is developed to synthesize N,P-codoped hierarchical porous carbon.Phosphoric acid is innovatively introduced during the hydrothermal process to achieve in-situ P doping as well as create abundant pores,and the employment of sodamide is of vital importance to simultaneously serve as activating agent and N-source to succeed a high-level N doping.Thus,the obtained samples exhibit a unique three-dimensional hierarchical structure with an ultra-high specific surface area(3646 m^(2)g^(-1))and ultra-high N-doping level(9.81 at.%).Computational analyses confirm that N,P co-doping and higher N content can enhance active sites and widen potential differences of carbon materials to improve their capacitance.The as-prepared carbon materials demonstrate superior electrochemical performances,such as an ultra-high capacitance of 586 Fg^(-1)at 1 Ag^(-1),a superior rate capability of 409 Fg^(-1)at 20 Ag^(-1),and excellent long-term stability of 97%capacitance retention after10,000 cycles in 6 M KOH.Moreover,an assembled symmetric supercapacitor delivers a high energy density of 28.1 Wh kg^(-1)at the power density of 450 W kg^(-1)in 1 M Na_(2)SO_(4),demonstrating a great potential for applications in supercapacitors. | Xipeng Xin Na Song Ruiming Jia Bingnan Wang Hongzhou Dong Shuai Ma Lina Sui Yingjie Chen Qian Zhang Lifeng Dong Liyan Yu | 2021 | Journal of Materials Science & Technology2021，，29： | 2 |
| 8 | Microinterface intensification in hydrogenation and air oxidation processes显示文摘Hydrogenations and air oxidations usually have low apparent reaction rate,generally controlled by mass transfer rate,and widely exist in the modern chemical manufacturing process.The key to increase the mass transfer rate is the reduction of the liquid film resistance 1/kLa.In this work,the original concept of microinterface intensification for mass transfer and then for these reactions has been proposed.We derived the regulation model and set up the mathematical calculation method of micron-scale gas-liquid interface structure on mass transfer and reaction,designed the mechanical energy exchange device that can produce gas-liquid microinterface system on a large scale,and established the OMIS system which is able on line to measure the diameter and distribution of millions of microbubbles,interface area a and mass transfer film thicknessδM,as well as developed a series of microinterface intensified reactor systems(MIRs)for the applications of hydrogenation and air oxidation processes.It is believed that this research will provide an up-to-date development for the intensification of hydrogenation and air oxidation reactions. | Hongliang Qian Hongzhou Tian Guoqiang Yang Gaodong Yang Lei Li Feng Zhang Zheng Zhou Weihua Huang Yufu Chen Zhibing Zhang | 2022 | Chinese Journal of Chemical Engineering2022，，10： | 2 |
| 9 | Association between sleep duration and incidence of type 2 diabetes in China: the REACTION study显示文摘Backgrounds: Inadequate sleep duration is associated with a higher risk of type 2 diabetes and the relationship is nonlinear. We aim to assess the curve relationship between night sleep duration and the incidence of type 2 diabetes in China.Methods: A cohort of 11,539 participants from the REACTION study without diabetes at baseline (2011) were followed until 2014 for the development of type 2 diabetes. The average number of hours of sleep per night was grouped. Incidence rates and odds ratios (ORs) were calculated for the development of diabetes in each sleep duration category.Results: Compared to people who sleep for 7 to 8 h/night, people with longer sleep duration (≥9 h/night) had a greater risk of type 2 diabetes (OR: 1.27;95% CI: 1.01-1.61), while shorter sleep (<6 h/night) had no significant difference in risk of type 2 diabetes. When the dataset was stratified based on selected covariates, the association between type 2 diabetes and long sleep duration became more evident among individuals <65 years of age, male, body mass index <24 kg/m2 or with hypertension or hyperlipidemia, no interaction effects were observed. Furthermore, compared to people persistently sleeping 7 to 9 h/night, those who persistently slept ≥9 h/night had a higher risk of type 2 diabetes. The optimal sleep duration was 6.3 to 7.5 h/night.Conclusions: Short or long sleep duration was associated with a higher risk of type 2 diabetes. Persistently long sleep duration increased the risk. | Hongzhou Liu Gang Chen Junping Wen Anping Wang Yimin Mu Jingtao Dou Weijun Gu Li Zang Saichun Zhang Zhaohui Lyu | 2022 | Chinese Medical Journal2022，，10： | 1 |
| 10 | Analysis of Error Yielded by Scalar Approximation to the Properties of Laser Diode Beams显示文摘 | Dong Hongzhou Shi Shunxiang Chen Shouman | 2006 | Appl Opt2006，45，21： | 1 |
| 11 | Effect of Extrusion Parmeters on Physicochemical Properties of Hybrid Indica Rice (Type9718) Extudates显示文摘 | HAINING ZHUANG HONGZHOU AN HANQING CHEN | 2010 | Journal of Food Processing and Preservation2010，34，6： | 1 |
| 12 | Body Size but Not Food Size Determined Head Sexual Dimorphism in Rana kukunoris from the Tibetan Plateau显示文摘Sexual dimorphism between males and females is a common pattern observed in the natural world and has become one of the main focuses of evolutionary biology.Amphibian head size and shape are important factors that may influence food acquisition,but knowledge about the sexual differences between amphibian head size and shape is relatively scant.Here,intersexual differences in the head size and shape of Rana kukunoris,which is a high-elevation frog from the Qinghai-Tibet Plateau,were investigated.Significant differences were found in the head shape but not the head size between sexes.A significant correlation was also observed between prey size and head size.However,these correlations disappeared when individual body size was controlled,suggesting that body size but not food size was the main factor resulting in intersexual differences in head size/shape.The results suggested that food competition between sexes did not result in sexual dimorphism of head shape among these frogs. | Hongzhou CHEN Haifen QIN Zhenkun ZHAO Jiahong LIAO Yanfang WU Xueyan LIU Lichun JIANG Buddhi DAYANANDA Wei CHEN | 2023 | Asian Herpetological Research2023，14，2： | 1 |
| 13 | VOICE ACTIVITY DETECTION UNDER RAYLEIGH DISTRIBUTION显示文摘This paper presents an improved Voice Activity Detection (VAD) algorithm which uses the Signal-to-Noise Ratio (SNR) measure. We assume that noise Power Spectral Density (PSD) in each spectral bin follows a Rayleigh distribution. Rayleigh distributions with its asymmetric tail charac- teristics give a better description of the noise PSD distribution than Gaussian distribution. Under this assumption, a new threshold updating expression is derived. Since the analytical integral of the false alarm probability, the threshold updating expression can be represented without the inverse comple- mentary error function and low computational complexity is achieved in our system. Experimental results show that the proposed VAD outperforms or at least is comparable with the VAD scheme presented by Davis under several noise environments and has a lower computational complexity. | Li Yu Chen Jianming Tan Hongzhou | 2009 | Journal of Electronics(China)2009，26，4： | 1 |
| 14 | Effect of extrusion parameters on physieoehemieal properties of hybrid indica rice (Type 9718) extrudates显示文摘 | Zhuang Haining An Hongzhou Chen Hanqing | 2010 | Journal of Food Processing and Preservation2010，34，6： | 1 |
| 15 | DESIGN OF A SYSTEM SOFTWARE BASED ON A JAVA SOC PROCESSOR显示文摘Java technology is spreading rapidly all over the world in recent years. It is a popular application development language for its well-encapsulation, platform-independent and high security. There are great amounts of Java games and other gadgets on mobile platforms, as well as on set-up-box systems. As Java applications become more sophisticated, the Java Virtual Machine (JVM) mid-dle-wares in embedded systems are not satisfying, Java-specific chips extend in the market. All existing Java-based system software or Operating System (OS) are used on JVM, they cannot be used on Java processors. It is important to develop a pure Java system software or OS so that embedded systems using Java processors will have great performance in Java applications. This paper presents a set of system software designed for a Java-specified processor VP6K, which is also a System-on-Chip (SoC). This system software includes real-time multitask dispatching, file management, device management, hardware drivers, and infrastructural Application Programming Interface (APIs). According to ex-perimental results, the system software provides interfaces for Java programs to fully handle CPU resource, so that all applications can be executed properly and efficiently. VP6K embedded platform shows its good performance for Java applications when the system software is implemented. | Chen Zhirui Lin Chunyou Tan Hongzhou | 2010 | Journal of Electronics(China)2010，27，6： | 1 |
| 16 | Research and Application of Lightweight Index for Passenger Cars显示文摘Lightweight is an effective design strategy to conserve energy in automotive vehicles.It is a big challenge to evaluate the level of lightweight for passenger cars.This paper summarizes various evaluation methods for lightweight automotive vehicles.A lightweight index[Lv for internal combustion engine vehicles(ICEVs)and Lev for battery electric vehicles(BEVs)]is proposed to assess the lightweight of passenger cars.The proposed lightweight index is composed of the nominal density,weight-to-power ratio,and fuel consumption of footprint area(in the case of ICEVs)or electricity consumption of footprint area(in the case of BEVs).The validity and universality of the proposed lightweight index are demonstrated through a statis-tical analysis of 7018 ICEV and 326 BEV models.The calculation procedures of the standard partial regression coefficients of statistical multiple regression and elastic coefficients are employed in the proposed method.The results show that either Lv or Lev is most sensitive to the curb mass of the vehicles.The proposed lightweight index can help guide automakers in setting reasonable weight reduction targets during new product development.In addition,the proposed lightweight index can be applied to new hybrid electric vehicles with further efforts,to facilitate the development of lightweight automotive design. | Jun Li Ligang Wang Yunxia Chen Hongzhou Lu Haitao Jiang | 2020 | Automotive Innovation2020，3，3： | 1 |
| 17 | A SARS-CoV-2 antibody retains potent neutralization against Omicron by targeting conserved RBM residues显示文摘The newly emerged Omicron(B.1.1.529)variant of SARS-CoV-2 is quickly overtaking the Delta variant and becoming the dominant strain around the world due to its enhanced transmissibility and high immune escape potential[1,2].Compared to the Wuhan strain,the Omicron variant carries 37 spike mutations,of which 15 are within the receptor-binding domain(RBD)(Fig.1A).A high mutation rate is associated with remarkable resistance to current vaccines and RBD-specific antibody therapeutics[2,3,4]. | Chunyan Yi Zhiyang Ling Xiao Lu Yadong Fu Zhuo Yang Sonam Wangmo Shuangfeng Chen Yaguang Zhang Liyan Ma Wangpeng Gu Hongzhou Lu Xiaoyu Sun Bing Sun | 2022 | Cellular & Molecular Immunology2022，19，5： | 1 |
| 18 | Effect of extrusion parameters on physicochemical properties of hybrid indica rice (type 9718) extrudates显示文摘 | Zhuang Haining An Hongzhou Chen Hanqing | 2010 | Journal of Food Processing and Preservation2010，34，6： | 1 |
| 19 | In vitro crevice corrosion of biodegradable magnesium in different solutions显示文摘Magnesium(Mg)is a promising biomedical metal because of its biodegradability.The crevice between tissue and Mg implant can not be neglected in some implantation sites due to inducing crevice corrosion of Mg.In this paper,a new single mold was designed to build the in vitro experimental setup and four kinds of solutions,i.e.the deionized water(DW),the 0.9 wt.%sodium chloride solution(NaCl),the phosphate buffer saline(PBS)and the modified simulated body fluid(m-SBF)were used to explore necessary factors of crevice corrosion in Mg.It was observed that crevice corrosion in Mg sheets would occur in NaCl and PBS solution under 0.2,0.5 and 0.8 mm crevice thickness.And it was found that there were two necessary factors,i.e.chloride ion and crevice dimension,in crevice corrosion.For the high-purity Mg cannulated screws,crevice corrosion could occur inside tunnel when immersed in PBS. | Bowei Chen Hongliu Wu Ruibang Yi Wenhui Wang Haidong Xu Shaoxiang Zhang Hongzhou Peng Junwei Ma Haomiao Jiang Rui Zan Shuang Qiao Yu Sun Peng Hou Pei Han Jiahua Ni Xiaonong Zhang | 2020 | Journal of Materials Science & Technology2020，52，17： | 0 |
| 20 | Geology, environment, and life in the deepest part of the world’s oceans显示文摘The hadal zone,mostly comprising of deep trenches and constituting of the deepest part of the world’s oceans,represents the least explored habitat but one of the last frontiers on our planet.The present scientific understanding of the hadal environment is still relatively rudimentary,particularly in comparison with that of shallower marine environments.In the last 30 years,continuous efforts have been launched in deepening our knowledge regarding the ecology of the hadal trench.However,the geological and environmental processes that potentially affect the sedimentary,geochemical and biological processes in hadal trenches have received less attention.Here,we review recent advances in the geology,biology,and environment of hadal trenches and offer a perspective of the hadal science involved therein.For the first time,we release highdefinition images taken by a new full-ocean-depth manned submersible Fendouzhe that reveal novel species with an unexpectedly high density,outcrops of mantle and basaltic rocks,and anthropogenic pollutants at the deepest point of the world’s ocean.We advocate that the hydration of the hadal lithosphere is a driving force that influences a variety of sedimentary,geochemical,and biological processes in the hadal trench.Hadal lithosphere might host the Earth’s deepest subsurface microbial ecosystem.Future research,combined with technological advances and international cooperation,should focus on establishing the intrinsic linkage of the geology,biology,and environment of the hadal trenches. | Mengran Du Xiaotong Peng Haibin Zhang Cong Ye Shamik Dasgupta Jiwei Li Jiangtao Li Shuangquan Liu Hengchao Xu Chuanxu Chen Hongmei Jing Hongzhou Xu Jun Liu Shunping He Lisheng He Shanya Cai Shun Chen Kaiwen Ta | 2021 | The Innovation2021，2，2： | 0 |
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